Small vessel microembolization and acute glomerulonephritis following infection of aesthetic filler implants

Background: The systemic consequences of esthetic filler injections are poorly understood. Case presentation: We report a patient with a past history of subcutaneous injection of aesthetic filler material in the lower legs, who presented with post-infectious glomerulonephritis following necrotic leg ulcers at the injection site. Kidney biopsy revealed the presence of translucent, non-birefringent microspherical bodies compatible with polymethylmetacrylate (PMMA) microspheres in some capillary lumens. This had not previously been described. PMMA is a biphasic aesthetical filler composed of polymethylmetacrylate microspheres suspended in a biodegradable bovine collagen carrier. The solid phase (PMMA microspheres) persists in tissues for years. Although PMMA was thought to not disseminate systemically, tissue necrosis may have favored systemic dissemination of the microspheres, although entry in the circulation and microembolization at the time of administration cannot be ruled out. Conclusions: In conclusion, aesthetic filler implants may cause microembolization into small vessels. Recognition of the characteristic morphology may expedite diagnosis and avoid unnecessary further testing.AO and CMC were supported by ISCIII and FEDER funds PI13/00047, REDinREN RD012/0021, Comunidad de Madrid CIFRA S2010/BMD-2378 and Programa Intensificación Actividad Investigadora. BFF by ISCIII Joan Rodes

Crustacean amphipods from marsh ponds: a nutritious feed resource with potential for application in Integrated Multi-Trophic Aquaculture

Coastal protection, nutrient cycling, erosion control, water purification, and carbon sequestration are ecosystem services provided by salt marshes. Additionally, salt ponds offer coastal breeding and a nursery habitat for fishes and they provide abundant invertebrates, such as amphipods, which are potentially useful as a resource in aquaculture. Fishmeal and fish oil are necessary food resources to support aquaculture of carnivorous species due to their omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA). Currently, aquaculture depends on limited fisheries and feed with elevated n-3 LC-PUFA levels, but the development of more sustainable food sources is necessary. Amphipods appear to be a potential high quality alternative feed resource for aquaculture. Hence, a nutritional study was carried out for several main amphipod species—Microdeutopus gryllotalpa, Monocorophium acherusicum, Gammarus insensibilis, Melita palmata and Cymadusa filosa—in terrestrial ponds in the South of Spain. These species showed high protein content (up to 40%), high n-3 PUFA and phospholipid levels, and high levels of phophatidylcholine (PC), phosphatidylethanolamine (PE) and triacylglycerols (TAG), the latter being significantly high for M. acherusicum. M. gryllotalpa and M. acherusicum showed the highest proportion of lipids (19.15% and 18.35%, respectively). Isoleucine, glycine and alanine were the dominant amino acids in all species. In addition, amphipods collected from ponds showed low levels of heavy metals. Furthermore, the biochemical profiles of the five species of amphipods have been compared with other studied alternative prey. Therefore, pond amphipods are good candidates to be used as feed, and are proposed as a new sustainable economic resource to be used in aquaculture. G. insensibilis may be the best for intensive culture as an alternative feed resource because it shows: (1) adequate n-3 PUFA and PL composition; (2) high levels of glycine, alanine, tyrosine, isoleucine and lysine; (3) high natural densities; (4) large body size (≥1 cm), and (5) high concentration of calcium. Moreover, a combined culture of amphipods and fishes in these marsh ponds seems a promising and environmentally sustainable way to develop Integrate Multi-Trophic Aquaculture (IMTA) in these ecosystems.Junta de Andalucía Consejería de Innovación, Ciencia y Empresa P11-RNM-704

Triángulo del Arlanza. Proyectando en Sad Hill: Propuestas de hostería & film commission, Covarrubias. Intervenciones mínimas en el paisaje, Santo Domingo de Silos

El presente volumen contiene una recopilación de Proyectos Académicos desarrollados en el curso 2018-2019 en la Asignatura de Proyectos Arquitectónicos VII: Arquitecturas de programas mixto residencial e institucional. Los trabajos incluidos fueron realizados en la villa de Covarrubias y el paraje de Sad Hill, provincia de Burgos.Departamento de Teoría de la Arquitectura y Proyectos ArquitectónicosCoacyle BurgosAyuntamiento de CovarrubiasAsociación Cultural Sad Hil

Retomando presencialidad: una mirada diferente del retorno a las actividades extensionistas presenciales

En este trabajo se presentan las actividades desarrolladas en el marco del proyecto de extensión “Conversatorios de Ciencia Experimental en la Enseñanza Media”. Dichas actividades se enfocan en la vinculación Universidad-Sociedad, a través del desarrollo de conversatorios y diversas experiencias que abordan conceptos básicos de la ciencia y de la física en particular, a través de los cuales es posible fomentar el interés de los estudiantes del nivel secundario por la ciencia. Las actividades incluyen la visita a distintos establecimientos educativos de enseñanza media. El retorno a las actividades presenciales motivó al equipo extensionista a realizar un replanteamiento de actividades en función de las nuevas herramientas adquiridas. En calidad de ello,se reformularon las actividades interactivas vinculadas a experiencias y descubrimientos de Galileo Galilei. Estos cambios se realizaron basados en las encuestas realizadas en años anteriores (tanto en periodo presencial como en aislamiento). Como resultado, se presenta el análisis de las nuevas encuestas, se obtuvo una buena aceptación del taller reformulado y la motivación manifestada por los estudiantes.Facultad de Ingenierí

Centro de Estudios Hidrológicos : Propuestas en la dársena del Canal de Castilla, Valladolid

Producción CientíficaDurante el curso 2020/2021, en la asignatura de Proyectos VI, se desarrollaron dentro de la programación docente un conjunto de proyectos, que tenían como objetivo la intervención en la zona de la dársena del Canal de Castilla, en Valladolid, caracterizada por una gran multiplicidad de factores. El programa que se planteaba trataba de poner en valor dicho enclave, a través de la creación de un Centro de Estudios Hidrológicos para la Confederación Hidrográfica del Duero. Se trataba de reflexionar sobre el cauce y las zonas adyacentes, con proyectos que albergaran diversos servicios, ahora dispersos por las inmediaciones, además de ordenar los espacios libres e integrarlos en la trama urbana.During the 2020/2021 academic year, in the subject of Projects VI, a set of projects were developed within the teaching program, which aimed to intervene in the area of the Canal de Castilla dock, in Valladolid, characterized by a large multiplicity of factors. The program that was proposed tried to value said enclave, through the creation of a Center for Hydrological Studies for the Duero Hydrographic Confederation. It was a matter of reflecting on the riverbed and the adjacent areas, with projects that housed various services, now scattered around the vicinity, in addition to ordering the free spaces and integrating them into the urban plot.Departamento de Teoría de la Arquitectura y Proyectos ArquitectónicosZaparaín Hernández, F.; Rodríguez Andrés, J.; Paniagua García, A.; Ruiz Íñigo, M.; Fernández Catalina, M.; Llamazares Blanco, P. (coords.). Rodríguez Andrés, J.; Fernández Catalina, M.; Llamazares Blanco, P. (diseño gráfico y maquetación). Rodríguez Andrés, J.; Llamazares Blanco, P. (diseño de la colección

Prevalence of acromegaly in patients with symptoms of sleep apnea

Acromegaly is a rare disease with nonspecific symptoms with acral enlargement being almost universally present at diagnosis. The estimated prevalence is 40–125 cases/million but targeted universal screening studies have found a higher prevalence (about 10 fold). The aim of the ACROSAHS study was to investigate the prevalence of acromegaly and acromegaly comorbidities in patients with sleep apnea symptoms and acral enlargement. ACROSAHS was a Spanish prospective non-interventional epidemiological study in 13 Hospital sleep referral units. Facial and acral enlargement symptoms including: ring size and shoe size increase, tongue, lips and jaws enlargement, paresthesia or carpal tunnel syndrome and widening of tooth spaces, as well as other typical acromegaly comorbidities were recorded with a self-administered questionnaire of patients who attended a first visit for sleep apnea symptoms between 09/2013 and 07/2014. Serum insulin-like growth factor type 1 (IGF1) was measured in patients with ≥1 acral symptom to determine the prevalence of acromegaly. Of the 1557 patients enrolled, 1477 with complete data (72% male) were analyzed. 530 patients (36%) reported at least 1 acral enlargement symptom and were tested for IGF-1, 41 were above range, persisted in 7, and among those, 2 cases of acromegaly were diagnosed (prevalence of at least 1.35 cases/1000). Overall, 1019 patients (69%) had ≥2 acromegaly symptoms and should have been screened according to guidelines; moreover 373 patients (25%) had ≥1 symptom of acral enlargement plus ≥3 other acromegaly symptoms. In conclusion, in patients with sleep apnea symptoms and acral enlargement, we found an acromegaly prevalence of at least 1.35 cases per 1000 and a high prevalence of typical acromegaly symptoms. It is important that sleep specialists are aware of acromegaly symptoms to aid with acromegaly diagnosis.The study was investigator initiated and was partially sponsored by Ipsen Pharma, S.A., Spai

Experiencia de Arquímedes: principio de flotación

En este trabajo se aborda el proceso de generación de nuevas experiencias que fueron desarrolladas por un grupo de alumnos y alumnas beneficiarios/as de la Beca Manuel Belgrano, coordinado por docentes a cargo del proyecto de extensión “Conversatorios de Ciencia Experimental en la Enseñanza Media”, con la intención de incorporar dichas experiencias a las actividades realizadas en el marco del proyecto en cuestión. Este proceso, permitió desarrollar una actividad que aborda el principio de flotabilidad, basándose en la medición de algunos parámetros de un cuerpo sólido (masa y volumen) y su comportamiento al sumergirlo. Para esto, los estudiantes generaron un material didáctico con todos los contenidos trabajados. En dicha experiencia se aplican principios teóricos basados en el principio de Arquímedes. Como resultado se logró construir un prototipo compuesto por una pecera de vidrio, un cilindro metálico macizo, un dinamómetro y un soporte. Fue presentado por primera vez en la IV semana de la Promoción de la Extensión y en la 5ta jornada Territorial. En vista de la respuesta positiva que se obtuvo por el público que asistió a estas jornadas de divulgación, se incorporó como experiencia al desarrollo de las actividades llevadas a cabo por el equipo extensionista del mencionado proyecto.Facultad de Ingenierí

Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells

Background: A functional population of adipocyte precursors, termed adipose-derived stromal/stem cells (ASCs), is crucial for proper adipose tissue (AT) expansion, lipid handling, and prevention of lipotoxicity in response to chronic positive energy balance. We previously showed that obese human subjects contain a dysfunctional pool of ASCs. Elucidation of the mechanisms underlying abnormal ASC function might lead to therapeutic interventions for prevention of lipotoxicity by improving the adipogenic capacity of ASCs. Methods: Using epigenome-wide association studies, we explored the impact of obesity on the methylation signature of human ASCs and their differentiated counterparts. Mitochondrial phenotyping of lean and obese ASCs was performed. TBX15 loss- and gain-of-function experiments were carried out and western blotting and electron microscopy studies of mitochondria were performed in white AT biopsies from lean and obese individuals. Results: We found that DNA methylation in adipocyte precursors is significantly modified by the obese environment, and adipogenesis, inflammation, and immunosuppression were the most affected pathways. Also, we identified TBX15 as one of the most differentially hypomethylated genes in obese ASCs, and genetic experiments revealed that TBX15 is a regulator of mitochondrial mass in obese adipocytes. Accordingly, morphological analysis of AT from obese subjects showed an alteration of the mitochondrial network, with changes in mitochondrial shape and number. Conclusions: We identified a DNA methylation signature in adipocyte precursors associated with obesity, which has a significant impact on the metabolic phenotype of mature adipocytes