A obra de Edmundo Tavares no Funchal

Dissertação apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Arquitetura e UrbanismoA presente dissertação é resultado duma investigação sobre a obra do arquiteto Edmundo Tavares no Funchal. O trabalho realizado tem como intuito a conclusão do Mestrado Integrado em Arquitetura e Urbanismo, pela Universidade Fernando Pessoa. A obra deste arquiteto na cidade do Funchal é de importância maior, e pouco divulgada, nomeadamente face ao legado que esta constitui, e do corolário do mesmo, no progresso da arquitetura moderna na Ilha da Madeira. O primordial objetivo desta dissertação é levantar e analisar a produção arquitetónica do autor nos anos em que viveu no Funchal - 1932 a 1939 - particularmente através do levantamento arquivístico, tão exaustivo quanto possível, da documentação administrativa e da produção escrita com ela relacionada, sustentando essa análise numa contextualização histórica alargada. Esta investigação permitiu perceber e precisar documentalmente um percurso estilístico próprio, e uma produção grandemente ignorada. Numa fase de mudança de tendências arquitetónicas, Edmundo Tavares consegue ser um caso típico e ao mesmo tempo único da arquitetura portuguesa na década de 30 do século XX. The following dissertation is the result of the study of the work of the architect Edmundo Tavares in Funchal. The research conducted concludes my integrated master's degree program in Architecture and Urban Planning, followed at Fernando Pessoa University. The legacy left by this architect on Funchal is often underestimated and is poorly known, all the more so in face of the bulk of his production, and its consequences, bearing a substantial value on the evolution of the modern architecture on Madeira island. The foremost goal of this thesis is to list and analyze the architectural production of the architect in the years that he lived in Funchal - from 1932 to 1939 - particularly through archive survey, as thorough as possible, of administrative documentation related to his works, as well as his written testimony on architecture, and to ground an analysis on a broad historical context. The research allowed an understanding of a personal stylistic path and a largely ignored architectural heritage, and provided objective information about it. In a moment of changing architectural trends, Edmundo Tavares manages to be simultaneously a typical and a unique case within Portuguese architecture of the 1930's

A obra de Edmundo Tavares no Funchal

Dissertação apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Arquitetura e UrbanismoA presente dissertação é resultado duma investigação sobre a obra do arquiteto Edmundo Tavares no Funchal. O trabalho realizado tem como intuito a conclusão do Mestrado Integrado em Arquitetura e Urbanismo, pela Universidade Fernando Pessoa. A obra deste arquiteto na cidade do Funchal é de importância maior, e pouco divulgada, nomeadamente face ao legado que esta constitui, e do corolário do mesmo, no progresso da arquitetura moderna na Ilha da Madeira. O primordial objetivo desta dissertação é levantar e analisar a produção arquitetónica do autor nos anos em que viveu no Funchal - 1932 a 1939 - particularmente através do levantamento arquivístico, tão exaustivo quanto possível, da documentação administrativa e da produção escrita com ela relacionada, sustentando essa análise numa contextualização histórica alargada. Esta investigação permitiu perceber e precisar documentalmente um percurso estilístico próprio, e uma produção grandemente ignorada. Numa fase de mudança de tendências arquitetónicas, Edmundo Tavares consegue ser um caso típico e ao mesmo tempo único da arquitetura portuguesa na década de 30 do século XX. The following dissertation is the result of the study of the work of the architect Edmundo Tavares in Funchal. The research conducted concludes my integrated master's degree program in Architecture and Urban Planning, followed at Fernando Pessoa University. The legacy left by this architect on Funchal is often underestimated and is poorly known, all the more so in face of the bulk of his production, and its consequences, bearing a substantial value on the evolution of the modern architecture on Madeira island. The foremost goal of this thesis is to list and analyze the architectural production of the architect in the years that he lived in Funchal - from 1932 to 1939 - particularly through archive survey, as thorough as possible, of administrative documentation related to his works, as well as his written testimony on architecture, and to ground an analysis on a broad historical context. The research allowed an understanding of a personal stylistic path and a largely ignored architectural heritage, and provided objective information about it. In a moment of changing architectural trends, Edmundo Tavares manages to be simultaneously a typical and a unique case within Portuguese architecture of the 1930's

Environmental forcing of an estuarine gradient of zooplankton abundance and production

