Three-dimensional writing inside silicon using a 2-µm picosecond fiber laser

International audienc

Reduction in benefits of total flux expansion on divertor detachment due to parallel flows

The Super-X divertor (SXD) is an alternative divertor configuration leveraging total flux expansion at the outer strike point (OSP). Key features for the attractiveness of the SXD are facilitated detachment access and control, as predicted by the extended 2-point model (2PM). However, parallel flows are not consistently included in the 2PM. In this work, the 2PM is refined to overcome this limitation: the role of total flux expansion on the pressure balance is made explicit, by including the effect of parallel flows. In consequence, the effect of total flux expansion on detachment access and control is weakened, compared to predictions of the 2PM. This new model partially explains discrepancies between the 2PM and experiments performed on TCV, in ohmic L-mode scenarios, where in core density ramps in lower single-null (SN) configuration, the impact of the OSP major radius Rt on the CIII emission front movement in the divertor outer leg - used as a proxy for the plasma temperature - is substantially weaker than 2PM predictions; and in OSP sweeps in lower and upper SN configurations, with a constant core density, the peak parallel particle flux density at the OSP is almost independent of Rt, while the 2PM predicts a linear dependence. Finally, analytical and numerical modelling of parallel flows in the divertor is presented, to support the argument. It is shown that an increase in total flux expansion can favour supersonic flows at the OSP. Parallel flows are also shown to be relevant by analysing SOLPS-ITER simulations of TCV

Comparison of high density and nitrogen seeded detachment using SOLPS-ITER simulations of the tokamak á configuration variable

First of a kind SOLPS-ITER simulations on tokamak á configuration variable (TCV) that include nitrogen have been performed to model recent nitrogen seeded detachment experiments. Based on spectroscopic measurements, a nitrogen recycling coefficient RNp ≈ 0.3–0.5 on the graphite walls of TCV is estimated. The experimentally observed decrease of core nitrogen density with increasing plasma density is reproduced and linked to a reduction of the ionisation mean free path in the scrape-off layer. Although the influence of sputtered carbon impurities from TCV’s graphite wall cannot be fully eliminated, seeding nitrogen increases control over the total impurity density. This facilitates disentangling the effect of impurities from that of high upstream density on the main characteristics of detachment, namely target power and ion current reductions and the development of a parallel pressure drop. Increasing the density and the seeding rate reduce the power on the divertor targets in a different way: with density, the ion current increases and the target temperature strongly decreases, whereas seeding impurities decreases the ion current and affects less strongly the temperature. The reduction in ion current when seeding nitrogen is due to a lower ionisation source, which is not related to power limitation nor an increased momentum loss, but to a decrease of the ionisation reaction rate. Impurity seeding leads to less volumetric momentum losses (and hence pressure drop) than density ramps, for the same level of energy flux reduction. Additionally, main chamber sputtering of carbon is identified as a possible explanation for the missing target ion current roll-over during density ramps in the simulations

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

The tetraspanins CD9 and CD82 suppress Wnt signaling by promoting the discharge of β-catenin from cells

Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1

An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes

Pediatric Measles Vaccine Expressing a Dengue Antigen Induces Durable Serotype-specific Neutralizing Antibodies to Dengue Virus

Dengue disease is an increasing global health problem that threatens one-third of the world's population. Despite decades of efforts, no licensed vaccine against dengue is available. With the aim to develop an affordable vaccine that could be used in young populations living in tropical areas, we evaluated a new strategy based on the expression of a minimal dengue antigen by a vector derived from pediatric live-attenuated Schwarz measles vaccine (MV). As a proof-of-concept, we inserted into the MV vector a sequence encoding a minimal combined dengue antigen composed of the envelope domain III (EDIII) fused to the ectodomain of the membrane protein (ectoM) from DV serotype-1. Immunization of mice susceptible to MV resulted in a long-term production of DV1 serotype-specific neutralizing antibodies. The presence of ectoM was critical to the immunogenicity of inserted EDIII. The adjuvant capacity of ectoM correlated with its ability to promote the maturation of dendritic cells and the secretion of proinflammatory and antiviral cytokines and chemokines involved in adaptive immunity. The protective efficacy of this vaccine should be studied in non-human primates. A combined measles–dengue vaccine might provide a one-shot approach to immunize children against both diseases where they co-exist

The importance of Portuguese Continental Shelf Waters to Balearic Shearwaters revealed by aerial census

The Balearic shearwater Puffinus mauretanicus is one of the most threatened seabirds in the world. To evaluate the abundance and distribution of Balearic Shearwaters in Portuguese Continental Shelf Waters, during the post-breeding period when migrating birds are outside the Mediterranean Sea, we conducted 5 aerial surveys between 2010 and 2014 (21 survey days covering 62,716 km2). Following a line transect method, observers recorded a total of 181 Balearic Shearwaters sightings. Using Distance sampling software, we estimated an overall species abundance (2010–2014) of 10,182, ranging between 2338 in 2010 and 23,221 individuals in 2012. During the 2012 post-breeding period, the Portuguese Continental Shelf Waters were used by up to 96.8% of the latest migratory population assessment. Considering Balearic Shearwater estimates per sampling block, there was a preference for the North and Center sectors of the Portuguese coast (respectively, 7058 and 1366 individuals) where several SPAs were already designated. We computed the annual and overall habitat predictive models for Balearic Shearwaters using a maximum entropy algorithm on MaxEnt software. In all models, the Balearic shearwater distribution was best predicted by mean chlorophyll concentration. Balearic Shearwaters are mostly present in shallow shelf and coastal waters particularly in the widest portions of the continental shelf. These areas are strongly influenced by upwelling, which concurs with the chlorophyll concentration being the most important predicting variable. Portuguese Continental Shelf Waters are one of the most important post-breeding grounds to the Balearic ShearwaterPortuguese Wildlife Society and projects SafeSea EEA-Grants, FAME (Proj. 2009-1/089) and European Commission’s Life Programme (MarPro NAT/PT/00038). This study was also partly supported by the Portuguese Foundation for Science and Technology (FCT) with Grants SFRH/ BD/30240/2006 to M. Ferreira and SFRH/BD/32841/2006 to P. C. Rodrigues. C. Eira is supported by FCT through CESAM UID/AMB/50017/2013 co-funded by FCT/MEC and FEDER, within PT2020 and Compete 2020 and S. Monteiro is financed by a Grant (BPD/0043/AMB/50017) from UID/AMB/50017/2013. This work was also partially supported by the strategic programme UID/BIA/04050/2013 (POCI-01-0145-FEDER-007569) funded by FCT and by ERDF (COMPETE2020). The authors thank observers and airplane pilots who contributed to this workinfo:eu-repo/semantics/publishedVersio