14 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aarsland Dag
- Abdelnour Carla
- ADGC .
- Ahmad Shahzad
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Céline
- Below Jennifer E
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C
- Bizarro Alessandra
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J
- Brusco Luis Ignacio
- Bråthen Geir
- Buiza-Rueda Dolores
- Bullido María J
- Burholt Vanessa
- Bush William S
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B
- Carracedo Ángel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- CHARGE .
- Chen Hung-Hsin
- Chene Geneviève
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen AHR
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Cuccaro Michael L
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D
- Debette Stéphanie
- Deckert Jürgen
- DEGESCO .
- Del Ser Teodoro
- Deleuze Jean-François
- Demgene .
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- EADB .
- EADI .
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M
- Fabrizio Tagliavini
- Fardo David W
- Farotti Lucia
- Farrer Lindsay A
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B
- Ferri Evelyn
- Fin Bertrand
- FinnGen .
- Fischer Peter
- Fladby Tormod
- Fließbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- García-Alberca Jose Maria
- García-González Pablo
- GERAD .
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M
- Goldhardt Oliver
- Gomez-Fonseca Duber
- González-Pérez Antonio
- GR@ACE .
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- Grünblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L
- Hamilton-Nelson Kara L
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T
- Hernández Isabel
- Herrmann Martin J
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual Sánchez
- Jun Gyungah R
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H
- Kuksa Pavel P
- Kukull Walter A
- Kunkle Brian W
- Kuulasmaa Teemu
- Kuzma Amanda B
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleó Alberto
- Longstreth William
- Lopez Oscar
- Love Seth
- Luckcuck Lauren
- Lunetta Kathryn L
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martin Eden R
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montes Angel Martín
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Børge G
- Nöthen Markus M
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande AL
- Pineda Juan A
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M
- Puerta Raquel
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M
- Reinders Marcel JT
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid B
- Sarnowski Chloé
- Satizabal Claudia L
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M
- Selbæk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey A
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje JL
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- Ståhlbom Anne Kinhult
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Tartan Juan Pablo
- Tesí Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M
- van der Lee Sven J
- van der Lugt Aad
- van Duijn Cornelia M
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N
- Verhey Frans
- Vidal Jean-Sébastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-Gómez A.
- Adarmes-Gómez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- Alarcón-Martín Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
- Amer-Ferrer G.
- Amin N.
- Amouyel Philippe
- Anastasiou A.
- Anastasiou C.
- Andrade V.
- Andreassen Ole A.
- Andreoni S.
- Antequera M.
- Antikainen R.
- Antonell A.
- Anttonen V.
- Antúnez C.
- Aparicio H.J.
- Apostolova L.G.
- Appollonio I.
- Arcaro M.
- Archetti S.
- Armstrong N.J.
- Arnold S.E.
- Arosio B.
- Arvas M.
- Assogna F.
- Asthana S.
- Athanasiu L.
- Atwood C.S.
- Auge F.
- Auranen A.
- Auvinen P.
- Awaisa G.
- Ayres G.
- Bacha J.I.
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- Bahrami S.
- Bailly H.
- Baldwin C.T.
- Banaj N.
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- Barral S.
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- Bass N.J.
- Bastiani P.
- Bayer A.
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- Becker J.T.
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- Zulaica M.
- Álvarez V.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
- Author
- Aarsland Dag
- Abdelnour C.
- Abdelnour Carla
- Adarmes-Gomez A.D.
- Alarcon-Martin Emilio
- Alcolea Daniel
- Alegret Montserrat
- Alvarez Ignacio
- Alvarez Victoria
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A.
- Antonell Anna
- Antunez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Belen Pastor Ana
- Bellenguez Celine
- Benaque Alba
- Benussi Alberto
- Benussi Luisa
- Bernal Sanchez-Arjona Maria
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C.