Doutoramento em BiologiaOs copépodes são pequenos e frágeis crustáceos que constituem um dos grupos de organismos metazoários mais abundantes do mundo. Em ambientes marinhos e estuarinos, os copépodes assumem um papel de extrema relevância ao nível das cadeias tróficas, nomeadamente na transferência de matéria e energia de níveis tróficos inferiores (fitoplâncton) para níveis tróficos superiores (ex. larvas de peixe). A importância ecológica dos copépodes reflecte-se no elevado número de citações constantes no ISI Web of Knowledge (7716 citações entre 1969 e 2006) e no destaque que os mesmos continuam a possuir em estudos recentes de planctologia marinha e estuarina. Esta dissertação teve como objectivos principais (1) descrever variações espacio-temporais em termos de abundância e biomassa de populações estuarinas de copépodes da Ria de Aveiro (Portugal) e a sua relação com parâmetros hidrológicos (salinidade, temperatura, clorofila a e precipitação; (2) comparar as taxas de crescimento e desenvolvimento de populações alopátricas de copépodes; (3) definir modelos de crescimento dependentes da temperatura para as formas juvenis (nauplius e copepoditos) de Acartia tonsa; (4) avaliar o forçamento ambiental na distribuição e abundância de populações de Acartia e (5) calcular taxas de produção secundária potenciais para as populações de Acartia. Numa primeira fase, foi objecto de estudo a comunidade de copépodes estuarinos, para a qual foram descritos os padrões temporais de abundância e biomassa e obtidas estimativas de produção secundária. Os resultados obtidos neste estudo permitiram concluir que, entre outros aspectos, a abundância e biomassa da comunidade de copépodes da Ria de Aveiro se encontra significativamente correlacionada de modo positivo com a salinidade e com a temperatura da água. As estimativas das taxas de produção secundária derivadas da aplicação de modelos gerais de crescimento mostraram ser algo diferentes, sendo a estimativa dada pelo modelo de Hunthey & Lopez (1992) mais elevada do que a obtida pelo modelo de Hirst & Bunker (2003). O crescimento e desenvolvimento de espécies de Acartia foram estudados sob condições controladas em termos de alimento e temperatura, de forma a serem definidos modelos de crescimento dependentes da temperatura. A partir destes estudos concluiu-se que as populações alopátricas possuem diferentes respostas à temperatura. Além deste aspecto, também se observou que, pelo menos no caso da A.tonsa, as taxas de crescimento das formas juvenis (nauplius e copepoditos) estimadas in situ ou sob condições saturantes de alimento são similares. resumo O forçamento ambiental das populações de Acartia no Canal de Mira foi avaliado através de uma análise de componentes principais (ACP), que permitiu a análise simultânea das alterações espaciais e temporais das diferentes populações. Esta análise identificou três zonas distintas no estuário com base na abundância de Acartia spp.. Para cada zona, análises de correlação com diferentes desfasamentos temporais entre as variáveis ambientais e a abundância de copépodes, permitiram detectar a existência de forçamentos ambientais específicos, assim como um efeito positivo da biomassa fitoplanctónica na abundância do zooplâncton verificada meses mais tarde. Esta tese demonstrou igualmente a grande importância que as populações de Acartia, especialmente a mais abundante – A. tonsa – assumem na transferência de matéria e energia no ambiente planctónico da Ria de Aveiro (Portugal).Copepods are small fragile and tiny crustaceans that form one of the world’s most abundant groups of metazoan organisms. In estuarine and marine environments copepods assume a key role in what trophic chains are concerned, namely in the transfer of matter and energy from lower trophic levels (phytoplankton) to higher trophic levels (ex. fish larvae). Copepods ecological importance is proven by the high number of quotations in ISI Web of Knowledge (7716 quotations between 1969 and 2006) and in the significance that they still have concerning current studies on estuarine and marine planktonic studies. The main goals of the present thesis were (1) to characterize and to describe the spatialtemporal patterns of abundance, biomass and production of the estuarine copepod community from Ria de Aveiro (Portugal) and its relationship with hydrological data (salinity, temperature, chlorophyll a and rainfall regime); (2) to compare growth and developmental rates of allopatric copepod populations; (3) to define temperature dependent growth models for nauplii and copepodites of Acartia tonsa; (4) to evaluate environmental forcing on the distribution and abundance of Acartia populations; and (5) to estimate potential secondary production rates of Acartia populations. In a first stage estuarine copepods community was studied, time patterns of abundance and biomass having been described and estimates of secondary production having been obtained. Results achieved by this study have led us to the conclusion that, among other aspects, abundance and biomass of the copepods community in Ria de Aveiro is positively correlated with water salinity and temperature. Estimates of secondary production rates deriving from the use of general growth models were different, the estimate obtained by Hunthey & Lopez (1992) model being higher than the one resulting from the Hirst & Bunker (2003) one. In order to define specific temperature-dependent copepod growth models, the growth and development of Acartia species were studied under controlled conditions of food and temperature. From those studies it was concluded that allopatric populations have different temperature responses. Additionally, it was also observed that, at least for A.tonsa, the growth rates of nauplii and copepodites at saturated food conditions and in situ conditions of food are similar. Environmental forcing of Acartia populations in Canal de Mira was evaluated by means of 3-mode PCA, which analyses simultaneously spatial and temporal changes of multispecies assemblages. This analysis identified three distinct zones along the estuary based on Acartia spp. abundance. For each zone time-lagged correlations between environmental variables and copepods abundance indicated that different zones were forced by different combinations of variables and the existence of delayed effects of phytoplanktonic biomass on the abundance of A.tonsa. This thesis also demonstrated the high importance that Acartia populations, in particular the most abundant A.tonsa, assume on the transfer of matter and energy in the planktonic realm of Ria de Aveiro (Portugal)

