60 research outputs found
Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia
- Author
- Antibiotic Expert Group
- Benjamin P. Howden
- Brown
- Charles
- Charlson
- Clinical and Laboratory Standards Institute
- Cockcroft
- Craig
- Craig
- del Mar Fernandez de Gatta Garcia
- Deresinski
- Drusano
- Gould
- Hidayat
- Holland
- Holmes
- Holmes
- Howden
- Hsu
- J. Owen Robinson
- Jeffres
- John D. Turnidge
- Knaus
- Kullar
- Le Gall
- Lodise
- Lodise
- Mathew
- Mathew
- Matthew V. N. O'Sullivan
- McGregor
- Mohr
- Moise
- Moise
- Moise-Broder
- Musta
- Natasha E. Holmes
- Neuner
- Paterson
- Paul D. R. Johnson
- Prakash
- Price
- Rehm
- Rose
- Rule
- Rybak
- Rybak
- Sader
- Sakoulas
- Sally A. Roberts
- Sanchia J. C. Warren
- Soriano
- Tara L. Anderson
- Tony M. Korman
- van Hal
- van Hal
- Wei Gao
- Wendy J. Munckhof
- Publication venue
- 'American Society for Microbiology'
- Publication date
- 01/01/2013
- Field of study
A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥ 400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin therapeutic monitoring consensus guidelines for treating all serious S. aureus infections. Here, vancomycin serum trough levels and vancomycin AUC/MIC were evaluated in a "real-world" context by following a cohort of 182 patients with S. aureus bacteremia (SAB) and analyzing these parameters within the critical first 96 h of vancomycin therapy. The median vancomycin trough level at this time point was 19.5 mg/liter. There was a significant difference in vancomycin AUC/MIC when using broth microdilution (BMD) compared with Etest MIC (medians of 436.1 and 271.5, respectively; P373, derived using classification and regression tree analysis, was associated with reduced mortality (P=0.043) and remained significant in a multivariable model. This study demonstrated that we obtained vancomycin trough levels in the target therapeutic range early during the course of therapy and that obtaining a higher vancomycin AUC/MIC (in this case, >373) within 96 h was associated with reduced mortality. The MIC test method has a significant impact on vancomycin AUC/MIC estimation. Clinicians should be aware that the current target AUC/MIC of ≥400 was derived using the reference BMD method, so adjustments to this target need to be made when calculating AUC/MIC ratio using other MIC testing methods. Copyrigh
The ATLAS fast tracKer system
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- Zhou M.
- Zhou N.
- Zhou Y.
- Zhu C.
- Zhu C. G.
- Zhu H.
- Zhu H. L.
- Zhu J.
- Zhu Y.
- Zhuang X.
- Zhukov K.
- Zhulanov V.
- Zieminska D.
- Zimine N. I.
- Zimmermann S.
- Zinonos Z.
- Ziolkowski M.
- Zoccoli A.
- Zoch K.
- Zorbas T. G.
- Zou R.
- Zwalinski L.
- Åkesson T. P. A.
- Öncel Ö. O.
- Ženiš T.
- Živković L.
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2021
- Field of study
The ATLAS Fast TracKer (FTK) was designed to provide full tracking for the ATLAS high-level trigger by using pattern recognition based on Associative Memory (AM) chips and fitting in high-speed field programmable gate arrays. The tracks found by the FTK are based on inputs from all modules of the pixel and silicon microstrip trackers. The as-built FTK system and components are described, as is the online software used to control them while running in the ATLAS data acquisition system. Also described is the simulation of the FTK hardware and the optimization of the AM pattern banks. An optimization for long-lived particles with large impact parameter values is included. A test of the FTK system with the data playback facility that allowed the FTK to be commissioned during the shutdown between Run 2 and Run 3 of the LHC is reported. The resulting tracks from part of the FTK system covering a limited η-ϕ region of the detector are compared with the output from the FTK simulation. It is shown that FTK performance is in good agreement with the simulation. © The ATLAS collaboratio
The 6R’s of drug induced nephrotoxicity
- Author
- A Mocroft
- A Trevisan
- AK Daly
- AM Vilay
- AT Gerlach
- BS Moffett
- CA Fux
- CR Smith
- D Tziakas
- D Tziakas
- DG Klepser
- E Gonzalez
- E Ramirez
- EA Hoste
- F Mizokami
- F Paquette
- FA Sgura
- G Bragadottir
- GR Betton
- GR Matzke
- Group. KDIGOKAKIW
- GS Markowitz
- H Xie
- HE Hansen
- HE Smith
- IJ Simpson
- J Dixon
- J Wi
- JA Bosso
- JB Kopp
- JC Gautier
- JC Rotschafer
- JF Oliveira
- JG Kendrick
- JJ Cies
- JJ Schentag
- JJ Schentag
- JK Farry
- JM Allais
- JM Prins
- JM Prins
- JO Hernandez
- JP Flandrois
- JW Davis
- K Buchholtz
- KJ Boudonck
- KK Filipski
- KP Platz
- L Awdishu
- L Gallon
- L Harmark
- Linda Awdishu
- M Fukudo
- M McCormack
- M Rybak
- M Smythe
- M Zaidan
- MA Winter
- MB O’Connell
- MD Fernandez de Gatta
- MF Hebert
- MJ Dooley
- MJ Rybak
- MJ Rybak
- ML Blank
- MN Jeffres
- MR Nelson
- N Fu
- NM Selby
- NN Lam
- P Labarga
- R Boton
- R Chu
- R Grenda
- R Jones
- R Mehran
- R Schreiber
- R Skinner
- R Skinner
- Ravindra L. Mehta
