92 research outputs found
Endpoint Estimates for N-dimensional Hardy Operators and Their Commutators
In this paper, it is proved that the higher dimensional Hardy operator is
bounded from Hardy space to Lebesgue space. The endpoint estimate for the
commutator generated by Hardy operator and (central) BMO function is also
discussed.Comment: 8 page
Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer
Background: Citizen science, scientific research conducted by non-specialists, has the potential to facilitate biomedical research using available large-scale data, however validating the results is challenging. The Cell Slider is a citizen science project that intends to share images from tumors with the general public, enabling them to score tumor markers independently through an internet-based interface.
Methods: From October 2012 to June 2014, 98,293 Citizen Scientists accessed the Cell Slider web page and scored 180,172 sub-images derived from images of 12,326 tissue microarray cores labeled for estrogen receptor (ER). We evaluated the accuracy of Citizen Scientist's ER classification, and the association between ER status and prognosis by comparing their test performance against trained pathologists.
Findings: The area under ROC curve was 0.95 (95% CI 0.94 to 0.96) for cancer cell identification and 0.97 (95% CI 0.96 to 0.97) for ER status. ER positive tumors scored by Citizen Scientists were associated with survival in a similar way to that scored by trained pathologists. Survival probability at 15 years were 0.78 (95% CI 0.76 to 0.80) for ER-positive and 0.72 (95% CI 0.68 to 0.77) for ER-negative tumors based on Citizen Scientists classification. Based on pathologist classification, survival probability was 0.79 (95% CI 0.77 to 0.81) for ER-positive and 0.71 (95% CI 0.67 to 0.74) for ER-negative tumors. The hazard ratio for death was 0.26 (95% CI 0.18 to 0.37) at diagnosis and became greater than one after 6.5 years of follow-up for ER scored by Citizen Scientists, and 0.24 (95% CI 0.18 to 0.33) at diagnosis increasing thereafter to one after 6.7 (95% CI 4.1 to 10.9) years of follow-up for ER scored by pathologists.
Interpretation: Crowdsourcing of the general public to classify cancer pathology data for research is viable, engages the public and provides accurate ER data. Crowdsourced classification of research data may offer a valid solution to problems of throughput requiring human input
Differential body composition effects of protease inhibitors recommended for initial treatment of HIV infection: A randomized clinical trial
This article has been accepted for publication in Clinical Infectious Diseases ©2014 The Authors .Published by Oxford University Press on Clinical Infectious Disease 60.5. DOI: 10.1093/cid/ciu898Background. It is unclear whether metabolic or body composition effects may differ between protease inhibitor-based regimens recommended for initial treatment of HIV infection.
Methods. ATADAR is a phase IV, open-label, multicenter randomized clinical trial. Stable antiretroviral-naive HIV-infected adults were randomly assigned to atazanavir/ritonavir 300/100 mg or darunavir/ritonavir 800/100 mg in combination with tenofovir/emtricitabine daily. Pre-defined end-points were treatment or virological failure, drug discontinuation due to adverse effects, and laboratory and body composition changes at 96 weeks.
Results. At 96 weeks, 56 (62%) atazanavir/ritonavir and 62 (71%) darunavir/ritonavir patients remained free of treatment failure (estimated difference 8.2%; 95%CI -0.6 to 21.6); and 71 (79%) atazanavir/ritonavir and 75 (85%) darunavir/ritonavir patients remained free of virological failure (estimated difference 6.3%; 95%CI -0.5 to 17.6). Seven vs. five patients discontinued atazanavir/ritonavir or darunavir/ritonavir due to adverse effects. Total and HDL cholesterol similarly increased in both arms, but triglycerides increased more in atazanavir/ritonavir arm. At 96 weeks, body fat (estimated difference 2862.2 gr; 95%CI 726.7 to 4997.7; P=0.0090), limb fat (estimated difference 1403.3 gr; 95%CI 388.4 to 2418.2; P=0.0071), and subcutaneous abdominal adipose tissue (estimated difference 28.4 cm2; 95%CI 1.9 to 55.0; P=0.0362) increased more in atazanavir/ritonavir than in darunavir/ritonavir arm. Body fat changes in atazanavir/ritonavir arm were associated with higher insulin resistance.
Conclusions. We found no major differences between atazanavir/ritonavir and darunavir/ritonavir in efficacy, clinically-relevant side effects, or plasma cholesterol fractions. However, atazanavir/ritonavir led to higher triglycerides and total and subcutaneous fat than darunavir/ritonavir and fat gains with atazanavir/ritonavir were associated with insulin resistanceThis is an Investigator Sponsored Research study. It was supported in part by research grants
from Bristol‐Myers Squibb and Janssen‐Cilag; Instituto de Salud Carlos III (PI12/01217) and Red
Temática Cooperativa de Investigación en SIDA G03/173 (RIS‐EST11), Ministerio de Ciencia e
Innovación, Spain. (Registration number: NCT01274780; registry name: ATADAR; EUDRACT; 2010‐021002‐38)
Gaia Focused Product Release: A catalogue of sources around quasars to search for strongly lensed quasars
Context. Strongly lensed quasars are fundamental sources for cosmology. The
Gaia space mission covers the entire sky with the unprecedented resolution of
" in the optical, making it an ideal instrument to search for
gravitational lenses down to the limiting magnitude of 21. Nevertheless, the
previous Gaia Data Releases are known to be incomplete for small angular
separations such as those expected for most lenses. Aims. We present the Data
Processing and Analysis Consortium GravLens pipeline, which was built to
analyse all Gaia detections around quasars and to cluster them into sources,
thus producing a catalogue of secondary sources around each quasar. We analysed
the resulting catalogue to produce scores that indicate source configurations
that are compatible with strongly lensed quasars. Methods. GravLens uses the
DBSCAN unsupervised clustering algorithm to detect sources around quasars. The
resulting catalogue of multiplets is then analysed with several methods to
identify potential gravitational lenses. We developed and applied an outlier
scoring method, a comparison between the average BP and RP spectra of the
components, and we also used an extremely randomised tree algorithm. These
methods produce scores to identify the most probable configurations and to
establish a list of lens candidates. Results. We analysed the environment of 3
760 032 quasars. A total of 4 760 920 sources, including the quasars, were
found within 6" of the quasar positions. This list is given in the Gaia
archive. In 87\% of cases, the quasar remains a single source, and in 501 385
cases neighbouring sources were detected. We propose a list of 381 lensed
candidates, of which we identified 49 as the most promising. Beyond these
candidates, the associate tables in this Focused Product Release allow the
entire community to explore the unique Gaia data for strong lensing studies
further.Comment: 35 pages, 60 figures, accepted for publication by Astronomy and
Astrophysic
Gaia Focused Product Release: Radial velocity time series of long-period variables
The third Gaia Data Release (DR3) provided photometric time series of more
than 2 million long-period variable (LPV) candidates. Anticipating the
publication of full radial-velocity (RV) in DR4, this Focused Product Release
(FPR) provides RV time series for a selection of LPVs with high-quality
observations. We describe the production and content of the Gaia catalog of LPV
RV time series, and the methods used to compute variability parameters
published in the Gaia FPR. Starting from the DR3 LPVs catalog, we applied
filters to construct a sample of sources with high-quality RV measurements. We
modeled their RV and photometric time series to derive their periods and
amplitudes, and further refined the sample by requiring compatibility between
the RV period and at least one of the , , or
photometric periods. The catalog includes RV time series and variability
parameters for 9\,614 sources in the magnitude range , including a flagged top-quality subsample of 6\,093 stars
whose RV periods are fully compatible with the values derived from the ,
, and photometric time series. The RV time series
contain a mean of 24 measurements per source taken unevenly over a duration of
about three years. We identify the great most sources (88%) as genuine LPVs,
with about half of them showing a pulsation period and the other half
displaying a long secondary period. The remaining 12% consists of candidate
ellipsoidal binaries. Quality checks against RVs available in the literature
show excellent agreement. We provide illustrative examples and cautionary
remarks. The publication of RV time series for almost 10\,000 LPVs constitutes,
by far, the largest such database available to date in the literature. The
availability of simultaneous photometric measurements gives a unique added
value to the Gaia catalog (abridged)Comment: 36 pages, 38 figure
Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy
Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA
Update on the safety of second generation antipsychotics in youths: a call for collaboration among paediatricians and child psychiatrists
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