As estruturas de capital nas empresas exportadoras em Portugal

Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Contabilidade e FinançasEste estudo teve como objetivo, identificar os determinantes da estrutura financeira das empresas portuguesas exportadoras para o mercado comunitário, que representa 80% do total das exportações nacionais. Assim, estudaram-se as 250 maiores empresas portuguesas exportadoras nesse segmento de mercado, de modo a identificar os principais condicionantes do financiamento da atividade dessas empresas e que possam dificultar a internacionalização dos competidores internacionais. Estudaram-se os dados económicos e financeiros do exercício mais recente com informação disponível (2015), sendo os resultados obtidos, comparados com os de outros estudos elaborados sobre o mesmo tema. Nos determinantes da estrutura financeira utilizaram-se as seguintes variáveis explicativas: o efeito de alavanca financeiro, a taxa efetiva de imposto, os outros benefícios fiscais, o custo de financiamento, o risco do negócio, a dimensão, as garantias colaterais, a reputação, os ativos intangíveis, a rendibilidade, o crescimento e o setor de atividade. De salientar que estas variáveis foram analisadas tendo em consideração o passivo total, o passivo de médio e longo prazo e o passivo de curto prazo. Os resultados obtidos, demonstraram, que as variáveis custos financeiros, garantias colaterais e rendibilidade (e o efeito de alavanca financeiro que lhe estava associado) eram significativas em todos os modelos estudados, condicionando claramente a estrutura financeira das empresas analisadas. Por outro lado, verificou-se que o risco de negócio, os ativos intangíveis e o ritmo de crescimento, não eram estatisticamente relevantes em nenhum dos modelos. Quanto à variável associada às especificidades dos setores de atividade, evidenciou que as características intrínsecas ao funcionamento de cada tipologia de negócio, condicionam as estruturas financeiras das empresas. Relativamente às restantes variáveis analisadas, não foram significativas em simultâneo nos três modelos utilizados. A taxa efetiva de imposto e a reputação condicionavam o nível de endividamento total e de curto prazo. Os outros benefícios fiscais e a Dimensão apresentavam uma relação significativa apenas com o passivo de médio e longo prazo.This study aimed to identify the determinants of the financial structure of Portuguese exporting companies to the Community market, which represent 80% of total national exports. Thus, we studied the 250 largest Portuguese exporting companies in this market segment, in order to identify the main constraints of the financing of the activity of these companies and that may hinder the internationalization of international competitors. The economic and financial data of the most recent exercise with available information (2015) were studied, and the results obtained, compared to other studies elaborated on the same theme. In the financial structure determinants, the following explanatory variables were used: financial leverage, effective tax rate, other tax benefits, financing cost, business risk, size, collateral guarantees, reputation, intangible assets, profitability, growth and the business sector. It should be noted that these variables were analyzed taking into account total liabilities, medium and long-term liabilities and short-term liabilities. The results showed that the variables financial costs, collateral guarantees and profitability (and associated leverage effect) were significant in all models studied, clearly determining the financial structure of the companies analyzed. On the other hand, it was verified that the business risk, the intangible assets and the growth rate, were not statistically relevant in any of the models. As for the variable associated with the specifics of the activity sectors, it was shown that the intrinsic characteristics of the operation of each type of business, condition the financial structures of the companies. Regarding the remaining variables analyzed, they were not significant simultaneously in the three models used. The effective tax rate and reputation conditioned the level of total and short-term indebtedness. The other tax benefits and the dimension had a significant relationship only with the medium and long-term liabilities

Self‐medication and pain catastrophizing in patients with myofascial pain : are they related?

