4 research outputs found
Mapping the human genetic architecture of COVID-19
- Author
- 23andMe COVID-19 Team
- Andrews Shea J.
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Cordioli Mattia
- Covid 19 Host Genetics Initiative
- CRiPSI
- Daly Mark J.
- Daly Mark J.
- Ding Yi
- Donner Kati
- FHoGID
- Ganna Andrea
- Ganna Andrea
- Ganna Andrea
- Genes & Hlth Res Team
- Humanitas COVID-19 Task Force
- Humanitas Gavazzeni COVID-19 Task
- Kanai Masahiro
- Karjalainen Juha
- Karjalainen Juha
- Karjalainen Juha
- Kaunisto Mari
- Kaunisto Mari
- Kivinen Katja
- Li Rui
- Liao Rachel G.
- Marttila Minttu
- Marttila Minttu
- Marttila Minttu
- Mehtonen Juha
- Nakanishi Tomoko
- Nakanishi Tomoko
- Nakanishi Tomoko
- Nakanishi Tomoko
- Neale Benjamin M.
- Neale Benjamin M.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Niemi Mari E. K.
- Norwegian SARS-CoV-2 Study Grp
- P-PredictUs
- Palotie Aarno
- Pathak Gita A.
- Perola Markus
- Pigazzini Sara
- Pigazzini Sara
- Pigazzini Sara
- Pigazzini Sara
- Pigazzini Sara
- RegCOVID
- SeroCOVID
- UCLA Hlth ATLAS Data Mart Working
- Publication venue
- Publication date
- 01/12/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19(1,2), host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases(3-7). They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.Peer reviewe
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Aarno Palotie
- Abdolmajid Hosseini
- Abdulaziz AlMalik
- Abdulraheem Alshareef
- Achille Iolascon
- Adam S. Butterworth
- Afshar Etemadi Aleagha
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ahmadreza Niavarani
- Ahna Girshick
- Aida Fiz-Lopez
- Alba Parra Martınez
- Albandary M. Alowayn
- Albert Tenesa
- Albert V. Smith
- Alessandra Guarnaccia
- Alessandra Renieri
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alex Serra-Llovich
- Alex Soriano
- Alex Stuckey
- Alexander Labkowsky
- Alexander T. Williams
- Alexander W. Charney
- Alexandra Aksentijevich
- Alexandre Belisle
- Ali Amirsavadkouhi
- Ali Sobh
- Alice Donati
- Alicia de Felipe Mimbrera
- Alicia R. Martin
- Alireza Adamsara
- Altaf Ali
- Amal Al Mutairi
- Amin K. Khattab
- Amr M. Yassen
- Amr Samir
- Amy Trankiem
- Anastasia Lucas
- Andre G. Uitterlinden
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Ganna
- Andrea Martın-Nalda
- Andrea Tommasi
- Andres Metspalu
- Andrew Beck
- Andrew P. Boughton
- Anil P. S. Ori
- Ann E. Woolley
- Anna Canaccini
- Anna Carreras
- Anna Dominguez-Mayoral
- Anna L. Guyatt
- Anna M. Planas
- Anna Maria Pinto
- Annarita Giliberti
- Anne E. Justice
- Anne Kallaste
- Anne Marie O’Connell
- Anne Richmond
- Anne Richmond
- Anne-Sophie Sauvage
- Annique Claringbould
- Anoud Albader
- Antonella D’Arminio Monforte
- Antonella Vincenti
- Antonio Di Biagio
- Antonio Perrella Francesco Bianchi
- Anu Tamm
- Anurag Verma
- Archie Campbell
- Archie Campbell
- Arianna Emiliozzi
- Arianna Gabrieli
- Aris Baras
- Arthur Timothy D
- Asher Haug Baltzell
- Ashish Yadav
- Athanasios Kousathanas
- Attia A. S. Mohamed
- Aubrey Annis
- Augusto Rendon
- Avromie Karp
- Bader Alghamdi
- Bahareh Sharififard
- Bandar A. Suliman
- Barbara Rossetti
- Bari Britvan
- Bartlomiej P. Przychodzen
- Beatriz Cortes
- Beatriz Dietl
- Ben M. Brumpton
- Benjamin M. Neale
- Benoit Misset
- Bernard Lambermont
- Bhavi Trivedi
- Binglan Li
- Biswarup Ghosh
- Bjørn Olav Asvold
- Bluma Brenner