- RD Beger
- RF Eyler
- RF Gagnon
- RG Deeter
- RG Hall 2nd
- RG Wunderink
- RL Mehta
- RP Bulacio
- S Ferrari
- S Gandhi
- S Robert
- S Uchino
- SJ Hal van
- SJ McWilliam
- SK Gupta
- SK Gupta
- SL Barriere
- SL Barriere
- SL Davis
- SL Goldstein
- SP Pushpakom
- SS Shord
- T Antoniou
- T Langer
- TE Bunchman
- TE Welty
- TN Fraser
- TP Gauthier
- TP Lodise
- V Eremina
- V Giacomet
- V Sinha
- X Zhu
- Y Tanihara
- Y Tonomura
- Y Zhou
- YJ Hwang
- ZK Ye
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
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- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
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- Abeloos J
- Abernethy C
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- Abrunhosa A
- Absar M
- Adam S
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- Adelaja Y
- Ademola A
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- Aimoniotou-Georgiou E
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- van der Merwe D
- van der Merwe L
- van Duivenvoorde Y
- Van Duyvenvoorde G
- van Klei W
- Van Liefland M
- Van Limmen J
- Van Mossevelde V
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- whitehouse A
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- Wiegand-Loehnert C
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- Wong JY
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- Wong KWK
- Wong SM
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- Wong WL
- Woodgate A
- Woolsey A
- Woon YL
- Worreth M
- Wouters P
- Wrench I
- Wright S
- Wu C
- Wu C
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- Wu J
- Wu Q
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- Wyffels P
- Wylie K
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- Xia Y
- Xia Z-Y
- Xiao W
- Xiao W
- Xie G
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- Xifara A
- Xiong X
- Xiong Y
- Xouplidis K
- Xu G-J
- Xu L
- Xu L
- Xu Q
- Xu S
- Xue R
- Yagnik A
- Yan Y
- Yang J
- Yang L
- Yang Q
- Yang S
- Yang T
- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
- Yuan J
- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
- Zhang H
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang M
- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Systematic Review of Potential Health Risks Posed by Pharmaceutical, Occupational and Consumer Exposures to Metallic and Nanoscale Aluminum, Aluminum Oxides, Aluminum Hydroxide and Its Soluble Salts
- Author
- Abd El-Rahman M
- Abd-Elghaffar SKH
- Abdel-Aal RA
- Abdel-Aal RA
- Abu-Taweel GM
- Abu-Taweel GM
- Abubakar MG
- Adamcakova-Dodd A
- Afriyie-Gyawu E
- Agah H
- Ahmed HH
- Akatsu H
- Akay C
- Akila R
- Akiyama H
- Akiyama H
- Al-Ashmawy MAM
- Albizzati A
- Alemmari A
- Alemmari A
- Alessio L
- Ali MA
- Alleyne T
- Altekruse EB
- Andreoli SP
- Andress DL
- Aremu DA
- Arenas MD
- Armstrong RA
- Arnich N
- Arnold CJ
- ASCN/ASPEN (American Society for Clinical Nutrition Working Group on Standards for Aluminum Content of Parenteral Nutrition Solutions)
- ATSDR (Agency for Toxic Substances and Disease Registry)
- Atwood CS
- Avcin S
- Azik FM
- Bachmanov AA
- Bakar C
- Baker DJ
- Balasubramanyam A
- Banasik A
- Barrow CJ
- Bast-Petterson R
- Bast-Petterson R
- Bates D
- Batista-Duharte A
- Baum L
- Beach JR
- Becaria A
- Belaid-Nouira Y
- Bell ML
- Berend K
- Bergfors E
- Bergfors E
- Berthon G
- Beveridge MG
- Bhadauria M
- Bhasin P
- Bishop NJ
- Bjertness E
- Bodhak S
- Bohrer D
- Bohrer D
- Bohrer D
- Bohrer D
- Bolognin S
- Bondy SC
- Bora T
- Borm PJA
- Bower C
- Bowler RM
- Bozynski MEA
- Bradford-Hill A
- Brady RC
- Braganca VL
- Bresson JL
- Buchta M
- Burdick D
- Burrell SA
- Bush AI
- Byrne JD
- Bémer D
- Calejo AI
- Calejo AI
- Calvin C. Willhite
- Campdelacreu J
- CAN/CSA-ISO (Canadian Standards Association)
- Cao H
- Carrasquillo MM
- Castorina A
- CDC (Centers for Disease Control)
- Chaitanya TV
- Chakrabarty M
- Chedid F
- Chen BB
- Chen L
- Chen TJ
- Chen TJ
- Chen WT
- Cheng D
- Childs CW
- Chiu HFK
- Chotpitayasunondh T
- Cifone MA
- Clapp T
- Coburn JW
- Colak S
- Contini del MC
- Costa C
- Couette M
- Crisponi G
- Crisponi G
- Crisponi G
- Cui X
- Czeizel AS
- Cárdenas O
- Da Silva SE
- Dabeka RW
- Daniel Krewski
- Darbre PD
- Darbre PD
- Darbre PD
- de Kom JF
- de Oliveira SR
- De Veer VM
- De-Paula VJ
- del Pilar Martínez MM
- Demont M
- Deveau M
- DFG (Deutsche Forschungsgemeinschaft)
- Di Virgilio AL
- DiVirgilio AL
- Dong E
- Donoghue AM
- Donoghue AM
- Dorea JG
- Dorea JG
- Dorea JG
- Dorea JG
- Dorea JG
- Drago D
- Drago D
- EC (European Commission)
- Edling NPG
- EFSA (European Food Safety Authority)
- Egan PM
- Ehrlich HJ
- Eickhoff TC
- Eisenbarth SC
- El-Demerdash FM
- El-Sayed WM
- Elsaid FG
- Elshamaa MF
- Erazi H
- Erkan N
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Fakri S
- Fanni D
- Felsenfeld AJ
- Fernandez-Lorenzo FJR
- Fewtrell MS
- Fiejka M
- Finnell RH
- Flarend R
- Flarend RE
- Flaten TP
- Floody MC
