RLZAP: Relative Lempel-Ziv with Adaptive Pointers

Relative Lempel-Ziv (RLZ) is a popular algorithm for compressing databases of genomes from individuals of the same species when fast random access is desired. With Kuruppu et al.'s (SPIRE 2010) original implementation, a reference genome is selected and then the other genomes are greedily parsed into phrases exactly matching substrings of the reference. Deorowicz and Grabowski (Bioinformatics, 2011) pointed out that letting each phrase end with a mismatch character usually gives better compression because many of the differences between individuals' genomes are single-nucleotide substitutions. Ferrada et al. (SPIRE 2014) then pointed out that also using relative pointers and run-length compressing them usually gives even better compression. In this paper we generalize Ferrada et al.'s idea to handle well also short insertions, deletions and multi-character substitutions. We show experimentally that our generalization achieves better compression than Ferrada et al.'s implementation with comparable random-access times

Aprovechamiento de desechos frutales en la producción de alcohol potable

En este trabajo se desarrolló un proceso para el aprovechamiento de desechos frutales, para producir alcohol potable. Se trabajó con desechos de ciruelas y manzanas provenientes de plantas de packing y deshidratado. Se determinó la influencia en el rendimiento alcohólico de: contenido inicial de sacarosa, concentración de levadura y temperatura de fermentación. Se realizaron las pruebas legales de potabilidad para determinar la posibilidad de consumo humano. Finalmente, se determinó el aumento de contenido proteico en las tortas de fermentación para un posible uso en alimentación animal. Las pruebas de potabilidad indicaron que los contenidos de impurezas fueron en todos los casos inferiores a los máx imos permitidos por la ley

The 3D Structure of CO Depletion in High-mass Prestellar Regions

Disentangling the different stages of the star formation process, in particular in the high-mass regime, is a challenge in astrophysics. Chemical clocks could help alleviate this problem, but their evolution strongly depends on many parameters, leading to degeneracy in the interpretation of the observational data. One of these uncertainties is the degree of CO depletion. We present here the first self-consistent magneto-hydrodynamic simulations of high-mass, star-forming regions at different scales, fully coupled with a nonequilibrium chemical network, which includes C-N-O bearing molecules. Depletion and desorption processes are treated time dependently. The results show that full CO depletion (i.e., all gas-phase CO frozen-out on the surface of dust grains) can be reached very quickly, in one-third or even smaller fractions of the freefall time, whether the collapse proceeds on slow or fast timescales. This leads to a high level of deuteration in a short time, both for typical tracers like N2H+, as well as for the main ion H3+, the latter being in general larger and more extended. N2 depletion is slightly less efficient, and no direct effects on N-bearing molecules and deuterium fractionation are observed. We show that CO depletion is not the only driver of deuteration, and that there is a strong impact on D frac when changing the grain size. We finally apply a two-dimensional Gaussian point-spread function to our results to mimic observations with single-dish and interferometers. Our findings suggest that the low-values observed in high-mass star-forming clumps are in reality masking a full-depletion stage in the inner 0.1 pc region

Propuesta de modelo para estimar el estado de carga de baterías de LiFePO4 para un vehículo eléctrico

CIES2020 - XVII Congresso Ibérico e XIII Congresso Ibero-americano de Energia SolarRESUMEN: El dimensionamiento de un sistema de almacenamiento juega un papel indispensable a la hora de proporcionar una fuente de energía constante. Sin embargo, estos sistemas luchan con la inestabilidad de los parámetros resistivos entre celda y celda, que finalmente logran variar la previsión de diseño. Este trabajo contribuye con una metodología de modelado y simulación para un sistema eléctrico de un vehículo eléctrico utilizando la plataforma Matlab-Simulink. El objetivo es estimar el estado de carga y, por tanto, la autonomía del sistema de tracción eléctrica. Se estudian las condiciones tanto internas como externas en las que funciona un EV y se construye un prototipo de EV para validar los resultados de las simulaciones. El modelo computacional propone el uso de polinomios característicos de las curvas de trabajo de un motor eléctrico y de los componentes RC del circuito equivalente de una batería. Se modelan las ecuaciones matemáticas que representan las fuerzas a las que está sometido el tren de tracción y se obtiene la corriente que se extrae del sistema de almacenamiento ().ABSTRACT: Sizing a storage system plays an indispensable role in providing a constant energy source. However, these systems struggle with the instability of resistive parameters between cell and cell, which finally manages to vary the design forecast. This work contributes with a modeling and simulation methodology for an EV power system using the Matlab-Simulink platform. The aim is to estimate the state of charge and, therefore, the autonomy of the electrical traction system. Both internal and external conditions in which an EV works are studied and an EV prototype is built to validate the results of the simulations. The computational model proposes the use of characteristic polynomials of the work curves of an electric motor and of the RC components of the equivalent circuit of battery. The mathematical equations that represent the forces to which the traction train is subjected are modeled and the current that is extracted from the storage system ().info:eu-repo/semantics/publishedVersio

Current Applications and Future Trends of Dehydrated Lactic Acid Bacteria for Incorporation in Animal Feed Products

Several lactic acid bacteria (LAB) species have been recognized as probiotics and are of considerable interest due to their potential ability to confer health benefits upon consumption. In the animal feed sector, probiotics offer an alternative to the use of antibiotic growth promoters. The preservation and incorporation of probiotics into dry products requires carefully meeting several criteria and overcoming technological challenges to maintain their functionality. Drying is a crucial step in the process, but the probiotic properties of the resulting powder and the final cell viability in the food product are significantly influenced by the type of protective compounds and drying techniques employed. In light of the growing demand for functional animal products, this review focuses on the damages incurred during microorganism dehydration processes for food incorporation, and explores strategies to minimize such damages. It provides an overview of the effects of probiotic products in the animal feed industry, including their incorporation in low-moisture food matrices and key considerations for success. Additionally, it highlights postbiotics as an attractive alternative for live probiotic cells with many technological advantages.Centro de Investigación y Desarrollo en Criotecnología de Alimento

Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors

Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence. Conversely, THC also has potentially therapeutic effects, including analgesia, muscle relaxation, and neuroprotection. However, the mechanisms that dissociate these responses are still not known. Using mice lacking the serotonin receptor 5-HT2A, we revealed that the analgesic and amnesic effects of THC are independent of each other: while amnesia induced by THC disappears in the mutant mice, THC can still promote analgesia in these animals. In subsequent molecular studies, we showed that in specific brain regions involved in memory formation, the receptors for THC and the 5-HT2A receptors work together by physically interacting with each other. Experimentally interfering with this interaction prevented the memory deficits induced by THC, but not its analgesic properties. Our results highlight a novel mechanism by which the beneficial analgesic properties of THC can be dissociated from its cognitive side effects