- Brett L. Collins
- Brooke Rhead
- Brooke Wolford
- Brooke Wolford
- Brooke Wolford Sebastian Zo¨ llner
- Bruno Frediani
- Carlo Rivolta
- Carlos Domingo
- Carlota Dobano
- Carmelo Piscopo
- Carmen Marciano
- Carolina Medina-Gomez
- Caroline Cusick
- Caroline Hayward
- Caroline Hayward
- Caterina Lo Rizzo
- Catherine A. Ball
- Catherine E. Bee
- Catherine John
- Cathy Voide
- Cesira Nencioni
- Charlotte Guzman
- Chiara Barbieri
- Chiara Batini
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Fawns-Ritchie
- Chloe Fawns-Ritchie
- Chris C. A. Spencer
- Chris Tselios
- Christelle Meuris
- Christian Von Frenckell
- Christine Stevens
- Christine Stevens
- Christopher A. Odhams
- Christopher J. Griffiths
- Christopher J. O’Donnell
- Christopher R. Gignoux
- Christos Polymeropoulos
- Chureerat Phokaew
- Claire Churchhouse
- Claudia Suardi
- Claudio Ferri
- Clive Hoggart
- Cotton Seed
- CRiPSI
- Cristen Willer
- Cristina Mussini
- D'Antonio Matteo
- D'Antonio-Chronowska Agnieszka
- Daiana Aguero
- Dan Mason
- Daniel Auld
- Daniel E. Kaufmann
- Daniel I. Chasman
- Daniel J. Wilson
- Daniel King
- Daniel M. Jordan
- Daniel Rader
- Daniel Rhodes
- Daniela Francisci
- Danielle Henry
- Danilo Tacconi
- Danny Park
- Darin Adra
- Dave J. Carey
- David A. van Heel
- David Bennett
- David Bernardo
- David Dalmau
- David H. Wyllie
- David J. Porteous
- David J. Porteous
- David R. Morrison
- David Torrents
- Davide Grassi
- Davide Romani
- Deema AlZahrani
- Derrick W. Crook
- Dhryata Kamdar
- Diana Alaverdian
- Diego Ripamonti
- Dionysios Neofytos
- Doaa Shahin
- Domenico A. Coviello
- Dona Baraka
- Donatella Acquilini
- Dorota Pasko
- Douglas M. Shaw
- Duncan Emma
- Duncan S. Palmer
- Ebrahim S. Mahmoud
- Ebtehal Alsolm
- Eco (E. J. C. ) de geus
- Edoardo Conticini
- Edward J. Hollox
- Edward Laane
- Eimear E. Kenny
- Elena Andreucci
- Elena Bargagli
- Elena Desanctis
- Elena Jimenez-Xarrie
- Elena Muino
- Eliecer Coto
- Elisa Arribas
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Elizabeth G. Atkinson
- Elizabeth W. Karlson
- Eman Barhoush
- Emanuele Catena
- Emanuele Di Angelantonio
- Emma F. Perez
- Emma L. Adams
- Ene Reimann
- Enrico Martinelli
- Eric E. Schadt
- Erik Solligard
- Erwin Schurr
- Esteban Lopera
- Esther Gonzalez-Villa
- Eugenia Quiros-Roldan
- Eurie L. Hong
- F. Kyle Satterstrom
- Fabio Lena
- Faisal Almalki
- Fatimah Alqubaishi
- Fawz Al Harthi
- Federica Gaia Miraglia
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- FHoGID RegCOVID
- Filippo Aucella
- Filippo Biscarini
- FinnGen
- Floriana Valentino
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Paciosi
- Francesco Paciosi
- Francesco Raimondi
- Francesco Vladimiro Segala
- Francisca Ruiz-Jaen
- Francisco Lozano
- Franco Maggiolo
- Frazer
- Frederic Frippiat
- G. Mark Lathrop
- Gabriella Coiro
- Gabriella Doddato
- Gabriella Maria Squeo
- Gavin Band
- Geetha Chittoor
- Gemma Castano-Vinyals
- Gemma Serrano-Heras
- Genes &
- Genevieve Roberts
- Genni Spargi
- Georgia Chan
- Giada Beligni
- Gian Piero Caldarelli
- Gianfranco Parati
- Gilles Darcis
- Gillian M. Belbin
- Gina Peloso
- Giordano Botta`
- Girish N. Nadkarni
- Gita A. Pathak
- Gita A. Pathak
- Giulianini Franco
- Giuseppe Fiorentino
- Giuseppe Merla
- Giusy Tiseo
- Gloria Pessina
- Goncalo R. Abecasis
- Gopal Sarma
- Guillaume Butler-Laporte
- Guillaume ButlerLaporte
- Guillermo M. Albaiceta
