The effect of hypothalamic deafferentation on somatostatin-like activity in the rat brain

Somatostatin-like activity (SLA) was determined by radioimmunoassay in several brain regions of animals which had either undergone complete deafferentation of the medial basal hypothalamus or a sham-operation. Surgical isolation of the medial basal hypothalamus caused this region to lose most of its SLA, but did not affect activity elsewhere. Similarly, partial (frontal) deafferentation of the medial basal hypothalamus resulted in a substantial decrease in SLA there

Somatostatin analogs which inhibit glucagon and growth hormone more than insulin release

Three analogs of somatostatin, [ D -Cys 14] -, [Ala 2, D -Cys 14] - and [ D -Trp 8, D -Cys 14] - somatostatin, were synthesized by the solid phase method, characterized by several means, and tested for their effects on the release of insulin, glucagon, and growth hormone. The peptides sharply suppressed the release of growth hormone in vitro and glucagon in vivo , but had less effect on insulin secretion in vivo . These analogs, particularly [ D -Trp 8, D -Cys 14] - somatostatin, could possibly be useful for the treatment of diabetes mellitus