Knowledge-based patient screening for rare and emerging infectious/parasitic diseases: a case study of brucellosis and murine typhus.

Many infectious and parasitic diseases, especially those newly emerging or reemerging, present a difficult diagnostic challenge because of their obscurity and low incidence. Important clues that could lead to an initial diagnosis are often overlooked, misinterpreted, not linked to a disease, or disregarded. We constructed a computer-based decision support system containing 223 infectious and parasitic diseases and used it to conduct a historical intervention study based on field investigation records of 200 cases of human brucellosis and 96 cases of murine typhus that occurred in Texas from 1980 through 1989. Knowledge-based screening showed that the average number of days from the initial patient visit to the time of correct diagnosis was significantly reduced (brucellosis-from 17.9 to 4.5 days, p = 0.0001, murine typhus-from 11.5 to 8.6 days, p = 0.001). This study demonstrates the potential value of knowledge-based patient screening for rare infectious and parasitic diseases

Inelastic Coulomb scattering rates due to acoustic and optical plasmon modes in coupled quantum wires

We report a theoretical study on the inelastic Coulomb scattering rate of an injected electron in two coupled quantum wires in quasi-one-dimensional doped semiconductors. Two peaks appear in the scattering spectrum due to the optical and the acoustic plasmon scattering in the system. We find that the scattering rate due to the optical plasmon mode is similar to that in a single wire but the acoustic plasmon scattering depends crucially on its dispersion relation at small $q$. Furthermore, the effects of tunneling between the two wires are studied on the inelastic Coulomb scattering rate. We show that a weak tunneling can strongly affect the acoustic plasmon scattering.Comment: 6 Postscript figure

Quantification of serotonin and eight of its metabolites in plasma of healthy volunteers by mass spectrometry.

Serotonin is transformed into melatonin under the control of the light/dark cycle, representing a cornerstone of circadian rhythmicity. Serotonin also undergoes extensive metabolism to produce 5-hydroxyindoleacetic acid (5-HIAA), a biomarker for the diagnosis and monitoring of serotonin secreting neuroendocrine tumors (NETs). While serotonin, melatonin and their metabolites are part of an integrated comprehensive system, human observations about their respective plasma concentrations are still limited. We report here for the first time a multiplex UHPLC-MS/MS assay for the quantification of serotonin, 5-HIAA, 5-hydroxytryptophol (5-HTPL), N-acetyl-serotonin (NAS), Mel, 6-OH-Mel, 5-methoxytryptamine (5-MT), 5-methoxytryptophol (5-MTPL), and 5-methoxyindoleacetic acid (5-MIAA) in human plasma. Analytes were extracted by protein precipitation and solid phase extraction. Plasma concentrations for these analytes were determined in 102 healthy volunteers. The LLOQ of the assay ranges from 2.2 nM for serotonin to 1.0 pM for 6-OH-Mel. This sensitivity enables the quantification of circulating serotonin, 5-HIAA, NAS, Mel, and 5-MIAA, even at their lowest diurnal concentrations. This assay will enable specific, precise and accurate measurement of serotonin, Mel and their metabolites to draw a detailed picture of this complex pineal metabolism, allowing a dynamic understanding of these pathways and providing promising biomarkers and a metabolic signature for serotonin-secreting NETs

Constraining the source regions of lunar meteorites using orbital geochemical data

Lunar meteorites provide important new samples of the Moon remote from regions visited by the Apollo and Luna sample return missions. Petrologic and geochemical analysis of these meteorites, combined with orbital remote-sensing measurements have enabled additional discoveries about the composition and age of the lunar surface on a global scale. However, the interpretation of these samples is limited by the fact that we do not know the source region of any individual lunar meteorite. Here we investigate the link between meteorite and source region on the Moon using the Lunar Prospector Gamma Ray Spectrometer remote sensing dataset for the elements Fe, Ti and Th. The approach has been validated using Apollo and Luna bulk regolith samples and we have applied it to 48 meteorites excluding paired stones. Our approach is able broadly to differentiate the best compositional matches as potential regions of origin for the various classes of lunar meteorites. Basaltic and intermediate-Fe regolith breccia meteorites are found to have the best constrained potential launch sites, with some impact breccias and pristine mare basalts also having reasonably well defined potential source regions. Launch areas for highland feldspathic meteorites are much less well constrained and the addition of another element, such as Mg, will probably be required to identify potential source regions for these

Lake-size dependency of wind shear and convection as controls on gas exchange

High-frequency physical observations from 40 temperate lakes were used to examine the relative contributions of wind shear (u*) and convection (w*) to turbulence in the surface mixed layer. Seasonal patterns of u* and w* were dissimilar; u* was often highest in the spring, while w * increased throughout the summer to a maximum in early fall. Convection was a larger mixed-layer turbulence source than wind shear (u */w*-1 for lakes* and w* differ in temporal pattern and magnitude across lakes, both convection and wind shear should be considered in future formulations of lake-air gas exchange, especially for small lakes. © 2012 by the American Geophysical Union.Jordan S. Read, David P. Hamilton, Ankur R. Desai, Kevin C. Rose, Sally MacIntyre, John D. Lenters, Robyn L. Smyth, Paul C. Hanson, Jonathan J. Cole, Peter A. Staehr, James A. Rusak, Donald C. Pierson, Justin D. Brookes, Alo Laas, and Chin H. W

High-Frequency (> 100 GHz) Electronic Devices

Contains reports on five research projects and a list of publications.MIT Lincoln LaboratoryNational Aeronautics and Space Administration Grant NAG2-693National Science Foundation Grant ECS 91-09330Defense Advanced Research Projects Agency Contract MDA972-90-C-0021U.S. Army - Research Office Grant DAAL03-92-G-025

High-Frequency (> 100 GHz) Electronic Devices

Contains reports on four research projects, the research facility and a list of publications.Defense Advanced Research Projects Agency Contract MDA972-90-C-0021National Aeronautics and Space Administration Grant NAG2-693National Science Foundation Grant ECS 91-0933

Geosciences Roadmap for Research Infrastructures 2025–2028 by the Swiss Geosciences Community

This community roadmap presents an integrative approach including the most urgent infrastructure requests for the future development of geosciences in Switzerland. It recommends to strengthen the multidisciplinary nature of the geosciences by putting all activities under the roof of the Integrated Swiss Geosciences supported by four specific research infrastructure pillars. The roadmap represents the view of the Swiss scientific community in the field of geosciences and is a formal element of the process to elaborate the Swiss Roadmap for Research Infrastructures 2023. This bottom-up contribution to the identification and selection of important national and international research infrastructures has been coordinated by the Swiss Academy of Sciences (SCNAT) on a mandate by the State Secretariat for Education, Research and Innovation (SERI).ISSN:2297-1564ISSN:2297-157

Partitioning of crystalline and amorphous phases during freezing of simulated Enceladus ocean fluids

This work was supported by The Leverhulme Trust (grant number RPG‐2016‐153).Saturn's ice‐covered moon Enceladus may contain the requisite conditions for life. Its potentially habitable subsurface ocean is vented into space as large cryovolcanic plumes that can be sampled by spacecraft, acting as a window to the ocean below. However, little is known about how Enceladus’ ocean fluids evolve as they freeze. Using cryo‐imaging techniques, we investigated solid phases produced by freezing simulated Enceladean ocean fluids at endmember cooling rates. Our results show that under flash‐freezing conditions (>10 K s−1), Enceladus‐relevant fluids undergo segregation, whereby the precipitation of ice templates the formation of brine vein networks. The high solute concentrations and confined nature of these brine veins means that salt crystallization is kinetically inhibited and glass formation (vitrification) can occur at lower cooling rates than typically required for vitrification of a bulk solution. Crystalline salts also form if flash‐frozen fluids are re‐warmed. The 10 µm‐scale distribution of salt phases produced by this mechanism differs markedly from that of gradually cooled (∼1 K min−1) fluids, showing that they inherit a textural signature of their formation conditions. The mineralogy of cryogenic carbonates can be used as a probe for cooling rate and parent fluid pH. Our findings reveal possible endmember routes for solid phase production from Enceladus’ ocean fluids and mechanisms for generating compositional heterogeneity within ice particles on a sub‐10 µm scale. This has implications for understanding how Enceladus' ocean constituents are incorporated into icy particles and delivered to space.Publisher PDFPeer reviewe

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE