COMPARISON OF PERCEIVED WEIGHT AS IDEAL AGAINST IDEAL BODY WEIGHT FORMULAS AND BODY MASS INDEX OF 22 KG/M2 IN YOUNG ADULT WOMEN.

SUMMARYIntroduction: Formulas of ideal body weight (IBW) including the body mass index (BMI) of 22 kg/m2 are used under the assumption to provide a healthy weight. Objective: We compare the perceived ideal body weight (PIBW) with the calculated IBW by formulas and the BMI of 22. Methods: We recruited 705 women (20-25 y). Six common formulas and 2 published equations by our team were used. Results: Group regression analysis determined that including the frame size improves the agreement of formulas of Robinson et al, Hammond and Hamwi with the PIBW (p>0.05). Individually, the concordance analysis (higher % of differences <2 kg: PIBW - IBW by formula), determined that for a measured BMI <20, only the Faspyn 1 formula needs to be adjusted by frame size; while Robinson et al, Hammond, Tokunaga (BMI of 22), Faspyn 2 (BMI of 22) and Broca, are equivalent with the PIBW in different intervals of BMI. Conclusions: According to the BMI perceived as overweight (23.8 kg/m2) and perceived as ideal (21.1 kg/m2), caution is suggested when using the IBW formulas for BMI of 22 as a diagnosis. The IBW formulas and BMI of 22 does not necessarily represent a desirable or aesthetic weight. Comparación del peso percibido como ideal con fórmulas de peso ideal y el IMC de 22 kg/m2 en mujeres jóvenes.RESUMEN Introducción: El peso ideal calculado con fórmulas (PIF) y con el índice de masa corporal (IMC) de 22 kg/m2 se emplea bajo el supuesto de proporcionar un peso saludable o estético. Objetivo: Comparar el peso percibido como ideal (PPI) contra el PIF y del IMC de 22. Métodos: Se reclutaron 705 mujeres (20-25 años). Empleamos seis fórmulas comunes y 2 publicadas previamente. Resultados: El análisis de regresión grupal determinó que incluir la complexión corporal mejora la concordancia de las fórmulas de Robinson et al, Hammond y Hamwi con el PPI (p>0.05). Individualmente, el análisis de concordancia (porcentaje mayor de diferencias <2 kg: PPI-PIF), determinó que para un IMC <20 kg/m2 solo la fórmula de Faspyn 1 debe ajustarse por la complexión corporal, mientras que las fórmulas de Robinson et al, Hammond, Tokunaga (IMC de 22), Faspyn 2 (IMC de 22) y Broca, son equivalentes con el PPI en diferentes intervalos de IMC. Conclusiones: de acuerdo con el IMC percibido como sobrepeso (23.8 kg/m2) y percibido como ideal (21.1 kg/m2), las fórmulas de peso ideal y el IMC de 22 deben ser usados con precaución en el diagnóstico de peso ideal ya que no necesariamente representan un peso deseable o estético.

Whole-Blood Mitochondrial DNA Copies Are Associated With the Prognosis of Acute Respiratory Distress Syndrome After Sepsis.

https://pubmed.ncbi.nlm.nih.gov/34557198/#:~:text=Resumen-,El%20s%C3%ADndrome%20de%20dificultad%20respiratoria%20aguda%20(SDRA)%20es%20un%20proceso,v%C3%ADnculos%20mec%C3%A1nicos%20de%20esta%20observaci%C3%B3n%20con%20la%20patogenia%20del%20SDRA.,-Palabras%20clave%3A%20SDR

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

WHO body mass index for age charts overestimate thinness and overweight compared to international and US charts applied to indigenous and non-indigenous Mexican children

Assessments of whether children are thin (low body mass index for age) or overweight are based on body mass index (BMI for age and sex) charts published by the World Health Organization (WHO), the International Obesity Task Force (IOTF), and the US Centers for Disease Control and Prevention (CDC). We aimed to determine whether these charts indicated different prevalence of thinness and overweight (obesity included) in indigenous and non-indigenous school aged children from different regions and ethnic groups in Mexico. A probability proportional to size, cluster sampling method was employed in four regions of the country. We recruited 1,731 children aged 7.0-9.9 (507 indigenous from six ethnic groups and 1,224 non-indigenous). BMI was calculated according to age, and thinness and overweight classifications were compared according to cutoff values in the WHO, IOTF, and CDC references. The WHO reference generated the highest rates for thinness (12.5%) and overweight (30%) in children across regions and ethnic groups. The CDC reference estimated the lowest rates of thinness in children (5.5%), and the IOTF reference estimated the lowest rates of overweight (24.7%). Estimates of both thinness (8.3%) and overweight (13.4%) rates were lower in indigenous than non-indigenous groups (14.3% and 37.5%, respectively). The WHO BMI for age chart estimated higher rates of thinness and overweight in children compared to the CDC and IOTF charts. Because thinness as indicator of undernutrition status is relatively new, differences in body composition among indigenous and non-indigenous children may justify the need for more appropriate screening criteria to compare the growth status.La clasificación del estado nutricio de los niños con delgadez o con sobrepeso se realiza empleando el índice de masa corporal (IMC para la edad y el sexo) con las tablas de la OMS, IOTF y CDC. El objetivo de esta investigación fue determinar si estas referencias resultan en diferentes prevalencias de delgadez y sobrepeso (obesidad incluida) en niños escolares indígenas y no indígenas de diferentes regiones de México. Se empleó un muestreo por conglomerados en cuatro regiones del país. Se reclutaron 1,731 niños con edades entre 7,0-9,9 (507 indígenas de cinco grupos étnicos y 1,224 no indigenas) durante 2006 y 2008. El IMC se calculó y se clasificó como delgadez y sobrepeso con los puntos de corte sugeridos por las referencias internacionales. Cuando se compararon las clasificaciones, la referencia de OMS generó la prevalencia más alta de delgadez (12,5%) y sobrepeso (30%) en niños de todas las regiones y grupos étnicos. La referencia de los CDC estimó las prevalencias más bajas de delgadez (5,5%) y la referencia IOTF produjo las proporciones más bajas de sobrepeso (24,7%). Las proporciones de delgadez (8,3%) y sobrepeso (13,4%) fueron más bajas en niños indígenas que en los no indígenas (14.3% y 37.5%, respectivamente). La referencia de la OMS del IMC para la edad produjo las prevalencias más altas de delgadez y sobrepeso en comparación con los estándares de CDC y IOTF. Dado que la delgadez como indicador de desnutrición en niños es de uso reciente, las diferencias encontradas entre indígenas y mestizos pueden justificar el contar con mejores herramientas de tamizaje en estudios de crecimiento

A vascular endothelial growth factor receptor gene variant is associated with susceptibility to acute respiratory distress syndrome

Abstract Background The acute respiratory distress syndrome (ARDS) is one of the main causes of mortality in adults admitted to intensive care units. Previous studies have demonstrated the existence of genetic variants involved in the susceptibility and outcomes of this syndrome. We aimed to identify novel genes implicated in sepsis-induced ARDS susceptibility. Methods We first performed a prioritization of candidate genes by integrating our own genomic data from a transcriptomic study in an animal model of ARDS and from the only published genome-wide association study of ARDS study in humans. Then, we selected single nucleotide polymorphisms (SNPs) from prioritized genes to conduct a case-control discovery association study in patients with sepsis-induced ARDS (n = 225) and population-based controls (n = 899). Finally, we validated our findings in an independent sample of 661 sepsis-induced ARDS cases and 234 at-risk controls. Results Three candidate genes were prioritized: dynein cytoplasmic-2 heavy chain-1, fms-related tyrosine kinase 1 (FLT1), and integrin alpha-1. Of those, a SNP from FLT1 gene (rs9513106) was associated with ARDS in the discovery study, with an odds ratio (OR) for the C allele of 0.76, 95% confidence interval (CI) 0.58–0.98 (p = 0.037). This result was replicated in an independent study (OR = 0.78, 95% CI = 0.62–0.98, p = 0.039), showing consistent direction of effects in a meta-analysis (OR = 0.77, 95% CI = 0.65–0.92, p = 0.003). Conclusions We identified FLT1 as a novel ARDS susceptibility gene and demonstrated that integration of genomic data can be a valid procedure to identify novel susceptibility genes. These results contribute to previous firm associations and functional evidences implicating FLT1 gene in other complex traits that are mechanistically linked, through the key role of endothelium, to the pathophysiology of ARDS

Sex-gender disparities in nonagenarians with acute coronary syndrome

Background: Acute coronary syndrome (ACS) remains one of the leading causes of mortality for women, increasing with age. There is an unmet need regarding this condition in a fast-growing and predominantly female population, such as nonagenarians. Hypothesis: Our aim is to compare sex-based differences in ACS management and long-term clinical outcomes between women and men in a cohort of nonagenarians. Methods: We included consecutive nonagenarian patients with ACS admitted at four academic centers between 2005 and 2018. The study was approved by the Ethics Committee of each center. Results: A total of 680 nonagenarians were included (59% females). Of them, 373 (55%) patients presented with non-ST-segment elevation ACS and 307 (45%) with ST-segment elevation myocardial infarction (STEMI). Men presented a higher disease burden compared to women. Conversely, women were frailer with higher disability and severe cognitive impairment. In the STEMI group, women were less likely than men to undergo percutaneous coronary intervention (PCI) (60% vs. 45%; p = .01). Overall mortality rates were similar in both groups but PCI survival benefit at 1-year was greater in women compared to their male counterparts (82% vs. 68%; p = .008), persisting after sensitivity analyses using propensity-score matching (80% vs. 64%; p = .03). Conclusion: Sex-gender disparities have been observed in nonagenarians. Despite receiving less often invasive approaches, women showed better clinical outcomes. Our finding may help increase awareness and reduce the current gender gap in ACS management at any age

Additional file 3: of A vascular endothelial growth factor receptor gene variant is associated with susceptibility to acute respiratory distress syndrome

Table S3. Protein interaction network analysis (data obtained from Acosta-Herrera et al. PLoS One 2015, 10:e0132296). Summary results of the protein-protein interaction network analysis as part of the lung transcriptomic study previously published. (DOC 40 kb

Additional file 1: of A vascular endothelial growth factor receptor gene variant is associated with susceptibility to acute respiratory distress syndrome

Table S1. Significant probe sets in the microarray-based differential gene expression analysis comparing experimental sepsis groups with a common control group (data obtained from Acosta-Herrera et al. PLoS One 2015, 10:e0132296). Description of data: statistics obtained from the pathway enrichment analysis performed for each experimental group included in the transcriptomic lung study before the prioritization of candidate genes. (XLS 431 kb

Additional file 2: of A vascular endothelial growth factor receptor gene variant is associated with susceptibility to acute respiratory distress syndrome

Table S2. Pathway enrichment analysis performed in each experimental septic group. Description of data: summary results of the pathway enrichment analysis. (DOC 51 kb

Additional file 5: of A vascular endothelial growth factor receptor gene variant is associated with susceptibility to acute respiratory distress syndrome

Table S5. Summary statistics of SNPs located at the pathways with SNPs significantly associated with ARDS by Christie et al. (PLoS One 2012, 7:e28268). Summary results of the prioritization performed from the 13 genes with significant SNPs at the GWAs of ARDS performed by Christie et al. (XLS 45 kb