Nonresidential Fathers Parenting Their Children Residing in Shelters: A Phenomenological Study

This phenomenological qualitative study explored the parenting role of nonresidential fathers of children living in shelters. Special attention was paid to the perceived contributions of these fathers to the overall health and general well-being of their children residing in shelters. Often separations of nonresidential fathers from their children in shelters decreased their contributions to their children\u27s health and well-being. Increased knowledge of these parental roles and contributions can enhance programs and policies to support these fathers in improving the health and well-being of their children. In-depth semistructured interviews were conducted with 6 demographically diverse nonresidential fathers living in Philadelphia. The health-belief model, in conjunction with the revised health-belief model, was used as a theoretical framework for this study. The research questions were designed to explore nonresidential fathers\u27 parenting roles, perceptions of their contributions, and the facilitators of and barriers to their parenting while their children resided in shelters. An inductive approach to data analysis informed study findings of nonresidential fathers\u27 active participation and engagement in their children\u27s lives, including involvement in their healthcare and health promotion. Perceived facilitators to their parenting role included internal and external motivators, whereas perceived challenges and barriers to their parenting role were externally based. Finally, study findings showed these fathers to be present and making significant contributions to the improved health and overall well-being of their children while they resided in homeless shelters

A FORTRESS BETWEEN ARTIFICE AND NATURE: THE LASER SCANNING SURVEY OF THE CASTLE OF PESCOPAGANO AS AN INSTRUMENT OF KNOWLEDGE, CONSERVATION AND ENHANCEMENT

Abstract. The castle of Pescopagano, a small village located on the border between Basilicata and Campania, is a complex of great historical and landscape value, for the inseparable combination that binds its stones to the rock where it stands. Founded perhaps in the Byzantine times, but certainly renovated and built in its current forms between the 11th and 12th century, the castle had considerable military importance under Frederick II of Swabia. Seriously damaged by the earthquake of 1694, the fortress underwent a partial reconstruction, but ended up suffering further collapses caused by the Irpinia earthquake of 1980, such as to motivate the first interventions of securing and, above all, the application of the listing process. Today the castle is still largely in ruins and is only partially accessible thanks to a limited intervention on the paths. The present research aims at deepening the knowledge of the state of conservation, the damage mechanisms and the previous restoration interventions of the castle, in order to define possible strategies for its restoration and enhancement. The analysis work uses the most advanced laser scanning and drone detection systems, in order to document, as accurately as possible, the complex patrimonial system of the castle. Thanks to the combined use of these techniques, the objective is also to define methods that can be replicated in other contexts where the relationship between geomorphology and construction is so relevant that it jeopardizes the use of any other traditional survey system

Relation of air mass history to nucleation events in Po Valley, Italy, using back trajectories analysis

International audienceIn this paper, we study the transport of air masses to San Pietro Capofiume (SPC) in Po Valley, Italy, by means of back trajectories analysis. Our main aim is to investigate whether air masses originate over different regions on nucleation event days and on nonevent days, during three years when nucleation events have been continuously recorded at SPC. The results indicate that nucleation events occur frequently in air masses arriving from Central Europe, whereas event frequency is much lower in the air transported from southern directions and from the Atlantic Ocean. We also analyzed the behaviour of meteorological parameters during 96 h transport to SPC, and found that, on average, event trajectories undergo stronger subsidence during the last 12 h before the arrival at SPC than nonevent trajectories. This causes a reversal in the temperature and relative humidity (RH) differences between event and nonevent trajectories: between 96 and 12 h back time, temperature is lower and RH is higher for event than nonevent trajectories and between 12 and 0 h vice versa. Boundary layer mixing is stronger along the event trajectories compared to nonevent trajectories. The absolute humidity (AH) is similar for the event and nonevent trajectories between about 96 h and about 60 h back time, but after that, the event trajectories AH becomes lower due to stronger rain. We also studied transport of SO2 to SPC, and conclude that although sources in Po Valley most probably dominate the measured concentrations, certain Central and Eastern European sources also make a substantial contribution

Gaia DR2 view of the Lupus V-VI clouds: the candidate diskless young stellar objects are mainly background contaminants

Extensive surveys of star-forming regions with Spitzer have revealed populations of disk-bearing young stellar objects. These have provided crucial constraints, such as the timescale of dispersal of protoplanetary disks, obtained by carefully combining infrared data with spectroscopic or X-ray data. While observations in various regions agree with the general trend of decreasing disk fraction with age, the Lupus V and VI regions appeared to have been at odds, having an extremely low disk fraction. Here we show, using the recent Gaia data release 2 (DR2), that these extremely low disk fractions are actually due to a very high contamination by background giants. Out of the 83 candidate young stellar objects (YSOs) in these clouds observed by Gaia, only five have distances of 150 pc, similar to YSOs in the other Lupus clouds, and have similar proper motions to other members in this star-forming complex. Of these five targets, four have optically thick (Class II) disks. On the one hand, this result resolves the conundrum of the puzzling low disk fraction in these clouds, while, on the other hand, it further clarifies the need to confirm the Spitzer selected diskless population with other tracers, especially in regions at low galactic latitude like Lupus V and VI. The use of Gaia astrometry is now an independent and reliable way to further assess the membership of candidate YSOs in these, and potentially other, star-forming regions.Comment: Accepted for publication on Astronomy&Astrophysics Letter

Toward a personalized therapy in soft-tissue sarcomas: State of the art and future directions

Soft-tissue sarcomas are rare tumors characterized by pathogenetic, morphological, and clinical intrinsic variability. Median survival of patients with advanced tumors are usually chemo-and radio-resistant, and standard treatments yield low response rates and poor survival results. The identification of defined genomic alterations in sarcoma could represent the premise for targeted treatments. Summarizing, soft-tissue sarcomas can be differentiated into histotypes with reciprocal chromosomal translocations, with defined oncogenic mutations and complex karyotypes. If the latter are improbably approached with targeted treatments, many suggest that innovative therapies interfering with the identified fusion oncoproteins and altered pathways could be potentially resolu-tive. In most cases, the characteristic genetic signature is discouragingly defined as “undruggable”, which poses a challenge for the development of novel pharmacological approaches. In this review, a summary of genomic alterations recognized in most common soft-tissue sarcoma is reported together with current and future therapeutic opportunities

Gas vs dust sizes of protoplanetary disks: effects of dust evolution

The extent of the gas in protoplanetary disks is observed to be universally larger than the extent of the dust. This is often attributed to radial drift and grain growth of the mm grains, but line optical depth produces a similar observational signature. We investigate in what parts of the disk structure parameter space dust evolution and line optical depth are the dominant drivers of the observed gas and dust size difference. Using the thermochemical model DALI with dust evolution included we ran a grid of models aimed at reproducing the observed gas and dust size dichotomy. The relation between R_dust and dust evolution is non-monotonic and depends on the disk structure. R_gas is directly related to the radius where the CO column density drops below 10^15 cm^-2 and CO becomes photodissociated. R_gas is not affected by dust evolution but scales with the total CO content of the disk. R_gas/R_dust > 4 is a clear sign for dust evolution and radial drift in disks, but these cases are rare in current observations. For disks with a smaller R_gas/R_dust, identifying dust evolution from R_gas/R_dust requires modelling the disk structure including the total CO content. To minimize the uncertainties due to observational factors requires FWHM_beam 10 on the 12CO emission moment zero map. For the dust outer radius to enclose most of the disk mass, it should be defined using a high fraction (90-95%) of the total flux. For the gas, any radius enclosing > 60% of the 12CO flux will contain most of the disk mass. To distinguish radial drift and grain growth from line optical depth effects based on size ratios requires disks to be observed at high enough angular resolution and the disk structure should to be modelled to account for the total CO content of the disk.Comment: 18 pages, 27 figures, accepted in A&

A Root in Synapsis and the Other One in the Gut Microbiome-Brain Axis: Are the Two Poles of Ketogenic Diet Enough to Challenge Glioblastoma?

Glioblastoma is the most frequent and aggressive brain cancer in adults. While precision medicine in oncology has produced remarkable progress in several malignancies, treatment of glioblastoma has still limited available options and a dismal prognosis. After first-line treatment with surgery followed by radiochemotherapy based on the 2005 STUPP trial, no significant therapeutic advancements have been registered. While waiting that genomic characterization moves from a prognostic/predictive value into therapeutic applications, practical and easy-to-use approaches are eagerly awaited. Medical reports on the role of the ketogenic diet in adult neurological disorders and in glioblastoma suggest that nutritional interventions may condition outcomes and be associated with standard therapies. The acceptable macronutrient distribution of daily calories in a regular diet are 45–65% of daily calories from carbohydrates, 20–35% from fats, and 10–35% from protein. Basically, the ketogenic diet follows an approach based on low carbohydrates/high fat intake. In carbohydrates starvation, body energy derives from fat storage which is used to produce ketones and act as glucose surrogates. The ketogenic diet has several effects: metabolic interference with glucose and insulin and IGF-1 pathways, influence on neurotransmission, reduction of oxidative stress and inflammation, direct effect on gene expression through epigenetic mechanisms. Apart from these central effects working at the synapsis level, recent evidence also suggests a role for microbiome and gut-brain axis induced by a ketogenic diet. This review focuses on rationales supporting the ketogenic diet and clinical studies will be reported, looking at future possible perspectives

Size-segregated aerosol chemical composition at a boreal site in southern Finland, during the QUEST project

International audienceSize-segregated aerosol samples were collected during the QUEST field campaign at Hyytiälä, a boreal forest site in Southern Finland, during spring 2003. Aerosol samples were selectively collected during both particle formation events and periods in which no particle formation occurred. A comprehensive characterisation of the aerosol chemical properties (water-soluble inorganic and organic fraction) and an analysis of the relevant meteorological parameters revealed how aerosol chemistry and meteorology combine to determine a favorable "environment" for new particle formation. The results indicated that all events, typically favored during northerly air mass advection, were background aerosols (total mass concentrations range between 1.97 and 4.31 µg m-3), with an increasingly pronounced marine character as the northerly air flow arrived progressively from the west and, in contrast, with a moderate SO2-pollution influence as the air arrived from more easterly directions. Conversely, the non-event aerosol, transported from the south, exhibited the chemical features of European continental sites, with a marked increase in the concentrations of all major anthropogenic aerosol constituents. The higher non-event mass concentration (total mass concentrations range between 6.88 and 16.30 µg m-3) and, thus, a larger surface area, tended to suppress new particle formation, more efficiently depleting potential gaseous precursors for nucleation. The analysis of water-soluble organic compounds showed that clean nucleation episodes were dominated by aliphatic biogenic species, while non-events were characterised by a large abundance of anthropogenic oxygenated species. Interestingly, a significant content of ?-pinene photo-oxidation products was observed in the events aerosol, accounting for, on average, 72% of their WSOC; while only moderate amounts of these species were found in the non-event aerosol. If the organic vapors condensing onto accumulation mode particles are responsible also for the growth of newly formed thermodynamically stable clusters, our finding allows one to postulate that, at the site, ?-pinene photo-oxidation products (and probably also photo-oxidation products from other terpenes) are the most likely species to contribute to the growth of nanometer-sized particles