- Florent C
- Foglio E
- Fraga CG
- Franchi L
- Franco Momoli
- Frankowski M
- Franzmann AW
- Fraser PE
- Freundlich M
- Freundlich M
- Freundlich M
- Friesen MC
- Friesen MS
- Fritschi I
- Froment DH
- GACVS (Global Advisory Committee on Vaccine Safety)
- Garcia EM
- Garcia-Patos V
- Garg S
- Garrosa M
- Gartner H
- Gatta V
- Gatti AM
- Gault PM
- Geyikoĝlu F
- Gherardi R
- Ghribi O
- Ghribi O
- Ghribi O
- Ghribi O
- Giaccio L
- Gibbs AR
- Gibbs GW
- Gies WJ
- Giorgianni CM
- Glenny AT
- Goffin V
- Golub MS
- Golub MS
- González MA
- González-Muñoz MJ
- González-Weller D
- Good DP
- Goodman WG
- Goto N
- Grasso G
- Graves AB
- Graves AB
- Greger JL
- Greger JL
- Guerin T
- Guillard O
- Guillard O
- Gun RT
- Guo C-H
- Guo CH
- Gupta RK
- Gupta VK
- Gutteridge JMC
- Guyton AJ
- Guzelian PS
- Gómez M
- Gómez M
- Güngör N
- Hale LW
- Hall PL
- Hamdy RC
- Hanninen H
- Hannouche D
- Hansen B
- Hansen B
- Harold D
- Health Council of the Netherlands
- Hellstrom HO
- Hem SL
- Hermansen JE
- Hirata-Koizumi M
- Hirata-Koizumi M
- Hirayama M
- Hollender D
- Hollingworth P
- Hou X-H
- House E
- Huang J
- Hull MJ
- Hutchison S
- Hyman BT
- Ian M.F. Arnold
- IFA (Insitiut für Abreitsschutz der Deutschen Gesetzlichen Unfallversicherung)
- ILSI (International Life Science Institute)
- Ingram AJ
- Israeli E
- Jefferson T
- Jenkins DAS
- Jenkins W
- Jimenez PM
- Jin P
- Johnson VJ
- Kaizer RR
- Kaizer RR
- Kakkar V
- Kamalov J
- Kan W-C
- Kaneko N
- Karlik SJ
- Karube J
- Kasa P
- Kaste PJ
- Kawahara M
- Kawahara M
- Keitel WA
- Kelly BC
- Kelso JM
- Keshri AK
- Khalaf AE
- Kiesswetter E
- Kiesswetter E
- Kim IS
- Kirkland D
- Kirshenbaum K
- Klatzo I
- Klein GL
- Klein GL
- Klein GL
- Klein GL
- Klein GL
- Klein GL
- Klimisch H-J
- Kong S
- Kongerud J
- Koo WW
- Koo WW
- Kool M
- Kool M
- Kool M
- Koponen IK
- Krewski D
- Kumar A
- Kumar V
- Kumar V
- Kuroda E
- Lambert JC
- Lambrecht BN
- Landry M
- Landsberg JP
- Lankoff A
- Lauricella AM
- Lehman HK
- Lemire J
- Lemire J
- Leventhal JS
- Lewis RC
- Li H
- Li H
- Li W
- Li X
- Li X
- Li XB
- Liang XF
- Lidsky TI
- Lima PDL
- Lin JL
- Lind PM
- Lindblad EB
- Lindquist B
- Liu YQ
- Lordan S
- Lukiw WJ
- Lynch KM
- Maduray K
- Maghraoui S
- Mahalakshmi M
- Mahieu ST
- Mailloux RJ
- Makjanic J
- Malluche HH
- Manna GK
- Mannello F
- Manzoli L
- Manzoli L
- Maquire-Boyle SJ
- Marques RC
- Marrack P
- Martin SC
- Mayeux G
- McGrath KG
- McGrath KG
- McGregor SJ
- McKee AS
- McKhann G
- McKhann GM
- McKinnon AJ
- Mendez-Alvarez E
- Meurman JH
- Meyer-Baron M
- Mikkelsen L
- Millour S
- Mirick DK
- Mitkus R
- Miu AC
- Mizoroki T
- Monteiro-Riviere NA
- Moore PB
- Morefield GL
- Morita T
- Morita T
- Moselhy W
- Mui S
- Mujika JI
- Mujika JI
- Mujika JI
- Mujika JI
- Murdock RC
- Nagarajkumar Yenugadhati
- Nagasawa K
- Naim JO
- Najafpour MM
- Namer M
- Nataliya A. Karyakina
- National Kidney Foundation
- Nayak P
- Nayak P
- Nday CM
- Nel A
- Netterlid E
- Newell KL
- Niedowicz DM
- Niemoeller OM
- Nishanth RP
- Noe SM
- Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and the Dutch Expert Committee on Occupational Safety
- NRC (National Research Council)
- Nøkleby H
- Oakley GP
- Oakley GP
- Oberdörster G
- Oberdörster G
- Oesterling E
- Ogimoto M
- Ohno K
- Olabanji O
- Oldham PD
- Orihuela D
- Ott SM
- Ou CY
- Pan SY
- Passeri E
- Patra AK
- Pauluhn J
- Pauluhn J
- Pechansky F
- Pei Y
- Pei Y
- Pennington JA
- Pepper R
- Percy ME
- Perl DP
- Pfefferkorn FE
- Phillips TD
- Pineau A
- Poirier J
- Polizzi S
- Poole RL
- Poole RL
- Poole RL
- Popinska K
- Potter H
- Powers KW
- Prabhakar PV
- Precioso AR
- Priest ND
- Priest ND
- Priest ND
- Priest ND
- Quatrale RP
- Rabe A
- Radzium E
- Ranau R
- Rao VS
- Rawlings W
- Reza SM
- Rezabal E
- Ribes D
- Ribes D
- Ricchelli F
- Riihimäki V
- Riihimäki V
- Rimaniol AC
- Robert A. Yokel
- Roberts NB
- Robertson JA
- Rocha MS
- Rosenlof K
- Rossbach B
- Rui D
- Rusina R
- Ryu RK
- Rödelsperger K
- Sadiq MI
- Sakula A
- Salib E
- Salusky IB
- Salusky IB
- Sandhu G
- Sandora TJ
- SanMartín CD
- Santibáñez M
- Sappino AP
- Sato K
- Savory J
- Savory J
- Savory J
- Schneider K
- Schrag M
- Schönholzer KW
- Seo J
- Sharma D
- Shati AA
- Shirodkar S
- Shoenfeld Y
- Shrivastava S
- Siegrist CA
- Sjogren B
- Slanina P
- Small GW
- Smith AJ
- Smith BS
- Sokolovska A
- Solfrizzi V
- Sood PK
- Sood PK
- Sorenson JR
- Stadler T
- Stahl T
- Steinhagen WH
- Stevanović ID
- Streker M
- Strozyk D
- Sumathi T
- Sun H
- Sun J
- Sun Z-Z
- Swaile DF
- Sánchez-Iglesias S
- Taiwo OA
- Tariba B
- Theeten H
- Theng BK
- Theng BKG
- Thinakaran G
- Thirunavukkarasu SV
- Thirunavukkarasu SV
- Thirunavukkarasu SV
- Thomas M. Wisniewski
- Toda S
- Tomljenovic L
- Tomljenovic L
- Tomljenovic L
- Tomljenovic L
- Touam M
- Tripathi S
- Tsaousi A
- Tsunoda M
- Turconi G
- Turkez H
- Turkez H
- Turkez H
- US DHHS (US Department of Health and Human Services)
- US DHHS (US Department of Health and Human Services)
- US FDA (US Food and Drug Administration)
- US FDA (US Food and Drug Administration)
- van der Put NM
- van der Voet GB
- Verbeken G
- Verdier F
- Verma NK
- Verstraeten SV
- Verstraeten SV
- Verstraeten T
- Viezeliene D
- Viezeliene D
- Vittori D
- Vota DM
- Wada K
- Wagner AJ
- Wagner L
- Wald N
- Walton JR
- Walton JR
- Walton JR
- Walton JR
- Wang B
- Wang N
- Watson LC
- Waxweiler RJ
- Weberg R
- Wei SH
- Weinbruch S
- Wharton SB
- Whitehead AS
- WHO (World Health Organization)
- Wier HA
- Wijnans L
- Wilhelm M
- Wilson JW
- Wilson JW
- Wisniewski HM
- Wisniewski HM
- Wood SJ
- Wu L
- Wu MJ
- Wu X
- Wu Z
- Xiao F
- Xie CX
- Yanagishita T
- Yang X
- Yang X
- Yang X
- Yates CM
- Yin da P
- Yiu G
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yoon PW
- Yoshida S
- Yousef MI
- Yu HY
- Yu SL
- Yu Z
- Yuan C-Y
- Yue CS
- Yumoto S
- Yumoto S
- Yumoto S
- Zagorski MG
- Zatta P
- Zeager M
- Zeng KW
- Zhang L
- Zhang QL
- Zhang QL
- Zhang QL
- Zhang QL
- Zhang XQ
- Zhu FC
- Zhu Y
- Zhu Y
- Zhu Y
- Zhu Y
- Zuo R
- Publication venue
- UKnowledge
- Publication date
- 01/10/2014
- Field of study
Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability. The present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007).
Challenges encountered in carrying out the present review reflected the experimental use of different physical and chemical Al forms, different routes of administration, and different target organs in relation to the magnitude, frequency, and duration of exposure. Wide variations in diet can result in Al intakes that are often higher than the World Health Organization provisional tolerable weekly intake (PTWI), which is based on studies with Al citrate. Comparing daily dietary Al exposures on the basis of “total Al”assumes that gastrointestinal bioavailability for all dietary Al forms is equivalent to that for Al citrate, an approach that requires validation. Current occupational exposure limits (OELs) for identical Al substances vary as much as 15-fold.
The toxicity of different Al forms depends in large measure on their physical behavior and relative solubility in water. The toxicity of soluble Al forms depends upon the delivered dose of Al+ 3 to target tissues. Trivalent Al reacts with water to produce bidentate superoxide coordination spheres [Al(O2)(H2O4)+ 2 and Al(H2O)6 + 3] that after complexation with O2•−, generate Al superoxides [Al(O2•)](H2O5)]+ 2. Semireduced AlO2• radicals deplete mitochondrial Fe and promote generation of H2O2, O2 • − and OH•. Thus, it is the Al+ 3-induced formation of oxygen radicals that accounts for the oxidative damage that leads to intrinsic apoptosis. In contrast, the toxicity of the insoluble Al oxides depends primarily on their behavior as particulates.
Aluminum has been held responsible for human morbidity and mortality, but there is no consistent and convincing evidence to associate the Al found in food and drinking water at the doses and chemical forms presently consumed by people living in North America and Western Europe with increased risk for Alzheimer\u27s disease (AD). Neither is there clear evidence to show use of Al-containing underarm antiperspirants or cosmetics increases the risk of AD or breast cancer. Metallic Al, its oxides, and common Al salts have not been shown to be either genotoxic or carcinogenic. Aluminum exposures during neonatal and pediatric parenteral nutrition (PN) can impair bone mineralization and delay neurological development. Adverse effects to vaccines with Al adjuvants have occurred; however, recent controlled trials found that the immunologic response to certain vaccines with Al adjuvants was no greater, and in some cases less than, that after identical vaccination without Al adjuvants.
The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances
The LHCb upgrade I
- Author
- Aaij R.
- Abdelmotteleb A.S.W.
- Abellan Beteta C.
- Abudinén F.
- Achard C.
- Ackernley T.
- Adeva B.
- Adinolfi M.
- Adlarson P.
- Afsharnia H.
- Agapopoulou C.
- Aidala C.A.
- Ajaltouni Z.
- Akar S.
- Akiba K.
- Albicocco P.
- Albrecht J.
- Alessio F.
- Alexander M.
- Alfonso Albero A.
- Aliouche Z.
- Alvarez Cartelle P.
- Amalric R.
- Amato S.
- Amey J.L.
- Amhis Y.
- An L.
- Anderlini L.
- Andersson M.
- Andreani A.
- Andreianov A.
- Andreotti M.
- Andreou D.
- Andrews J.E.
- Anelli M.
- Anjam A.
- Ao D.
- Archilli F.
- Arnaud K.
- Artamonov A.
- Artuso M.
- Ashby J.
- Aslanides E.
- Atzeni M.
- Audurier B.
- Ayres Rocha D.
- Bachiller Perea I.B.
- Bachmann S.
- Bachmayer M.
- Back J.J.
- Bailly-reyre A.
- Baladron Rodriguez P.
- Balagura V.
- Balbi G.
- Baldini W.
- Balla A.
- Baltazar M.
- Band H.
- Baptista de Souza Leite J.
- Barbetti M.
- Barclay P.
- Barlow R.J.
- Barsuk S.
- Barter W.
- Bartolini M.
- Baryshnikov F.
- Basels J.M.
- Bassi G.
- Baszczyk M.
- Batista Lopes J.C.
- Batsukh B.
- Battig A.
- Bay A.
- Beck A.
- Becker M.
- Bedeschi F.
- Bediaga I.B.
- Beigbeder-Beau C.
- Beiter A.
- Belin S.
