103 research outputs found
Anisotropy probe of galactic and extra-galactic Dark Matter annihilations
We study the flux and the angular power spectrum of gamma-rays produced by
Dark Matter (DM) annihilations in the Milky Way (MW) and in extra-galactic
halos. The annihilation signal receives contributions from: a) the smooth MW
halo, b) resolved and unresolved substructures in the MW, c) external DM halos
at all redshifts, including d) their substructures. Adopting a self-consistent
description of local and extra-galactic substructures, we show that the
annihilation flux from substructures in the MW dominates over all the other
components for angles larger than O(1) degrees from the Galactic Center, unless
an extreme prescription is adopted for the substructures concentration. We also
compute the angular power spectrum of gamma-ray anisotropies and find that, for
an optimistic choice of the particle physics parameters, an interesting
signature of DM annihilations could soon be discovered by the Fermi LAT
satellite at low multipoles, l<100, where the dominant contribution comes from
MW substructures with mass M>10^4 solar masses. For the substructures models we
have adopted, we find that the contribution of extra-galactic annihilations is
instead negligible at all scales.Comment: 14 pages, 7 figure
Influence of Mother Tongue on Dynamic Handwriting Features in Primary School
Handwriting is an essential fine motor skill in school-aged children and plays a crucial role for educational development and autonomy of everyday life. To analyze hand-writing movement an objective quantitative kinematic analysis can be performed by using digital tablets. Through this tech-nology it was possible to identify a lot of parameters useful to characterize the handwriting process.
In order to study the influence of mother tongue on the dy-namic of handwriting in primary school, we examined the writing response of 42 non-native speakers and compared their characteristics with those of 131 Italian mother tongue chil-dren. All children undertook one repetitive sequence of le and an Italian sentence written in two different ways: as accurately as and as fast as possible.
The results showed that the differences between native and non-native speakers were not significant in the repetitive se-quence while a clear influence of mother tongue was present only in the third grade for the sentence tasks
Shrec'16 Track: Retrieval of Human Subjects from Depth Sensor Data
International audienceIn this paper we report the results of the SHREC 2016 contest on "Retrieval of human subjects from depth sensor data". The proposed task was created in order to verify the possibility of retrieving models of query human subjects from single shots of depth sensors, using shape information only. Depth acquisition of different subjects were realized under different illumination conditions, using different clothes and in three different poses. The resulting point clouds of the partial body shape acquisitions were segmented and coupled with the skeleton provided by the OpenNI software and provided to the participants together with derived triangulated meshes. No color information was provided. Retrieval scores of the different methods proposed were estimated on the submitted dissimilarity matrices and the influence of the different acquisition conditions on the algorithms were also analyzed. Results obtained by the participants and by the baseline methods demonstrated that the proposed task is, as expected, quite difficult, especially due the partiality of the shape information and the poor accuracy of the estimated skeleton, but give useful insights on potential strategies that can be applied in similar retrieval procedures and derived practical applications. Categories and Subject Descriptors (according to ACM CCS): I.4.8 [IMAGE PROCESSING AND COMPUTER VISION]: Scene Analysis—Shap
Dark Matter Annihilation around Intermediate Mass Black Holes: an update
The formation and evolution of Black Holes inevitably affects the
distribution of dark and baryonic matter in the neighborhood of the Black Hole.
These effects may be particularly relevant around Supermassive and Intermediate
Mass Black Holes (IMBHs), the formation of which can lead to large Dark Matter
overdensities, called {\em spikes} and {\em mini-spikes} respectively. Despite
being larger and more dense, spikes evolve at the very centers of galactic
halos, in regions where numerous dynamical effects tend to destroy them.
Mini-spikes may be more likely to survive, and they have been proposed as
worthwhile targets for indirect Dark Matter searches. We review here the
formation scenarios and the prospects for detection of mini-spikes, and we
present new estimates for the abundances of mini-spikes to illustrate the
sensitivity of such predictions to cosmological parameters and uncertainties
regarding the astrophysics of Black Hole formation at high redshift. We also
connect the IMBHs scenario to the recent measurements of cosmic-ray electron
and positron spectra by the PAMELA, ATIC, H.E.S.S., and Fermi collaborations.Comment: 12 pages, 7 figures. Invited contribution to NJP Focus Issue on "Dark
Matter and Particle Physics
Dark Matter Candidates: A Ten-Point Test
An extraordinarily rich zoo of non-baryonic Dark Matter candidates has been
proposed over the last three decades. Here we present a 10-point test that a
new particle has to pass, in order to be considered a viable DM candidate: I.)
Does it match the appropriate relic density? II.) Is it {\it cold}? III.) Is it
neutral? IV.) Is it consistent with BBN? V.) Does it leave stellar evolution
unchanged? VI.) Is it compatible with constraints on self-interactions? VII.)
Is it consistent with {\it direct} DM searches? VIII.) Is it compatible with
gamma-ray constraints? IX.) Is it compatible with other astrophysical bounds?
X.) Can it be probed experimentally?Comment: 29 pages, 12 figure
Dark Matter and Fundamental Physics with the Cherenkov Telescope Array
The Cherenkov Telescope Array (CTA) is a project for a next-generation
observatory for very high energy (GeV-TeV) ground-based gamma-ray astronomy,
currently in its design phase, and foreseen to be operative a few years from
now. Several tens of telescopes of 2-3 different sizes, distributed over a
large area, will allow for a sensitivity about a factor 10 better than current
instruments such as H.E.S.S, MAGIC and VERITAS, an energy coverage from a few
tens of GeV to several tens of TeV, and a field of view of up to 10 deg. In the
following study, we investigate the prospects for CTA to study several science
questions that influence our current knowledge of fundamental physics. Based on
conservative assumptions for the performance of the different CTA telescope
configurations, we employ a Monte Carlo based approach to evaluate the
prospects for detection. First, we discuss CTA prospects for cold dark matter
searches, following different observational strategies: in dwarf satellite
galaxies of the Milky Way, in the region close to the Galactic Centre, and in
clusters of galaxies. The possible search for spatial signatures, facilitated
by the larger field of view of CTA, is also discussed. Next we consider
searches for axion-like particles which, besides being possible candidates for
dark matter may also explain the unexpectedly low absorption by extragalactic
background light of gamma rays from very distant blazars. Simulated
light-curves of flaring sources are also used to determine the sensitivity to
violations of Lorentz Invariance by detection of the possible delay between the
arrival times of photons at different energies. Finally, we mention searches
for other exotic physics with CTA.Comment: (31 pages, Accepted for publication in Astroparticle Physics
Primed T Cell Responses to Chemokines Are Regulated by the Immunoglobulin-Like Molecule CD31
CD31, an immunoglobulin-like molecule expressed by leukocytes and endothelial cells, is thought to contribute to the physiological regulation T cell homeostasis due to the presence of two immunotyrosine-based inhibitory motifs in its cytoplasmic tail. Indeed, loss of CD31 expression leads to uncontrolled T cell-mediated inflammation in a variety of experimental models of disease and certain CD31 polymorphisms correlate with increased disease severity in human graft-versus-host disease and atherosclerosis. The molecular mechanisms underlying CD31-mediated regulation of T cell responses have not yet been clarified. We here show that CD31-mediated signals attenuate T cell chemokinesis both in vitro and in vivo. This effect selectively affects activated/memory T lymphocytes, in which CD31 is clustered on the cell membrane where it segregates to the leading edge. We provide evidence that this molecular segregation, which does not occur in naïve T lymphocytes, might lead to cis-CD31 engagement on the same membrane and subsequent interference with the chemokine-induced PI3K/Akt signalling pathway. We propose that CD31-mediated modulation of memory T cell chemokinesis is a key mechanism by which this molecule contributes to the homeostatic regulation of effector T cell immunity
Gamma rays from Dark Matter Annihilation in the Central Region of the Galaxy
In this article, we review the prospects for the Fermi satellite (formerly
known as GLAST) to detect gamma rays from dark matter annihilations in the
Central Region of the Milky Way, in particular on the light of the recent
astrophysical observations and discoveries of Imaging Atmospheric Cherenkov
Telescopes. While the existence of significant backgrounds in this part of the
sky limits Fermi's discovery potential to some degree, this can be mitigated by
exploiting the peculiar energy spectrum and angular distribution of the dark
matter annihilation signal relative to those of astrophysical backgrounds.Comment: v3: corrected typos, content unchange
CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease
Animal models and clinical studies have linked the innate and adaptive immune system to the pathology of Parkinson’s disease (PD). Despite such progress, the specific immune responses that influence disease progression have eluded investigators. Herein, we assessed relationships between T cell phenotype and function with PD progression. Peripheral blood lymphocytes from two separate cohorts, a discovery cohort and a validation cohort, totaling 113 PD patients and 96 age- and environment-matched caregivers were examined by flow cytometric analysis and T cell proliferation assays. Increased effector/memory T cells (Tem), defined as CD45RO+ and FAS+ CD4+ T cells and decreased CD31+ and α4β7+ CD4+ T cells were associated with progressive Unified Parkinson’s Disease Rating Scale III scores. However, no associations were seen between immune biomarkers and increased age or disease duration. Impaired abilities of regulatory T cells (Treg) from PD patients to suppress effector T cell function was observed. These data support the concept that chronic immune stimulation, notably Tem activation and Treg dysfunction is linked to PD pathobiology and disease severity, but not disease duration. The association of T cell phenotypes with motor symptoms provides fresh avenues for novel biomarkers and therapeutic designs
Large-scale ICU data sharing for global collaboration: the first 1633 critically ill COVID-19 patients in the Dutch Data Warehouse
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