Evidence shows that acute symptoms of temporomandibular dysfunction (TMD) would eventually lead to chronicity and self‐medication would play a significant interfering role on such dynamics (Dias, Bastos, Alves, & Leite, 2019; Pastore, Goulart, Pastore, Prati, & de Moraes, 2018). Furthermore, some authors concluded that both propensity to catastrophize and depression contribute to the progression of chronic temporomandibular muscle and joint disorders (Velly et al., 2011). Hence, the aim of this study was to assess the relationship between the habit of self‐medicating and the propensity to catastrophize pain in a clinical population with myofascial pain (MP).© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reservedinfo:eu-repo/semantics/publishedVersio

Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli

Background: Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America. It does not cause human disease, but it can be mistaken for the etiologic agent of Chagas disease, Trypanosoma cruzi. We have sequenced the T. rangeli genome to provide new tools for elucidating the distinct and intriguing biology of this species and the key pathways related to interaction with its arthropod and mammalian hosts.  Methodology/Principal Findings: The T. rangeli haploid genome is ,24 Mb in length, and is the smallest and least repetitive trypanosomatid genome sequenced thus far. This parasite genome has shorter subtelomeric sequences compared to those of T. cruzi and T. brucei; displays intraspecific karyotype variability and lacks minichromosomes. Of the predicted 7,613 protein coding sequences, functional annotations could be determined for 2,415, while 5,043 are hypothetical proteins, some with evidence of protein expression. 7,101 genes (93%) are shared with other trypanosomatids that infect humans. An ortholog of the dcl2 gene involved in the T. brucei RNAi pathway was found in T. rangeli, but the RNAi machinery is non-functional since the other genes in this pathway are pseudogenized. T. rangeli is highly susceptible to oxidative stress, a phenotype that may be explained by a smaller number of anti-oxidant defense enzymes and heatshock proteins.  Conclusions/Significance: Phylogenetic comparison of nuclear and mitochondrial genes indicates that T. rangeli and T. cruzi are equidistant from T. brucei. In addition to revealing new aspects of trypanosome co-evolution within the vertebrate and invertebrate hosts, comparative genomic analysis with pathogenic trypanosomatids provides valuable new information that can be further explored with the aim of developing better diagnostic tools and/or therapeutic targets

MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains

Ruiz JC, D'Afonseca V, Silva A, et al. Evidence for Reductive Genome Evolution and Lateral Acquisition of Virulence Functions in Two Corynebacterium pseudotuberculosis Strains. PLoS ONE. 2011;6(4): e18551.Background: Corynebacterium pseudotuberculosis, a Gram-positive, facultative intracellular pathogen, is the etiologic agent of the disease known as caseous lymphadenitis (CL). CL mainly affects small ruminants, such as goats and sheep; it also causes infections in humans, though rarely. This species is distributed worldwide, but it has the most serious economic impact in Oceania, Africa and South America. Although C. pseudotuberculosis causes major health and productivity problems for livestock, little is known about the molecular basis of its pathogenicity. Methodology and Findings: We characterized two C. pseudotuberculosis genomes (Cp1002, isolated from goats; and CpC231, isolated from sheep). Analysis of the predicted genomes showed high similarity in genomic architecture, gene content and genetic order. When C. pseudotuberculosis was compared with other Corynebacterium species, it became evident that this pathogenic species has lost numerous genes, resulting in one of the smallest genomes in the genus. Other differences that could be part of the adaptation to pathogenicity include a lower GC content, of about 52%, and a reduced gene repertoire. The C. pseudotuberculosis genome also includes seven putative pathogenicity islands, which contain several classical virulence factors, including genes for fimbrial subunits, adhesion factors, iron uptake and secreted toxins. Additionally, all of the virulence factors in the islands have characteristics that indicate horizontal transfer. Conclusions: These particular genome characteristics of C. pseudotuberculosis, as well as its acquired virulence factors in pathogenicity islands, provide evidence of its lifestyle and of the pathogenicity pathways used by this pathogen in the infection process. All genomes cited in this study are available in the NCBI Genbank database (http://www.ncbi.nlm.nih.gov/genbank/) under accession numbers CP001809 and CP001829