- Hadeel AlBardis
- Hakon Hakonarson
- Hakon Hakonarson
- Hamed Abdollahi
- Hani Al-Afghani
- Hannah Polikowski
- Hanteera S. Moahmed
- Harendra Guturu
- Health Research Team
- Helene Alavere
- Hengameh Ansari Tadi
- Hilary C. Martin
- Hilary Finucane
- Howard D. Sesso
- Hugo Zeberg
- Hung-Hsin Chen
- Huy Nguyen
- Ilaria Meloni
- Ilaria Rancan
- Iman Almohammed
- Immacolata Andolfo
- Inge Ringmets
- Irene Salib
- Irene van Blokland
- Isabella Zanella
- Israel Fernandez-Cadenas
- Ivan Galvan-Femenia
- J. Brent Richards
- J. Brent Richards
- J. Michael Gaziano
- Jaana Pesukova
- Jack A. Kosmicki
- Jacob Armstrong
- Jacqueline I. Goldstein
- Jahad Alghamdi
- Jaime Masjuan
- James B. Meigs
- James F. Wilson
- Jara Carcel-Marquez
- Jean-Baptiste Giot
- Jehad K. Albakri
- Jehan J. El-Jawhari
- Jekaterina Tabri
- Jennifer Below
- Jennifer E. Huffman
- Jennifer R. Harris
- Jessica Jacques
- Jiannis Ragoussis
- Jing Hua Zhao
- Jiongming Wang
- Joan Marti-Fabregas
- Joan Montaner Villalonga
- JoAnn E. Manson
- Joel Starkopf
- John Danesh
- John Wright
- Jonathan Afilalo
- Jonathan Grip
- Jonathan Shortt
- Jonathon LeFaive
- Jordan W. Smoller
- Jordi Perez-Tur
- Josep L. Bedini
- Josep Maria Mercader
- Josep Mercader
- Joseph B. Leader
- Joseph B. McCormick
- Joseph D. Buxbaum
- Joseph R. Glessner
- Joseph T. Glessner
- Jouke Jan Hottenga
- Juan Gomez
- Judith Garcia-Aymerich
- Judith. M. Vonk
- Judy H. Cho
- Juha Karjalainen
- Julie E. Buring
- Julie E. Horowitz
- Julien Guiot
- Julien Guntz
- Junghyun Jung
- Justine K. Rudkin
- Kai Kisand
- Kamal Okasha
- Karen A. Hunt
- Kari North
- Karolina Chwialkowska
- Katherine Keller
- Kathleen C. Barnes
- Kathrin Aprile von Hohenstaufen
- Kati Donner
- Kati Hensen
- Kati Kristiansson
- Katia Capitani
- Katja Kivinen
- Keith Noto
- Kelly A
- Kelly Cho
- Kenton D’Mellow
- Kevin W. Li
- Konrad J. Karczewski
- Kristi Lall
- Kristi Niblo
- Kristian Hveem
- Kristin Rand
- Kristin Tsuo
- Kristina Zguro
- Kristjan Metsalu
- Kristy Crooks
- Kumar Veerapen
- Kumardeep Chaudhary
- Kyle Gettler
- Laetitia Laurent
- Laia Llucia-Carol
- Laila Al-Awdah
- Lara Lloret Iglesias
- Lara Tang
- Laura Bergantini
- Laura D. Venn
- Laura Di Sarno
- Laura G. Sloofman
- Laura M. Huckins
- Lauro Sumoy
- Leen Abu Safieh
- Leonardo Croci
- Leonardo Marquez
- Lia Crotti
- Liam L. Hiester
- Lili Milani
- Lill-Iren S. Trogstad
- Lindo Nkambul
- Lindokuhle Nkambul
- Lindokuhle Nkambul
- Lindokuhle Nkambule
- Lindokuhle Nkambule
- Lorenzo Salerni
- Louis Petitjean
- Louise V. Wain
- Loukas Moutsianas
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Lude Franke Marike Boezen
- Luisa Tavecchia
- Luong Ruiz
- M. Arfan Ikram
- Maarja Lepamets
- Madeleine Durand
- Madonna M. Eltoukhy
- Maha Albeladi
- Mahmoud Abdel-Aziz
- Mairo Puusepp
- Malak Abedalthagafi
- Manal Alaamery
- Manolis Kogevinas
- Mansour Almutairi
- Manuel A. R. Ferreira
- Marc Afilalo
- Marcela Morris
- Marco Castori
- Marco Falcone
- Marco Feri
- Marco Gori
- Marco Mandala`
- Marco Rizzi
- Marco Tanfoni
- Marco Vecchia
- Margherita Baldassarri
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari Kaunisto
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria J. Arranz
- Maria Lorubbio
- Maria Palmieri
- Maria Teresa La Rovere
- Marie Coignet
- Marie Thys
- Mario Capasso
- Mario Tumbarello
- Mario Umberto Mondelli
- Marissa Zyndorf.
- Mark Daly
- Mark J. Caulfield
- Markus Perola
- Marta Corridi
- Marta Garcıa-Clemente
- Marta GuindoMartinez
- Marta L. DeDiego
- Martin D. Tobin
- Marwa H. Elnagdy
- Mary Ann Belli
- Mary K. Balaconis
- Marylyn D. Ritchie
- Masahiro Kanai
- Masahiro Kanai
- Masahiro Kanai
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Di Pietro
- Massimo Girardis
- Massimo Mangino
- Massimo Vaghi
- Mathieu Quinodoz
- Matsui Hiroko
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Matthew C. Gass
- Matthew Solomonson
- Matthew Solomonson
- Matti Pirinen
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Maureen Oliveira
- Maurizio Bussotti
- Maurizio Sanarico
- Maurizio Sanguinetti
- May Alrashed
- Meike Bartels
- Melania Degli Antoni
- Menachem Zlatopolsky
- Meriem Bouab
- Miao Zhang
- Michael Gaddis
- Michael Hultstro¨ m
- Michael N. Cantor
- Michael Peruggia
- Michael Preuss
- Michae¨ l Chasse´
- Michel (M. G. ) Nivard
- Michel Georges
- Michel Moutschen
- Michelle Daya
- Mihael H. Polymeropoulos
- Miklos Lipcsey
- Milos Pavlovic
- Mirella Bruttini
- Miriam Lucia Carriero
- Miriana D’Alessandro
- Mirjam Lista
- Mohamed A. F. Hegazy
- Mohamed R. El-shanshory
- Mohamed S. Abd Elghafar
- Mohamed S. Torky
- Mohammad S. Fawzy
- Mohammed A. Eid
- Mona Sawaji
- Moneera Alswailm
- Monica Poscente
- Monnat Pongpanich
- Monpat Chamnanphon
- Morteza Saeedi
- Nadia Harerimana
- Nardin Rezk Branka Vulesevic
- Natalia Blay
- Natalia Cullell
- Nathalie Brassard
- Nathan Berkowitz
- Nathan Cheng
- Nattiya Hirankarn
- Navya Shilpa Josyula
- Nguyen Jennifer P
- Nicholas Rafaels
- Nick Shrine
- Nicola Picchiotti
- Nicolas Arning
- Nicolas Tardif
- Nicole Soranzo
- Nikolas Baya
- Nils Koelling
- Noam D. Beckmann
- Noemie Boillat
- Noemie Suh
- Nofar Kimchi
- Noor Mamlouk
- Nora Aljawini
- Nouf AlDhawi
- Nour Albesher
- Noura S. Abul-Husn
- Olav Rooyackers
- Olivier Malaise
- Olumide Adeleye
- Opass Putchareon
- Oreste De Vivo
- P-PredictUs SeroCOVID
- Pajaree Chariyavilaskul
- Paloma de la Cal-Sabater
- Paloma Menendez-Valladares
- Pamela Raggi
- Paola Bergomi
- Paola Petrocelli
- Paolo Cameli
- Paolo Di Domenico
- Paolo Piacentini
- Part Peterson
- Pascale Huynen
- Patrick Deelen
- Patrick Turley
- Patrizia Zucchi
- Pattama Torvorapanit
- Paul H. Lee
- Paul M. Ridker
- Paul Naaber
- Paul O’Reilly
- Paul R. H. J. Timmers
- Pauline Lanting
- Per Magnus
- Pere Soler
- Petty E. Lauren
- Phil Tsao
- Philippe Le´ onard
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pierre Lepage
- Pierre-Yves Bochud
- Pietro Pinoli
- Pimpayao Sodsai
- Pintip Suchartlikitwong
- Prabhu Arumugam
- Qin Qin Huang
- Rachel G. Liao
- Rafael de Cid
- Raffaele Bruno
- Raffaele Scala
- Raghavendran Partha
- Rahul Gupta
- Raili Allos
- Rana Hasanato
- Rasoul Aliannejad
- Ravaglia Sabrina
- Raymond K. Walters
- Reedik Magi
- Renato Polimanti
- Renzo Scaggiante
- Riccardo Colombo
- Richard C. Trembath
- Richard H. Scott
- Richard J. Packer
- Rita Perna
- Roaa T. Halawani
- Robert C. Free
- Robert C. Green
- Robert Frithiof
- Robert P. Sebra
- Robert Warmerdam
- Roberta Russo
- Roger Colobran
- Ron Do
- Rosangela Artuso
- Rossella Tita
- Rui Li
- Ruth J. F. Loos
- Ryan C. Thompson
- Sabine Claassen
- Sabino Scolletta
- Sabrina Ravaglia
- Saeideh Ahmadi
- Salam Massadeh
- Saleh Alqahtani
- Sam Bryant
- Sam Bryant
- Sam Choi
- Sameer Chavan
- Sameera AlJohani
- Sami Koskelainen
- Samira Azarzar
- Samuli Ripatti
- Sandra P. Smieszek
- Sandro Mancarella
- Sandro Panese
- Sanni Ruotsalainen
- Sara Alotaibi
- Sara Amitrano
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sarah Alkwai
- Sarah Finer
- Sarah G. Earle
- Sauro Luchi
- Saverio Giuseppe Parisi
- Scott T. Weiss
- Sebastian Garcıa Madrona
- Semira Gonseth Nussle
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Seyed Behrooz Mohseni Moghaddam
- Shang-Kuan Lin
- Shannon McCurdy
- Shawn N. Murphy
- Shawneequa Callier
- Shea J. Andrews
- Shea J. Andrews
- Shea J. Andrews
- Shefali S. Verma
- Shona M. Kerr
- Silvia Baroni
- Silvia Cappelli
- Silvia Rojo
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slayton J. Underwood
- Sophie Venturelli
- Souad Rahmouni
- Spencer Knight
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Stephanie Bibert
- Stephen J. Wicks
- Steven Ascolillo
- Ste´ phanie Gofflot
- Stuart C. Sealfon
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Tala Abdullah
- Tamer A. Elhadidy
- Tess Levy
- Thanyawee Puthanakit
- Thitima B. Suttichet
- Tim D. Spector
- Tiziana Bachetti
- Tom Fowler
- Tomas Segura
- Tomislav Maricic
- Tomoko Nakanishi
- Tomoko Nakanishi
- Tonu Esko
- Tooraj Mirshahi
- Tormod Rogne
- Triin Laisk
- Tullio Trotta
- Valentina Anemoli
- Vasilios Polymeropoulos
- Veronica Rico
- Veronica Robles
- Ve´ronique Erard
- Victor Moreno
- Vincent Mooser
- Vincenzo Forgetta
- Vincenzo Forgetta
- Voraphoj Nilaratanakul
- Vorasuk Shotelersuk
- Walaa A. Felemban
- Walaa M. El-Lawaty
- Walid T. Khafaga
- Wanna Chetruengchai
- Watsamon Jantarabenjakul
- Wei Zhou
- Wei Zhou
- Wenhan Lu
- Werner Albrich
- Xavier Farre
- Xiao Chang
- Xiao Chang
- Xiaoqing Xue
- Xueyang Wang
- Yan V. Sun
- Yaseen M. Arabi
- Yasmine Belhaj
- Yasser M. El-Sherbiny
- Yen-Chen Anne Feng
- Yuk-Lam Ho
- Yuki Bradford
- Yunsung Lee
- Yuval Itan
- Yves Beguin
- Zaman Afrasiabi
- Zeinab Naderpour
- Zhu Wanying
- Ziab Z. Alahmadey
- Øyvind Helgeland
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
Mapping the human genetic architecture of COVID-19
- Author
- 23andMe COVID-19 Team
- Acosta Herrera Marialbert
- Alarcón Riquelme Marta Eugenia
- Carnero Montoro Elena
- Chueca Porcuna Natalia
- CRiPSI
- FHoGID
- García García Federico
- Genes & Hlth Res Team
- González Cejudo Trinidad
- Hernández Quero José
- Humanitas COVID-19 Task Force
- Humanitas Gavazzeni COVID-19 Task
- Martín Ibáñez Javier
- Martínez Bueno Manuel
- Niemi Mari E. K.
- Norwegian SARS-CoV-2 Study Grp
- P-PredictUs
- RegCOVID
- Salazar Adolfo de
- SeroCOVID
- The COVID-19 Host Genetics Initiative
- UCLA Hlth ATLAS Data Mart Working
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/07/2021
- Field of study
We thank the entire COVID-19 HGI community for their contributions and
continued collaboration. The work of the contributing studies was supported by numerous
grants from governmental and charitable bodies. Acknowledgements specific to contributing
studies are provided in Supplementary Table 13. We thank G. Butler-Laporte, G. Wojcik,
M.-G. Hollm-Delgado, C. Willer and G. Davey Smith for their extensive feedback and discussion.The genetic make-up of an individual contributes to the susceptibility and response to
viral infection. Although environmental, clinical and social factors have a role in the
chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may
also be important. Identifying host-specific genetic factors may reveal biological
mechanisms of therapeutic relevance and clarify causal relationships of modifiable
environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a
global network of researchers to investigate the role of human genetics in SARS-CoV-2
infection and COVID-19 severity. Here we describe the results of three genome-wide
association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46
studies across 19 countries. We report 13 genome-wide significant loci that are
associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of
these loci correspond to previously documented associations to lung or autoimmune
and inflammatory diseases3–7. They also represent potentially actionable mechanisms
in response to infection. Mendelian randomization analyses support a causal role for
smoking and body-mass index for severe COVID-19 although not for type II diabetes.
The identification of novel host genetic factors associated with COVID-19 was made
possible by the community of human genetics researchers coming together to
prioritize the sharing of data, results, resources and analytical frameworks. This
working model of international collaboration underscores what is possible for future
genetic discoveries in emerging pandemics, or indeed for any complex human
disease
Mapping the human genetic architecture of COVID-19
- Author
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- Abdullah T
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- Abecasis GR
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- Oyamada Y
- Ozaki S
- P-PredictUs
- Paccapelo C
- Paciosi F
- Paciosi F
- Paciosi F
- Packham S
- Padden G
- Pagani JL
- Pagani JL
- Page VJ
- Paik N-J
- Pairo-Castineira E
- Pais M
- Palmarini M
- Palmer DS
- Palmieri C
- Palmieri M
- Palmieri O
- Palom A
- Palotie A
- Palotie A
- Panchatsharam S
- Pancrazi A
- Panese S
- Pantet O
- Papakonstantinou D
- Papineni P
- Pappa E
- Paraboschi EM
- Paraiso H
- Paramsothy R
- Parati G
- Parikh V
- Parisi SG
- Park D
- Park JS
- Park KU
- Park L
- Park S-K
- Park WB
- Parker R
- Parkin J
- Parkinson N
- Parkinson N
- Parkinson P
- Parmar C
- Parravicini P
- Parris V
- Parris V
- Parsons P
- Partha R
- Partridge R
- Parzibut G
- Pasaniuc B
- Pasaniuc B
- Pascual-Iglesias A
- Pasko D
- Pasko D
- Pasko D
- Passmore H
- Patel A
- Patel B
- Patel B
- Patel BV
- Patel K
- Patel M
- Patel S
- Patel T
- Paterson T
- Pathak GA
- Pathak GA
- Pathak GA
- Pathan N
- Pattaro C
- Pattaro C
- Pattison N
- Pattison N
- Paul P
- Paulus F
- Pavlovic M
- Paxton WA
- Pazos MDLM
- Pearson H
- Pearson NM
- Pearson S
- Peasgood E
- Peasgood E
- Peculis R
- Peloso G
- Pelusi S
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- Pendergrass S
- Pendlebury J
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- Perumal S
- Peschuck A
- Pesenti A
- Pessina G
- Pestana D
- Pesukova J
- Peter W
- Peters C
- Peters E
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- Peters MJ
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- Petitjean L
- Petrocelli P
- Petrocelli P
- Petty LE
- Peyrassol X
- Peyvandi F
- Pezzoli G
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- Pink I
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- Pogreban T
- Pogson D
- Polgar O
- Polgarova P
- Polikowsky HG
- Polimanti R
- Pollakis G
- Pollard R
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- Ponting CP
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- Poole A
- Pooni JS
- Popescu M
- Popov I
- Porteous DJ
- Portopena L
- Poscente M
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- Post F
- Posthuma D
- Pothecary C
- Pothecary C
- Potla D
- Potoczna D
- Potts K
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- Poultney U
- Povysil G
- Prady H
- Prager K
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- Pratley A
- Preatoni P
- Preckel B
- Prendergast C
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- Preston S
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- Priest J
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- Prijatelj V
- Prime Z
- Prince T
- Prins JM
- Pristopan V
- Pritchard K
- Prokic I
- Protti A
- Protzer U
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- Regina J
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- Ringmets I
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- Rojo R
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- Saito F
- Saito F
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- Salberg A
- Salciute E
- Saleem M
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- Sales D
- Salib I
- Salmi S
- Salmon K
- Salpietro V
- Saluja T
- Salutous D
- Saluzzio RP
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- Sander LE
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- Seed C
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- Seilmaier MJ
- Sekikawa Y
- Sell C
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- Semple G
- Semple MG
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- Senaratne D
- Sengupta S
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- Shah A
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- Shankar-Hari M
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- Shankar-Hari M
- Shanmuga P
- Shanmugasundaram P
- Sharma A
- Shastri AJ
- Shaw CA
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- Shelton JF
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- Shen X
- Shepardson S
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- Shibata Y
- Shibusawa T
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- Shih B
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- Shuey MM
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- Slawson N
- Slevin K
- Sloan B
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- Sloofman L
- Sloofman LG
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- Smedley C
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- Smith AV
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- Smoller JW
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- Spinner CD
- Spittle N
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- Springle P
- Squeo GM
- Sri-Chandana C
- Srikaran S
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- Stacey A
- Staderoli A
- Staines N
- Staines N
- Stambach T
- Stammers K
- Starkopf J
- Stead R
- Stefansson K
- Stella A
- Stenhouse A
- Stephens D
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- Stetsenko I
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- Stewart R
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- Stijnis CS
- Stilma W
- Stoddard E
- Stone S
- Stones E
- Stowe B
- Strachan D
- Striano P
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- Stuckey A
- Suardi C
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- Subramaniam KS
- Subramanian D
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- Subudhi P
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- Sugiura H
- Suh N
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- Sun YV
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- Sutherland I
- Sutherland S-B
- Suttels V
- Sutton S
- Suwalski P
- Suzuki K
- Suzuki S
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- Sveinbjornsson G
- Swain A
- Swann OV
- Sweeney L
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- Tada MT
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- Tahmasebi F
- Takada M
- Takagi H
- Takahashi K
- Takahashi K
- Takahashi K
- Takahashi M
- Takahashi M
- Takahashi T
- Takaku Y
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- Takeda Y
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- Tamm A
- Tanaka A
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- Taneski F
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- Tanigawa Y
- Tanigawa Y
- Tanino Y
- Taniyama D
- Tanudjaja F
- Tariq A
- Task HGC
- Tateishi T
- Tateno H
- Tatham K
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- Tavares S
- Tavecchia L
- Taylor A
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- Team AC
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- Tedder RS
- Teles A
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- Templeton M
- Tench H
- Tenesa A
- Tentorio P
- Terai H
- Terranova L
- Terron Arcos V
- Tetla D
- Teumer A
- Teunissen C
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- Thanasi M
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- Thibeault C
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- Thirumaran M
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- Thompson AAR
- Thompson C
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- Thomson N
- Thonon R
- Thoral P
- Thornton D
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- Thorpe C
- Thorsteinsdottir U
- Thrasyvoulou L
- Thrush J
- Thwaites RS
- Thwaites V
- Thwaites V
- Thys M
- Tibke C
- Tierney C
- Tilbey S
- Tilney E
- Timens W
- Timlick E
- Ting L
- Tiseo G
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- Tita R
- Tivenan H
- Toapanta D
- Todd A
- Togashi Y
- Tohda S
- Tokunaga K
- Tolson M
- Tomas AL
- Tommasi A
- Tomono K
- Tonby K
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- Torrents D
- Tran F
- Trankiem A
- Trankiem A
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- Trembath RC
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- Tridente A
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- Trivedi B
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- Trochu E
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- Tsao P
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- Tselios C
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- Tsonas A
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- Turki S
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- Turney S
- Turtle LCW
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- Tutton R
- Twagira M
- Twiss S
- Tyl D
- Tyler A
- Uchimura Y
- Uddin MJ
- Uddin MM
- Ueda S
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- Uellendahl-Werth F
- Uffelmann E
- Umeda A
- Underwood SJ
- Urrechaga E
- Ustianowski A
- Ustinova M
- Utrilla A
- Utsugi M
- Uwamino Y
- Vadgama N
- Vadla MS
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- Valente S
- Valenti L
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- Valentine J
- Valentino F
- Valino K
- Vallerga C
- Vallotton N
- Valsecchi MG
- van Agtmael M
- van Baarle F
- van Blokland I
- van de Beek D
- van den Berge M
- van der Poll T
- van der Valk M
- van Heel D
- van Heel DA
- van Heel DA
- van Koutrik L
- van Mourik N
- Van Singer M
- van Tonder L
- van Uffelen KWJ
- van Vugt M
- Vandernoot I
- Varghese M
- Vari MS
- Varnai R
- Vecchia M
- Vedage D
- Veelo D
- Veerapen K
- Veerapen K
- Veerapen K
- Vehreschild MJGT
- Velho M
- Venkatesh H
- Venturelli S
- Verdugo RA
- Vergori A
- Verlander M
- Verma A
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- Vertue M
- Vertue M
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- Viala B
- Vigurs C
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- Vincenti A
- Viollet RM
- Visuvanathan S
- Vitart V
- Vizcaychipi MP
- Vlaar APJ
- Vochin A
- Voide C
- Voide C
- Volland S
- Vollenweider P
- Vollenweider P
- Von Frenckell C
- von Hohenstaufen K
- von Mering C
- Vonk JM
- Voza A
- Vulesevic B
- Vuylsteke A
- Vuylsteke A
- Wacker EM
- Wackett T
- Wadams B
- Waddington N
- Waddy S
- Wagstaff V
- Waite AAC
- Wakabayashi A
- Wakahara K
- Wake R
- Wakefield P
- Wakinshaw F
- Walden A
- Waldron J
- Walker D
- Walker R
- Walker S
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- Walker S
- Wall A
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- Wang Q
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- Ward G
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- Washington NL
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- Watanabe K
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- Watson G
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- Waugh V
- Weaver J
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- Whiteley S
- Whiteside J
- Whittaker P
- Whittington A
- Whittle H
- Whitton C
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- Wicks SJ
- Wienbrandt L
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- Williams M
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- Woodford C
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- Wooton DG
- Working UCLAHATLASDM
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- Wulandari R
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yadav A
- Yagi K
- Yamada M
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- Yamagata K
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- Yang Z
- Yaspan B
- Yasui Y
- Yates B
- Yates B
- Yatomi M
- Ye C
- Yengo L
- Yermakovich D
- Yi X
- Yonekawa A
- Yoon H
- Yoon KJ
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Youlton N
- Younes SE
- Young P
- Yun N
- Zak A
- Zaki A
- Zambon M
- Zamikula J
- Zanella A
- Zanella I
- Zanelli G
- Zara F
- Zara F
- Zarate R
- Zarate R
- Zborowski AC
- Zeberg H
- Zechner M
- Zechner M
- Zguro K
- Zhai R
- Zhang JE
- Zhang M
- Zhao JH
- Zhen J
- Zheng C
- Zheng T
- Zhou W
- Zhou W
- Zhu W
- Zitter L
- Zlatopolsky M
- Zoller H
- Zollner S
- Zongo O
- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease