Race and Resistance in the Communication Classroom

Teaching diversity is no longer segregated to ethnic studies departments or to intercultural communication courses. Consequently, many students have become resistant to the idea of spending time-- yet again --on the issue of race. Communication scholars have described a kind of resistance found frequently in the basic communication classroom and likewise proposed various responses to this resistance. Through a review of the literature and drawing on my ten years of experience teaching diversity in the university, this essay assesses these responses. One source of white student discomfort comes from the increasing visibility of whiteness, so two strategies used to address this discomfort are considered: insuring a safe classroom environment and emphasizing the complexity of student identities. While valuable in some contexts, these strategies ultimately limit the ability of students to understand the power of race in contemporary society. In addition, although many teaching strategies emphasize that racism is a structural phenomenon, most continue to rely on individually based solutions to racism. The essay suggests how students might be motivated to end racism in coalition with others, not out of individual self-interest but out of a genuine desire to create a more socially just world

The Impact of Summer Camp Experiences on Young Adults with Down Syndrome: A Case Study

Background: The purpose of this research was to examine the impact of an inclusive camp setting on young adults with Down syndrome, with a specific focus on personal growth and meaningful friendships. The aim of this exploratory case study was to describe the experiences of returning young adult campers in depth and examine the impact of Camp PALS on their personal growth and meaningful friendships over time using the 5 C’s of Positive Youth Development. Method: Data were collected from ten returning campers between the ages of 21-29. A narrative case study design was utilized and included observations and semi-structured interviews. Results: Findings suggest that inclusive, residential camps can promote positive outcomes for individuals with DS. Conclusion: This study indicates that Camp PALS promotes personal growth and meaningful friendships through the promotion and evolution of the 5 C’s of Positive Youth Development. Implications for research are discussed

Bifurcation analysis near the cessation of complete chatter and Shilnikov homoclinic trajectories in a pressure relief valve model

This thesis investigates bifurcations associated with periodic orbits with complete chatter, as well as bifurcations associated with homoclinic trajectories, in the dynamics of a pressure relief valve model. A combination of original numerical implementations with analytical tools found in the existing literature enables a deeper understanding of the dependence of the valve dynamics on system parameters. In particular, the transition from complete to incomplete chatter along a family of periodic orbits is explored to find a cascade of bifurcations that are then investigated further using a discrete-time approximation to the system dynamics. In addition, a toolbox that formulates a boundary value problem associated with a complete chatter sequence is developed within the computational framework of the continuation package coco. Lastly, a Shilnikov-type homoclinic bifurcation is located and the global manifold structure near this bifurcation point is explored using continuation methods applied to appropriate boundary value problems

Assessment Procedures for Paved and Gravel Roads

The funding available to local agencies in Indiana to manage roadways has decreased in recent years, and many agencies cannot provide adequate maintenance with the available resources. Consequently, agencies are doing everything they can to evaluate the least expensive method to maintain their roads that will meet their objectives and needs. In some cases, the most appropriate surface type is a paved road, and in some cases, it is a gravel road. The decision as to the most appropriate surface type depends on a variety of factors, such as cost, traffic volume, development and public input. The purpose of this study was to review the applicable research and develop an assessment procedure that local agencies in Indiana can use to help determine the most appropriate surface type for a given road

Genetic diversity between mouse strains allows identification of the CC027/GeniUnc strain as an orally reactive model of peanut allergy

Background: Improved animal models are needed to understand the genetic and environmental factors that contribute to food allergy. Objective: We sought to assess food allergy phenotypes in a genetically diverse collection of mice. Methods: We selected 16 Collaborative Cross (CC) mouse strains, as well as the classic inbred C57BL/6J, C3H/HeJ, and BALB/cJ strains, for screening. Female mice were sensitized to peanut intragastrically with or without cholera toxin and then challenged with peanut by means of oral gavage or intraperitoneal injection and assessed for anaphylaxis. Peanut-specific immunoglobulins, T-cell cytokines, regulatory T cells, mast cells, and basophils were quantified. Results: Eleven of the 16 CC strains had allergic reactions to intraperitoneal peanut challenge, whereas only CC027/GeniUnc mice reproducibly experienced severe symptoms after oral food challenge (OFC). CC027/GeniUnc, C3H/HeJ, and C57BL/6J mice all mounted a T H 2 response against peanut, leading to production of IL-4 and IgE, but only the CC027/GeniUnc mice reacted to OFC. Orally induced anaphylaxis in CC027/GeniUnc mice was correlated with serum levels of Ara h 2 in circulation but not with allergen-specific IgE or mucosal mast cell protease 1 levels, indicating systemic allergen absorption is important for anaphylaxis through the gastrointestinal tract. Furthermore, CC027/GeniUnc, but not C3H/HeJ or BALB/cJ, mice can be sensitized in the absence of cholera toxin and react on OFC to peanut. Conclusions: We have identified and characterized CC027/GeniUnc mice as a strain that is genetically susceptible to peanut allergy and prone to severe reactions after OFC. More broadly, these findings demonstrate the untapped potential of the CC population in developing novel models for allergy research

Patient Access to U.S. Physicians Who Conduct Internet or E-mail Consults

BACKGROUND: E-mail communication has the potential to improve communication between patients and doctors. OBJECTIVE: The objective of the study is to describe the access of patients to physicians who conduct e-mail consults. METHODS: We analyzed data from the National Ambulatory Medical Care Survey (NAMCS), a nationally representative cross-sectional survey of office-based physician visits, in 2001, 2002, and 2003. The main outcome measure was the percentage of visits to a provider who reported doing internet or e-mail consults. RESULTS: There was fewer than 1 in 10 outpatient visits in 2001 (9.2%) to physicians who reported doing internet or e-mail consults, and this did not increase in 2002 (5.8%) or 2003 (5.5%). Access to these physicians was greater among patients who were male, nonminority, lived in the Western United States, seen for pre-/postoperative care, seen by a primary care provider, and not seen by a nurse during their visit. Access to physicians who conducted internet or e-mail consults was independent of other patient (e.g., chronic conditions), provider (e.g., office setting), and visit (e.g., medications prescribed) characteristics. CONCLUSIONS: Access to physicians who do internet or e-mail consults is generally low and did not increase between 2001 and 2003, despite growth in internet access and in other internet-related activities

Adamantyl Ethanone Pyridyl Derivatives: Potent and Selective Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1

Elevated levels of active glucocorticoids have been implicated in the development of several phenotypes of metabolic syndrome, such as type 2 diabetes and obesity. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyses the intracellular conversion of inactive cortisone to cortisol. Selective 11β-HSD1 inhibitors have shown beneficial effects in various conditions, including diabetes, dyslipidemia and obesity. A series of adamantyl ethanone pyridyl derivatives has been identified, providing potent and selective inhibitors of human 11β-HSD1. Lead compounds display low nanomolar inhibition against human and mouse 11β-HSD1 and are selective for this isoform, with no activity against 11β-HSD2 and 17β-HSD1. Structure–activity relationship studies reveal that an unsubstituted pyridine tethered to an adamantyl ethanone motif through an ether or sulfoxide linker provides a suitable pharmacophore for activity. The most potent inhibitors have IC50 values around 34–48 nm against human 11β-HSD1, display reasonable metabolic stability in human liver microsomes, and weak inhibition of key human CYP450 enzymes

Discovery of Adamantyl Heterocyclic Ketones as Potent 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays a key role in converting intracellular cortisone to physiologically active cortisol, which is implicated in the development of several phenotypes of metabolic syndrome. Inhibition of 11β-HSD1 activity with selective inhibitors has beneficial effects on various conditions, including diabetes, dyslipidemia and obesity, and therefore constitutes a promising strategy to discover novel therapies for metabolic and cardiovascular diseases. A series of novel adamantyl heterocyclic ketones provides potent and selective inhibitors of human 11β-HSD1. Lead compounds display low nanomolar inhibition against human and mouse 11β-HSD1 and are selective with no activity against 11β-HSD2 and 17β-HSD1. Selected potent 11β-HSD1 inhibitors show moderate metabolic stability upon incubation with human liver microsomes and weak inhibition of human CYP450 enzymes

Local perceptions of the relative contributions of enclave tourism and agritourism to community well-being: The case of Mauritius

To date, limited attention has been paid to the contribution of tourism to the well-being of island residents in general and to whether such well-being varies according to the nature of tourism development in particular. Specifically, island tourism is frequently manifested in resort-based enclave development, a form of tourism that is often criticised for its assumed limited benefits to the wider community. As a consequence, alternative approaches such as agritourism, are increasingly proposed as a means of enhancing community development and well-being yet the relative merits of enclave and agritourism have not been explored within an island tourism context. This paper addresses this notable gap in the literature. Drawing on a questionnaire-based survey in Mauritius, it considers and compares the perceptions of local people of the extent to which enclave tourism and agritourism contribute to their well-being. The results reveal that both types of tourism development contribute both positively and negatively to community well-being although enclave tourism is perceived to have fewer positive outcomes. On the one hand, enclave tourism provides valuable cultural opportunities but damages the environment, restricts entrepreneurship and favours local elites; on the other hand, agritourism, although not yet well-established in Mauritius, is perceived to positively enhance the cultural and social spheres of community life whilst supporting entrepreneurship