Cittadini senza diritti: abitare e lavorare a Milano da clandestini

Lo scopo di questo rapporto è di presentare le principali caratteristiche socio-demografiche dell’utenza Naga (Associazione Volontaria di Assistenza SocioSanitaria e per i Diritti di Stranieri e Nomadi Onlus), che costituisce una delle più grandi banche dati sull’immigrazione irregolare. A tal fine analizzeremo i dati contenuti nelle cartelle mediche del Naga per i pazienti che sono stati registrati tra il gennaio 2000 e il dicembre 2006, soffermandoci sulla loro nazionalità, genere, situazione familiare, anzianità migratoria, livello di istruzione, condizione lavorativa e situazione abitativa. Dall’analisi emerge un quadro delle caratteristiche e delle condizioni dei migranti privi di permesso di soggiorno del tutto diverso da quello spesso proposto nel dibattito politico e mediatico italiano. Gli immigrati irregolari sono giovani giunti di recente in Italia, ma hanno livelli di istruzione e tassi di occupazione che eguagliano – se non addirittura superano – quelli della popolazione residente in Italia. Le loro condizioni socioabitative, invece, sono assolutamente critiche e lontanissime dagli standard italiani

A conceptual model for the prediction of sexual intercourses in permanent couples

The problem of the frequency of sexual intercourses in permanent couples is investigated for the first time with a purely conceptual model. The model, based on a few axioms involving very simple notions like sexual appetite and erotic potential, is composed of two ordinary differential equations which are exactly the same than those proposed almost one century ago in epidemiology. The model can be used to discuss the possibility of estimating strategic parameters from real data, as well as to criticize the rule of "the beans in the yar" proposed in 1970 by David Martin in The Journal of Sex Research

Understanding the Role of Immigrants’ Legal Status: Evidence from Policy Experiments

This is a pre-copyedited, author-produced version of an article accepted for publication in CESifo Economic Studies following peer review. The version of record Fasani, F. (2015). "Understanding the Role of Immigrants’ Legal Status: Evidence from Policy Experiments." CESifo Economic Studies 61(3-4): 722-763. is available online at: https://doi.org/10.1093/cesifo/ifv00

On The Economics and Politics of Refugee Migration

This paper provides a comprehensive analysis of refugee migration, with emphasis on the current refugee crisis. After first reviewing the institutional framework laid out by the Geneva Convention for Refugees, we demonstrate that, despite numerous attempts at developing a common European asylum policy, EU countries continue to differ widely in interpretation and implementation. We then describe key features of the current refugee crisis and document the overall magnitudes and types of refugee movements, illegal border crossings and asylum applications to EU Member States. We next study the labour market integration of past refugee migrants to EU countries and draw conclusions for the current situation. Finally, we turn to the economics of refugee migrations, contrasting economic and refugee migrants, discussing the trade-offs between long-term asylum and temporary protection and highlighting the benefits of well-coordinated national asylum policies. We conclude with several policy recommendations

Climate and land-use change during the late Holocene at Lake Ledro (southern Alps, Italy)

International audienceThis paper investigates the relative influences of climatic and anthropogenic factors in explaining environmental and societal changes in the southern Alps, Italy. We investigate a deep sediment core (LL081) from Lake Ledro (652 m a.s.l.). Environmental changes are reconstructed through multiproxy analysis, that is, pollen-based vegetation and climate reconstruction, magnetic susceptibility (MS), lake level, and flood frequency, and the paper focuses on the climate and land-use changes which occurred during the late Holocene. For this time interval, Lake Ledro records high mean water table, increasing amount of pollen-based precipitation, and more erosive conditions. Therefore, while a more humid late Holocene in the southern Alps has the potential to reinforce the forest presence, pollen evidence suggests that anthropogenic activities changed the impact of this regional scenario. Land-use activity (forest clearance for pastoralism, farming, and arboriculture) opened up the large vegetated slopes in the catchment of Lake Ledro, which in turn magnified the erosion related to the change in the precipitation pattern. The record of an almost continuous human occupation for the last 4100 cal. BP is divided into several land-use phases. On the one hand, forest redevelopments on abandoned or less cultivated areas appear to be climatically induced as they occurred in relation with well-known events such as the 2.8-kyr cold event and the ‘Little Ice Age’. On the other hand, climatically independent changes in land use or habitat modes are observed, such as the late-Bronze-Age lake-dwellings abandonment, the human population migration at c. 1600 cal. BP, and the period of the Black Death and famines at 600 cal. BP

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HER2-Enriched Subtype and ERBB2 Expression in HER2-Positive Breast Cancer Treated with Dual HER2 Blockade

Background: Identification of HER2-positive breast cancers with high anti-HER2 sensitivity could help de-escalate chemotherapy. Here, we tested a clinically applicable RNA-based assay that combines ERBB2 and the HER2-enriched (HER2-E) intrinsic subtype in HER2-positive disease treated with dual HER2-blockade without chemotherapy. Methods: A research-based PAM50 assay was applied in 422 HER2-positive tumors from five II-III clinical trials (SOLTI-PAMELA, TBCRC023, TBCRC006, PER-ELISA, EGF104090). In SOLTI-PAMELA, TBCRC023, TBCRC006, and PER-ELISA, all patients had early disease and were treated with neoadjuvant lapatinib or pertuzumab plus trastuzumab for 12-24 weeks. Primary outcome was pathological complete response (pCR). In EGF104900, 296 women with advanced disease were randomized to receive either lapatinib alone or lapatinib plus trastuzumab. Progression-free survival (PFS), overall response rate (ORR), and overall survival (OS) were evaluated. Results: A total of 305 patients with early and 117 patients with advanced HER2-positive disease were analyzed. In early disease, HER2-E represented 83.8% and 44.7% of ERBB2-high and ERBB2-low tumors, respectively. Following lapatinib and trastuzumab, the HER2-E and ERBB2 (HER2-E/ERBB2)-high group showed a higher pCR rate compared to the rest (44.5%, 95% confidence interval [CI] = 35.4% to 53.9% vs 11.6%, 95% CI = 6.9% to 18.0%; adjusted odds ratio [OR] = 6.05, 95% CI = 3.10 to 11.80, P <. 001). Similar findings were observed with neoadjuvant trastuzumab and pertuzumab (pCR rate of 66.7% in HER2-E/ERBB2-high, 95% CI = 22.3% to 95.7% vs 14.7% in others, 95% CI = 4.9% to 31.1%; adjusted OR = 11.60, 95% CI = 1.66 to 81.10, P =. 01). In the advanced setting, the HER2-E/ERBB2-high group was independently associated with longer PFS (hazard ratio [HR] = 0.52, 95% CI = 0.35 to 0.79, P <. 001); higher ORR (16.3%, 95% CI = 8.9% to 26.2% vs 3.7%, 95% CI = 0.8% to 10.3%, P =. 02); and longer OS (HR = 0.66, 95% CI = 0.44 to 0.97, P =. 01). Conclusions: Combining HER2-E subtype and ERBB2 mRNA into a single assay identifies tumors with high responsiveness to HER2-targeted therapy. This biomarker could help de-escalate chemotherapy in approximately 40% of patients with HER2-positive breast cancer

Living-floors and Structures from the Lower Palaeolithic to the Bronze Age in Italy

Summary report of the research carried out on the Living floors of the Palaeolithic to Neolithic periods in many prehistoric sites of northern Ital