- Blennow Kaj
- Blesa Rafael
- Boada Merce
- Boerwinkle Eric
- Borroni Barbara
- Boschi Silvia
- Bossu Paola
- Buerger Katharina
- Buiza-Rueda Dolores
- Bullido Maria J.
- Caffarra Paolo
- Calero Miguel
- Carolina Dalmasso Maria
- Carracedo Angel
- Cecchetti Roberta
- Cervera-Carles Laura
- Charbonnier Camille
- Chene Genevieve
- Chillotti Caterina
- Ciccone Simona
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corbaton-Anchuelo Arturo
- Corma-Gomez Anais
- Dardiotis Efthimios
- de Mendonca Alexandre
- de Rojas Itziar
- Deckert Juergen
- Deckert Jurgen
- del Ser Teodoro
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Monica
- Djurovic Srdjan
- Duezel Emrah
- Dufouil Carole
- Duron Emmanuelle
- Duzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Esiri Margaret
- Espinosa Ana
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernandez-Fuertes Marta
- Ferreira Catarina B.
- Ferri Evelyn
- Fischer Peter
- Fliessbach Klaus
- Fornage Myriam
- Fortea Juan
- Fostinelli Silvia
- Franco-Macias Emilio
- Frank-Garcia Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Gelpi Ellen
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil Silvia
- Goldhardt Oliver
- Gonzalez-Perez Antonio
- Graff Caroline
- Grande Giulia
- Grenier-Boley Benjamin
- Grimmer Timo
- Gruenblatt Edna
- Grunblatt Edna
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haegg Sara
- Hagg Sara
- Haines Jonathan L.
- Hampel Harald
- Hanon Oliver
- Hartmann Annette M.
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernandez Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Huerto Vilas Raquel
- Huisman Martijn
- Hulsman Marc
- Ikram M. Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- K\ufc\ue7\ufckali Fahri
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kehoe Patrick Gavin
- Kern Silke
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Kok Almar A.L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Lage Carmen
- Lambert Jean-Charles
- Lebouvier Thibaud
- Lehtisalo Jenni
- Lemstra Afina W.
- Lerch Ondrej
- Lleo Alberto
- Loewenmark Malin
- Lopez de Munain Adolfo
- Lowenmark Malin
- Macias Juan
- Macleod C.
- Maier Wolfgang
- Mangialasche Francesca
- Maria Garcia-Alberca Jose
- Marquie Marta
- Marshall Rachel
- Martin Montes Angel
- Martinez Rodriguez Carmen
- Masullo Carlo
- Mather Karen A.
- Mayeux Richard
- Mead Simon
- Medina Miguel
- Meggy Alun
- Mendoza Silvia
- Menendez-Gonzalez Manuel
- Mir Pablo
- Molina-Porcel Laura
- Montrreal Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Munoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gael
- Noethen Markus M.
- Nordestgaard Borge G.
- Nothen Markus M.
- Orellana Adelina
- Ortega Gemma
- Padovani Alessandro
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Pau
- Pedersen Nancy L.
- Perez-Cordon Alba
- Perez-Tur Jordi
- Pericak-Vance Margaret A.
- Peters Oliver
- Pijnenburg Yolande A. L.
- Pineda Juan A.
- Pinol-Ripoll Gerard
- Pisanu Claudia
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Quenez Olivier
- Quintela Ines
- Rabano Alberto
- Rainero Innocenzo
- Ramirez Alfredo
- Real Luis M.
- Reynolds Chandra A.
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca Maitee
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustin
- Rujescu Dan
- Saez Maria Eugenia
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Angela
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sanchez-Valle Raquel
- Sando Sigrid Botne
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Seidu Nazib M.
- Selbaek Geir
- Seripa Davide
- Serrano-Rios Manuel
- Seshadri Sudha
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Smith A. David
- Soininen Hilkka
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stahlbom Anne Kinhult
- Stringa Najada
- Tagliavini Fabrizio
- Tankard Rick M.
- Tarraga Lluis
- Teresa Martinez-Larrad Maria
- Tesi Niccolo
- Thomassen Jesper Qvist
- Tremolizzo Lucio
- Tsolaki Magda
- Tybjaerg-Hansen Anne
- Tybjorg-Hansen Anne
- Ullgren Abbe
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje M.
- van der Lee Sven J.
- Van Dongen Jasper
- van Duijn Cornelia M.
- van Schoor Natasja M.
- Vandenberghe Rik
- Vidal Jean-Sebastien
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zulaica Miren
- Publication venue
- Nat Commun
- Publication date
- 01/01/2021
- Field of study
Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-Gómez A.D.
- Adarmes-Gómez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez Céline
- Bellenguez Céline
- Bellenguez Céline
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada Mercè
- Boada Mercè
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- Bråthen Geir
- Bråthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido María J.
- Bullido María J.
- Burguera J.A.
- Burholt Vanessa
- BÛrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ángel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- Carrión-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene Geneviève
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clarimon Jordi
- Clarimon Jordi
- Clarimón J.
- Clark Christopher
- Clarke Robert
- Collinge John
- Collinge John
- Conti Elisa
- Corbatón-Anchuelo A.
- Cores Valeria
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
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- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
- Dartigues Jean-François
- David Smith A.
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- Davies Chloe
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Pancorbo M.M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso María
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
- Dufouil Carole
- Dufouil Carole
- During Emmanuel
- Duron Emmanuelle
- Düzel Emrah
- Düzel Emrah
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Escott-Price Valentina
- Escott-Price Valentina
- Escuela R.
- Escuela R.
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Eugenia Sáez María
- Ewers Michael
- Fabrizio Tagliavini
- Fallgaard Nielsen Sune
- Farotti Lucia
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
- Fievet Nathalie
- Fin Bertrand
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- Fladby Tormod
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- Foo Jia Nee
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- Forsell Charlotte
- Fortea J.
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- Fox Nick
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- García-Alberca José María
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- García-González Pablo
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- Germani Sandra
- Gerrish Amy
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- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
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- Giegling Ina
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- Gill Michael
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- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
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- González-Péerez A.
- González-Pérez Antonio
- Graff Caroline
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- Grande Giulia
- Green Emma
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- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
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- Grimmer Timo
- Grünblatt Edna
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- Gu Wei
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart M.
- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
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- Gómez-Garre P.
- Gómez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
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- Hanon Olivier
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- Hardy John
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- Harwood Janet
- Hausner Lucrezia
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- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
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- Heun Reinhard
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- Hodges Angela
- Hoffmann Per
- Hoffmann Per
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- Hort Jakub
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- Hulsman Marc
- Hüll Michael
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- Ignacio Brusco Luis
- Ikeuchi Takeshi
- Ingelsson Martin
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- Kinhult Ståhlbom Anne
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- Kleineidam Luca
- Klopp Norman
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- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
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- Kosmidis Mary H.
- Kuulasmaa Teemu
- Kuulasmaa Teemu
- Kölsch Heike
- Küçükali Fahri
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- Laatikainen Tiina
- Labrador Espinosa M.A.
- Labrador Ma
- Lacidogna Giordano
- Lacour ndré
- Laczo Jan
- Lafuente A.
- Lafuente Asunción
- Lage C.
- Lage Carmen
- Lage Carmen
- Lambert Jean-Charles
- Lambert Jean-Charles
- Lambert Jean-Charles
- Laske Christoph
- Laukka Erika J
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- Le Guen Yann
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- Lehtisalo Jenni
- Lerch Ondrej
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- Lim Shen-Yang
- Lin Juei-Jueng
- Lin Ling
- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- Lleó Alberto
- Lleóo A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
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- Lynch Aoibhinn
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- Thomas Charlene
- Thomas Tegos
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- Thonberg Håkan
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- Traykov Latchezar
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- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
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- Waern Margda
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- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
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- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Ungew�hnliche Hofmann-Eliminierung bei niederer Temperatur. Die Reaktion von 3-Hydroxymethylpyrrolidinen mitp-Toluolsulfonylchlorid (Kurze Mitt.)
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
- Author
- Aarsland Dag
- Abdelnour C.
- Abdelnour Carla
- Adarmes-Gomez A.D.
- Alarcon-Martin Emilio
- Alcolea Daniel
- Alegret Montserrat
- Alvarez Ignacio
- Alvarez Victoria
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A.
- Antonell Anna
- Antunez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Belen Pastor Ana
- Bellenguez Celine
- Benaque Alba
- Benussi Alberto
- Benussi Luisa
- Bernal Sanchez-Arjona Maria
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C.
- Blennow Kaj
- Blesa Rafael
- Boada Merce
- Boerwinkle Eric
- Borroni Barbara
- Boschi Silvia
- Bossu Paola
- Buerger Katharina
- Buiza-Rueda Dolores
- Bullido Maria J.
- Caffarra Paolo
- Calero Miguel
- Carolina Dalmasso Maria
- Carracedo Angel
- Cecchetti Roberta
- Cervera-Carles Laura
- Charbonnier Camille
- Chene Genevieve
- Chillotti Caterina
- Ciccone Simona
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corbaton-Anchuelo Arturo
- Corma-Gomez Anais
- Dardiotis Efthimios
- de Mendonca Alexandre
- de Rojas Itziar
- Deckert Juergen
- Deckert Jurgen
- del Ser Teodoro
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Monica
- Djurovic Srdjan
- Duezel Emrah
- Dufouil Carole
- Duron Emmanuelle
- Duzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Esiri Margaret
- Espinosa Ana
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernandez-Fuertes Marta
- Ferreira Catarina B.
- Ferri Evelyn
- Fischer Peter
- Fliessbach Klaus
- Fornage Myriam
- Fortea Juan
- Fostinelli Silvia
- Franco-Macias Emilio
- Frank-Garcia Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Gelpi Ellen
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil Silvia
- Goldhardt Oliver
- Gonzalez-Perez Antonio
- Graff Caroline
- Grande Giulia
- Grenier-Boley Benjamin
- Grimmer Timo
- Gruenblatt Edna
- Grunblatt Edna
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haegg Sara
- Hagg Sara
- Haines Jonathan L.
- Hampel Harald
- Hanon Oliver
- Hartmann Annette M.
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernandez Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Huerto Vilas Raquel
- Huisman Martijn
- Hulsman Marc
- Ikram M. Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- K\ufc\ue7\ufckali Fahri
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kehoe Patrick Gavin
- Kern Silke
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Kok Almar A.L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Lage Carmen
- Lambert Jean-Charles
- Lebouvier Thibaud
- Lehtisalo Jenni
- Lemstra Afina W.
- Lerch Ondrej
- Lleo Alberto
- Loewenmark Malin
- Lopez de Munain Adolfo
- Lowenmark Malin
- Macias Juan
- Macleod C.
- Maier Wolfgang
- Mangialasche Francesca
- Maria Garcia-Alberca Jose
- Marquie Marta
- Marshall Rachel
- Martin Montes Angel
- Martinez Rodriguez Carmen
- Masullo Carlo
- Mather Karen A.
- Mayeux Richard
- Mead Simon
- Medina Miguel
- Meggy Alun
- Mendoza Silvia
- Menendez-Gonzalez Manuel
- Mir Pablo
- Molina-Porcel Laura
- Montrreal Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Munoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gael
- Noethen Markus M.
- Nordestgaard Borge G.
- Nothen Markus M.
- Orellana Adelina
- Ortega Gemma
- Padovani Alessandro
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Pau
- Pedersen Nancy L.
- Perez-Cordon Alba
- Perez-Tur Jordi
- Pericak-Vance Margaret A.
- Peters Oliver
- Pijnenburg Yolande A. L.
- Pineda Juan A.
- Pinol-Ripoll Gerard
- Pisanu Claudia
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Quenez Olivier
- Quintela Ines
- Rabano Alberto
- Rainero Innocenzo
- Ramirez Alfredo
- Real Luis M.
- Reynolds Chandra A.
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca Maitee
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustin
- Rujescu Dan
- Saez Maria Eugenia
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Angela
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sanchez-Valle Raquel
- Sando Sigrid Botne
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Seidu Nazib M.
- Selbaek Geir
- Seripa Davide
- Serrano-Rios Manuel
- Seshadri Sudha
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Smith A. David
- Soininen Hilkka
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stahlbom Anne Kinhult
- Stringa Najada
- Tagliavini Fabrizio
- Tankard Rick M.
- Tarraga Lluis
- Teresa Martinez-Larrad Maria
- Tesi Niccolo
- Thomassen Jesper Qvist
- Tremolizzo Lucio
- Tsolaki Magda
- Tybjaerg-Hansen Anne
- Tybjorg-Hansen Anne
- Ullgren Abbe
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje M.
- van der Lee Sven J.
- Van Dongen Jasper
- van Duijn Cornelia M.
- van Schoor Natasja M.
- Vandenberghe Rik
- Vidal Jean-Sebastien
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zulaica Miren
- Publication venue
- Publication date
- 01/01/2021
- Field of study
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aarsland Dag
- Abdelnour Carla
- Ahmad Shahzad
- Alarcon-Martin Emilio
- Alcolea Daniel
- Alegret Montserrat
- Alvarez Ignacio
- Alvarez Victoria
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A.
- Antunez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Celine
- Below Jennifer E.
- Benchek Penelope
- Benussi Luisa
- Bernal Sanchez-Arjona Maria
- Berr Claudine
- Besse Celine
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C.
- Bizarro Alessandra
- Blesa Rafael
- Boada Merce
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossu Paola
- Brathen Geir
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Brookes Keeley J.
- Buiza-Rueda Dolores
- Bullido Maria J.
- Burger Katharina
- Burholt Vanessa
- Bush William S.
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B.
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- Chen Hung-Hsin
- Chene Genevieve
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gomez Anais
- Costa Marcos R.
- Costantini Emanuele
- Cuccaro Michael L.
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-Francois
- De Deyn Peter Paul
- de Mendonca Alexandre
- De Rojas Itziar
- De Witte Lot D.
- Debette Stephanie
- Deckert Jurgen
- del Ser Teodoro
- Deleuze Jean-Francois
- Denning Nicola
- Destefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Monica
- Djurovic Srdjan
- Dufouil Carole
- Duron Emmanuelle
- Duzel Emrah
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Eugenia Saez Maria
- Ewers Michael
- Faber Kelley M.
- Fabrizio Tagliavini
- Fardo David W.
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernandez-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B.
- Ferri Evelyn
- Fin Bertrand
- Fischer Peter
- Fladby Tormod
- Fliessbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C.
- Franco-Macias Emlio
- Frank-Garcia Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M.
- Goldhardt Oliver
- Gomez-Fonseca Duber
- Gonzalez-Perez Antonio
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunblatt Edna
- Grunin Michelle
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernandez Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- Humphrey Jack
- Ignacio Brusco Luis
- Ikram M. Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Jun Gyungah R.
- K\ufc\ue7\ufckali Fahri
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G.
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuksa Pavel P.
- Kukull Walter A.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Kuzma Amanda B.
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J.
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleo Alberto
- Longstreth William
- Lopes Katia de Paiva
- Lopez de Munain Adolfo
- Lopez Oscar
- Love Seth
- Lowemark Malin
- Luckcuck Lauren
- Luis Royo Jose
- Lunetta Kathryn L.
- Ma Yiyi
- Macias Juan
- Macleod Catherine A.
- Maier Wolfgang
- Mangialasche Francesca
- Maria Garcia-Alberca Jose
- Marquie Marta
- Marshall Rachel
- Martin Montes Angel
- Martin Eden R.
- Martinez Rodriguez Carmen
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menendez-Gonzalez Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Borge G.
- Nothen Markus M.
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Pablo Tartan Juan
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Ana Belen
- Pastor Pau
- Peloso Gina
- Perez-Cordon Alba
- Perez-Tur Jordi
- Pericak-Vance Margaret A.
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande A. L.
- Pineda Juan A.
- Pinol-Ripoll Gerard
- Pisanu Laudia
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M.
- Puerta Raquel
- Quenez Olivier
- Quintela Ines
- Rabano Alberto
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M.
- Reinders Marcel J.T.
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca Maitee
- Rossi Giacomina
- Rossi Paolo Dionigi
- Rubino Elisa
- Ruiz Agustin
- Rujescu Dan
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanchez Juan Pascual
- Sanchez-Garcia Florentino
- Sanchez-Valle Raquel
- Sando Sigrid B.
- Sarnowski Chloe
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M.
- Selbaek Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey A.
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje J.L.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stahlbom Anne Kinhult
- Stordal Eystein
- Tarraga Lluis
- Tesi Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjaerg-Hansen Anne
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- Van Broeckhoven Christine
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N.
- Verhey Frans
- Vidal Jean-Sebastien
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Publication venue
- Publication date
- 01/01/2022
- Field of study
New insights into the genetic etiology of Alzheimer's disease and related dementias.
- Author
- Aarsland Dag
- Abdelnour Carla
- ADGC
- Ahmad Shahzad
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Céline
- Below Jennifer E
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C
- Bizarro Alessandra
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J
- Brusco Luis Ignacio
- Bråthen Geir
- Buiza-Rueda Dolores
- Bullido María J
- Burholt Vanessa
- Bush William S
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B
- Carracedo Ángel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- CHARGE
- Chen Hung-Hsin
- Chene Geneviève
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen AHR
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Cuccaro Michael L
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D
- Debette Stéphanie
- Deckert Jürgen
- DEGESCO
- Del Ser Teodoro
- Deleuze Jean-François
- Demgene
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- EADB
- EADI
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M
- Fabrizio Tagliavini
- Fardo David W
- Farotti Lucia
- Farrer Lindsay A
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B
- Ferri Evelyn
- Fin Bertrand
- FinnGen
- Fischer Peter
- Fladby Tormod
- Fließbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- García-Alberca Jose Maria
- García-González Pablo
- GERAD
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M
- Goldhardt Oliver
- Gomez-Fonseca Duber
- González-Pérez Antonio
- GR@ACE
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- Grünblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L
- Hamilton-Nelson Kara L
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T
- Hernández Isabel
- Herrmann Martin J
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual Sánchez
- Jun Gyungah R
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H
- Kuksa Pavel P
- Kukull Walter A
- Kunkle Brian W
- Kuulasmaa Teemu
- Kuzma Amanda B
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleó Alberto
- Longstreth William
- Lopez Oscar
- Love Seth
- Luckcuck Lauren
- Lunetta Kathryn L
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martin Eden R
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montes Angel Martín
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Børge G
- Nöthen Markus M
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande AL
- Pineda Juan A
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M
- Puerta Raquel
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M
- Reinders Marcel JT
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid B
- Sarnowski Chloé
- Satizabal Claudia L
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M
- Selbæk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey A
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje JL
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- Ståhlbom Anne Kinhult
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Tartan Juan Pablo
- Tesí Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M
- van der Lee Sven J
- van der Lugt Aad
- van Duijn Cornelia M
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N
- Verhey Frans
- Vidal Jean-Sébastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- Nat Genet
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aarsland Dag
- Abdelnour Carla
- Ahmad Shahzad
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J.
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Céline
- Below Jennifer E.
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C.
- Bizarro Alessandra
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J.
- Brusco Luis Ignacio
- Bråthen Geir
- Buiza-Rueda Dolores
- Bullido María J
- Burholt Vanessa
- Bush William S.
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B.
- Carracedo Ángel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- Chen Hung-Hsin
- Chene Geneviève
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen A H R
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gómez Anaïs
- Costa Marcos R.
- Costantini Emanuele
- Cuccaro Michael L.
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D.
- Debette Stéphanie
- Deckert Jürgen
- Del Ser Teodoro
- Deleuze Jean-François
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M.
- Fabrizio Tagliavini
- Fardo David W.
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B.
- Ferri Evelyn
- Fin Bertrand
- Fischer Peter
- Fladby Tormod
- Fließbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C.
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- García-Alberca Jose Maria
- García-González Pablo
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M.
- Goldhardt Oliver
- Gomez-Fonseca Duber
- González-Pérez Antonio
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- Grünblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual Sánchez
- Jun Gyungah R.
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G.
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuksa Pavel P.
- Kukull Walter A.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Kuzma Amanda B.
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J.
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleó Alberto
- Longstreth William
- Lopez Oscar
- Love Seth
- Luckcuck Lauren
- Lunetta Kathryn L.
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A.
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martin Eden R.
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montes Angel Martín
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Børge G
- Nöthen Markus M.
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A.
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande A L
- Pineda Juan A.
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M.
- Puerta Raquel
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M.
- Reinders Marcel J T
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid Botne
- Sarnowski Chloé
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M.
- Selbæk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje J L
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- Ståhlbom Anne Kinhult
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Tartan Juan Pablo
- Tesí Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- van Duijn Cornelia M.
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N.
- Verhey Frans
- Vidal Jean-Sébastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Nature Research Society'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aarsland Dag
- Abdelnour Carla
- Ahmad Shahzad
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J.
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Céline
- Below Jennifer E.
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C.
- Bizarro Alessandra
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J.
- Brusco Luis Ignacio
- Bråthen Geir
- Buiza-Rueda Dolores
- Bullido María J
- Burholt Vanessa
- Bush William S.
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B.
- Carracedo Ángel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- Chen Hung-Hsin
- Chene Geneviève
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen A H R
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gómez Anaïs
- Costa Marcos R.
- Costantini Emanuele
- Cuccaro Michael L.
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D.
- Debette Stéphanie
- Deckert Jürgen
- Del Ser Teodoro
- Deleuze Jean-François
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M.
- Fabrizio Tagliavini
- Fardo David W.
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B.
- Ferri Evelyn
- Fin Bertrand
- Fischer Peter
- Fladby Tormod
- Fließbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C.
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- García-Alberca Jose Maria
- García-González Pablo
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M.
- Goldhardt Oliver
- Gomez-Fonseca Duber
- González-Pérez Antonio
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- Grünblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual Sánchez
- Jun Gyungah R.
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G.
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuksa Pavel P.
- Kukull Walter A.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Kuzma Amanda B.
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J.
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleó Alberto
- Longstreth William
- Lopez Oscar
- Love Seth
- Luckcuck Lauren
- Lunetta Kathryn L.
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A.
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martin Eden R.
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montes Angel Martín
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Børge G
- Nöthen Markus M.
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A.
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande A L
- Pineda Juan A.
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M.
- Puerta Raquel
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M.
- Reinders Marcel J T
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid Botne
- Sarnowski Chloé
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M.
- Selbæk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje J L
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- Ståhlbom Anne Kinhult
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Tartan Juan Pablo
- Tesí Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- van Duijn Cornelia M.
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N.
- Verhey Frans
- Vidal Jean-Sébastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'The Nature Conservancy'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele