80 research outputs found
The impact of electronic palliative care coordination systems (EPaCCS) on care at the end of life across multiple care sectors, in one clinical commissioning group area, in England:A realistic evaluation protocol
The View from the Haua Fteah: Cave Sediments and Environmental Change During the Middle to Later Stone Age in Cyrenaica, Libya
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Health service use of infants involved in family justice care and supervision proceedings in Wales: a longitudinal national data linkage study.
Health service use of infants involved in family justice care and supervision proceedings in Wales: a data linkage study
IntroductionWhen a child has suffered, or is at risk of suffering, significant harm from parents or caregivers, the local authority may issue Section 31 (s.31) Care and Supervision proceedings under the Children Act (1989).ObjectivesWe compared the healthcare use of infants less than one year old subject to s.31 proceedings in Wales (n = 1,332),to that of a comparison group of infants not subject to s.31 proceedings (n = 204,417), between January 2011 and February 2020.MethodsPopulation-based e-cohort study utilising data held in the Secure Anonymised Information Linkage (SAIL) Databank. Infants in s.31 proceedings were identified using the Children and Family Court Advisory and Support Service dataset. This was linked to demographic and healthcare datasets, to identify General Practice (GP) visits, emergency department (ED) attendances, and hospital admissions (emergency and elective); before the study end date or the child's first birthday for the comparison group, orbefore the s.31 application date.Regression analysis calculated event rate ratios [RR] and incidence rate ratios [IRR] for healthcare events, adjusting for widerdeterminants of health (e.g. perinatal factors, maternal mental health, deprivation), and investigated reasons for healthcare use.ResultsInfants in s.31 proceedings had ahigher number and incidence of healthcare events compared with the comparison group, across all healthcare settings. Differences were greatest for emergency hospital admissions (IRR = 4.03, 95% confidence interval [CI] = 3.53 - 4.59; RR = 4.60, CI = 3.90 - 5.41). "Injury and poisoning" was the main reason for emergency admissions amongst infants in s.31 proceedings. For ED presentations, emergency hospital admissions, and GP visits, there were proportionally more events for these infants across all top ten reasons for healthcare.ConclusionsFindings highlight greater healthcare utilisation for infants involved in s.31 proceedings in Wales, helping to build a better understanding of their needs and vulnerabilities
Shanidar Cave and the Baradostian, a Zagros Aurignacian industry
Whilst there has been significant interest in the origins and spread of the Aurignacian industry, usually linked with the physical dispersal of anatomically modern humans into Europe, comparatively little attention has been paid to possible origins or movements further east. Recent work at Shanidar Cave, a site better known for the Neanderthal evidence discovered by Ralph Solecki in his 1951â1960 excavations, has recovered new information on the âBaradostianâ Upper Palaeolithic in Iraq. This paper reviews the regional evidence for the Baradostian as an example of the Zagros Aurignacian and discusses its place in debates about Neanderthal/Modern Human relations.The financial support of the Leverhulme Trust (Research Grant RPG-2013-105), the Rust Family Foundation, and Natural Environment Research Council's Oxford Radiocarbon Dating Facility (grant NF/2016/2/14) is also gratefully acknowledged
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New Neanderthal remains associated with the âflower burialâ at Shanidar Cave
Shanidar Cave in Iraqi Kurdistan became an iconic Palaeolithic site following Ralph Solecki's mid twentieth-century discovery of Neanderthal remains. Solecki argued that some of these individuals had died in rockfalls andâcontroversiallyâthat others were interred with formal burial rites, including one with flowers. Recent excavations have revealed the articulated upper body of an adult Neanderthal located close to the âflower burialâ locationâthe first articulated Neanderthal discovered in over 25 years. Stratigraphic evidence suggests that the individual was intentionally buried. This new find offers the rare opportunity to investigate Neanderthal mortuary practices utilising modern archaeological techniques.Leverhulme Trust (Research Grant RPG-2013-105), the Rust Family Foundation, the British Academy, the Wenner-Gren Foundation, the Society of Antiquaries, the McDonald Institute of Archaeological Research at the University of Cambridge and the Natural Environment Research Councilâs Oxford Radiocarbon Dating Facility (grant NF/2016/2/14). The ongoing dating program is supported by the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013) / ERC grant agreement number 324139 âPalaeoChronâ awarded to Professor Tom Higham, University of Oxfor
Human interactions with tropical environments over the last 14,000 years at Iho Eleru, Nigeria
The IhĂČ ElĂ©Ă©rĂș (or Iho Eleru) rock shelter, located in Southwest Nigeria, is the only site from which Pleistocene-age hominin fossils have been recovered in western Africa. Excavations at Iho Eleru revealed regular human occupations ranging from the Later Stone Age (LSA) to the present day. Here, we present chronometric, archaeobotanical, and paleoenvironmental findings, which include the taxonomic, taphonomic, and isotopic analyses of what is the only Pleistocene faunal assemblage documented in western Africa. Our results indicate that the local landscape surrounding Iho Eleru, although situated within a regional open-canopy biome, was forested throughout the past human occupation of the site. At a regional scale, a shift from forest- to savanna-dominated ecotonal environment occurred during a mid-Holocene warm event 6,000 years ago, with a subsequent modern reforestation of the landscape. Locally, no environmental shift was observable, placing Iho Eleru in a persistent forested âislandâ during the period of occupation
The chronostratigraphy of the Haua Fteah cave (Cyrenaica, northeast Libya) â optical dating of early human occupation during Marine Isotope Stages 4, 5 and 6
The paper presents the results of optical dating of potassium-rich feldspar grains obtained from the Haua Fteah cave in Cyrenaica, northeast Libya, focussing on the chronology of the Deep Sounding excavated by Charles McBurney in the 1950s and reexcavated recently. Samples were also collected from a 1.25 m-deep trench (Trench S) excavated during the present project below the basal level of the Deep Sounding. Optically stimulated luminescence (OSL) data sets for multi-grain, single aliquots of quartz for samples from the Middle Trench were previously published. Re-analyses of these OSL data confirm significant variation in the dose saturation levels of the quartz signal, but allow the most robust OSL ages to be determined for comparison with previous age estimates and with those obtained in this study for potassium-rich feldspars from the Deep Sounding. The latter indicate that humans may have started to visit the cave as early as ~150 ka ago, but that major use of the cave occurred during MIS 5, with the accumulation of the Deep Sounding sediments. Correlations between optical ages and episodes of âPre-Aurignacianâ artefact discard indicate that human use of the cave during MIS 5 was highly intermittent. The earliest phases of human activity appear to have occurred during interstadial conditions (5e and 5c), with a later phase of lithic discard associated with more stadial conditions, possibly MIS 5b. We argue that the âPre-Aurignacianâ assemblage can probably be linked with modern humans, like the succeeding âLevalloiso-Mousterianâ assemblage; two modern human mandibles associated with the latter are associated with a modelled age of 73â65 ka. If this attribution is correct, then the new chronology implies that modern humans using âPre-Aurignacianâ technologies were in Cyrenaica as early as modern humans equipped with âAterianâ technologies were in the Maghreb, raising new questions about variability among lithic technologies during the initial phases of modern human dispersals into North Africa
The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)
Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic stroke and animal welfare. It provides a number of recommendations to minimise the level of severity in the most common rodent models of middle cerebral artery occlusion, while sustaining or improving the scientific outcomes. The recommendations cover basic requirements pre-surgery, selecting the most appropriate anaesthetic and analgesic regimen, as well as intraoperative and post-operative care. The aim is to provide support for researchers and animal care staff to refine their procedures and practices, and implement small incremental changes to improve the welfare of the animals used and to answer the scientific question under investigation. All recommendations are recapitulated in a summary poster (see supplementary information)
The chronostratigraphy of the Haua Fteah cave (Cyrenaica, northeast Libya)
The 1950s excavations by Charles McBurney in the Haua Fteah, a large karstic cave on the coast of
northeast Libya, revealed a deep sequence of human occupation. Most subsequent research on North
African prehistory refers to his discoveries and interpretations, but the chronology of its archaeological
and geological sequences has been based on very early age determinations. This paper reports on the
initial results of a comprehensive multi-method dating program undertaken as part of new work at the
site, involving radiocarbon dating of charcoal, land snails and marine shell, cryptotephra investigations,
optically stimulated luminescence (OSL) dating of sediments, and electron spin resonance (ESR) dating of
tooth enamel. The dating samples were collected from the newly exposed and cleaned faces of the upper
7.5 m of the w14.0 m-deep McBurney trench, which contain six of the seven major cultural phases that
he identified. Despite problems of sediment transport and reworking, using a Bayesian statistical model
the new dating program establishes a robust framework for the five major lithostratigraphic units
identified in the stratigraphic succession, and for the major cultural units. The age of two anatomically
modern human mandibles found by McBurney in Layer XXXIII near the base of his Levalloiso-Mousterian
phase can now be estimated to between 73 and 65 ka (thousands of years ago) at the 95.4% confidence
level, within Marine Isotope Stage (MIS) 4. McBurneyâs Layer XXV, associated with Upper Palaeolithic
Dabban blade industries, has a clear stratigraphic relationship with Campanian Ignimbrite tephra.
Microlithic Oranian technologies developed following the climax of the Last Glacial Maximum and the
more microlithic Capsian in the Younger Dryas. Neolithic pottery and perhaps domestic livestock were
used in the cave from the mid Holocene but there is no certain evidence for plant cultivation until the
Graeco-Roman period
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