9 research outputs found

    Discovery of <i>Tirasemtiv</i>, the First Direct Fast Skeletal Muscle Troponin Activator

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    The identification and optimization of the first activators of fast skeletal muscle are reported. Compound <b>1</b> was identified from high-throughput screening (HTS) and subsequently found to improve muscle function via interaction with the troponin complex. Optimization of <b>1</b> for potency, metabolic stability, and physical properties led to the discovery of tirasemtiv (<b>25</b>), which has been extensively characterized in clinical trials for the treatment of amyotrophic lateral sclerosis

    Old and new variables, old and new optical concepts in high-energy hadron-hadron interactions

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    Novel Antithrombotic Strategies

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    Section C. Dairy Chemistry and Physics: Part I. Chemistry and Physical Chemistry

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