Map-Aware Models for Indoor Wireless Localization Systems: An Experimental Study

The accuracy of indoor wireless localization systems can be substantially enhanced by map-awareness, i.e., by the knowledge of the map of the environment in which localization signals are acquired. In fact, this knowledge can be exploited to cancel out, at least to some extent, the signal degradation due to propagation through physical obstructions, i.e., to the so called non-line-of-sight bias. This result can be achieved by developing novel localization techniques that rely on proper map-aware statistical modelling of the measurements they process. In this manuscript a unified statistical model for the measurements acquired in map-aware localization systems based on time-of-arrival and received signal strength techniques is developed and its experimental validation is illustrated. Finally, the accuracy of the proposed map-aware model is assessed and compared with that offered by its map-unaware counterparts. Our numerical results show that, when the quality of acquired measurements is poor, map-aware modelling can enhance localization accuracy by up to 110% in certain scenarios.Comment: 13 pages, 11 figures, 1 table. IEEE Transactions on Wireless Communications, 201

Statistical Characterization and Mitigation of NLOS Errors in UWB Localization Systems

In this paper some new experimental results about the statistical characterization of the non-line-of-sight (NLOS) bias affecting time-of-arrival (TOA) estimation in ultrawideband (UWB) wireless localization systems are illustrated. Then, these results are exploited to assess the performance of various maximum-likelihood (ML) based algorithms for joint TOA localization and NLOS bias mitigation. Our numerical results evidence that the accuracy of all the considered algorithms is appreciably influenced by the LOS/NLOS conditions of the propagation environment

Reduced-Complexity Algorithms for Indoor Map-Aware Localization Systems

The knowledge of environmental maps (i.e., map-awareness) can appreciably improve the accuracy of optimal methods for position estimation in indoor scenarios. This improvement, however, is achieved at the price of a significant complexity increase with respect to the case of map-unawareness, specially for large maps. This is mainly due to the fact that optimal map-aware estimation algorithms require integrating highly nonlinear functions or solving nonlinear and nonconvex constrained optimization problems. In this paper, various techniques for reducing the complexity of such estimators are developed. In particular, two novel strategies for restricting the search domain of map-aware position estimators are developed and the exploitation of state-of-the-art numerical integration and optimization methods is investigated; this leads to the development of a new family of suboptimal map-aware localization algorithms. Our numerical and experimental results evidence that the accuracy of these algorithms is very close to that offered by their optimal counterparts, despite their significantly lower computational complexity

A code to perform harmonic analysis of a time series

Nella fisica degli acceleratori, un parametro importante è il tune di betatrone, definito come la frequenza di oscillazione trasversale del fascio. La ricerca del tune è matematicamente equivalente al calcolo della frequenza principale (ed eventualmente delle frequenze successive) di una sequenza di numeri complessi. Lo scopo di questo lavoro di tesi è produrre un programma C++ che implementi alcuni algoritmi noti di ricerca della frequenza principale e delle frequenze successive, e confermare che gli errori di questi metodi concordino con l’andamento teorico. Questa procedura è stata svolta sia per sequenze di ampiezza costante, che di ampiezza variabile nel tempo. È stato inoltre verificato che, nel secondo caso, metodi alternativi per il calcolo dell'inviluppo non sono migliori di quello usato al momento. Infine, è stato studiato e implementato un nuovo algoritmo per il calcolo simultaneo delle due frequenze dominanti. È stato verificato che, se le frequenze sono abbastanza vicine, il nuovo algoritmo è più preciso degli altri considerati

New achievements in orbital angular momentum beam characterization using a Hartmann wavefront sensor and the Kirkpatrick-Baez active optical system KAOS

Advances in physics have been significantly driven by state-of-the-art technology, and in photonics and X-ray science this calls for the ability to manipulate the characteristics of optical beams. Orbital angular momentum (OAM) beams hold substantial promise in various domains such as ultra-high-capacity optical communication, rotating body detection, optical tweezers, laser processing, super-resolution imaging etc. Hence, the advancement of OAM beam-generation technology and the enhancement of its technical proficiency and characterization capabilities are of paramount importance. These endeavours will not only facilitate the use of OAM beams in the aforementioned sectors but also extend the scope of applications in diverse fields related to OAM beams. At the FERMI Free-Electron Laser (Trieste, Italy), OAM beams are generated either by tailoring the emission process on the undulator side or, in most cases, by coupling a spiral zone plate (SZP) in tandem with the refocusing Kirkpatrick–Baez active optic system (KAOS). To provide a robust and reproducible workflow to users, a Hartmann wavefront sensor (WFS) is used for both optics tuning and beam characterization. KAOS is capable of delivering both tightly focused and broad spots, with independent control over vertical and horizontal magnification. This study explores a novel non-conventional `near collimation\u27 operational mode aimed at generating beams with OAM that employs the use of a lithographically manufactured SZP to achieve this goal. The article evaluates the mirror\u27s performance through Hartmann wavefront sensing, offers a discussion of data analysis methodologies, and provides a quantitative analysis of these results with ptychographic reconstructions

COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study

Background: Early reports on patients with cancer and COVID-19 have suggested a high mortality rate compared with the general population. Patients with thoracic malignancies are thought to be particularly susceptible to COVID-19 given their older age, smoking habits, and pre-existing cardiopulmonary comorbidities, in addition to cancer treatments. We aimed to study the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with thoracic malignancies. Methods: The Thoracic Cancers International COVID-19 Collaboration (TERAVOLT) registry is a multicentre observational study composed of a cross-sectional component and a longitudinal cohort component. Eligibility criteria were the presence of any thoracic cancer (non-small-cell lung cancer [NSCLC], small-cell lung cancer, mesothelioma, thymic epithelial tumours, and other pulmonary neuroendocrine neoplasms) and a COVID-19 diagnosis, either laboratory confirmed with RT-PCR, suspected with symptoms and contacts, or radiologically suspected cases with lung imaging features consistent with COVID-19 pneumonia and symptoms. Patients of any age, sex, histology, or stage were considered eligible, including those in active treatment and clinical follow-up. Clinical data were extracted from medical records of consecutive patients from Jan 1, 2020, and will be collected until the end of pandemic declared by WHO. Data on demographics, oncological history and comorbidities, COVID-19 diagnosis, and course of illness and clinical outcomes were collected. Associations between demographic or clinical characteristics and outcomes were measured with odds ratios (ORs) with 95% CIs using univariable and multivariable logistic regression, with sex, age, smoking status, hypertension, and chronic obstructive pulmonary disease included in multivariable analysis. This is a preliminary analysis of the first 200 patients. The registry continues to accept new sites and patient data. Findings: Between March 26 and April 12, 2020, 200 patients with COVID-19 and thoracic cancers from eight countries were identified and included in the TERAVOLT registry; median age was 68·0 years (61·8-75·0) and the majority had an Eastern Cooperative Oncology Group performance status of 0-1 (142 [72%] of 196 patients), were current or former smokers (159 [81%] of 196), had non-small-cell lung cancer (151 [76%] of 200), and were on therapy at the time of COVID-19 diagnosis (147 [74%] of 199), with 112 (57%) of 197 on first-line treatment. 152 (76%) patients were hospitalised and 66 (33%) died. 13 (10%) of 134 patients who met criteria for ICU admission were admitted to ICU; the remaining 121 were hospitalised, but were not admitted to ICU. Univariable analyses revealed that being older than 65 years (OR 1·88, 95% 1·00-3·62), being a current or former smoker (4·24, 1·70-12·95), receiving treatment with chemotherapy alone (2·54, 1·09-6·11), and the presence of any comorbidities (2·65, 1·09-7·46) were associated with increased risk of death. However, in multivariable analysis, only smoking history (OR 3·18, 95% CI 1·11-9·06) was associated with increased risk of death. Interpretation: With an ongoing global pandemic of COVID-19, our data suggest high mortality and low admission to intensive care in patients with thoracic cancer. Whether mortality could be reduced with treatment in intensive care remains to be determined. With improved cancer therapeutic options, access to intensive care should be discussed in a multidisciplinary setting based on cancer specific mortality and patients' preference

Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types

Abstract Background A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. Results We apply a novel analytical approach to measure and compare transcriptional and epigenetic variability genome-wide across CD14+CD16− monocytes, CD66b+CD16+ neutrophils, and CD4+CD45RA+ naïve T cells from the same 125 healthy individuals. We discover substantially increased variability in neutrophils compared to monocytes and T cells. In neutrophils, genes with hypervariable expression are found to be implicated in key immune pathways and are associated with cellular properties and environmental exposure. We also observe increased sex-specific gene expression differences in neutrophils. Neutrophil-specific DNA methylation hypervariable sites are enriched at dynamic chromatin regions and active enhancers. Conclusions Our data highlight the importance of transcriptional and epigenetic variability for the key role of neutrophils as the first responders to inflammatory stimuli. We provide a resource to enable further functional studies into the plasticity of immune cells, which can be accessed from: http://blueprint-dev.bioinfo.cnio.es/WP10/hypervariability