A diferença da água doce e água salgada: trabalhando conceitos de física com alunos do ensino fundamental pelo PIBID

Anais do II Seminário Seminário Estadual PIBID do Paraná: tecendo saberes / organizado por Dulcyene Maria Ribeiro e Catarina Costa Fernandes — Foz do Iguaçu: Unioeste; Unila, 2014Este artigo é um breve relato da experiência da primeira intervenção realizada na Escola Municipal Professor Joaquim Tramujas Filho, pelos estudantes do curso de Licenciatura em Física, vinculados com o PIBID, do Instituto Federal do Paraná, Câmpus Paranaguá. A intervenção foi realizada no primeiro semestre de 2014, na turma de 4o ano do ensino fundamental abordando o tema: "A diferença entre a água doce e a água salgada", com o objetivo principal de apresentar aos alunos conceitos de Física presentes no seu dia-a-dia. Considerando que a Física é uma disciplina não presente na grade curricular nas séries iniciais, esse projeto foi proposto para demonstrar em atividades dinâmicas os conceitos e fundamentos teóricos da forma mais simples possível para que os alunos do ensino fundamental sejam capazes de assimilar situações e problemas envolvidos na sociedade e no seu cotidian

O TRABALHO INTERDISCIPLINAR DE GRADUAÇÃO E SEUS IMPACTOS NO APRENDIZADO SIGNIFICATIVO NO ENSINO SUPERIOR: UM ESTUDO DE CASO UNIBH

O presente artigo possui como objetivo ilustrar como o aprendizado significativo têm sido praticado no Centro Universitário de Belo Horizonte - UniBH (Brasil) por meio da instituição do Trabalho Interdisciplinar de Graduação como disciplina obrigatória durante todo o percurso formativo dos alunos em cursos de graduação. Para tanto, foi pesquisado sobre a atualização das matrizes curriculares dos cursos de graduação do UniBH a partir do segundo semestre de 2009 até o ano de 2015. O estudo de caso se apóia em uma análise documental assim como em entrevistas com os gestores acadêmicos responsáveis por tal atualização. A análise posteriormente descrita enfatiza os resultados positivos alcançados com a introdução do TIG na matriz curricular dos cursos do UniBH, dentre os quais destaca-se: a interdisciplinaridade entre conteúdos ministrados ao longo dos cursos; o engajamento imediato dos alunos na produção de conteúdo teórico-prático; o aumento intensivo no desenvolvimento de competências técnicas, acadêmicas e interpessoais ao longo de todo o percurso formativo dos alunos; conquistas e visibilidade nacionais aos projetos e soluções propostos por graduandos; assim como a dinamização das rotinas de gestão das Coordenações e a integração do corpo docente

Evaluation of the nicotine metabolite ratio in smoking patients treated with varenicline and bupropion

Background: Smoking is the leading cause of preventable death worldwide. It is responsible for several types of cancer, cardiovascular diseases, and diseases of the reproductive system, among others. Therefore, advances in research are increasingly necessary in order to make smoking cessation treatment more effective. Some studies have investigated the association of the nicotine metabolite ratio (NMR) with general characteristics and treatment outcomes. In the present study, the main aim was to evaluate the NMR in smoking patients from an Assistance Program of a tertiary cardiology hospital.Methodology: Serum samples were collected from 185 patients at T0 (while patients were still smoking and before starting pharmacological treatment). Cotinine and hydroxycotinine analytes were measured using liquid-chromatography tandem mass-spectrometry (LC-MS/MS). By looking at the relationship between hydroxycotinine and cotinine, we can obtain the NMR, with which it is possible to classify patients into slow metabolizers (NMR < 0.31), as well as normal or fast metabolizers (NMR ≥ 0.31).Results: From 185 patients, 55 were considered slow metabolizers and 130 as normal/fast. The metabolite averages were associated with the number of cigarettes smoked per day (p < 0.001 for cotinine and 0.023 hydroxycotinine). However, we were unable to analyze the association of the NMR with general and clinical characteristics of patients under smoking cessation treatment.Conclusion: We were able to evaluate the NMR, and to observe categories of metabolizers in Brazilian patients under pharmacological treatments. Thus, this study can contribute to the indication of a form of analysis, which might form part of the customization of smoking cessation treatments and, consequently, improve the success rates

The ER luminal binding protein (BiP) mediates an increase in drought tolerance in soybean and delays drought-induced leaf senescence in soybean and tobacco

The ER-resident molecular chaperone BiP (binding protein) was overexpressed in soybean. When plants growing in soil were exposed to drought (by reducing or completely withholding watering) the wild-type lines showed a large decrease in leaf water potential and leaf wilting, but the leaves in the transgenic lines did not wilt and exhibited only a small decrease in water potential. During exposure to drought the stomata of the transgenic lines did not close as much as in the wild type, and the rates of photosynthesis and transpiration became less inhibited than in the wild type. These parameters of drought resistance in the BiP overexpressing lines were not associated with a higher level of the osmolytes proline, sucrose, and glucose. It was also not associated with the typical drought-induced increase in root dry weight. Rather, at the end of the drought period, the BiP overexpressing lines had a lower level of the osmolytes and root weight than the wild type. The mRNA abundance of several typical drought-induced genes [NAC2, a seed maturation protein (SMP), a glutathione-S-transferase (GST), antiquitin, and protein disulphide isomerase 3 (PDI-3)] increased in the drought-stressed wild-type plants. Compared with the wild type, the increase in mRNA abundance of these genes was less (in some genes much less) in the BiP overexpressing lines that were exposed to drought. The effect of drought on leaf senescence was investigated in soybean and tobacco. It had previously been reported that tobacco BiP overexpression or repression reduced or accentuated the effects of drought. BiP overexpressing tobacco and soybean showed delayed leaf senescence during drought. BiP antisense tobacco plants, conversely, showed advanced leaf senescence. It is concluded that BiP overexpression confers resistance to drought, through an as yet unknown mechanism that is related to ER functioning. The delay in leaf senescence by BiP overexpression might relate to the absence of the response to drought

Erratum to: The study of cardiovascular risk in adolescents – ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents

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