970 research outputs found
Herpes zoster, its epidemicity, and association with chicken pox
Hutchinson many years ago, while raising
the question as to whether Herpes Zoster should be
classified as a neurosis or an exanthem, is reported
to have said, "My own suspicion is that i t belongs to
neither of these classes, and further, I feel convinced
that whoever may succeed in unravelling the
mystery which at present surrounds it , must at the
same time make a discovery in Physiology**The clinical observations that certain cases of
Herpes Zoster are infectious and occur in small
epidemics; that the disease may be associated with
Chicken Pox; and that its etiology and mode of
infection are entirely unknown, add further great
interest to this particular malady. These facts
amongst others led me to decide to investigate this
much discussed and in many respects obscure disease.SCOPE OF THESIS.
(1 ) I decided to investigate the
records of all the cases of Herpes Zoster, 270 in
number, which have been seen in the Dermatological
Department of the Royal Infirmary Edinburgh, during
the last sixteen years, that is for the years 1907 to
1922 inclusive, with a view to gaining critical information
as to Etiology, Predisposing causes, Distributional
characteristics, Age and Seasonal incidence,
and Epidemicity of Herpes Zoster.
(2 ) I have decided to lay special stress on the
Epidemicity of Herpes Zoster.
(3) I will discuss at some length the division
of Herpes Zoster into Idiopathic and Symptomatic, such
a differentiation being of the greatest importance in
connection with the association of certain cases of
Herpes Zoster with Chicken Pox.
(4) Much attention has lately been given to the
association of Herpes Zoster and Chicken Pox, and
realising Herpes Zoster to be infectious and capable
not only of infecting another person with Herpes Zoste
but also with Chicken Pox, I decided to investigate
the recorded cases in the literature of this association
of the two diseases, and also to consult the
articles dealing with this subject, in order to make
a critical digest of the literature, with a view to
drawing some conclusions on this matter. Further, to
show from clinical manifestations the association of
the Idiopathic variety of Herpes Zoster with Chicken
Pox. I t would perhaps be as well to make mention of
the fact here, that such an investigation would necessarily
be curtailed because:- (1) Although the Dermatological
Department of the Royal Infirmary probably
records more cases of Herpes Zoster than any other
institution in Edinburgh, it does not drain a ll the
cases of the Town, many going to other Medical wards,
Leith and other hospitals, and many being seen by
general practitioners only. Further the disease not
being notifiable all the cases cannot be recorded, so
that an absolute and true record of the Epidemicity
of Herpes Zoster as representing the whole town cannot
be given. However the Royal Infirmary consistently
and regularly draws a certain class and part of the
community, so that from the records of this special
department we can draw a conclusion which is constant,
accurate, and which will also give us a very near idea
as regards the characteristics of this disease for the
whole community of Edinburgh. (2) Chicken Pox not
being notifiable we cannot give statistics showing
that an epidemic of Herpes Zoster occurs at the same
time as an epidemic of Chicken Pox, but we can however
clinically show the close association of the two
diseases, as w ill be described later
Lead contamination in raptors in Europe: a systematic review and meta-analysis
Lead contamination is a widely recognised conservation problem for raptors worldwide. There are a number of studies in individual raptor species but those data have not been systematically evaluated to understand raptor-wide lead exposure and effects at a pan-European scale. To critically assess the extent of this problem, we performed a systematic review compiling all published data on lead in raptors (1983–2019) and, through a meta-analysis, determined if there was evidence for differences in exposure across feeding traits, geographical regions, between hunting and non-hunting periods, and changes over time. We also reviewed the impact of lead on raptors and the likely main source of exposure. We examined 114 studies that were unevenly distributed in terms of time of publication and the countries in which studies were performed. Peer-reviewed articles reported data for 39 raptor species but very few species were widely monitored across Europe. Obligate (vultures) and facultative scavengers (golden eagle, common buzzard and white-tailed sea eagle) accumulated the highest lead concentrations in tissues and generally were the species most at risk of lead poisoning. We found no evidence of a spatial or decadal trend in lead residues, but we demonstrated that high lead blood levels relate to hunting season. Exposure at levels associated with both subclinical and lethal effects is common and lead from rifle bullets and shot is often the likely source of exposure. Overall, our review illustrates the high incidence and ubiquity of lead contamination in raptors in Europe. However, we did not find studies that related exposure to quantitative impacts on European raptor populations nor detailed studies on the impact of mitigation measures. Such information is urgently needed and requires a more harmonised approach to quantifying lead contamination and effects in raptors across Europe
A probabilistic approach to emission-line galaxy classification
We invoke a Gaussian mixture model (GMM) to jointly analyse two traditional
emission-line classification schemes of galaxy ionization sources: the
Baldwin-Phillips-Terlevich (BPT) and vs. [NII]/H
(WHAN) diagrams, using spectroscopic data from the Sloan Digital Sky Survey
Data Release 7 and SEAGal/STARLIGHT datasets. We apply a GMM to empirically
define classes of galaxies in a three-dimensional space spanned by the
[OIII]/H, [NII]/H, and EW(H), optical
parameters. The best-fit GMM based on several statistical criteria suggests a
solution around four Gaussian components (GCs), which are capable to explain up
to 97 per cent of the data variance. Using elements of information theory, we
compare each GC to their respective astronomical counterpart. GC1 and GC4 are
associated with star-forming galaxies, suggesting the need to define a new
starburst subgroup. GC2 is associated with BPT's Active Galaxy Nuclei (AGN)
class and WHAN's weak AGN class. GC3 is associated with BPT's composite class
and WHAN's strong AGN class. Conversely, there is no statistical evidence --
based on four GCs -- for the existence of a Seyfert/LINER dichotomy in our
sample. Notwithstanding, the inclusion of an additional GC5 unravels it. The
GC5 appears associated to the LINER and Passive galaxies on the BPT and WHAN
diagrams respectively. Subtleties aside, we demonstrate the potential of our
methodology to recover/unravel different objects inside the wilderness of
astronomical datasets, without lacking the ability to convey physically
interpretable results. The probabilistic classifications from the GMM analysis
are publicly available within the COINtoolbox
(https://cointoolbox.github.io/GMM\_Catalogue/).Comment: Accepted for publication in MNRA
Towards harmonisation of chemical monitoring using avian apex predators: identification of key species for pan-European biomonitoring
Biomonitoring in raptors can be used to study long-term and large-scale changes in environmental pollution. In Europe, such monitoring is needed to assess environmental risks and outcomes of chemicals regulation, which is harmonised across the European Union. To be effective, the most appropriate sentinels need to be monitored. Our aim was to identify which European raptor species are the likely most appropriate biomonitors when pollutant quantification is based on analysing tissues. Our current study was restricted to terrestrial exposure pathways and considered four priority pollutant groups: toxic metals (lead and mercury), anticoagulant rodenticides, pesticides and medicinal products. We evaluated information on the distribution and key ecological traits (food web, foraging trait, diet, preferred habitat, and migratory behaviour) of European raptors to identify the most appropriate sentinel species. Common buzzard (Buteo buteo) and/or tawny owl (Strix aluco) proved the most suitable candidates for many of the pollutants considered. Moreover, they are abundant in Europe, enhancing the likelihood that samples can be collected. However, other species may be better sentinels for certain pollutants, such as the golden eagle (Aquila chrysaetos) for lead, the northern goshawk (Accipiter gentilis) for mercury across areas including Northern Europe, and vultures (where they occur in Europe) are likely best suited for monitoring non-steroidal anti-inflammatory drugs (NSAIDs). Overall, however, we argue the selection of candidate species for widescale monitoring of a range of pollutants can be reduced to very few raptor species. We recommend that the common buzzard and tawny owl should be the initial focus of any pan-European raptor monitoring. The lack of previous widespread monitoring using these species suggests that their utility as sentinels for environmnetal pollution has not been widely recognised. Finally, although the current study focussed on Europe, our trait-based approach for identifying raptor biomonitors can be applied to other continents and contaminants
Functional consequences of seven novel mutations in the CYP11B1 Gene: four mutations associated with nonclassic and three mutations causing classic 11 -Hydroxylase Deficiency
Context: Steroid 11β-hydroxylase (CYP11B1) deficiency (11OHD) is the second most common form of congenital adrenal hyperplasia (CAH). Cases of nonclassic 11OHD are rare compared with the incidence of nonclassic 21-hydroxylase deficiency.
Objective: The aim of the study was to analyze the functional consequences of seven novel CYP11B1 mutations (p.M88I, p.W116G, p.P159L, p.A165D, p.K254_A259del, p.R366C, p.T401A) found in three patients with classic 11OHD, two patients with nonclassic 11OHD, and three heterozygous carriers for CYP11B1 mutations.
Methods: We conducted functional studies employing a COS7 cell in vitro expression system comparing wild-type (WT) and mutant CYP11B1 activity. Mutants were examined in a computational three-dimensional model of the CYP11B1 protein.
Results: All mutations (p.W116G, p.A165D, p.K254_A259del) found in patients with classic 11OHD have absent or very little 11β-hydroxylase activity relative to WT. The mutations detected in patients with nonclassic 11OHD showed partial functional impairment, with one patient being homozygous (p.P159L; 25% of WT) and the other patient compound heterozygous for a novel mild p.M88I (40% of WT) and the known severe p.R383Q mutation. The two mutations detected in heterozygous carriers (p.R366C, p.T401A) also reduced CYP11B1 activity by 23 to 37%, respectively.
Conclusion: Functional analysis results allow for the classification of novel CYP11B1 mutations as causative for classic and nonclassic 11OHD, respectively. Four partially inactivating mutations are predicted to result in nonclassic 11OHD. These findings double the number of mild CYP11B1 mutations previously described as associated with mild 11OHD. Our data are important to predict phenotypic expression and provide important information for clinical and genetic counseling i
DIAGNOSIS OF ENDOCRINE DISEASE: Steroid Hormone Analysis in Diagnosis and Treatment of DSD Position Paper of EU COST Action BM 1303 "DSDnet".
Disorders or differences in sex development (DSD) comprise a heterogeneous group of conditions with an atypical sex development. For optimal diagnosis highly specialized laboratory analyses are required across European countries. Working group 3 of EU COST (European Cooperation in Science and Technology) Action BM 1303 "DSDnet" "Harmonisation of Laboratory Assessment" has developed recommendations on laboratory assessment for DSD regarding the use of technologies and analytes to be investigated. This position paper on steroid hormone analysis in diagnosis and treatment of DSD was compiled by a group of specialists in DSD and/or hormonal analysis, either from participating European Countries or international partner countries. The topics discussed comprised analytical methods (immunoassay/mass spectrometry based methods), matrices (urine/serum/saliva) and harmonisation of laboratory tests. The following positions were agreed upon: Support of the appropriate use of immunoassay and mass spectrometry based methods for diagnosis and monitoring of DSD. Serum/plasma and urine are established matrices for analysis. Laboratories performing analyses for DSD need to operate within a quality framework and actively engage in harmonisation processes so that results and their interpretation are the same irrespective of the laboratory they are performed in. Participation in activities of peer comparison such as sample exchange or when available subscribing to a relevant external quality assurance program should be achieved. The ultimate aim of the guidelines is the implementation of clinical standards for diagnosis and appropriate treatment of DSD to achieve the best outcome for patients, no matter where patients are investigated or managed
Neutrino propagation in a random magnetic field
The active-sterile neutrino conversion probability is calculated for neutrino
propagating in a medium in the presence of random magnetic field fluctuations.
Necessary condition for the probability to be positive definite is obtained.
Using this necessary condition we put constraint on the neutrino magnetic
moment from active-sterile electron neutrino conversion in the early universe
hot plasma and in supernova.Comment: 11 page
Kinematic parameters and membership probabilities of open clusters in the Bordeaux PM2000 catalogue
We derive lists of proper-motions and kinematic membership probabilities for
49 open clusters and possible open clusters in the zone of the Bordeaux PM2000
proper motion catalogue (). We test
different parametrisations of the proper motion and position distribution
functions and select the most successful one. In the light of those results, we
analyse some objects individually. The segregation between cluster and field
member stars, and the assignment of membership probabilities, is accomplished
by applying a new and fully automated method based on both parametrisations of
the proper motion and position distribution functions, and genetic algorithm
optimization heuristics associated with a derivative-based hill climbing
algorithm for the likelihood optimization. We present a catalogue comprising
kinematic parameters and associated membership probability lists for 49 open
clusters and possible open clusters in the Bordeaux PM2000 catalogue region. We
note that this is the first determination of proper motions for five open
clusters. We confirm the non-existence of two kinematic populations in the
region of 15 previously suspected non-existent objects.Comment: 14 pages, 6 figures, 4 tables. Accepted for publication in Astronomy
& Astrophysic
Identification and Analysis of a New Hepadnavirus in White Storks
AbstractWe identified, cloned, and functionally characterized a new avian hepadnavirus infecting storks (STHBV). STHBV has the largest DNA genome of all avian hepadnaviruses and, based on sequence and phylogenetic analysis, is most closely related to, but distinct from, heron hepatitis B virus (HHBV). Unique for STHBV among the other avian hepadnaviruses is a potential HNF1 binding site in the preS promoter. In common only with HHBV, STHBV has a myristylation signal on the S and not the preS protein, two C terminally located glycosylation sites on the precore/core proteins and lacks the phosphorylation site essential for the transcriptional transactivation activity of duck-HBV preS protein. The cloned STHBV genomes were competent in gene expression, replication, and viral particle secretion. STHBV infected primary duck hepatocytes very inefficiently suggesting a restricted host range, similar to other hepadnaviruses. This discovery of stork infections unravels novel evolutionary aspects of hepadnaviruses and provides new opportunities for hepadnavirus research
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