Developing a timetable for radiant and circular transport organization with implementation of the Transportation Requirements Planning method

Summary   This paper contains the results of preliminary research on the use of the Transportation Requirements Planning method to develop a timetable for radial  and circular transport organization. It begins with a discussion on the method of Transportation Requirements Planning. Then the problem of developing a timetable in radial and circular transport is formulated. Successively results obtained by applying of the Transportation Requirements Planning method to develop the timetable under assumed conditions are presented. The summary and discussion of the perspectives for further research are the final part of the paper.

A production control support system based on the concept of an artificial pseudo neural network

PURPOSE: The goal of the paper is to present the concept of a pseudo-neural network developed for production control in an industrial enterprise that produces complex products under discrete production conditions. This paper contains an attempt to use the theoretical basis of artificial neural networks to build a specialized tool. This tool is called a pseudo-network.DESIGN/METHODOLOGY/APPROACH: It is based not on the whole of the theory of artificial neural networks but only on the targeted elements selected for it. The selection criterion is the use of an artificial neural pseudo-network to control production.FINDINGS: The concept of artificial pseudo neural network is fully presented in previous works by the authors.PRACTICAL IMPLICATIONS: The network is part of the production planning and control system. In this system, the network acts as a subsystem responsible for production control. It cooperates with the production planning subsystem from which it periodically downloads the data on production task covering the assortment of manufactured products, production programs of individual assortment items, production start and end dates as well as its updates. In turn, it reports to the production planning subsystem about the progress of the implementation of the launched production task.ORIGINALITY/VALUE: The presented approach is original and can be developed to meet requirements of various production systems. It has both cognitive and utilitarian potential.peer-reviewe

Bindung von Nanopartikeln (NP) an Proteine aus dem Blutserum

Mensch und Tier sind in der Umwelt täglich ultrafeinen Partikeln aus verschiedenen Quellen ausgesetzt, zudem nimmt die Verwendung von synthetischen Nanopartikeln (NP) in Wissenschaft und Technik rapide zu, sodass NP in immer mehr alltäglichen Produkten sowie medizinischen Anwendungen zum Einsatz kommen. Da die Exposition vorwiegend über den Weg der Inhalation erfolgt, und die UFP/NP in der Lunge auf eine proteinhaltige Flüssigkeit treffen, sollte untersucht werden, inwieweit NP in der Lage sind, Proteine zu binden und wodurch diese Bindungen beeinflusst werden. Als Modelle dienten bovines Serumalbumin, Transferrin und Apolipoprotein A-1 sowie verschiedene NP (PS-NP unterschiedlicher Ladung, SiO2-NP, TiO2 P25-NP, TiO2 4.5 nm- NP sowie Printex G- und Printex 90-NP). Allgemein konnte bestätigt werden, dass manche NP Komplexe mit verschiedenen Proteinen bilden, wobei NP mit unterschiedlichen chemischen und physikalischen Eigenschaften unterschiedliche Bindungsaktivität aufweisen. Für alle NP wurde eine lineare Abhängigkeit von eingesetzter NP-Menge und der Menge an gebundenem Protein gefunden. Diese Bindungsaktivität kann durch Bindungsindices quantitativ beschrieben werden. Die Bindung der Proteine an die NP erfolgt durch unspezifische Mechanismen und erfolgt vermutlich als unvollständige Monolayer. Neben den chemischen Eigenschaften der NP-Oberfläche ist die zur Verfügung stehende Gesamtoberfläche der eingesetzten NP entscheidend für das Ausmaß der Bindung in einer gegebenen Proteinlösung. BSA, Transferrin und auch Apo A-1 wurden im größten Umfang durch hydrophobe NP gebunden, doch auch für die hydrophilen NP konnte eine Bindungsaktivität nachgewiesen werden, so dass je nach Art von Protein und NP hydrophobe Wechselwirkungen und elektrostatische Kräfte für die Bindung von Bedeutung sein dürften. Die vorliegende Arbeit zeigt daher, dass inkorporierte NP in teils erheblichem Ausmaß mit körpereigenen Proteinen interagieren können und bietet die Basis für weitergehende Untersuchungen zur Translokation von NP und deren Effekten im Organismus sowie die Wirkung der NP auf Proteine in der Lunge und im Blut

Intelligent transport solutions of Logistics 4.0 in the context of changes in driving style : a systematic literature review

PURPOSE: The aim of this paper is to analyze the relationship between the use of Logistics 4.0 tools and a change in the behavior of drivers to more ecological and safer. We analyze the social acceptance of the intelligent tools implemented in vehicles, and identify a possible research gap in this area.DESIGN/METHODOLOGY/APPROACH: In this article, a systematic review is used for the quantitative and qualitative assessment of publications available in two digital databases – WoS and Scopus. The review allows verifying whether there is a significant research gap within the analyzed problem.FINDINGS: In the article, is indicated that the digital databases of publications contain only 26 full-text papers relating to the analyzed research problem, which confirms the hypothesis of the existence of a research gap.PRACTICAL IMPLICATIONS: The practical implications of this publication include the need to refine research on the social aspect and the readiness of drivers to implement and use intelligent transport systems with benefits for reduction of the environmental impact and increased safety.ORIGINALITY/VALUE: The importance of the Smart City tools and their use as part of increasing the safety and environmental friendliness of driving is a key factor in changing driver behavior. The pro-ecological policy of the European Union imposes a change in the style of driving. Only 26 related publications have been identified, thus this paper contributes to the literature by proving in-depth analysis of the problem under consideration.This article was funded by Poznan University of Technology, Faculty of Engineering Management [project number: 504101/0812/SBAD/4177].peer-reviewe

Efficient Elimination of Inhaled Nanoparticles from the Alveolar Region: Evidence for Interstitial Uptake and Subsequent Reentrainment onto Airways Epithelium

BACKGROUND: There is ongoing discussion that inhaled nanoparticles (NPs, < 100 nm) may translocate from epithelial deposition sites of the lungs to systemic circulation. OBJECTIVES AND METHODS: We studied the disappearance of NPs from the epithelium by sequential lung retention and clearance and bronchoalveolar lavage (BAL) measurements in healthy adult Wistar Kyoto (WKY) rats at various times over 6 months after administration of a single 60- to 100-min intratracheal inhalation of iridium-192 ((192)Ir)–radiolabeled NPs. A complete (192)Ir balance of all organs, tissues, excretion, remaining carcass, and BAL was performed at each time point. RESULTS: Directly after inhalation we found free NPs in the BAL; later, NPs were predominantly associated with alveolar macropages (AMs). After 3 weeks, lavageable NP fractions decreased to 0.06 of the actual NP lung burden. This is in stark contrast to the AM-associated fraction of micron-sized particles reported in the literature. These particles remained constant at about 0.8 throughout a 6-month period. Three weeks after inhalation, 80% of the retained Ir NPs was translocated into epithelium and interstitium. CONCLUSION: There is a strong size-selective difference in particle immobilization. Furthermore, AM-mediated NP transport to the larynx originates not only from the NP fraction retained on the epithelium but also from NPs being reentrained from the interstitium to the luminal side of epithelium. We conclude that NPs are much less phagocytized by AMs than large particles but are effectively removed from the lung surface into the interstitium. Even from these interstitial sites, they undergo AM-mediated long-term NP clearance to the larynx

Oncoplastic breast surgery: A guide to good practice

Oncoplastic Breast Surgery has become standard of care in the management of Breast. Cancer Patents. These guidelines written by an Expert Advisory Group; convened by the Association of Breast Surgery (ABS) and the British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS), are designed to provide all members of the breast cancer multidisciplinary team (MDT) with guidance on the best breast surgical oncoplastic and reconstructive practice at each stage of a patient's journey, based on current evidence. It is hoped they will also be of benefit to the wide range of professionals and service commissioners who are involved in this area of clinical practice

Alpha interferon in the treatment of hematologic malignancies

The interferons are an important first member of a family of biologic response-modifiers used in treating human malignancies. Activities associated with the interferons include inhibition of viral replication, influence on cellular protein production, direct antiproliferative effects, and a variety of modulatory effects on the immune response. These regulatory functions of interferon underlie the interest in its use as an anticancer agent. Alpha interferon is the most extensively studied interferon species. Although antitumor activity has been seen both in vitro and in vivo in some solid malignancies, the most impressive responses have occurrred in the hematologic malignancies. More than 90 percent of patients with hairy cell leukemia have a sustained recovery of their peripheral blood cell counts with alpha interferon therapy. Approximately 50 percent of patients with low-grade non-Hodgkin's lymphoma and cutaneous T cell lymphoma demonstrate a response to alpha interferon. More than 80 percent of patients with chronic myelogenous leukemia have a response to alpha interferon, and in one study, nearly half of the patients with response had complete suppression of the Philadelphia chromosome clone on at least one examination. Ongoing clinical trials are addressing such issues as optimal dosage, duration of alpha interferon therapy, and combinations of alpha interferon with other biologic agents, chemotherapy drugs, and radiation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26440/1/0000528.pd

Family and Learning-disorders

Auf dem Hintergrund der Theorie der psychoanalytischen Familientherapie werden bestimmte Familien-Interaktionen und zentrale unbewußte Konflikte, die in Familien mit lerngestörten Kindern häufig anzutreffen sind, vorgestellt, so der Mechanismus der Projektion des Versagens auf einen Symptomträger, die symbiotische Mutter-Kind-Beziehung, die lernhemmende Wirkung eines Familiengeheimnisses, das Schulversagen als Aggressionsäußerung, die narzißtischen Anteile einer Lernstörung und die Rolle von verbotenen sexuellen Phantasien. Jeweils ein Fallbeispiel illustriert die Dynamik und den Ansatz zur Veränderung. (DIPF/Orig.)On the background of the theory of psychoanalytical family therapy, certain family interactions and central unconscious conflicts are demonstrated which are often to be found in families with children deranged in their learning process, such as the mechanism of the projection of failure on a symptom carrier, the symbiotic mother-child-relationship, the learning impediment effect of a family secret, the failure in school as shown in expressions of aggression, the narcistic components of a learning disorder and the role of forbidden sexual fantasies. In each case an example illustrates the dynamic and the beginning of change. (DIPF/Orig.

Framework of the Architecture of the Communication Process Within Industry 4.0 Oriented Production System

Part 7: Regular Session: Frameworks and Conceptual Modelling for Systems and Services EfficiencyInternational audienceImplementation of the Industry 4.0 concept requires changes on many levels. Implementation of technical solutions (ICT technologies, automation, robotization, AI) entails changes in the organization of processes, as well as in management and communication patterns. The article presents the concept of the IT system architecture supporting communication between the production planner and the production system in the enterprise. The aim was to develop a solution supporting and improving communication between a man and a machine. This area is important for the effectiveness, completeness and quality of information flow and the quality of decisions made on the basis of interpreted feedback. The solution presented in the article was developed as part of the study work on the preparation of the concept of reorganization of the company’s production system during the preparation for the implementation of the Industry 4.0 concept. The analyzed enterprise manufactures single large-size machines. The technologies used include casting, machining and assembly. The analyzed production unit was the machining department, as it was selected as a pilot department for the implementation of Industry 4.0. The developed solution will be exemplary and will be the best practice to be used at the next stages of the implementation of Industry 4.0 in the enterprise

Gender differences in computer attitudes among middle-school-age students

This study investigated gender differences in computer attitudes and the relationships between these attitudes and grade level, mathematics achievement, computer courses, computer experience, and prior programming and word processing experience. The study involved 115 seventh- and eighth-grade students enrolled in computer literacy courses in a suburban school district. Three different attitudes toward computers were studied: 1) in general, 2) as a problem-solving tool, and 3) as a writing tool. Multiple regression techniques were used to analyze the attitude models. Analysis of the data indicated no significant effects of gender upon any of the attitudes. Of all the factors investigated, prior computer experience had the most effect upon the attitudes, although its greatest impact was on the general attitude. Grade level and number of computer courses also influenced general attitude. The problem-solving and writing attitudes were found to be affected primarily by experience with the respective application. It appears that while general computer experiences and formal classes influence the formation of positive attitudes towards computers in general, formation of positive attitudes toward specific uses of computers depends upon interactive experiences with the respective application. Although no significant direct effects due to gender were found, analysis revealed that gender was interacting with other factors. It was found that gender in combination with number of computer courses impacted the attitudes. Taken as a whole, these interactions do represent a pattern of indirect effects upon computer attitudes. This study was, by its nature, exploratory. The findings should be of interest to those educators engaged in equitable computer education at all levels. The findings and recommendations should also be of interest to those seeking to identify and enhance those factors which could significantly influence the formation of positive attitudes toward computers, both in general and as tools for specific applications.Education, College o