- Bellee V.
- Belous K.
- Belov I.
- Belyaev I.
- Ben-Haim E.
- Benane G.
- Bencivenni G.
- Benettoni M.
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- Wormser G.
- Wotton S.A.
- Wraight K.
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- Wyllie K.
- Xiang Z.
- Xie Y.
- Xu A.
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- Yeroshenko V.
- Yeung H.
- Yin H.
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- Zaffaroni E.
- Zavertyaev M.
- Zdybal M.
- Zenaiev O.
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- Zhelezov A.
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- Zhukov V.
- Zivkovic V.
- Zou Q.
- Zucchelli S.
- Zuliani D.
- Zunica G.
- Zvyagintsev S.
- Publication venue
- IOP Publishing
- Publication date
- 01/05/2024
- Field of study
The LHCb upgrade represents a major change of the experiment. The detectors have been almost completely renewed to allow running at an instantaneous luminosity five times larger than that of the previous running periods. Readout of all detectors into an all-software trigger is central to the new design, facilitating the reconstruction of events at the maximum LHC interaction rate, and their selection in real time. The experiment's tracking system has been completely upgraded with a new pixel vertex detector, a silicon tracker upstream of the dipole magnet and three scintillating fibre tracking stations downstream of the magnet. The whole photon detection system of the RICH detectors has been renewed and the readout electronics of the calorimeter and muon systems have been fully overhauled. The first stage of the all-software trigger is implemented on a GPU farm. The output of the trigger provides a combination of totally reconstructed physics objects, such as tracks and vertices, ready for final analysis, and of entire events which need further offline reprocessing. This scheme required a complete revision of the computing model and rewriting of the experiment's software
A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction
- Author
- A Akhmedov
- A Alrefai
- A Antonini
- A Aranega
- A Aranega
- A Armani
- A Augustyniak
- A Berezin
- A Berezin
- A Bielli
- A Blanco Fernandez
- A Budko
- A Butt
- A Bykov
- A Cai
- A Campo
- A Cochrane
- A Dello Russso
- A Dickhout
- A Dinnyes
- A Diokmetzidou
- A Dyachenko
- A Eder
- A Evans
- A Evtushenko
- A Fiordelisi
- A Francke
- A Franco
- A Gafarova
- A Genis
- A Ghigo
- A Gorbe
- A Gorbe
- A Gradzka
- A Grochot-Przeczek
- A Gromotowicz
- A Hussain
- A I Suceveanu
- A Irmukhamedov
- A Jozkowicz
- A Kitmitto
- A Kopacz
- A Korda
- A Kremzer
- A Kremzer
- A Kumar
- A Kvasilova
- A Lualdi
- A Lupieri
- A Magenta
- A Margariti
- A Margariti
- A Muchir
- A Noriega De La Colina
- A Orlandi
- A P Suceveanu
- A Panasewicz
- A Ranieri
- A Raucci
- A Raya
- A Swiader
- A Szantai
- A Uitterdijk
- A Varela
- A Verzijl
- A Verzijl
- A Vlachou
- A Vlad
- A W Stitt
- A Zaninoni
- AA Kostareva
- AB Gevaert
- AB Malashicheva
- ABV Ana Barral
- AC Popescu
- AC Van Rossum
- AF Leite-Moreira
- AH Gershlick
- AH Van Den Meiracker
- AJ Leloup
- AM Jones
- AM Mahmoud
- AM Smits
- AR Babaeva
- AR Pries
- AS Kostina
- AV Sima
- B Davenport
- B Isermann
- B Kapornai
- B Maimone
- B Malinowska
- B Medic
- B Merkely
- B Nitzsche
- B Paltineanu
- B Porro
- B Reglin
- B Trimarco
- B Trimarco
- B Trimarco
- BCW Groenendijk
- BK Lim
- C A Carr
- C Arnold
- C Barsanti
- C Bras-Silva
- C Carbucicchio
- C Daraio
- C Davos
- C Deffge
- C Deffge
- C Del Giudice
- C Diaz-Canestro
- C Fresia
- C Ginghina
- C Gorsse-Bakker
- C Hauser
- C Korn
- C Kusmic
- C Lopez Sanchez
- C Lopez-Sanchez
- C M Terracciano
- C Macquart
- C Maia-Rocha
- C Mogler
- C Pellet-Many
- C Pena
- C Pinali
- C R Revnic
- C Sanjurjo-Rodriguez
- C Storelli
- C Tarquini
- C Tondo
- C Vindis
- C Voellenkle
- C Watson
- CE Van Hove
- CG Mitrofan
- CH Chimed
- CHG Metz
- CJ Mee
- CJ Schofield
- CJ Vrints
- CM Cesar Moris
- CS Stancu
- D Avitabile
- D Catalucci
- D Catrinoiu
- D De Stefani
- D E Tofoleanu
- D Franco
- D Franco
- D Grieve
- D I Roshchupkin
- D Jovicic
- D Kloska
- D Krstic
- D Merkus
- D Merkus
- D Merkus
- D Panov
- D Santos-Ribeiro
- D Sedmera
- D Sorriento
- D Sorriento
- D Sorriento
- D Tempel
- D Tihanyi
- DD Zhernossekov
- DG Sedding
- DJ Duncker
- DJ Duncker
- DJ Duncker
- DJ Duncker
- DP Naidoo
- DPM De Wijs-Meijler
- DPM De Wijs-Meijler
- DR Dimulescu
- E A Supit
- E Ambrozewicz
- E Cartwright
- E Chabielska
- E Dellambra
- E Esposito
- E Forizs
- E Gromova
- E Gronenko
- E Gronenko
- E Hirsch
- E J Humphrey
- E Kemp
- E L Stepien
- E Lazzarini
- E O'connell
- E Pavlyukova
- E Ruivo
- E Ruivo
- E Scoditti
- E Scoditti
- E Sommariva
- E Soumaka
- E Szigetfu
- E Terzuoli
- E Tremoli
- E Vernieri
- E Zima
- E Zocchi
- E-S Jeon
- ECM Van Eeuwijk
- EM Van Craenenbroeck
- ES Ju
- EV Kalinina
- F Ahlin
- F Carlomosti
- F Da Silva
- F De Santa
- F Diomede
- F Faita
- F J Enguita
- F Lenzarini
- F M Farina
- F Martelli
- F Revnic
- F Stea
- F Verhaegen
- F Zeni
- FJ Blanco
- FL Wilkinson
- FO Levy
- FP Everson
- G A Barnett
- G Basta Jovanovic
- G Bonne
- G Borile
- G Bruschetta
- G Camici
- G Chiva-Blanch
- G Cooper
- G Faggian
- G Grudzien
- G I Colombo
- G Iaccarino
- G Iaccarino
- G Iaccarino
- G Kullak-Ublick
- G Pompilio
- G Pompilio
- G Stellin
- G Teruzzi
- G Zaccagnini
- GG Vorobyov
- GM Sanda
- GRY De Meyer
- GSB Guillermo Solache Berrocal
- GY Lee
- H Bennett
- H El-Barbary
- H Girouard
- H Khader
- H Khalaf
- H Kozlowska
- H Nahapetyan
- H Palahniuk
- H Shakeri
- H Strijdom
- H Wojta
- HG Augustin
- HG Hiis
- HJ Park
- I Aidonidis
- I Badi
- I Burba
- I Dijkgraaf
- I Gagulin
- I Heinonen
- I Kloukina
- I Limon
- I Merciaro
- I Olivotto
- I R Parepa
- I Squellerio
- I Stadiotti
- I Zachary
- IA Tuktarova
- II Dementieva
- IKM Reiss
- IP Pashkova
- IR Isabel Rodriguez
- J Bauersachs
- J Baugh
- J Benes
- J Benes
- J Bojdo
- J Crespo
- J Duarte
- J Dulak
- J Dutzmann
- J F Ainscough
- J Faccini
- J G R De Mey
- J Gambardella
- J Herold
- J Herold
- J Hytonen
- J Hyttinen
- J Knuuti
- J Kobolak
- J Lappalainen
- J Lee
- J O'reilly
- J Paloczi
- J Paloczi
- J Pigler
- J Pizzicannella
- J Rys
- J Skopal
- J Szemraj
- J Taavitsainen
- J Van Der Velden
- J Wojta
- JA Maring
- JA Wilkinson
- JB Michel
- JBCA Jorge B Cannata-Andia
- JCLL Juan Carlos Llosa
- JH Hsu
- JL Yeh
- JM Daniel
- JM Daniel
- JM Taavitsainen
- JO Choi
- JP Hytonen
- JPG Sluijter
- JR Wu
- JWM Niessen
- K Al-Lamee
- K Donde
- K E Hemmings
- K E Porter
- K Huber
- K Huber
- K Kalliokoski
- K Kramkowski
- K Krobert
- K Lemmens
- K Lodder
- K Mcdonald
- K Otsu
- K Rawojc
- K Ruskova
- K Savic Vujovic
- K Smyshlyaev
- K Stam
- K Stam
- K V Buravleva
- KH Batmyagmar
- KL Harvey
- KR Vrijsen
- KS Avdeeva
- KS Solodenkova
- L Badimon
- L Badimon
- L Barile
- L Bherer
- L Borges
- L Desjardins-Creapeau
- L Guida
- L Korte
- L Malinova
- L Malinova
- L Mazilu
- L Morbidelli
- L Murfitt
- L Murphy
- L S Niculescu
- L Turnu
- L Woudstra
- L Zeng
- LA Mys
- LAA Alvarenga
- LE Smith
- LI Gapon
- LJM Juffermans
- LP Riber
- M Avkiran
- M Baranowska-Kuczko
- M Bertolotti
- M Bova
- M Campolo
- M Casella
- M Chatzifrangkeskou
- M Chiesa
- M Ciccarelli
- M Ciccarelli
- M Ciccarelli
- M Cordaro
- M D'agostino
- M DE C Lee-Rueckert
- M Elbaz
- M Gegenava
- M Giacca
- M J Drinkhill
- M Kloza
- M Kozlowski
- M L Sasonko
- M Laffargue
- M Lamarre-Cliche
- M Ledwidge
- M Levay
- M M Mazo
- M M Stevens
- M Magnone
- M Maibier
- M Makridakis
- M Martin Fernandez
- M Massaro
- M Massaro
- M Melenovsky
- M Miranda
- M Mongillo
- M Monti
- M Murina
- M Orije
- M Paci
- M Pellegrino
- M Pellegrino
- M Prostran
- M Rademaker
- M Reiner
- M Rohla
- M Romero
- M Sandri
- M Shamyunov
- M Teichert
- M Tscharre
- M Tsikitis
- M Van Kranenburg
- M Vila Gonzalez
- M Voevoda
- M Wagner
- M Wagner
- M Ziche
- MA Carluccio
- MA Carluccio
- MA Charnaia
- MA Melnikova
- MANOJ Manickam
- Maryam Alshamrani
- MC Arokiaraj
- MC Capogrossi
- MC Capogrossi
- MG Carnuta
- MG Scioli
- MJ Goumans
- MK Bae
- MK Kim
- MM Iqbal
- MN Usachiova
- MND Manuel Naves Diaz
- MR Popescu
- MV Cosson
- MV Krestjyaninov
- MY Alexander
- MY White
- N A Dorofeyeva
- N A Turner
- N Amdursky
- N Bitsch
- N Calabriso
- N Calabriso
- N Di Lascio
- N El-Helbawy
- N Furman
- N Goswami
- N Jegard
- N Malet
- N Morrell
- N S Peters
- N Simionescu
- N Sunderland
- N Vignier
- NA Musikhina
- NA Strutynska
- NF Smirnova
- NV Olezov
- NV Zhebel
- O Karpinska
- O Sorop
- O Trubiani
- O YU Atkov
- OE Mustafina
- OL Starzhynska
- P Ameri
- P Benzoni
- P Bianchi
- P Boya
- P Campiglia
- P Carullo
- P Ceriotti
- P De Boever
- P Dell'era
- P Dolotovskaya
- P Ferdinandy
- P Ferdinandy
- P Halonen
- P Kolodziejczyk
- P Korpisalo
- P Larochelle
- P Mendes-Ferreira
- P Pugliatti
- P Vincent
- PA Doevendans
- PAJ Krijnen
- Paul A Cahill
- PH Puhakka
- PJ Halonen
- PRG Pablo Roman Garcia
- PS Biesbroek
- PS Gutierrez
- PT Kovanen
- Q Xu
- R Adao
- R Blaise
- R Ciarapica
- R Coppini
- R Crupi
- R De Caterina
- R De Caterina
- R Di Paola
- R Dworakowski
- R Estruch
- R Ferrer-Lorente
- R Fusco
- R Gaspar
- R Koenen
- R Martinelli
- R Mcgeogh
- R Prakaschandra
- R Rizzuto
- R Siracusa
- R Stamatiou
- R Suades
- R Van Duin
- R Widmer-Teske
- R Wu
- RC Braun-Dullaeus
- RC Braun-Dullaeus
- RH Gimaev
- RJ Van Geuns
- RR Dias
- RSP Falcao
- RWB Van Duin
- RWE Emmens
- S A Bageghni
- S Agostinelli
- S Appleby
- S Beji
- S Brambilla
- S Briand
- S Bruzzone
- S Cassambai
- S Comer
- S Cordisco
- S Cuzzocrea
- S De Falco
- S Dean
- S Egginton
- S Fiorelli
- S Gayral
- S Hertel
- S Kelaini
- S Keller
- S Kostin
- S Lacchini
- S Loffredo
- S Malandraki-Miller
- S Nowak
- S Omiya
- S Pennington
- S Piper
- S Popov
- S Radojevic Skodric
- S Severi
- S Sneep
- S Stojkovic
- S Subramaniam
- S Tarvainen
- S Tayel
- S Tayel
- S Van Hoof
- S Voinea
- S Weinert
- S Yla-Herttuala
- S Yla-Herttuala
- S-H Jung
- SAJ Chamuleau
- SJ Cordwell
- SJ Tarvainen
- SK Bae
- SM Dyachkov
- SM Kanse
- SM Van Dommelen
- SS Kapel
- T Andric
- T Berezina
- T Berezina
- T Denisova
- T Eschenhagen
- T Gegenava
- T Gibbs
- T Grandjean
- T Hiltunen
- T Korff
- T Liimatainen
- T Luscher
- T Mcdonagh
- T Ogundipe
- T Samura
- T Vigliarolo
- T Wieland
- T Zaglia
- TI Petelina
- TM Hackeng
- TM Leurgans
- TN Nguyen
- TR Nasibullin
- TV Grinenko
- TW Weiss
- V Catto
- V Cavalca
- V Di Stefano
- V Evtushenko
- V Gafarov
- V Garcia-Lopez
- V Garcia-Lopez
- V Garcia-Martinez
- V Garcia-Martinez
- V Gatta
- V Maximov
- V Mehta
- V Ryabukho
- V Tarallo
- V Verhage
- V Vida
- VF Sagach
- VF Sagach
- VI Ruzov
- VI Sergienko
- VJ De Beer
- VM Rybachuk
- VM Zhebel
- VV Erdman
- W Hamed
- W Hamed
- W Miltyk
- W Rong
- W Xiang
- WJ Van Der Giessen
- Y Anfinogenova
- Y Capetanaki
- Y D'alessandra
- Y Hu
- Y Octavia
- Y Omori
- Y Richaud-Patin
- Y Timasheva
- YJ Lee
- YM Roka-Moiia
- YU I Gurfinkel
- YU Lishmanov
- YU Saushkina
- YUA Morozov
- Z Lkhagvasuren
- Z Nagy
- Z Todorovic
- ZK Dai
- ZS Jenei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
Background: Carbohydrates play a major role in cell signaling in many biological processes. We have developed a set of glycomimetic drugs that mimic the structure of carbohydrates and represent a novel source of therapeutics for endothelial dysfunction, a key initiating factor in cardiovascular complications. Purpose: Our objective was to determine the protective effects of small molecule glycomimetics against free fatty acidinduced endothelial dysfunction, focusing on nitric oxide (NO) and oxidative stress pathways. Methods: Four glycomimetics were synthesized by the stepwise transformation of 2,5dihydroxybenzoic acid to a range of 2,5substituted benzoic acid derivatives, incorporating the key sulfate groups to mimic the interactions of heparan sulfate. Endothelial function was assessed using acetylcholineinduced, endotheliumdependent relaxation in mouse thoracic aortic rings using wire myography. Human umbilical vein endothelial cell (HUVEC) behavior was evaluated in the presence or absence of the free fatty acid, palmitate, with or without glycomimetics (1µM). DAF2 and H2DCFDA assays were used to determine nitric oxide (NO) and reactive oxygen species (ROS) production, respectively. Lipid peroxidation colorimetric and antioxidant enzyme activity assays were also carried out. RTPCR and western blotting were utilized to measure Akt, eNOS, Nrf2, NQO1 and HO1 expression. Results: Ex vivo endotheliumdependent relaxation was significantly improved by the glycomimetics under palmitateinduced oxidative stress. In vitro studies showed that the glycomimetics protected HUVECs against the palmitateinduced oxidative stress and enhanced NO production. We demonstrate that the protective effects of preincubation with glycomimetics occurred via upregulation of Akt/eNOS signaling, activation of the Nrf2/ARE pathway, and suppression of ROSinduced lipid peroxidation. Conclusion: We have developed a novel set of small molecule glycomimetics that protect against free fatty acidinduced endothelial dysfunction and thus, represent a new category of therapeutic drugs to target endothelial damage, the first line of defense against cardiovascular disease
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos A.
- Abbas A.M.
- Abbas M.
- Abbasi M.
- Abbott T.
- Abdalaal I.
- Abdel-Galil K.
- Abdelemam R.
- Abdelgawad A.
- Abdelkarim M.
- Abdelkhalek M.
- Abdelmageed A.
- Abdelmawgoud S.
- Abdelmohsen S.
- Abdelrahman A.S.
- Abdelrahman M.
- Abdelwahab K.
- Abdou H.
- Abdulai D.R.
- Abdulkhaleq M.
- Abdullah B.
- Abdulsalam K.
- Abdulsalam S.
- Abdur-Rahman L.
- Abdus-Salam R.
- Abdussalam H.O.
- Abebrese J.T.
- Abeldaño A.
- Abou-Khalil J.
- Abou-Taleb H.
- Abozid A.
- Abozied H.
- Abrate A.
- Abu-Zaid A.
- Abubakar M.K.
- Abud B.
- Abuzaid M.
- Adam A.A.
- Adamina M.
- Adamou H.
- Adamu A.
- Adamu K.M.
- Adanu K.
- Adebara I.
- Adebola O.
- Ademuyiwa A.
- Adeniran A.
- Adepiti A.
- Aderogba A.A.
- Adesunkanmi A.
- Adeyeye A.
- Adisa A.
- Adjeso T.J.K.
- Ads A.M.
- Ads A.M.
- Adu-Aryee N.A.
- Adumah C.
- Afzal I.
- Agapov M.
- Agarwal G.
- Agarwal R.
- Agbeko A.E.
- Agbeno E.K.
- Agbonrofo P.
- Agboola O.
- Aggarwal G.
- Aghadi I.
- Aghtarafi N.
- Agrawal A.
- Agresta F.
- Aguado H.J.
- Aguilera-Arevalo M.-L.
- Aherne T.
- Ahmad A.
- Ahmad M.
- Ahmad M.
- Ahmad S.
- Ahmad S.
- Ahmad S.
- Ahmed H.T.A.
- Ahmed K.
- Ahmed S.
- Ahmed S.
- Ahmed U.
- Aisuodionoe-Shadrach O.
- Aitken S.
- Ajenifuja K.
- Ajiya A.
- Akeel N.
- Akin E.
- Akinajo O.
- Akinyemi T.
- Akrida I.
- Aktokmakyan T.V.
- Akwaisah A.
- Al-Badawi I.A.
- Al-Juaifari M.
- Al-Khyatt W.
- Al-Mallah A.
- Al-Nusairi A.
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- Šantak G.
- Šimko K.
- Žatecký J.
- Publication venue
- Oxford University Press (OUP)
- Publication date
- 01/07/2023
- Field of study
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
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- Becerra Angel
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- Borges Miguel Fróis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
- Bortul Marina
- Botelho Pedro
- Bottari Andrea
- Bouchagier Konstantinos
- Bouliaris Konstantinos
- Bowan Antoinette Bediako
- Bowen Joel
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bramis Konstantinos
- Branagan Graham
- Branzan Daniela
- Brasset Camille
- Bratus Dejan
- Bravo Ana Maria Minaya
- Bravo Sybil Lizanne
- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
- Broglia Alessandro
- Brolese Alberto
- Browning Rebecca
- Bruzzaniti Placido
- Brzeszczyński Filip
- Bsisu Isam
- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
- Bumbasirevic Uros
- Bumber Boris
- Burgos-Blasco Barbara
- Burlov Nikita
- Bussu Francesco
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- Börner Nikolaus
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- Cabeza Leticia
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- Kapetanakis Emmanouil
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- Kassab Mohamad B.
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- Katechia Devvrat
- Katorkin Sergey
- Katsaros Ioannis
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- Katsura Morihiro
- Kauppila Joonas H
- Kaur Amanjot
- Kausar Nabila
- Kavalakat Alfie
- Kavanagh Marcel Marjanović
- Kazan Ozgur
- Kealey Joshua
- Kebede Ephrem
- Kedwany Ahmed
- Kelly Michael
- Ken-Amoah Sebastian
- Kenington Cleo
- Kennerton A.S.
- Kent Alistair J
- Keramati Mohammad Reza
- Kethy Fagnon
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- Kroon Hidde M.
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- Laborde Mario Mella
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- Lakpriya Sathya
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- Lazarou Lazaros
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- Lieske Bettina
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- Lohmann Tibor Karl
- Lohse Helmut Alfredo Segovia
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- Losada Manuel
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- Loubani Mahmoud
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- Luc Jessica
- Lucas Miriam Abellan
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- Lule Herman
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- Lyra Humberto Fenner
- Mabood Waleed
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- Madhuri Thumuluru Kavitha
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- Maffuz-Aziz Antonio
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- Maguire Patrick J.
- Mahečić Tina Tomić
- Mahmood Fahad
- Mahmoud Abdelrahman
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- Makanjuola Ayomide
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- Malek Bouhani
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- Malik Sobia
- Mallick Rebecca
- Mallmann Christoph
- Mallmann Michael R.
- Mambrilla Sara
- Manangi Mallikarjuna
- Manesh Hassan Fatemi
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- Mangi Ali
- Maniaci Antonino
- Manickavasagam Jaiganesh
- Manigrasso Michele
- Manjula S.
- Mannan Syed
- Mantziari Styliani
- Maquilón Alejandra Jara
- Marafante Chiara
- Marano Luigi
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- Mariani Nicolò Maria
- Marino Fabio
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- Martinez-Leo Bruno
- Martinez-Mier Gustavo
- Martinez-Perez Carolina
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- Martins Ana
- Martins Claudia Pinto
- Martins Paulo N.
- Martínez Daniel Fernández
- Martínez Eunate Ganuza
- Martínez Verónica Martín
- Martínez-Sánchez Marta Isabel
- Masciello Fabrizio
- Masri Ruqaya
- Massaguer Clara
- Massoud John
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- Mathew Ryan
- Matos Leandro
- Matos Philomena Alice Wawer
- Matthews Emily
- Mauriello Claudio
- Maurus Christine
- Mayer Horacio F.
- Mayo-Yáñez Miguel
- Mazzarella Gennaro
- Mbodi Langanani
- Mbwele Bernard
- McAleer Stephen
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- McGrath John
- McKay Joseph
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- McLeish Bethan
- McPherson Duncan
- Meara John G.
- Meead Adullah
- Mehraj Asif
- Meilak Joseph
- Meleiro Hugo
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- Meneghini Simona
- Mengesha Mengistu G.
- Menna Maria Paola
- Menon Arun
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- Migliore Marcello
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- Mohamed Ahmed Mohamed Ibrahim
- Mohamed Guleed
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- Mohamedahmed Ali Yasen Y.
- Mohammed Alhassan Datti
- Mohammed Alsnosy Abdullah Khalefa
- Mohammed-Durosinlorun Amina
- Mohan Helen
- Mohan Rajashekar
- Mok Chi Wei
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Lack of Correlation Between MMF Dose and MPA Level in Pediatric and Young Adult Cardiac Transplant Patients: Does the MPA Level Matter?1
- Publication venue
- 'Wiley'
- Publication date
- Field of study
- …