12 research outputs found
Psychometric evaluation of the Disabilities of the Arm, Shoulder and Hand (DASH) with Dupuytren's contracture: validity evidence using Rasch modeling
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Background Dupuytrenâs contracture is a progressive, fibroproliferative disorder that causes fixed finger contractures and can lead to disability. With the advances of new therapeutic interventions, the necessity to assess the functional repercussions of this condition using valid, reliable and sensitive outcome measures is of growing interest. The Disabilities of the Arm, Shoulder and Hand (DASH) is one frequently used patient-reported outcome measure but its reliability and validity have never been demonstrated specifically for a population affected with Dupuytrenâs contracture. The objective of this study was to evaluate the psychometric properties of the DASH, with focus on validity evidence using the Rasch measurement model. Methods Secondary analysis was performed on data collected as part of a randomised clinical trial. One hundred fifty-three participants diagnosed with Dupuytrenâs contracture completed the DASH at four time points (pre-op, 3, 6 and 12 months post-op). Baseline data were analysed using traditional analysis and to test whether they adhered to the expectations of the Rasch model. Post-intervention data were subsequently included and analyzed to determine the effect of the intervention on the items. Results DASH scores demonstrated large ceiling effects at all time points. Initial fit to the Rasch model revealed that the DASH did not adhere to the expectations of the Rasch partial credit model (Ï2â=â119.92; pâ<â0.05). Multiple items displayed inadequate response categories and two items displayed differential item functioning by gender. Items were transformed and one item deleted leading to an adequate fit. Remaining items fit the Rasch model but still do not target well the population under study. Conclusions The original version of the 30-item DASH did not display adequate validity evidence for use in a population with Dupuytrenâs contracture. Further development is required to improve the DASH for this population
14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins
- Author
- Afonine
- Ahearn
- Andrew Purkiss
- Andrew J. Thompson
- Anne J. Ridley
- Bokoch
- Bonnefoy-BĂ©rard
- Boureux
- Brad McColl
- Chandra
- Corey
- Dalal
- Emsley
- Forget
- Foster
- Ganka Bineva
- Guasch
- Hancock
- Hidalgo-Carcedo
- Hoffman
- Hogan
- Hu
- Ismail
- Kostelecky
- Lebedev
- Madigan
- McCoy
- Michaelson
- Morrison
- Muslin
- Nancy
- Neil Q. McDonald
- Nicola OâReilly
- Nicolas Reymond
- Nishikawa
- Nobes
- Obsil
- Ottmann
- OâReilly
- Pacary
- Pearce
- Peter J. Parker
- Pflugrath
- Philippe Riou
- Quilliam
- Riento
- Riento
- Riou
- Ritu Garg
- Roberts
- Robert J. Cain
- Roger George
- Svend KjĂŠr
- Thorson
- Vagin
- van Hennik
- Wennerberg
- Williamson
- Yaffe
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2013
- Field of study
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol. Rnd proteins are atypical constitutively GTP-bound Rho proteins, whose regulation remains elusive. Here, we report a high-affinity 14-3-3-binding site at the C terminus of Rnd3 consisting of both the Cys241-farnesyl moiety and a Rho-associated coiled coil containing protein kinase (ROCK)-dependent Ser240 phosphorylation site. 14-3-3 binding to Rnd3 also involves phosphorylation of Ser218 by ROCK and/or Ser210 by protein kinase C (PKC). The crystal structure of a phosphorylated, farnesylated Rnd3 peptide with 14-3-3 reveals a hydrophobic groove in 14-3-3 proteins accommodating the farnesyl moiety. Functionally, 14-3-3 inhibits Rnd3-induced cell rounding by translocating it from the plasma membrane to the cytosol. Rnd1, Rnd2, and geranylgeranylated Rap1A interact similarly with 14-3-3. In contrast to the canonical GTP/GDP switch that regulates most Ras superfamily members, our results reveal an unprecedented mechanism for G protein inhibition by 14-3-3 proteins
Going beyond Activity and Participation: Development of the DIF-CHUMâA patient-reported outcome measure for individuals with Dupuytren's contracture
- Author
- Bailey
- Ball
- Beaton
- Beaudreuil
- Benson
- Chung
- Colquhoun
- Constand
- de Vet
- DiBenedetti
- Dijkers
- Dimick
- Engstrand
- Eyssen
- Fitzpatrick
- Forget
- Forget
- Franchignoni
- Giladi
- Guyatt
- Hudak
- Jerosch-Herold
- Jette
- Jette
- Johanne Higgins
- Kaskutas
- Keller
- Kielhofner
- Lang
- Law
- MacDermid
- Macey
- Maneesriwongul
- Mayo
- McKee
- McKenna
- MichĂšle Rivard
- Mohan
- Nancy J. Forget
- Patel
- Patrick G. Harris
- Polatajko
- Post
- Pratt
- Rand
- Rand
- Rodrigues
- Roush
- Schkade
- Seaton
- Shih
- Streiner
- Townsend
- Turesson
- Valdes
- Wilburn
- Wilson
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Becoming Applied: The Transformation of Economics after 1970
- Author
- A D Dalmedico
- A W Coats
- A W Coats
- Angrist
- Arthur Burns
- Backhouse
- beatrice cherrier
- Beatrice Cherrier
- Bennett T Mccallum
- D Edgerton
- D F Hendry
- David Card
- David F Hendry
- David R Jardini
- E Weintraub
- Edward Leamer
- Evelyn Forget
- Forman
- Frank H Hahn
- Fred Lee
- Friedman
- Fritz Machlup
- Howard R Bowen
- J A Renfro
- J A Renfro
- Jean-Baptiste Fleury
- Jennifer Alexander
- John Macmillan
- Lawrence Klein
- Malcolm Rutherford
- Mark Solovey
- Mary S Morgan
- Michele Alacevich
- Mitra-Kahn
- Nancy Ruggles
- Paul Lucier
- Peter Diamond
- Philippe Mongin
- Robert Bud
- Roger Backhouse
- Roger E Backhouse
- Roger E Backhouse
- Roger E Backhouse
- Roger E Backhouse
- Roger E Backhouse
- Roger E Backhouse
- Rutledge Vining
- S Banzhaf
- Thomas Stapleford
- Till Duppe
- Tjalling Koopmans
- Wassily Leontief
- William G Dewald
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Alpha-1 Adrenergic Receptors are Localized on Presynaptic Elements in the Nucleus Accumbens and Regulate Mesolimbic Dopamine Transmission
- Author
- A Auclair
- A Auclair
- A Peters
- B Forget
- C Drouin
- C Drouin
- CA Jiménez-Rivera
- CA Mejias-Aponte
- CA Paladini
- CA Paladini
- CR McKittrick
- CW Berridge
- CW Berridge
- D Calebiro
- D Weinshenker
- D Weinshenker
- DA Mitrano
- Darlene A Mitrano
- David Weinshenker
- DV Raju
- EA Stone
- EA Stone
- EA Stone
- EA Stone
- G Masilamoni
- G Paxinos
- GE Meredith
- GJ Marek
- H Sommermeyer
- H Varoqui
- J Grenhoff
- J Grenhoff
- J Grenhoff
- J Grenhoff
- James J Cortright
- Jason P Schroeder
- JH Kim
- JH Morrison
- JJ Kyncl
- JM Delfs
- K Fuxe
- K Nakadate
- KKL Yung
- KM Alsene
- KS Rommelfanger
- L Darracq
- LA Liprando
- LS Jones
- LW Swanson
- Nancy Bubula
- P Vezina
- Paul Vezina
- PJ Meyer
- R Ventura
- R Ventura
- R Ventura
- RC Pierce
- RJ Smith
- RR Gainetdinov
- RT Fremeau Jr
- S Dallvechia-Adams
- S Wee
- TC Rainbow
- TN Greenwell
- V Montana
- VA Pieribone
- VG Olson
- WH Pan
- XY Zhang
- XY Zhang
- Y Lin
- Yoland Smith
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Parenting predictors of cognitive skills and emotion knowledge in socioeconomically disadvantaged preschoolers
- Author
- Ainsworth
- Bentler
- Bernier
- Beth M. Phillips
- Bierman
- Blank
- Bonawitz
- Bornstein
- Borovsky
- Bowlby
- Bullock
- Catts
- Chapman
- Christopher J. Lonigan
- Cohen
- Cook
- Coolahan
- Cristofaro
- Cutting
- De Rosnay
- Denham
- Denham
- Denham
- Denham
- Dieterich
- Duncan
- Emily C. Merz
- Enders
- Enders
- Fernald
- Forget-Dubois
- Garner
- Greig
- Grolnick
- Hammett
- Heather B. Taylor
- Hindman
- Hirsh-Pasek
- Hoff
- Hu
- Huttenlocher
- Izard
- Izard
- Jeanine Clancy-Menchetti
- Jeffrey M. Williams
- JeliÄiÄ
- Jill de Villiers
- Katz
- Kendeou
- Lagattuta
- Laible
- Landry
- Landry
- Landry
- Lengua
- Lonigan
- Lugo-Gil
- Marcia A. Barnes
- Matthews
- McClelland
- Michael Assel
- Mistry
- Muter
- Muthén
- Nancy Eisenberg
- NICHD Early Child Care Research Network
- Ontai
- Paul
- Perlman
- Pungello
- Raikes
- Raudenbush
- Razza
- Reese
- Rogoff
- Roth
- Rowe
- Salmon
- Schulze
- Seidenberg
- Shields
- Sigel
- Snow
- Snow
- Sobel
- Stams
- Starkey
- Storch
- Susan H. Landry
- Tamis-LeMonda
- Tricia A. Zucker
- van Kleeck
- van Kleeck
- Vygotsky
- Widen
- Zimmerman
- Zucker
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Associations among parental education, home environment quality, effortful control, and preacademic knowledge
- Author
- AdiâJapha
- Allan
- Anders
- Bauer
- Beck
- Belsky
- Bernier
- Beth M. Phillips
- Blair
- Blevins-Knabe
- Bracken
- Bradley
- Bradley
- Bradley
- Britto
- Burchinal
- Cadima
- Caldwell
- Camp
- Carlos Valiente
- Casey
- Christopher J. Lonigan
- Cole
- Connell
- Cunningham
- Dilworth-Bart
- DilworthâBart
- Dreyer
- Duncan
- Elardo
- Else-Quest
- Emily C. Merz
- Espy
- Evans
- Evans
- ForgetâDubois
- Foster
- Frankenburg
- Garon
- Geary
- Goldsmith
- Goldsmith
- Heather B. Taylor
- Hoff
- Hughes
- Jeanine Clancy-Menchetti
- Jeffrey M. Williams
- Justice
- Kochanska
- Kochanska
- Landry
- Leech
- Lengua
- Li-Grining
- Li-Grining
- Lonigan
- Lonigan
- Lonigan
- MacKinnon
- Mahone
- Marcia A. Barnes
- McClelland
- McLoyd
- Mezzacappa
- Michael Assel
- Mistry
- Nancy Eisenberg
- NICHD Early Child Care Research Network
- Noble
- Preacher
- Raudenbush
- Raver
- Razza
- Rhoades
- Roisman
- Rosvold
- Rothbart
- Rueda
- Sarsour
- Sektnan
- Selig
- Son
- Spinrad
- Stams
- Starkey
- Stipek
- Sulik
- Susan H. Landry
- Swanson
- Tracy L. Spinrad
- Wass
- Welsh
- Wiebe
- Willoughby
- Zhou
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Tax and Welfare in a Post-Labour Defence Society
- Author
- Alan Johnson
- Amy Bernstein
- Andrew Vincent
- Andrïżœ Gorz
- Andrïżœ Gorz
- Arne L Kalleberg
- Ashifa Kassam
- Bengt Larssson
- Bernard Cadogan
- Bryan Perry
- Bryan Perry
- Business Council
- Butler
- Carl Frey
- Chapman Institute Of Directors
- Chris Pierson
- Claire Trevett
- Colin James
- David A Preston
- David Grant
- Deloitte
- Deloitte
- Dorothy Day
- Eleanor Roy
- Engin F Isin
- Eric Bovim
- Evelyn L Forget
- F A Hayek
- Francis G Castles
- Francis G Castles
- Frank Lovett
- Geoffrey Palmer
- Guy Standing
- Guy Standing
- H Butterfield
- Harald Sundmaeker
- Harrison Moore
- Hazel Sheffield
- Helen Hodgson
- Howard Glennerster
- James Manyika
- Jane Scott
- John Braithwaite
- John Keynes
- Jonah D Levy
- Jonathan Barrett
- Jonathan M. Barrett
- Keith Rankin
- Ken ( Loach
- Kim Dunstan
- Kiwisaver
- Klaus Schwab
- Kurt Vonnegut
- Linda Bryder
- Lutz Leisering
- M Brewer
- Martha Crowley
- Martin Seeleib-Kaiser
- Matt Payton
- Matthew Beard
- Maura Thomas
- Maureen Baker
- Melanie Arntz
- Michael Chui
- Michael Mandel
- Miguel Glatzer
- Nancy Fraser
- Nick Srnicek
- Nicole Maestas
- Nigel Murphy
- Nz Super Fund
- Owen Hatherley
- Paul A Samuelson
- Paul Mason
- Peter King
- Pierre Bourdieu
- Radio New Zealand
- Richard Wilkinson
- Robert J Shiller
- Rory Cellan-Jones
- Siena Yates
- Simon Chapple
- St John
- St John
- St John
- Statistics New Zealand
- Statistics New Zealand
- Susanne Kraatz
- T H Marshall
- Tim Dunlop
- Tom Clark
- Tony Fahey
- Treasury
- Will Hutton
- William Beveridge
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo FĂĄbia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angel Miguel Paludi
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Anizi Mashel Al
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Applewhaite Christopher
- Aquino Laura Patricia GonzĂĄlez
- Ar Praburaj
- Araujo Daniela Marques
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Aribawa Mahaalit Alit
- Arkalaki Eleni
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam M
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azam Ummi Azmira Ahmad
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Baillie Shelley
- Baines Duncan
- Baio Thalissa HermĂnia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto SĂ©rgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beattie Scott
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Beer Johan
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
- Bell Rachel
- Bell Stephanie
- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Berg Bianca
- Bergin Colin
- Bernard Andre
- Bernard Andre
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais M.
- Biais Matthieu
- Biais Matthieu
- Biccard Bruce
- Biccard Bruce M
- Bidd Heena
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boer Hans Donald
- Boereboom Catherine
- Boggiano Victoria
- Bokkel-Andela Janneke
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
- Bottrill Fiona
- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bouwman Arthur
- Bowrey Sarah
- Boxall Leigh
- Boyd Christine
- Bradburn Mike
- Bradburn Mike
- Bradley Jacqueline
- Branagan Graham
- Branco Teresa
- Brand Bastiaan
- Brandsborg Birgitte
- Breitenstein Stefan
- Brennan Andrew
- Brennan Emma
- Brenner Laura
- Brincat Maximilian
- Briscoe Richard
- Bristogiannis Sotirios
- Brooke Jenny
- Brookes Jamie
- Brookes Morag
- Brooks Carolyn
- Broomby Rupert
- Brotto Ana Flavia
- Brown Andrew
- Brown Caroline Wrey
- Brown Gemma
- Brown Jamie
- Brown Janette
- Brown Lynne
- Brown Richard
- Brown Robyn
- Browning Julie
- Bruma Dana
- Brunete Tamara
- Brunswicker Annemarie
- Bryant Helen
- Bua Emmanuel
- Buccimazza Ines
- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
- Burston Ben
- Burtenshaw Andrew
- Burton Megan
- Busuioc Mihai
- Butryn Izabella
- Butt Georgina
- Byrne Kelly
- BĂŒhrer Thomas
- Cabezuelo Estefania
- Cabral Raquel
- Cabrini Luca
- Cacala Sharon
- Cai Fang
- Cai Yunfei
- Cain Helen
- Cairns Carel
- Cakova Veronika
- Calderwood Claire
- Callaghan Mark
- Campbell Debbie
- Campbell Doug
- Campbell Doug
- Campbell Douglas
- Campbell Gill
- Campbell Graham
- Campbell Kathleen
- Campbell Marta
- Campbell Tara
- Campey Lorraine
- Campos Ferreira Mariana Fosch
- Camsooksai Julie
- Cancho David
- Candido Keulle
- Cang Jing
- Cannavo Maurizio
- Cao Jianqiao
- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
- Cardy Jon
- Carmino Livio
- Carp Cristina Paula
- Carr Adrienne
- Carrera Ronald
- Carroll Christine
- Carroll Jo
- Caser Eliana
- Castaño Beatriz
- Castle Gail
- Castro Gabriel Isaac Pereira
- Cavanagh Sarah
- Cawthorn Louise
- Cernea Daniela Denisa
- Chaddock Mark
- Chaloulis Panagiotis
- Chan Alexander
- Chan Hey Man Heymans
- Chan Mathew
- Chan Matthew
- Chan Matthew
- Chan Peter
- Chan Vincent
- Chan Wai Kit Jacky
- Chan Weng Ken
- Chan Yik Lam
- Chande Shiv
- Chandler Ben
- Chandra Susilo
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R
- Chew Michelle
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Michelle
- Collins Nwokoro
- Colvin Carolyn
- Commey Thelma
- Comptaer Nicolas
- Conceição Soares Maria
- Conde Carlos
- Conradie Alae
- Constantin Kathryn
- Cook Tim
- Cooper Lauren
- Cooper Lucy
- Cooper Mariese
- Cooper Richard
- Cooper Sarah
- Copaciu Elena
- Cope Jennifer
- Copley Edward
- Copotoiu Sanda Maria
- Coppens Marc
- Corneci Dan
- Cornell Jonathan
- Cornish Julie
- Corti Daniele
- Costa Fischer Bruna Ferreira
- Costa Ana Cristina Miranda Martins
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- De Kegel Dirk
- De Meyer Jenine N
- De Oliveira Mirella Cristine
- Deacon Matthew
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- Deja Maria
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- Delgado GarcĂa David R
- Demartines Nicolas
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- Denham Samuel
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- Greaves Rosanna
- Green Garyth M
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- Mosxogiannidis Dimitris
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- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- Ă„kring Irene
- Ăgren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The ClavienâDindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the ClavienâDindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using ClavienâDindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using ClavienâDindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally