350 research outputs found
baseline predictive factors for efficacy of anti pd1 used in first line in melanoma patients an italian melanoma intergroup study
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Factors associated with dropout from treatment for eating disorders: a comprehensive literature review
<p>Abstract</p> <p>Background</p> <p>Dropout (DO) is common in the treatment of eating disorders (EDs), but the reasons for this phenomenon remain unclear. This study is an extensive review of the literature regarding DO predictors in EDs.</p> <p>Methods</p> <p>All papers in PubMed, PsycINFO and Cochrane Library (1980-2009) were considered. Methodological issues and detailed results were analysed for each paper. After selection according to inclusion criteria, 26 studies were reviewed.</p> <p>Results</p> <p>The dropout rates ranged from 20.2% to 51% (inpatient) and from 29% to 73% (outpatient). Predictors of dropout were inconsistent due to methodological flaws and limited sample sizes. There is no evidence that baseline ED clinical severity, psychiatric comorbidity or treatment issues affect dropout. The most consistent predictor is the binge-purging subtype of anorexia nervosa. Good evidence exists that two psychological traits (high maturity fear and impulsivity) and two personality dimensions (low self-directedness, low cooperativeness) are related to dropout.</p> <p>Conclusion</p> <p>Implications for clinical practice and areas for further research are discussed. Particularly, these results highlight the need for a shared definition of dropout in the treatment of eating disorders for both inpatient and outpatient settings. Moreover, the assessment of personality dimensions (impulse control, self-efficacy, maturity fear and others) as liability factors for dropout seems an important issue for creating specific strategies to reduce the dropout phenomenon in eating disorders.</p
Rapporto sulle attività geofisiche, oceanografiche e di campionamento durante la crociera PANSTR12 con Nave Aretusa: Isole Eolie (Stromboli, Panarea, Salina) (2012-06-30 - 2012-07-14)
All’interno della collaborazione Coordinamento Nazionale per la Geofisica Marina (CO.NA.GEM.),
che riunisce i vari Istituti e organizzazioni tecnico-scientifiche italiani, si è svolta la campagna denominata
PANSTR12, realizzata con Nave Aretusa della Marina Militare Italiana (MMI). PANSTR12 ha avuto come
obbiettivi principali la caratterizzazione morfologica e geofisica della porzione sommersa della Sciara del
Fuoco, Isola di Stromboli e la ripetizione di rilievi multibeam e magnetometrici dell’area degli isolotti di
Panarea realizzati a partire dal 2002, nell’ottica di permettere analisi e valutazioni sul percorso evolutivo dei
fenomeni legati all’eruzione gassosa, anche in relazione all’assetto tettonico e geodinamico dell’arco
vulcanico delle Eolie. La campagna PANSTR12 è stata realizzata attraverso una proficua collaborazione tra
l’Istituto Nazionale di Geofisica e Vulcanologia (INGV), gli Istituti di Scienze Marine (ISMAR) di Bologna
(ISMAR-BO) e di La Spezia (ISMAR-SP), entrambi del Consiglio Nazionale delle Ricerche (CNR), e
l’Istituto Idrografico della Marina (IIM).Istituto Idrografico della Marina, Marina Militare ItalianaPublished2.6. TTC - Laboratorio di gravimetria, magnetismo ed elettromagnetismo in aree attiveope
Search for anomalies in the neutrino sector with muon spectrometers and large LArTPC imaging detectors at CERN
A new experiment with an intense ~2 GeV neutrino beam at CERN SPS is proposed
in order to definitely clarify the possible existence of additional neutrino
states, as pointed out by neutrino calibration source experiments, reactor and
accelerator experiments and measure the corresponding oscillation parameters.
The experiment is based on two identical LAr-TPCs complemented by magnetized
spectrometers detecting electron and muon neutrino events at Far and Near
positions, 1600 m and 300 m from the proton target, respectively. The ICARUS
T600 detector, the largest LAr-TPC ever built with a size of about 600 ton of
imaging mass, now running in the LNGS underground laboratory, will be moved at
the CERN Far position. An additional 1/4 of the T600 detector (T150) will be
constructed and located in the Near position. Two large area spectrometers will
be placed downstream of the two LAr-TPC detectors to perform charge
identification and muon momentum measurements from sub-GeV to several GeV
energy range, greatly complementing the physics capabilities. This experiment
will offer remarkable discovery potentialities, collecting a very large number
of unbiased events both in the neutrino and antineutrino channels, largely
adequate to definitely settle the origin of the observed neutrino-related
anomalies.Comment: Contribution to the European Strategy for Particle Physics - Open
Symposium Preparatory Group, Kracow 10-12 September 201
COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety
Feasibility studies of time-like proton electromagnetic form factors at PANDA at FAIR
Simulation results for future measurements of electromagnetic proton form
factors at \PANDA (FAIR) within the PandaRoot software framework are reported.
The statistical precision with which the proton form factors can be determined
is estimated. The signal channel is studied on the basis
of two different but consistent procedures. The suppression of the main
background channel, , is studied.
Furthermore, the background versus signal efficiency, statistical and
systematical uncertainties on the extracted proton form factors are evaluated
using two different procedures. The results are consistent with those of a
previous simulation study using an older, simplified framework. However, a
slightly better precision is achieved in the PandaRoot study in a large range
of momentum transfer, assuming the nominal beam conditions and detector
performance
Prognostic Factors for Overall Survival In Chronic Myeloid Leukemia Patients: A Multicentric Cohort Study by the Italian CML GIMEMA Network
Quality of life and treatment satisfaction in adults with Type 1 diabetes: A comparison between continuous subcutaneous insulin infusion and multiple daily injections
Aims: The aim of this case-control study was to compare quality of life (QoL) and treatment satisfaction in adults with Type 1 diabetes (T1DM) treated with either continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI). Methods: Consecutive patients aged between 18 and 55 years, and attending diabetes clinics for a routine visit, completed the Diabetes-Specific Quality-of-Life Scale (DSQOLS), the Diabetes Treatment Satisfaction Questionnaire (DTSQ) and the SF-36 Health Survey (SF-36). Case (CSII) and control subjects (MDI) were recruited in a 1 : 2 ratio. Results: Overall, 1341 individuals were enrolled by 62 diabetes clinics; 481 were cases and 860 control subjects. Cases had a longer diabetes duration and were more likely to have eye and renal complications. Age, school education, occupation and HbA1c were similar. Of control subjects, 90% followed glargine-based MDI regimens and 10% used NPH-based MDI regimens. On multivariate analysis, after adjusting for socioeconomic and clinical characteristics, scores in the following areas of the DSQOLS were higher in cases than control subjects: diet restrictions (β = 5.96; P < 0.0001), daily hassles (β = 3.57; P = 0.01) and fears about hypoglycaemia (β = 3.88; P = 0.006). Treatment with CSII was also associated with a markedly higher DTSQ score (β = 4.13; P < 0.0001) compared with MDI. Results were similar when CSII was compared separately with glargine- or NPH-based MDI regimens. Conclusions: This large, non-randomized, case-control study suggests quality of life gains deriving from greater lifestyle flexibility, less fear of hypoglycaemia, and higher treatment satisfaction, when CSII is compared with either glargine-based or NPH-based MDI regimens. © 2008 The Authors
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