21 research outputs found
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Ackers M
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- Adelman J
- Aderholz M
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- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
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- Zhemchugov A
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.
- Author
- Aban M
- Abeyskera KWM
- Aboagye J
- Adam M
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- Adamson JP
- Adewatan G
- Adlou S
- Ahmed K
- Akhalwaya S
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- Alcock A
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- Ali A
- Allen ER
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- Alvernaz FB
- Amorim FS
- Andrade CS
- Andritsou F
- Angus B
- Anslow R
- Arbe-Barnes EH
- Ariaans MP
- Arns B
- Arruda L
- Assad L
- Azi LDA
- Azi PDA
- Babbage G
- Bailey C
- Baillie VL
- Baker KF
- Baker M
- Baker N
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- Baleanu I
- Bandeira D
- Bara A
- Barbosa MAS
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- Barlow GD
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- Barrett J
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- Phohu MK
- Pickup L
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- Price V
- Primeira MR
- Proud PC
- Provstgaard-Morys S
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- Pulido D
- Quaid S
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- Rajapaska D
- Rajeswaran T
- Ramasamy MN
- Ramos Lopez F
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- Sampaio MD
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- Satti I
- Saunders C
- Saunders JE
- Sayed ABA
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- Schmid AB
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- Schwarzbold AV
- Screaton GR
- Seddiqi S
- Segireddy RR
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- Wroblewska M
- Yao A
- Yim YTN
- Zambrano MB
- Zimmer RL
- Zizi D
- Zuidewind P
- Publication venue
- Elsevier
- Publication date
- 01/02/2021
- Field of study
BACKGROUND: The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4-12 weeks. The planned roll-out in the UK will involve vaccinating people in high-risk categories with their first dose immediately, and delivering the second dose 12 weeks later. Here, we provide both a further prespecified pooled analysis of trials of ChAdOx1 nCoV-19 and exploratory analyses of the impact on immunogenicity and efficacy of extending the interval between priming and booster doses. In addition, we show the immunogenicity and protection afforded by the first dose, before a booster dose has been offered. METHODS: We present data from three single-blind randomised controlled trials-one phase 1/2 study in the UK (COV001), one phase 2/3 study in the UK (COV002), and a phase 3 study in Brazil (COV003)-and one double-blind phase 1/2 study in South Africa (COV005). As previously described, individuals 18 years and older were randomly assigned 1:1 to receive two standard doses of ChAdOx1 nCoV-19 (5 × 1010 viral particles) or a control vaccine or saline placebo. In the UK trial, a subset of participants received a lower dose (2·2 × 1010 viral particles) of the ChAdOx1 nCoV-19 for the first dose. The primary outcome was virologically confirmed symptomatic COVID-19 disease, defined as a nucleic acid amplification test (NAAT)-positive swab combined with at least one qualifying symptom (fever ≥37·8°C, cough, shortness of breath, or anosmia or ageusia) more than 14 days after the second dose. Secondary efficacy analyses included cases occuring at least 22 days after the first dose. Antibody responses measured by immunoassay and by pseudovirus neutralisation were exploratory outcomes. All cases of COVID-19 with a NAAT-positive swab were adjudicated for inclusion in the analysis by a masked independent endpoint review committee. The primary analysis included all participants who were SARS-CoV-2 N protein seronegative at baseline, had had at least 14 days of follow-up after the second dose, and had no evidence of previous SARS-CoV-2 infection from NAAT swabs. Safety was assessed in all participants who received at least one dose. The four trials are registered at ISRCTN89951424 (COV003) and ClinicalTrials.gov, NCT04324606 (COV001), NCT04400838 (COV002), and NCT04444674 (COV005). FINDINGS: Between April 23 and Dec 6, 2020, 24 422 participants were recruited and vaccinated across the four studies, of whom 17 178 were included in the primary analysis (8597 receiving ChAdOx1 nCoV-19 and 8581 receiving control vaccine). The data cutoff for these analyses was Dec 7, 2020. 332 NAAT-positive infections met the primary endpoint of symptomatic infection more than 14 days after the second dose. Overall vaccine efficacy more than 14 days after the second dose was 66·7% (95% CI 57·4-74·0), with 84 (1·0%) cases in the 8597 participants in the ChAdOx1 nCoV-19 group and 248 (2·9%) in the 8581 participants in the control group. There were no hospital admissions for COVID-19 in the ChAdOx1 nCoV-19 group after the initial 21-day exclusion period, and 15 in the control group. 108 (0·9%) of 12 282 participants in the ChAdOx1 nCoV-19 group and 127 (1·1%) of 11 962 participants in the control group had serious adverse events. There were seven deaths considered unrelated to vaccination (two in the ChAdOx1 nCov-19 group and five in the control group), including one COVID-19-related death in one participant in the control group. Exploratory analyses showed that vaccine efficacy after a single standard dose of vaccine from day 22 to day 90 after vaccination was 76·0% (59·3-85·9). Our modelling analysis indicated that protection did not wane during this initial 3-month period. Similarly, antibody levels were maintained during this period with minimal waning by day 90 (geometric mean ratio [GMR] 0·66 [95% CI 0·59-0·74]). In the participants who received two standard doses, after the second dose, efficacy was higher in those with a longer prime-boost interval (vaccine efficacy 81·3% [95% CI 60·3-91·2] at ≥12 weeks) than in those with a short interval (vaccine efficacy 55·1% [33·0-69·9] at <6 weeks). These observations are supported by immunogenicity data that showed binding antibody responses more than two-fold higher after an interval of 12 or more weeks compared with an interval of less than 6 weeks in those who were aged 18-55 years (GMR 2·32 [2·01-2·68]). INTERPRETATION: The results of this primary analysis of two doses of ChAdOx1 nCoV-19 were consistent with those seen in the interim analysis of the trials and confirm that the vaccine is efficacious, with results varying by dose interval in exploratory analyses. A 3-month dose interval might have advantages over a programme with a short dose interval for roll-out of a pandemic vaccine to protect the largest number of individuals in the population as early as possible when supplies are scarce, while also improving protection after receiving a second dose. FUNDING: UK Research and Innovation, National Institutes of Health Research (NIHR), The Coalition for Epidemic Preparedness Innovations, the Bill & Melinda Gates Foundation, the Lemann Foundation, Rede D'Or, the Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca
Noninvasive Characterization of Epicardial Activation in Humans With Diverse Atrial Fibrillation Patterns
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- Field of study
Surgery after Complications of PTCA: An Overview on Strategy, Techniques, and Results
- Author
- AR Connor
- AS Norell
- CE Bredlau
- DA Murphy
- DJ Farrar
- E Mundth
- Empfehlungen für die Durchführung der perkutanen transluminalen Koronarangioplastie (PTCA)
- Executive Committee of the NHLBI PTCA Registry
- GJ Brahos
- HJ Krebber
- J Bardet
- J Schofer
- JF Marquis
- JL Cox
- JM Wilson
- JW Kirklin
- LC Pelletier
- MA Wood De
- P Satter
- RC Leinbach
- TB Ferguson
- TB Ferguson
- V Parsonnet
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1991
- Field of study
Erkrankungen und Leitsymptome des proximalen Intestinaltraktes
- Author
- A Baraka
- A Koch
- A Schärli
- A Taneja
- AD Magilner
- AF White
- AR Euler
- AR Euler
- AR Euler
- B Ajdukiewicz
- BC Manegold
- BF Felsher
- CC Roy
- CGF Seagram
- D Krause
- D Valerio
- D Weitzel
- DB Darling
- DH Shmerling
- DL Keramidas
- DM Lane
- DS Blatnik
- E Hafter
- E Willich
- E Willich
- EA Franken Jr
- EBD Neuhauser
- F Ferguson
- F Helmer
- F Höpner
- F Keiner
- FA London
- FJ Tedesco
- FJ Tedesco
- G Landbeck
- G Töndury
- GSM Botha
- GW Friedland
- H Eaton
- H Huchzermeyer
- H Huchzermeyer
- H Watanabe
- HF Otto
- HG Keitel
- HG Posselt
- IJ Carré
- IJ Welsh
- J Abrahamson
- J Farman
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- J Medrano
- JA Dodge
- JB Elder
- JD Gryboski
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- JDA Robb
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- L Demling
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- M Gebel
- M Höllwarth
- M Meradji
- M Rosetti
- ME Ament
- MH Shamma’a
- MJ Asch
- MJ Bell
- MJ Bell
- MR Curci
- NB Ackerman
- OA Sorsdahl
- P Bedard
- P Puri
- PP Forget
- R Arnold
- R Astley
- R Grüttner
- R Joseph
- R Siewert
- R Teschke
- RB Tudor
- RG Allen
- RJ Deckelbaum
- RJ Touloukian
- S Cadranel
- S Cadranel
- StW Bender
- T Gilat
- TB Denzler
- TJ Tachovski
- TM Holder
- W Lorenz
- WCh Hecker
- WM Liebman
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1981
- Field of study
Effect of Radiofrequency Catheter Ablation on Doppler Echocardiographic Parameters in Patients With Wolff-Parkinson-White Syndrome
- Author
- Abdurrahman Eksik
- Ahmet Akyol
- Ahmet Alper
- Arruda MS McClelland JH, Wang X,
- Breithardt OA Stellbrink C, Franke A,
- Caso P D'Andrea A, Musto C,
- Choong CY Abascal VM, Thomas JD, Guerrero JL, McGlew S, Weyman AE
- d'Avila A Brugada J, Skeberis V, Andries E, Sosa E, Brugada P
- Enis Oguz
- Feigenbaum H
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- Gras D Leclercq C, Tang ASL, Bucknall C, Luttikhuis HO, Kirstein-Pedersen A
- Grines CL Bashore TM, Boudoulas H, Olson S, Shafer P, Wooley CF
- Hakan Hasdemir
- Hale Yilmaz
- Hina K Murakami T, Kusachi S,
- Hishida H Sotobata I, Koike Y, Okumura M, Mizuno Y
- Horwich T Foster E, De Marco T, Tseng Z, Saxon L
- Izzet Erdinler
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- Kadir Gurkan
- Katritsis DG Hossein-Nia M, Anastasakis A,
- Kucherer HF Abbott JA, Botvinick EH,
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- Mahmut Cakmak
- Milstein S Sharma AD, Guiraudon GM, Klein GJ
- Nakayama K Miyatake K, Uematsu M,
- Nazmiye Cakmak
- Nurten Sayar
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- Xiao HB Brecker SJ, Gibson DG
- Xiao HB Lee CH, Gibson DG
- Zhang M Zhou QC, Fan P
- Publication venue
- 'International Heart Journal (Japanese Heart Journal)'
- Publication date
- 01/01/2007
- Field of study
The Psychopharmacology of Feeding
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- A Abdallah
- A Bernier
- A Bizzi
- A Randrup
- A Reinberg
- A Routtenberg
- A Soulairac
- A Stunkard
- A Weissman
- AA Borbely
- AA Kattus
- AE Fisher
- AH Tang
- AJ Azzaro
- AKS Ho
- AL Welsh
- AN Epstein
- AN Epstein
- AN Epstein
- AN Epstein
- AN Epstein
- AP Zis
- AR Mawson
- AS Chakrabarty
- AS Chakrabarty
- B Krengel
- BA Campbell
- BA Campbell
- BA Rosenberg
- BC Sproule
- BD Berger
- BG Hoebel
- BG Hoebel
- BG Hoebel
- BG Hoebel
- BG Hoebel
- BG Hoebel
- BG Hoebel
- BG Hoebel
- BK Koe
- BL Baxter
- BL Jacobs
- BL Jacobs
- BM Breckenridge
- BP Poschel
- BR Cooper
- BS Uehling
- BV Clineschmidt
- BV Clineschmidt
- BV Clineschmidt
- C Broekkamp
- C Broekkamp
- CA Baile
- CA Sorensen
- CB Neill
- CD Wise
- CL Kornblith
- D Ghezzi
- D Joyce
- D Lehr
- D Lovett
- D Novin
- DA Booth
- DA Booth
- DA Booth
- DA Booth
- DA Booth
- DB Neill
- DD Avery
- DE Smith
- DE Smith
- DH Overstreet
- DH Overstreet
- DJ Lonowski
- DL Margules
- DL Margules
- DL Margules
- DL Margules
- DL Margules
- DL Margules
- DM Nance
- DP Mertz
- DR Hadden
- DS Bell
- DV Coscina
- E Costa
- E Marley
- EE Coons
- EF Swanson
- EM Stricker
- FJ Kuhn
- FR Stowe
- G Bartholini
- G Kapatos
- G Pepeu
- G Rindi
- G Sciorelli
- G Singer
- G Singer
- G Singer
- GA Oltmans
- GC Heil
- GJ Mogenson
- GLS Pawan
- GM Everett
- GP Smith
- GR Breese
- GR Breese
- GS Chhina
- H Cappell
- H Kelman
- H Krebs
- HA Jordan
- HC Fibiger
- HC Fibiger
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- HH Frey
- HI Silverman
- HJ Carlisle
- HM Jackson
- HP Zeigler
- HW Goldman
- IP Stolerman
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- J Duhault
- J Ferguson
- J Hano
- J Lorden
- J Mouret
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- J Perez-Cruet
- J Ruedy
- J Yelnosky
- JA Dominic
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- JB Simpson
- JD Fernstrom
- JE Ahlskog
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- MK Menon
- ML Tainter
- MP Zanna
- MV Silbert
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- NH Colton
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- PB Bradley
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- PH Glow
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- RH Cox Jr.
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- S Armstrong
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- SG Holtzman
- SN Pradhan
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1977
- Field of study
The potential role of transforming growth factor beta family ligand interactions in prostate cancer
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- Valderrama-Carvajal H Cocolakis E, Lacerte A, et
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- Wakefield LM Hill CS
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2017
- Field of study
Über die (aseptische) Harnstauungsniere
- Author
- A Adler-Ràcz von
- A Akerlund
- A Androulakakis
- A Androulakakis
- A Angelov
- A Babies
- A Babies
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- A Batzenschlager
- A Berndorfer
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- A Lardelli
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- A Lichtenberg
- A Lichtenberg
- A Lisnell
- A Litwak
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- A Napolitano
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- A Pichler
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- A Pieper
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- A Sigel
- A Sigel
- A Sigel
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- A Theilhaber
- A Theilhaber
- A Thelen
- A Thelen
- A Thelen
- A Thiemann
- A Tormene
- A Trabucco
- A Tzank
- A Villanueva
- A Weicheisbaum
- A Wojewski
- A Wojewski
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- A Zinner
- A-A Kollwitz
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- D Ashley
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- DA Gordon
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- DN Eisendraht
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- DR Brock
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- DS Baldwin
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- E Asshauer
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- E Becher
- E Beer
- E Bergenfeldt
- E Berne
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- Evaluation of intubation ureterotomy with description of surgical technique
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- Experimental hydronephrosis without mechanical obstruction of the ureter
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- I Bulbuca
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- PP Fidgor
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- PS Chen
- PW Boer
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- R Allemann
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- R Bregman
- R Chute
- R Chwalla
- R Chwalla
- R Chwalla
- R Chwalla
- R Chwalla
- R Chwalla
- R Chwalla
- R Couvelaire
- R Couvelaire
- R Deakin
- R Deila
- R Dominguez
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- R Dossot
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- R Helsby
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- Relationship of juxtaglomerular apparatus to renin and angiotensin
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- S Bergendahl
- S Boyarsky
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- T Bledsoe
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- U Heim
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- V Becker
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- WD Jarman
- WE Goodwin
- WE Goodwin
- WE Goodwin
- WE Goodwin
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- WF Braasch
- WF Braasch
- WF Braasch
- WF Braasch
- WF Katzenstein
- WF Melick
- WF Melick
- WF Melick
- WFW Southwood
- WH Brinkmann
- WH Falor
- WH Howell
- WJ Baker
- WJ Engel
- WJ Forsythe
- WJ Forsythe
- WJ Israel
- WJ Rapp
- WJ Rapp
- WL Fitzgerald
- WM Bayliss
- WM Bochove van
- WM Davidson
- WM Drake
- WM Perelman
- WP Mulvaney
- WR McCune
- WR Schmalhorst
- WR Smart
- WS Kerr
- WS Kerr
- WS Kerr
- WS Mack
- WT Hunter
- WT Snodgrass
- WW Davey
- WW Milner
- WW Scott
- WW Summerville
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- Y Fumio
- Y Kitani
- Y Lazebnik
- Y Satani
- Y Suzuki
- YG Miterev
- YJ Katz
- Z Kairis
- Z Kairis
- Z Kairis
- Z Kairis
- Z Nagy
- Z Piasecki
- ZHJ Vuurst Van Der
- Zur Behandlung postoperativer bzw. posttraumatischer Harnleiterfibrosen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1968
- Field of study
Listing of Protein Spectra
- Author
- . Sugimura and E. Yakushiji J
- . Yeshoda S. C. Dhar., and M. Santappa, Ital
- A Anastasi
- A Arens
- A Bartkowiak
- A Berg
- A Berg
- A Berg
- A Bezkorovainy
- A Binder
- A Claiborne
- A Clairborne
- A Colosimo
- A Danchin
- A Ducastaing
- A D’Aniello
- A Ehrenberg
- A Fattoum
- A Finazzi-Agro
- A Finazzi-Agro
- A Finazzi-Agro
- A Finazzi-Agro
- A Fiori
- A Flangas
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- Y Watanabe
- Y Yamasai
- Y Yasukochi
- Y Yasukochi
- Y Yoshida
- Y Yoshida
- Y Yoshida
- Y. Miyake T. Abe, and T. Yamano, in International Symposium on Oxidases and Related Redox Systems
- YA Sharonov
- YA Sharonov
- YA Sharonov
- YE Erokhin
- YJ Kang
- YK Turakulov
- YK Turakulov
- YK Yip
- YP Lin
- YP Meyer
- YP Meyer
- YP Meyer
- YP Myer
- YS Choong
- YS Choong
- YV Peive
- YV Peive
- YV Pieve
- YV Shtamm
- YY Vasilev
- YYH Chao
- Z Bradic
- Z Gasyna
- Z Vogel
- Z Zak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study