Why do some intermediate polars show soft X-ray emission? A survey of XMM-Newton spectra

We make a systematic analysis of the XMM-Newton X-ray spectra of intermediate polars (IPs) and find that, contrary to the traditional picture, most show a soft blackbody component. We compare the results with those from AM Her stars and deduce that the blackbody emission arises from reprocessing of hard X-rays, rather than from the blobby accretion sometimes seen in AM Hers. Whether an IP shows a blackbody component appears to depend primarily on geometric factors: a blackbody is not seen in those that have accretion footprints that are always obscured by accretion curtains or are only visible when foreshortened on the white-dwarf limb. Thus we argue against previous suggestions that the blackbody emission characterises a separate sub-group of IPs which are more akin to AM Hers, and develop a unified picture of the blackbody emission in these stars.Comment: 9 pages, 6 figures. Accepted for publication in Ap

Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques

Background: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors. However, such models do not predict involvement of P2Y(12) in the clinically relevant situation of thrombosis upon rupture of atherosclerotic plaques. We investigated the role of P2Y(12) in thrombus formation on (collagen-containing) atherosclerotic plaques in vitro and in vivo, by using a novel mouse model of atherothrombosis. Methodology: Plaques in the carotid arteries from Apoe(-/-) mice were acutely ruptured by ultrasound treatment, and the thrombotic process was monitored via intravital fluorescence microscopy. Thrombus formation in vitro was assessed in mouse and human blood perfused over collagen or plaque material under variable conditions of shear rate and coagulation. Effects of two reversible P2Y(12) blockers, ticagrelor (AZD6140) and cangrelor (AR-C69931MX), were investigated. Principal Findings: Acute plaque rupture by ultrasound treatment provoked rapid formation of non-occlusive thrombi, which were smaller in size and unstable in the presence of P2Y(12) blockers. In vitro, when mouse or human blood was perfused over collagen or atherosclerotic plaque material, blockage or deficiency of P2Y(12) reduced the thrombi and increased embolization events. These P2Y(12) effects were present at shear rates >500 s(-1), and they persisted in the presence of coagulation. P2Y(12)-dependent thrombus stabilization was accompanied by increased fibrin(ogen) binding. Conclusions/Significance: Platelet P2Y(12) receptors play a crucial role in the stabilization of thrombi formed on atherosclerotic plaques. This P2Y(12) function is restricted to high shear flow conditions, and is preserved in the presence of coagulation

The role of long-term mechanical circulatory support in patients with advanced heart failure

In patients with end-stage heart failure, advanced therapies such as heart transplantation and long-term mechanical circulatory support (MCS) with a left ventricular assist device (LVAD) have to be considered. LVADs can be implanted as a bridge to transplantation or as an alternative to heart transplantation: destination therapy. In the Netherlands, long-term LVAD therapy is gaining importance as a result of increased prevalence of heart failure together with a low number of heart transplantations due to shortage of donor hearts. As a result, the difference between bridge to transplantation and destination therapy is becoming more artificial since, at present, most patients initially implanted as bridge to transplantation end up receiving extended LVAD therapy. Following LVAD implantation, survival after 1, 2 and 3 years is 83%, 76% and 70%, respectively. Quality of life improves substantially despite important adverse events such as device-related infection, stroke, major bleeding and right heart failure. Early referral of potential candidates for long-term MCS is of utmost importance and positively influences outcome. In this review, an overview of the indications, contraindications, patient selection, clinical outcome and optimal time of referral for long-term MCS is given

XMM-Newton observations of three short period polars: V347 Pav, GG Leo and EU UMa

We present phase-resolved XMM_Newton data of three short period polars: V347 Pav, GG Leo and EU UMa. All three systems show one dominant accretion region which is seen for approximately half of the orbital cycle. GG Leo shows a strong dip feature in its X-ray and UV light curves which is due to absorption of X-rays from the accretion site by the accretion stream. The emission in the case of EU UMa is dominated by soft X-rays: its soft/hard X-ray ratio is amongst the highest seen in these objects. In contrast, GG Leo and V347 Pav shows a ratio consistent with that predicted by the standard shock model. We infer the mass of the white dwarf and explore the affect of restricting the energy range on the derived parameters.Comment: accepted MNRA

FUSE and HST/STIS far-ultraviolet observations of AM Herculis in an extended low state

We have obtained FUSE and HST/STIS time-resolved spectroscopy of the polar AM Herculis during a deep low state. The spectra are entirely dominated by the emission of the white dwarf. Both the far-ultraviolet (FUV) flux as well as the spectral shape vary substantially over the orbital period, with maximum flux occurring at the same phase as during the high state. The variations are due to the presence of a hot spot on the white dwarf, which we model quantitatively. The white dwarf parameters can be determined from a spectral fit to the faint phase data, when the hot spot is self-eclipsed. Adopting the distance of 79+8-6pc determined by Thorstensen, we find an effective temperature of 19800+-700K and a mass of Mwd=0.78+0.12-0.17Msun. The hot spot has a lower temperature than during the high state, ~34000-40000K, but covers a similar area, ~10% of the white dwarf surface. Low state FUSE and STIS spectra taken during four different epochs in 2002/3 show no variation of the FUV flux level or spectral shape, implying that the white dwarf temperature and the hot spot temperature, size, and location do not depend on the amount of time the system has spent in the low state. Possible explanations are ongoing accretion at a low level, or deep heating, both alternatives have some weaknesses that we discuss. No photospheric metal absorption lines are detected in the FUSE and STIS spectra, suggesting that the average metal abundances in the white dwarf atmosphere are lower than 1e-3 times their solar values.Comment: ApJ in press, 12 pages, 11 figure

A Solar Prominence Model

We propose a model for solar prominences based on converging flow observed in the chromosphere and photosphere. In contrast with existing models we do not apply a shearing motion along the neutral line. Instead we assume that bipolar loops approaching on different sides of the neutral line have a non-vanishing magnetic helicity of the SAME sign. In the converging flow the individual loops kink and develop a skew. For loops of the same helicity the skew is in the same sense. As a result the `chiral' symmetry of an aligned distribution of loops is broken and the reconnecting loop system forms a filament with the observed magnetic orientation and anchoring of the barbs in regions of parasytic polarity. The filament consists of a number of individual strands of coaxial coronal electric currents each of which is current neutralised. The filament material is suspended in dips in the magnetic field and the transverse field direction coincides with that in the Kuperus-Raadu model. Above the filament a cavity forms with an overlying arcade consisting of the outer portions of the reconnected loops.Comment: 17 pages, Late

Wavelet and R/S analysis of the X-ray flickering of cataclysmic variables

Recently, wavelets and R/S analysis have been used as statistical tools to characterize the optical flickering of cataclysmic variables. Here we present the first comprehensive study of the statistical properties of X-ray flickering of cataclysmic variables in order to link them with physical parameters. We analyzed a sample of 97 X-ray light curves of 75 objects of all classes observed with the XMM-Newton space telescope. By using the wavelets analysis, each light curve has been characterized by two parameters, alpha and Sigma, that describe the energy distribution of flickering on different timescales and the strength at a given timescale, respectively. We also used the R/S analysis to determine the Hurst exponent of each light curve and define their degree of stochastic memory in time. The X-ray flickering is typically composed of long time scale events (1.5 < alpha < 3), with very similar strengths in all the subtypes of cataclysmic variables (-3 < Sigma < -1.5). The X-ray data are distributed in a much smaller area of the alpha-Sigma parameter space with respect to those obtained with optical light curves. The tendency of the optical flickering in magnetic systems to show higher Sigma values than the non-magnetic systems is not encountered in the X-rays. The Hurst exponents estimated for all light curves of the sample are larger than those found in the visible, with a peak at 0.82. In particular, we do not obtain values lower than 0.5. The X-ray flickering presents a persistent memory in time, which seems to be stronger in objects containing magnetic white dwarf primaries. The similarity of the X-ray flickering in objects of different classes together with the predominance of a persistent stochastic behavior can be explained it terms of magnetically-driven accretion processes acting in a considerable fraction of the analyzed objects.Comment: 10 pages, 3 figures, 2 tables. Language revision. Accepted for publication in A&

New Low Accretion-Rate Magnetic Binary Systems and their Significance for the Evolution of Cataclysmic Variables

Discoveries of two new white dwarf plus M star binaries with striking optical cyclotron emission features from the Sloan Digital Sky Survey (SDSS) brings to six the total number of X-ray faint, magnetic accretion binaries that accrete at rates < 10^{-13} Msun/yr, or <1% of the values normally encountered in cataclysmic variables. This fact, coupled with donor stars that underfill their Roche lobes and very cool white dwarfs, brand the binaries as post common-envelope systems whose orbits have not yet decayed to the point of Roche-lobe contact. They are pre-magnetic CVs, or pre-Polars. The systems exhibit spin/orbit synchronism and apparently accrete by efficient capture of the stellar wind from the secondary star, a process that has been dubbed a ``magnetic siphon''. Because of this, period evolution of the binaries will occur solely by gravitational radiation, which is very slow for periods >3 hr. Optical surveys for the cyclotron harmonics appear to be the only means of discovery, so the space density of pre-Polars could rival that of Polars, and the binaries provide an important channel of progenitors (in addition to the asynchronous Intermediate Polars). Both physical and SDSS observational selection effects are identified that may help to explain the clumping of all six systems in a narrow range of magnetic field strength around 60 MG.Comment: 25 pages, 13 figures, Accepted to Ap

Modelling pathogen load dynamics to elucidate mechanistic determinants of host-Plasmodium falciparum interactions

During infection, increasing pathogen load stimulates both protective and harmful aspects of the host response. The dynamics of this interaction are hard to quantify in humans, but doing so could improve understanding of mechanisms of disease and protection. We sought to model the contributions of parasite multiplication rate and host response to observed parasite load in individual subjects with Plasmodium falciparum malaria, using only data obtained at the time of clinical presentation, and then to identify their mechanistic correlates. We predicted higher parasite multiplication rates and lower host responsiveness in severe malaria cases, with severe anemia being more insidious than cerebral malaria. We predicted that parasite growth-inhibition was associated with platelet consumption, lower expression of CXCL10 and type-1 interferon-associated genes, but increased cathepsin G and matrix metallopeptidase 9 expression. We found that cathepsin G and matrix metallopeptidase 9 directly inhibit parasite invasion into erythrocytes. Parasite multiplication rate was associated with host iron availability and higher complement factor H levels, lower expression of gametocyte-associated genes but higher expression of translation-associated genes in the parasite. Our findings demonstrate the potential of using explicit modelling of pathogen load dynamics to deepen understanding of host-pathogen interactions and identify mechanistic correlates of protection

Prospects for joint radio telescope and gravitational wave searches for astrophysical transients

The radio skies remain mostly unobserved when it comes to transient phenomena. The direct detection of gravitational waves will mark a major milestone of modern astronomy, as an entirely new window will open on the universe. Two apparently independent phenomena can be brought together in a coincident effort that has the potential to boost both searches. In this paper we will outline the scientific case that stands behind these future joint observations and will describe the methods that might be used to conduct the searches and analyze the data. The targeted sources are binary systems of compact objects, known to be strong candidate sources for gravitational waves. Detection of transients coincident in these two channels would be a significant smoking gun for first direct detection of gravitational waves, and would open up a new field for characterization of astrophysical transients involving massive compact objects.Comment: 12 pages, Amaldi 8 Conference (New York, 2009) proceedings pape