33 research outputs found
Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint
- Author
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Human DNA polymerase (pol) λ functions in base excision repair and non-homologous end joining. We have previously shown that DNA pol λ is involved in accurate bypass of the two frequent oxidative lesions, 7,8-dihydro-8-oxoguanine and 1,2-dihydro-2-oxoadenine during the S phase. However, nothing is known so far about the relationship of DNA pol λ with the S phase DNA damage response checkpoint. Here, we show that a knockdown of DNA pol λ, but not of its close homologue DNA pol β, results in replication fork stress and activates the S phase checkpoint, slowing S phase progression in different human cancer cell lines. We furthermore show that DNA pol λ protects cells from oxidative DNA damage and also functions in rescuing stalled replication forks. Its absence becomes lethal for a cell when a functional checkpoint is missing, suggesting a DNA synthesis deficiency. Our results provide the first evidence, to our knowledge, that DNA pol λ is required for cell cycle progression and is functionally connected to the S phase DNA damage response machinery in cancer cell
Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2017
- Field of study
DNA translesion synthesis (TLS) is a crucial damage tolerance pathway that oversees the completion of DNA replication in the presence of DNA damage. TLS polymerases are capable of bypassing a distorted template but they are generally considered inaccurate and they need to be tightly regulated. We have previously shown that polη is phosphorylated on Serine 601 after DNA damage and we have demonstrated that this modification is important for efficient damage bypass. Here we report that polη is also phosphorylated by CDK2, in the absence of damage, in a cell cycle-dependent manner and we identify serine 687 as an important residue targeted by the kinase. We discover that phosphorylation on serine 687 regulates the stability of the polymerase during the cell cycle, allowing it to accumulate in late S and G2 when productive TLS is critical for cell survival. Furthermore, we show that alongside the phosphorylation of S601, the phosphorylation of S687 and S510, S512 and/or S514 are important for damage bypass and cell survival after UV irradiation. Taken together our results provide new insights into how cells can, at different times, modulate DNA TLS for improved cell survival
A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres.
- Author
- Bergoglio Valerie
- Bertoletti Federica
- Bione Silvia
- Chen Liuh-Yow
- Crespan Emmanuele
- Fagagna Fabrizio d'Adda di
- Ferrari Elena
- Francia Sofia
- Galli Silvia
- Garbelli Anna
- Hoffmann Jean-Sébastien
- Hübscher Ulrich
- Kissova Miroslava
- Lingner Joachim
- Maffia Antonio
- Maga Giovanni
- Mentegari Elisa
- Sabbioneda Simone
- Tagliavini Giulia
- Zucca Elisa
- Publication venue
- Int J Mol Sci
- Publication date
- 01/01/2021
- Field of study
Telomerase negative cancer cell types use the Alternative Lengthening of Telomeres (ALT) pathway to elongate telomeres ends. Here, we show that silencing human DNA polymerase (Pol λ) in ALT cells represses ALT activity and induces telomeric stress. In addition, replication stress in the absence of Pol λ, strongly affects the survival of ALT cells. In vitro, Pol λ can promote annealing of even a single G-rich telomeric repeat to its complementary strand and use it to prime DNA synthesis. The noncoding telomeric repeat containing RNA TERRA and replication protein A negatively regulate this activity, while the Protection of Telomeres protein 1 (POT1)/TPP1 heterodimer stimulates Pol λ. Pol λ associates with telomeres and colocalizes with TPP1 in cells. In summary, our data suggest a role of Pol λ in the maintenance of telomeres by the ALT mechanism
The association of indwelling urinary catheter with delirium in hospitalized patients and nursing home residents: an explorative analysis from the "Delirium Day 2015"
- Author
- Albert March
- Alberto Castagna
- Alberto Cester
- Alberto Ferrari
- Alberto Ferrari
- Alberto Pilotto
- Alessandra Marengoni
- Alessandro Margiotta
- Alessandro Morandi
- Alessandro Morandi
- Alessandro Padovani
- Alice Pluderi
- Amalia Cecilia Bruni
- Amedeo Zurlo
- Andrea Fabbo
- Andrea Mazzone
- Andrea Mazzone
- Andrea Ungar
- Angelo Bianchetti
- Angelo Bianchetti
- Anna Lasagni
- Anna Maria Scotuzzi
- Annachiara Cagnin
- Antonella Mandas
- Antonino Chiarello
- Antonino Maria Cotroneo
- Antonio Cherubini
- Antonio Cherubini
- Arcangelo Ceretti
- Babette Dijik
- Bruno Bernardini
- Carla Corsini
- Carlo A. Biagini
- Carlo Gabelli
- Carlo Serrati
- Carmelinda Ruggiero
- Chiara Mussi
- Christian Wenter
- Clara Raimondi
- Claudia Filippini
- Claudio Bellamoli
- Claudio Ivaldi
- Claudio Mariani
- Daniela Mari
- Daniela Moretti
- Daniele Villani
- Desireè Addesi
- Diletta Cereda
- Donatella Petritola
- Edo Bottacchi
- Elena Sinforiani
- Elio Scarpini
- Emilio Martini
- Enrico Mossello
- Enrico Mossello
- Enzo Canonico
- Erik Bertoletti
- Ermellina Zanetti
- Ettore Muti
- Fabio Di Stefano
- Fabio Guerini
- Fausto Fantò
- Federica Boschi
- Ferdinando D’Amico
- Fiammetta Monacelli
- Francesco De Filippi
- Gabriele Noro
- Gabriele Toigo
- Gabriele Tripi
- Gianbattista Guerrini
- Giancarlo Isaia
- Gianluca Isaia
- Giorgio Basile
- Giovanni Galli
- Giovanni Ruotolo
- Giovanni Sgrò
- Giovanni Zuliani
- Giuliano Ceschia
- Giuseppe Barbagallo
- Giuseppe Battaglia
- Giuseppe Bellelli
- Giuseppe Bellelli
- Giuseppe Provenzano
- Giuseppe Romanelli
- Giuseppina Dell’Aquila
- Ildebrando Appollonio
- Italian Study Group on Delirium (ISGoD): Stefano Boffelli
- Lara Bianchi
- Luca Rozzini
- Luca Serchisu
- Luciano Terranova
- Lucio Lucchetti
- Lucio Tremolizzo
- Luigi M. Pernigotti
- Marco Trabucchi
- Marco Trabucchi.
- Marco Zoli
- Maria C. Cavallini
- Maria C. Ubezio
- Maria Chiara Cavallini
- Maria Cottino
- Maria Infante
- Maria Lia Lunardelli
- Marino Formilan
- Mario Bo
- Mario Bo
- Mario Lo Storto
- Maristella Piccinini
- Massimo Musicco
- Massimo Musicco
- Niccolò Marchionni
- Nicola Ferrara
- Nicola Ferrara
- Paola Forti
- Paola Porrino
- Paola Porrino
- Paolo Bonino
- Paolo Caffarra
- Paolo Putzu
- Pasqualina Carbone
- Patrizia Crippa
- Patrizia Mecocci
- Patrizio Odetti
- Piero Rapazzini
- Pietro Bonati
- Pietro Gareri
- Raffaele Antonelli Incalzi
- Raffaele Latella
- Renato Bottura
- Renato Turco
- Renzo Rozzini
- Rosanna Castiglia
- Sara Fascendini
- Sara Tognini
- Silvia Vitali
- Simona Di Santo
- Simona G Di Santo
- Simona Gentile
- Simona Umidi
- Stefano Avanzi
- Teresa Suardi
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Backround: Use of indwelling urinary catheter (IUC) in older adults has negative consequences, including delirium.
Aim: This analysis, from the "Delirium Day 2015", a nationwide multicenter prevalence study, aim to evaluate the association of IUC with delirium in hospitalized and Nursing Homes (NHs) patients.
Methods: Patients underwent a comprehensive geriatric assessment, including the presence of IUC; inclusion criteria were age > 65 years, being Italian speaker and providing informed consent; exclusion criteria were coma, aphasia, end-of-life status. Delirium was assessed using the 4AT test (score ≥ 4: possible delirium; scores 1-3: possible cognitive impairment).
Results: Among 1867 hospitalized patients (mean age 82.0 ± 7.5 years, 58% female), 539 (28.9%) had IUC, 429 (22.9%) delirium and 675 (36.1%) cognitive impairment. IUC was significantly associated with cognitive impairment (OR 1.60, 95% CI 1.19-2.16) and delirium (2.45, 95% CI 1.73-3.47), this latter being significant also in the subset of patients without dementia (OR 2.28, 95% CI 1.52-3.43). Inattention and impaired alertness were also independently associated with IUC. Among 1454 NHs residents (mean age 84.4 ± 7.4 years, 70.% female), 63 (4.3%) had IUC, 535 (36.8%) a 4AT score ≥ 4, and 653 (44.9%) a 4AT score 1-3. The multivariate logistic regression analysis did not show a significant association between 4AT test or its specific items with IUC, neither in the subset of patients without dementia.
Discussion: We confirmed a significant association between IUC and delirium in hospitalized patients but not in NHs residents.
Conclusion: Environmental and clinical factors of acute setting might contribute to IUC-associated delirium occurrence
"Delirium Day": A nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool
- Author
- Albert March
- Alberto Cester
- Alberto Ferrari
- Alberto Ferrari
- Alberto Pilotto
- Alessandra Marengoni
- Alessandro Margiotta
- Alessandro Morandi
- Alessandro Morandi
- Alessandro Padovani
- Alice Pluderi
- Amalia Cecilia Bruni
- Amedeo Zurlo
- and on behalf of the Italian Study Group on Delirium (ISGoD)
- Andrea Fabbo
- Andrea Mazzone
- Andrea Mazzone
- Andrea Ungar
- Angelo Bianchetti
- Angelo Bianchetti
- Anna Lasagni
- Anna Maria Scotuzzi
- Annachiara Cagnin
- Antonella Mandas
- Antonino Chiarello
- Antonino Maria Cotroneo
- Antonio Cherubini
- Antonio Cherubini
- Arcangelo Ceretti
- Babette Dijik
- Bruno Bernardini
- Carla Corsini
- Carlo A. Biagini
- Carlo Gabelli
- Carlo Serrati
- Chiara Mussi
- Christian Wenter
- Clara Raimondi
- Claudio Bellamoli
- Claudio Ivaldi
- Claudio Mariani
- Daniela Mari
- Daniele Villani
- Desireè Addesi
- Diletta Cereda
- Donatella Petritola
- Edo Bottacchi
- Elena Sinforiani
- Elio Scarpini
- Emilio Martini
- Enrico Mossello
- Enrico Mossello
- Enzo Canonico
- Erik Bertoletti
- Ermellina Zanetti
- Ermellina Zanetti
- Ettore Muti
- Fabio Di Stefano
- Fabio Guerini
- Fausto Fantò
- Federica Boschi
- Ferdinando D'Amico
- Fiammetta Monacelli
- Francesco De Filippi
- Gabriele Noro
- Gabriele Toigo
- Gabriele Tripi
- Gianbattista Guerrini
- Giancarlo Isaia
- Gianluca Isaia
- Giorgio Annoni
- Giorgio Basile
- Giovanni Galli
- Giovanni Ruotolo
- Giovanni Sgrò
- Giovanni Zuliani
- Giuliano Ceschia
- Giuseppe Barbagallo
- Giuseppe Battaglia
- Giuseppe Bellelli
- Giuseppe Bellelli
- Giuseppe Provenzano
- Giuseppe Romanelli
- Giuseppina Dell’Aquila
- Ildebrando Appollonio
- Lara Bianchi
- Luca Rozzini
- Luca Serchisu
- Luciano Terranova
- Lucio Lucchetti
- Lucio Tremolizzo
- Luigi M. Pernigotti
- Marco Trabucchi
- Marco Trabucchi
- Marco Zoli
- Maria C. Cavallini
- Maria C. Ubezio
- Maria Chiara Cavallini
- Maria Cottino
- Maria Infante
- Maria Lia Lunardelli
- Marino Formilan
- Mario Bo
- Mario Bo
- Mario Lo Storto
- Maristella Piccinini
- Massimo Musicco
- Massimo Musicco
- Niccolò Marchionni
- Nicola Ferrara
- Nicola Ferrara
- Paola Forti
- Paola Porrino
- Paolo Bonino
- Paolo Caffarra
- Paolo Putzu
- Pasqualina Carbone
- Patrizia Crippa
- Patrizia Mecocci
- Patrizio Odetti
- Piero Rapazzini
- Pietro Bonati
- Pietro Gareri
- Raffaele Antonelli Incalzi
- Raffaele Latella
- Renato Bottura
- Renato Turco
- Renzo Rozzini
- Renzo Rozzini
- Rita Maria Melotti
- Rosanna Castiglia
- Sara Fascendini
- Sara Tognini
- Silvia Vitali
- Simona Di Santo
- Simona G. Di Santo
- Simona Gentile
- Stefano Avanzi
- Stefano Boffelli
- Teresa Suardi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background: To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy. Methods: This is a point prevalence study (called "Delirium Day") including 1867 older patients (aged 65 years or more) across 108 acute and 12 rehabilitation wards in Italian hospitals. Delirium was assessed on the same day in all patients using the 4AT, a validated and briefly administered tool which does not require training. We also collected data regarding motoric subtypes of delirium, functional and nutritional status, dementia, comorbidity, medications, feeding tubes, peripheral venous and urinary catheters, and physical restraints. Results: The mean sample age was 82.0 ± 7.5 years (58 % female). Overall, 429 patients (22.9 %) had delirium. Hypoactive was the commonest subtype (132/344 patients, 38.5 %), followed by mixed, hyperactive, and nonmotoric delirium. The prevalence was highest in Neurology (28.5 %) and Geriatrics (24.7 %), lowest in Rehabilitation (14.0 %), and intermediate in Orthopedic (20.6 %) and Internal Medicine wards (21.4 %). In a multivariable logistic regression, age (odds ratio [OR] 1.03, 95 % confidence interval [CI] 1.01-1.05), Activities of Daily Living dependence (OR 1.19, 95 % CI 1.12-1.27), dementia (OR 3.25, 95 % CI 2.41-4.38), malnutrition (OR 2.01, 95 % CI 1.29-3.14), and use of antipsychotics (OR 2.03, 95 % CI 1.45-2.82), feeding tubes (OR 2.51, 95 % CI 1.11-5.66), peripheral venous catheters (OR 1.41, 95 % CI 1.06-1.87), urinary catheters (OR 1.73, 95 % CI 1.30-2.29), and physical restraints (OR 1.84, 95 % CI 1.40-2.40) were associated with delirium. Admission to Neurology wards was also associated with delirium (OR 2.00, 95 % CI 1.29-3.14), while admission to other settings was not. Conclusions: Delirium occurred in more than one out of five patients in acute and rehabilitation hospital wards. Prevalence was highest in Neurology and lowest in Rehabilitation divisions. The "Delirium Day" project might become a useful method to assess delirium across hospital settings and a benchmarking platform for future surveys
Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism
- Author
- Adarraga María Dolores
- Agud María
- Aibar Jesús
- Aibar Miguel Ángel
- Ait Abdallah Nassim
- Amado Cristina
- Arcelus Juan Ignacio
- Baeza Carlos
- Ballaz Aitor
- Barba Raquel
- Barba Raquel
- Barbagelata Cristina
- Barrón Manuel
- Barrón‐Andrés Belén
- Bertoletti Laurent
- Bertoletti Laurent
- Bikdeli Behnood
- Bikdeli Behnood
- Bilora Franca
- Blanco‐Molina Ángeles
- Bosevski Marijan
- Bosevski Marijan
- Botella Ernesto
- Bounameaux Henri
- Bounameaux Henri
- Braester Andrei
- Brenner Benjamin
- Brenner Benjamin
- Bucherini Eugenio
- Bui Hanh My
- Bui Hanh My
- Bura‐Riviere Alessandra
- Camon Ana María
- Caprini Joseph A.
- Caprini Joseph A.
- Casado Ignacio
- Castro Joaquín
- Castro Joaquín
- Cañas Inmaculada
- Chasco Leyre
- Ciammaichella Maurizio
- Criado Juan
- Crichi Benjamin
- de Ancos Cristina
- de Miguel Javier
- Debourdeau Philippe
- del Toro Jorge
- del Toro Jorge
- del Valle Morales María
- Demelo‐Rodríguez Pablo
- Di Campli Mario Virgilio
- Di Micco Pierpaolo
- Di Micco Pierpaolo
- Domínguez Irene Milagros
- Díaz‐Peromingo José Antonio
- Díez‐Sierra Javier
- Engelen Matthias
- Escribano José Carlos
- Falgá Conxita
- Falvo Nicolas
- Farfán‐Sedano Ana Isabel
- Farge‐Bancel Dominique
- Farge‐Bancel Dominique
- Fernández‐Capitán Carmen
- Fernández‐Reyes Jose Luis
- Fernández‐Reyes José Luis
- Fidalgo María Ángeles
- Flores Katia
- Fonseca Samuel
- Font Carme
- Font Llorenç
- Francisco Iria
- Gabara Cristina
- Galeano‐Valle Francisco
- Galindo David
- Galliazzo Silvia
- García de Herreros Marta
- García María Angelina
- García‐Bragado Ferrán
- García‐Hernáez Raquel
- García‐Mullor María Mar
- García‐Raso Arantxa
- Gavín‐Sebastián Olga
- Gibietis Valdis
- Gil‐Díaz Aida
- Goldhaber Samuel Z.
- Grau Enric
- Guirado Leticia
- Gutiérrez Javier
- Gutiérrez Paula
- Gómez‐Cuervo Covadonga
- Helfer Hélène
- Hernando Elena
- Hernández‐Blasco Luis
- Herreros Miguel
- Hirmerova Jana
- Imbalzano Egidio
- Jaras María Jesús
- Jara‐Palomares Luis
- Jiménez David
- Jiménez David
- Jiménez Rafael
- Joya Maria Dolores
- Kigitovica Dana
- León José Manuel
- Lima Jorge
- Lip Gregory Y. H.
- Llamas Pilar
- Lobo José Luis
- Lorenzo Alicia
- López‐Jiménez Luciano
- López‐Miguel Patricia
- López‐Núñez Juan José
- López‐Reyes Raquel
- López‐Ruiz Antonio
- López‐Sáez Juan Bosco
- Madridano Olga
- Maestre Ana
- Mahé Isabelle
- Maida Rosa
- Malý Radovan
- Malý Radovan
- Marchena Pablo Javier
- Martins Filipa
- Martín del Pozo Mar
- Martín‐Guerra Javier Miguel
- Martín‐Guerra Javier Miguel
- Martín‐Martos Francisco
- Mastroiacovo Daniela
- Mazzolai Lucia
- Meireles Jose
- Mella Carmen
- Mellado Meritxell
- Mercado Maria Isabel
- Moisés Jorge
- Monreal Manuel
- Monreal Manuel
- Monreal Manuel
- Moustafa Farès
- Muriel Alfonso
- Muñoz‐Blanco Arturo
- Muñoz‐Rivas Nuria
- Navas María Sierra
- Nieto Jose Antonio
- Núñez‐Fernández Manuel Jesús
- Obispo Berta
- Ochoa‐Chaar Cassius Iyad
- Olid Mónica
- Olivares María Carmen
- Olivier Espitia
- Orcastegui José Luis
- Ortega‐Michel Clara
- Osorio Jeisson
- Otalora Sonia
- Otero Remedios
- Otero Remedios
- Pace Federica
- Parra Pedro
- Parra Virginia
- Pedrajas José María
- Pellejero Galadriel
- Pesavento Raffaele
- Piazza Gregory
- Poenou Geraldine
- Pomero Fulvio
- Porras José Antonio
- Portillo José
- Prandoni Paolo
- Prandoni Paolo
- Quintavalla Roberto
- Reis Abilio
- Riera‐Mestre Antoni
- Rivas Agustina
- Rivas Agustina
- Rivera‐Civico Francisco
- Rocci Anna
- Rodríguez‐Chiaradía Diego Agustín
- Rodríguez‐Cobo Ana
- Rodríguez‐Matute Consolación
- Rogado Jacobo
- Roig Sonia
- Romualdi Roberta
- Rosa Vladimir
- Ruiz‐Artacho Pedro
- Ruiz‐Giménez Nuria
- Ruiz‐Ruiz Justo
- Ruiz‐Sada Pablo
- Salgado Estuardo
- Salgueiro Giorgina
- Sampériz Ángel
- Sancho Teresa
- Schellong Sebastian
- Schellong Sebastian
- Siniscalchi Carmine
- Siniscalchi Carmine
- Sirisi Merçe
- Skride Andris
- Soler Silvia
- Suriñach José María
- Suriñach José María
- Sánchez‐Martínez Rosario
- Sánchez‐Muñoz‐Torrero Juan Francisco
- Tafur Alfonso J.
- Tirado Raimundo
- Tolosa Carles
- Torres María Isabel
- Trujillo‐Santos Javier
- Tufano Antonella
- Tzoran Inna
- Tzoran Inna
- Uresandi Fernando
- Valero Beatriz
- Valle Reina
- Vanassche Thomas
- Vela Jerónimo Ramón
- Verhamme Peter
- Verhamme Peter
- Vidal Gemma
- Villares Paula
- Visonà Adriana
- Vázquez Fernando Javier
- Weinberg Ido
- Wilkins Hannah
- Zalunardo Beniamino
- Zamora Carles
- Publication venue
- Wiley-Blackwell
- Publication date
- 01/09/2021
- Field of study
Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio
Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years
- Author
- Adarraga Ma Dolores
- Adela Rodriguez-Hernandez A
- Aibar Jesus
- Alejandro Lorente Manuel
- Alfonso Maria
- Amado Cristina
- Angel Aibar Miguel
- Angeles Rodriguez-Davila Ma
- Angelina Garcia Maria
- Antonio Diaz-Peromingo Jose
- Antonio Nieto Jose
- Antonio Porras Jose
- Ballaz Aitor
- Barba Raquel
- Barillari Giovanni
- Barron Manuel
- Barron-Andres Belen
- Bascunana Jose
- Benzidia Ilham
- Bertoletti Laurent
- Bilora Franca
- Blanco-Molina Angeles
- Bortoluzzi Cristiano
- Bosco Lopez-Saez Juan
- Bosevski Marijan
- Bounameaux Henri
- Braester Andrei
- Brandolin Barbara
- Brenner Benjamin
- Bucherini Eugenio
- Bura-Riviere Alessandra
- Canas Inmaculada
- Caprini Joseph A
- Carles Sahuquillo Joan
- Carmen Olivares Maria
- Carrasco Cristina
- Castro Joaquin
- Celis Gregory
- Ciammaichella Maurizio
- de Ancos Cristina
- Debourdeau Philippe
- Del Carmen Fernandez-Criado Maria
- del Carmen Gayol Maria
- del Pozo Gustavo
- Del Toro Jorge
- del Valle Morales Ma
- Demelo Pablo
- Dentali Francesco
- Di Micco Pierpaolo
- Diaz-Simon Raquel
- Dolores Joya Maria
- Falga Conxita
- Farge-Bancel Dominique
- Fernandez-Capitan Carmen
- Fernandez-Nunez Sandra
- Fidalgo Angeles
- Font Carme
- Font Llorenc
- Garcia-Bragado Fernando
- Garcia-Morillo Marcial
- Garcia-Raso Aranzzu
- Gavin-Sebastian Olga
- Gibietis Valdis
- Gil-Diaz Aida
- Gomez Vicente
- Gomez-Cuervo Covadonga
- Gonzalez-Martinez Jose
- Grau Enric
- Gutierrez Javier
- Gutierrez Paula
- Gutierrez-Gonzalez Sara
- Hanh My Bui
- Hernandez Blasco Luis
- Hij Adrian
- Hirmerova Jana
- Hong Ngoc Vo
- Iglesias Marina
- Ignacio Arcelus Juan
- Isabel Farfan Ana
- Isabel Torres Maria
- Jara-Palomares Luis
- Jaras Ma Jesus
- Javier Marchena Pablo
- Javier Vazquez Fernando
- Jesus Nunez Manuel
- Jimenez David
- Jose Lopez-Nunez Juan
- Jou Ines
- Khanh Quoc Pham
- Kigitovica Dana
- Lalueza Antonio
- Lima Jorge
- Llamas Pilar
- Lopez Reyes Raquel
- Lopez-Jimenez Luciano
- Lopez-Miguel Patricia
- Lorenzo Alicia
- Loring Monica
- Luis Lobo Jose
- Luisa Nieto Maria
- Madridano Olga
- Maestre Ana
- Mahe Isabelle
- Maida Rosa
- Maly Radovan
- Maria Camon Ana
- Maria Pedrajas Jose
- Maria Surinach Jose
- Mastroiacovo Daniela
- Mazzolai Lucia
- Mellado Meritxell
- Miguel Martin Javier
- Monreal Manuel
- Moustafa Fares
- Mumoli Nicola
- Otero Remedios
- Pace Federica
- Parisi Roberto
- Pellejero Galadriel
- Peris Ma Luisa
- Pesavento Raffaelle
- Prandoni Paolo
- Prez-Rus Gloria
- Quintavalla Roberto
- Reis Abilio
- Rivas Agustina
- Rocci Anna
- Romualdi Roberta
- Rubio Carmen Ma
- Ruiz-Artacho Pedro
- Ruiz-Ruiz Justo
- Ruiz-Sada Pablo
- Salazar Vladimir
- Salgado Estuardo
- Samperiz Angel
- Sanchez Munoz-Torrero Juan Francisco
- Sancho Teresa
- Schellong Sebastian
- Sharif-Kashani Babak
- Sinicalchi Carmine
- Skride Andris
- Soler Silvia
- Tapia Elena
- Tolosa Caries
- Trujillo-Santos Javier
- Tufano Antonella
- Tzoran Inna
- Uresandi Fernando
- Valle Reina
- Vanassche Thomas
- Vandenbriele Christophe
- Verhamme Peter
- Vidal Gemma
- Vilaseca Alicia
- Villares Paula
- Visona Adriana
- Zalunardo Beniamino
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
publishersversionPeer reviewe
Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia
- Author
- Abbaldo A.
- Abraham E.
- Acampora R.
- Addesi D.
- Addolorata M.
- Adobati A.
- Adversi M.
- Agata M. M.
- Agosta L.
- Alberto C.
- Alberto L.
- Alberto S.
- Alberto Z.
- Alessandra B.
- Alessandra F.
- Alessandra F.
- Alessandra P.
- Alessandro C.
- Alessandro D.
- Alessandro G.
- Alessandro G.
- Alessandro M.
- Alessia D.
- Alessio M.
- Alfredo D. G.
- Alice F.
- Alius F.
- Aloisio P.
- Amici S.
- Amoruso R.
- Anastasio L.
- Andrea A.
- Andrea A.
- Andrea B.
- Andrea C.
- Andrea G.
- Andrea S.
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- Andreani L.
- Andreolli Antonino C. G.
- Andretto D.
- Andriolli A.
- Angela B.
- Angela B. M.
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- Appollonio I.
- Arduini P.
- Arenare F.
- Arighi A.
- Asprinio V.
- Assunta S.
- Avanzi S.
- Azzini M.
- Bacci M.
- Balestri F.
- Ballardini G.
- Ballino E.
- Balotta A.
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- Stefano G.
- Stefano M.
- Strazzacapa M.
- Striuli R.
- Suardi T.
- Sugo A.
- Suigo G.
- Suraci D.
- Tafuto S.
- Tagliabue B.
- Tagliani G.
- Tarozzi A.
- Tassinari T.
- Terenzi L.
- Terranova L.
- Teruzzi F.
- Tesi F.
- Testoni M.
- Tezza F.
- Thomas A.
- Thomas F.
- Tibaldi V.
- Tina S.
- Tironi S.
- Titoldini G.
- Tiziana C.
- Tobaldini C.
- Tognini S.
- Toigo G.
- Tomasoni A.
- Tomassini P. F.
- Tombesi F.
- Tommaso R.
- Tongiorgi C.
- Tonini G.
- Tonino M.
- Toniolo M.
- Toniolo S.
- Tonon E.
- Tortorolo U.
- Tosoni P.
- Tremolada M. L.
- Tremolizzo L.
- Tricca M.
- Tripi G.
- Troisi E.
- Trotta L.
- Turcato E.
- Turco R.
- Ubaldo B.
- Ubezio M. C.
- Ugenti F.
- Ugo P.
- Umidi S.
- Ungar A.
- Urso G.
- Valchera A.
- Valente C.
- Valenti L.
- Valentina D. S.
- Valentina G.
- Valentina L.
- Valeria D. A.
- Valeria G.
- Valeria P. G.
- Valeria S.
- Valerio P.
- Valerio V.
- Valiani V.
- Varesi M.
- Vena S.
- Veneziani S.
- Venturiero V.
- Vera R. F.
- Vera R. F.
- Verbo B.
- Vezzadini G.
- Villani D.
- Vincenzo S.
- Vincenzo S.
- Viola M. C.
- Visioli S.
- Vita N.
- Vitale E.
- Vitali M.
- Vitali S.
- Vito A.
- Viviana A. T.
- Wenter C.
- Xhani R.
- Zaccarini C.
- Zagnoni P.
- Zambon A.
- Zanasi M.
- Zanocchi M.
- Zappa P.
- Zara D.
- Zatti G.
- Zavarise G.
- Zhirajr M.
- Zoli M.
- Zuccher P.
- Zuliani G.
- Zurlo A.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
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- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
- Blanc Agnès
- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
- Bogarin Javier
- Bogoevska-Miteva Zaneta
- Bonaccorso Luciano
- Bongiorno Benjamin
- Bonsignore Pablo Julio Maldonaldo
- Borgognoni Cinzia
- Borin Christophe
- Borkowska Marta
- Bormans Laura
- Boroli Filippo
- Borys Michal
- Boschetto Margherita
- Bossolasco Matteo
- Bota Marc
- Boulanger Carole
- Boulton Karen
- Bowes Bonnie
- Boyer Laetitia
- Bozbay Suha
- Bozena Armanda
- Bratsberg Bjorn
- Bravo Silvina
- Brett Carole
- Brett Stephen
- Brett Stephen J.
- Briva Arturo
- Brizio Elisabetta
- Brizuela Patricia
- Broadhurst Phil
- Brown Wendy
- Browne Troy
- Bruel Cédric
- Bruhn Louise
- Brumwell Sarah
- Bruni Andrea
- Bruno Anna Vita
- Buckley Sarah
- Bull Rhian
- Bumbasirevic Vesna
- Buregeya Egide
- Burns Karen
- Butcher Rand
- Byers Heather
- Bösl Kathrin
- Cabral Dolly Mabel Bordon
- Cabral João
- Cabrita Paula
- Caddell Paul
- Caicedo Nestor
- Calamai Italo
- Calili Duygu Kayar
- Caliskan Gulbahar
- Calleja Pablo Lopez-Arcas
- Calpe Neus
- Calvino-Gunther Silvia
- Campanili Ticiane
- Campbell Elizabeth
- Campos Pierina Arias
- Campos-Perez Margarita
- Camputaro Luis
- Camsooksai Julie
- Canales Julieta
- Canete Fidelina
- Cani Alma
- Cano Anastasio Espejo
- Cao Deyan
- Cao Wenzhen
- Cao Ying
- Cao Zu Qing
- Capuzzi Fabio
- Cardenas Yenny
- Carey Annette
- Carney Dominic
- Carter Charlotte
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- Castelain Vincent
- Castiglione Giacomo
- Cata Juan
- Cavaco Raquel
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- Cerezo Franklin Dean
- Cesar Helena
- Cespedes Laura
- Chaboyer Wendy
- Chadwick Llesley
- Chang Shu Chuan
- Chang Youjin
- Chantziara Vasiliki
- Chao Yu
- Chaparro Javiera
- Chaparro Silvia
- Chapeta Edwin
- Chapman Carmel
- Charalabous Iwy
- Chatzis Marinos
- Chee Hyun Keun
- Chen Feifei
- Chen Haiyan
- Chen Hongjuan
- Chen Jingfang
- Chen Lei
- Chen Meili
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- Chen Wenmin
- Chen Xiaoyan
- Chen Zhihong
- Cheng
- Cheng Jiyin
- Chime Christiana
- Chimunda Tim
- Chinardet Benoît
- Chovas Achilleas
- Christ Martin
- Christofis Christos
- Chueca Ramon Molina
- Chunhua Gao
- Cinel İsmail
- Ciorba Paolo
- Clark Michele
- Clement Ana Isabel
- Clesi Tara
- Cody Caitriona
- Collet Marie
- Collins Amy
- Coman Mary
- Conde Belen Burgos
- Conejo Isabel
- Constantinou Constantina
- Corcoran Ailesh
- Coremans Stefano
- Correia Malcolm C.
- Corso Amalia
- Cortegiani Andrea
- Cortellazi Paolo
- Cosano Rosario
- Cossu Maria
- Costa Humberto
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- Coyer Fiona
- Craig Geraldine
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- Cranmer Karen
- Cranshaw Julius
- Creber Peter
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- Cui Xia
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- Cupitt Jason
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- Czuczwar Miroslaw
- Dagooc Rica
- Dai Zhaoxing
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- Dallaire Julie
- Das Sasidharan Nair Vishnu
- Daubin Cédric
- Davidow Jon
- Davidson Cheryl
- Dawn Frances
- Dayan Meneses
- de Almeida Angelica Olivetto
- de Anda Gilberto Felipe Vazquez
- De Bels David
- de Ceballos José Peral Gutierrez
- De Decker Koen
- De Haan Marina
- de Jesús Ortiz Alberto
- de la Ventana Ana Belén Sánchez
- De lange Dylan
- De Lange Dylan
- de Molina Serrano José Ivan Rodriguez
- De Montmollin Etienne
- De Pablo Ana María
- De Rosa Silvia
- De Sanctis Francesca
- De Schryver Nicolas
- De Wit Irene
- Dean Emiliano
- Debue Anne-Sophie
- Del Bosque Diez Rosa
- del Cotillo Mercedes
- del Mar Diaz Salcedo Maria
- Del Moral Armengol Mario
- Del Rio Cabajo Lorena
- del Rosario Villar Redondo M.
- del Valle Gimenez Graciela
- Delgado Carlos Castro
- Delgado Patricia
- Dellafiore Federica
- Delossantos Shella
- Delve Peter
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- Dendane Tarek
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- Derbyshire Claire
- Derrick Helen
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- Diaz Ana
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- Dieperink Willem
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- Dilek Ozcengiz
- Dimoula Aikaterini
- Dimski Thomas
- Ding Min
- Ding Xinran
- Ding Yajun
- Ding Yanming
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- Dobric Milena
- Dolenc Simon
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- Domenech Laura Claramunt
- Dong Jingwen
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- Donvito Maria
- Dormans Tom
- Douschan Philipp
- Doyle Deirdre
- Dragoumanis Christos
- Du Guifang
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- Dugernier Thierry
- Duggal Abhijit
- Dullenkopf Alexander
- Dungca Adonis
- Dunne Lisa
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- Déserts Marc Danguy des
- D’Ambrosio Francesco
- D’Ambrosio Paolo
- Ebaid Maie
- Ebaid Maie Salem
- Efe Serdar
- Efthimiou Aikaterini
- Efthymiou Anna
- Egi Moritoki
- Egorova Natalya
- Ei Poe Poe
- Elatrous Souheil
- Elay Gülseren
- Elgammudi Mala
- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
- Eneas Antony
- Eng Timothy
- Erdivanli Başar
- Erdogan Elif
- Eroglu Ahmet
- Ershova Olga
- Escalante Rosana Gabriela
- Espinosa Cristina Paños
- Esposito Romina
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- Etourneau Fabienne
- Evers Mirjam
- Fadeeva Liudmila
- Fan Limei
- Fang Xiuhua
- Farkas Jean-christophe
- Farmakis Epaminontas
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- Farre Olga
- Fartoukh Muriel
- Favre René
- Feghaly Michel El
- Fei Qin
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- Feng Zhaoxia
- Feranandes Ana Margarida
- Fernadez Inmaculada Lorenzo
- Fernandes Fatima
- Fernandez Alejandra Azahara Marguello
- Fernandez Maria Alejandra
- Fernandez Maria Cristina Iglesias
- Fernandez Oscar
- Fernandez Ruben
- Fernandez Silvia
- Fernández Ana Wensell
- Ferreira Amelia
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- Ferretti Christian
- Ffarcsi Madiha Hashmi
- Fiedler Christine
- Fielding Clare
- Fielding Mark
- Figaro-Barclay Dianne
- Figueiredo Margarida Ferreira
- Fijen Jan-Willem
- Filipescu Daniela Carmen
- Filipović-Grčić Ina
- Finn Damien O’Connell Rosemary
- Finnstrom Inger Johanne
- Fioretti Audrey
- Firment Peter
- Fischer Susanne
- Fishman Anne
- Fister Misa
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- Fivecoat Pauline
- Flessel Nadine
- Fletcher Kelly
- Fleury Yvan
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- Foong Kit Weng
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- François Guy
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- From Mette
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- Galazzi Alessandro
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- Guerrero Alvaro Ortega
- Guerrero Fausto
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- Gunter Una
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- Gupta Manish
- Guran Catalin Traian
- Gurevich Vladimir
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- Gusarov V.
- Gusarov Vitaly
- Gutierrez Pedro
- Gutysz-Wojnicka Aleksandra
- Gül Fethi
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- Günther Silvia Calvino
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- Hachimi Abdelhamid
- Hacking Danielle
- Hadri Burhan
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- Hagau Natalia
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- Han Ting
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- Hansen Anja
- Hansen Siri
- Hansen Tina Charlotte Bitsch
- Hao Junping
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- Harding-Goldson Hyacinth
- Hargott Rita Foss
- Haringman Jasper
- Harris Stephanie
- Hashemian Seyed Mohammadreza
- Hashimoto Satoru
- Hashmi Madiha
- Hassan W. Nazaruddin W.
- Hastings Jennifer
- Hatton Kevin
- Haugom Hanne
- Hawchar Fatime
- Hayashi Yoshiro
- Hayden Paul
- He Guoxue
- He Yin
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- Heinicke Tobias
- Heitzler Nathalie
- Hellkvist Viveca Hamback
- Henning Grit
- Hentchoya Romuald
- Herceg Ivana
- Hernandez Aaron Mark
- Hernandez Juan Sebastian
- Hernandez-Ponce Lucia
- Hernandez-Romero Marcos
- Hernandez-Sanchez Nancy
- Herrera Jorge Guerra
- Herrera María Ocotlan Gonzalez
- Higgins David
- Hilario Badiola
- Hirao Akemi
- Ho Sung Wai
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- Holmquist Dagmar
- Hong Li
- Hong Liu
- Hong Ma
- Honore Patrick M.
- Honoré Patrick M.
- Horner Daniel
- Horrigan Nicola
- Hoste Pieter
- Houghton Victoria
- Howcroft Clare
- Hsu Mei Yu
- Hu Li Ping
- Hu Lili
- Hu Rongjun Ling
- Hu XiaoChun
- Hua Ngu Pei
- Huang LiPing
- Huang Qingping
- Huang Rong Fen
- Huang Xia
- Hughes Jennifer
- Hughes Mandy
- Huh Jin Won
- Hui Caihong
- Huo Yuxia
- Hurtado Cintia Valencia
- Hurtado Clara
- Husted Birthe
- Hylen Mia
- Hyska Genci
- Høgvall Lisa
- Ibao Jowena
- Ibarra Alejandro
- Iburrigarro Sergio Reyes
- Idowu Olakunle
- Iglesias Federico
- Ignatenko Olga
- Ilesanmi Rose
- Ilesanmi Rose Ekama
- Inal Volkan
- InSu Lin
- Ioannides Panagiotis
- Iovenko Ihor
- Iozzo Pasquale
- Isanan Michael
- Isasi Maria Aranzazu
- Ismail Nahla
- Ismail Wan Nasrudin Wan
- İzdes Seval
- Jackson Matthew
- Jacob Reni
- Jacquet Luc-Marie
- Jafaraghaee Fateme
- Jali Phumele
- Jankovic Radmilo
- Jans Anita
- Jansson Erika Backlund
- Jarman Rachel
- Jaschinski Ulrich
- Jasiewicz Przemyslaw
- Jaundoo Helen
- Jensen Hanne Irene
- Jensen Karianne Dale
- Jeon Kyeongman
- Jepsen Britta
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- Jianhong Mu
- Jiao Qing Feng
- Jiao Xueping
- Jibrin Deborah
- Jimenez Raquel
- Jin Wangyan
- Jochmans Sébastien
- Joelsson-Alm Eva
- Joffe Aaron
- Johansen Birgitte Fosser
- Johansen Edda
- Johansson Lotta
- John Sini
- Jonasdottir Rannveig J.
- Jones Jo
- Jones Sarah
- Jong Margaret Lynn
- Jorge Silvia Angelica
- Jovaisa Tomas
- Jovanovic Bojan
- Ju Wenjie
- Judd Harriet
- Kaasby Karin
- Kakaras Nikolaos
- Kamal Manoj
- Kamenshchikov Nikolaj
- Kamoun Salma
- Kampayana Betty Star
- Kanakaki Sofia
- Kanda Fumiya
- Kang Byung Ju
- Kannan Santhana
- Kapoor Ritoo
- Kara Iskender
- Karabacak Pınar
- Karakurt Sait
- Karamchandani Kunal
- Karaoren Gulsah
- Karathanou Antigoni
- Karjula Elina
- Kartalov Andrijan
- Kataoka Jun
- Katerina Kounougeri
- Katsenos Chrysostomos
- Kauppi Outi
- Kaushik Shuchi
- Kazakos Nikolaos
- Kağnıcı Ali
- Kehoe Jennifer
- Kerslake Ian
- Kesti Ulla
- Khaled Ala
- Khaled Taha
- Khanna Ashish
- Khanna Ashish K.
- Khoo Tien Meng
- Khoronenko Victoria
- Khwannimit Bodin
- Kilapong Bram
- Kim Je Hyeong
- Kim Junghyun
- Kim Kyung Chan
- Kim Seok Chan
- Kindgen-Milles Detlef
- Kiselev Alexander
- Kjærgård Inger Ebbesen
- Kleanthous Pavlina
- Knafelj Rihard
- Kodal Anne Marie
- Kolbe Nina
- Kolussi Uta
- Kondili Eumorfia
- Koopmans Matty
- Kotanidi Veronika
- Kotze Michelle
- Koulouras Vasilios
- Kourelea Styliani
- Koutsodimitropoulos Ioannis
- Kovaleva Julia
- Krastins Ivasr
- Kristoffersen Elin
- Kubisz-Pudelko Agnieszka
- Kuijpers Paul
- Kulakov Vladimir
- Kuscu Ozlem Ozkan
- Kushare Vilas
- Kusi-Appiah Anita-Chrysolyte
- Kuzmanovska Biljana
- Kyriakoudi Anna
- Kütimets Martin
- Labeau Sonia O.
- Lacaden Grace
- Lafuente Estevão
- Lagerhäll Caroline
- Laizner Andréa Maria
- Lajara Miguel Angel Gimenez
- Lajeunesse Jennifer
- Lakshmanan Ramanathan
- Lalor Jennifer
- Landaverde Antonio
- Lang Martin
- Langvad Anne
- Lančaričová Danca
- Larina Eugeniya
- Larsson Ing-Marie
- Lausch Martina
- Lavrentieva Athena
- Lavy Alinoy
- Le Guen Yann
- Lebon Richard
- Ledochowski Stanislas
- Lee Heung Bum
- Lee Jarone
- Lee Jongmin
- Lee Sang-Miin
- Lee Sang-Min
- Lee Seok Jeong
- Lee Won-Yeon
- Legorburo Maria Schofield
- Lei DeHong
- Lei Lei
- Lei Yang
- Leong Thomas
- Leonova Anna
- Lepida Dimitra
- Leslie Gavin D.
- Lestari Mayang Indah
- Levy Dassy
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- Li Biyan
- Li Chunxia
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- Li Jing
- Li Jinhua
- Li Li Chuntang
- Li Ling
- Li Miao
- Li Ning
- Li Qi
- Li Qing
- Li Tingting
- Li Weiwei
- Li Xiaohan
- Li Xingguo
- Li Xinjian
- Li Xinxia
- Li Xue Qin
- Li Yan
- Li Ying
- Li ZhangShuangzi
- Li Zhuqing
- Liang Jinxian
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- Volta Carlo Alberto
- von der Osten Ingrid
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- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
- Vullum Sylvi
- Vymazal Tamas
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- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
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- Wang Haiyan
- Wang Jing
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- Wang Shuo
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- Wang Xiaomin
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- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
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- Williams Lynne
- Wilting Rob
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- Woods Justin
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- Wu Xiaojun
- Wu Xiaoying
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- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
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- Owens Daniel
- Owojuyigbe Afolabi
- Ozgultekin Asu
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- Twagirumugabe Theogene
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- von der Osten Ingrid
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- von Lewinski Dirk
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- Wahab Sherliza
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- White Joanne
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- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
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- Wu Yun
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- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake