Space Propulsion Technology Program Overview

The topics presented are covered in viewgraph form. Focused program elements are: (1) transportation systems, which include earth-to-orbit propulsion, commercial vehicle propulsion, auxiliary propulsion, advanced cryogenic engines, cryogenic fluid systems, nuclear thermal propulsion, and nuclear electric propulsion; (2) space platforms, which include spacecraft on-board propulsion, and station keeping propulsion; and (3) technology flight experiments, which include cryogenic orbital N2 experiment (CONE), SEPS flight experiment, and cryogenic orbital H2 experiment (COHE)

A US History of Airbreathing/Rocket Combined-Cycle (RBCC) Propulsion for Powering Future Aerospace Transports, with a Look Ahead to the Year 2020

A technohistorical and forward-planning overview of U.S. developments in combined airbreathing/rocket propulsion for advanced aerospace vehicle applications is presented. Such system approaches fall into one of two categories: (1) Combination propulsion systems (separate, non-interacting engines installed), and (2) Combined-Cycle systems. The latter, and main subject, comprises a large family of closely integrated engine types, made up of both airbreathing and rocket derived subsystem hardware. A single vehicle-integrated, multimode engine results, one capable of operating efficiently over a very wide speed and altitude range, atmospherically and in space. While numerous combination propulsion systems have reached operational flight service, combined-cycle propulsion development, initiated ca. 1960, remains at the subscale ground-test engine level of development. However, going beyond combination systems, combined-cycle propulsion potentially offers a compelling set of new and unique capabilities. These capabilities are seen as enabling ones for the evolution of Spaceliner class aerospace transportation systems. The following combined-cycle hypersonic engine developments are reviewed: (1) RENE (rocket engine nozzle ejector), (2) Cryojet and LACE, (3) Ejector Ramjet and its derivatives, (4) the seminal NASA NAS7-377 study, (5) Air Force/Marquardt Hypersonic Ramjet, (6) Air Force/Lockheed-Marquardt Incremental Scramjet flight-test project, (7) NASA/Garrett Hypersonic Research Engine (HRE), (8) National Aero-Space Plane (NASP), (9) all past projects; and such current and planned efforts as (10) the NASA ASTP-ART RBCC project, (11) joint CIAM/NASA DNSCRAM flight test,(12) Hyper-X, (13) Trailblazer,( 14) W-Vehicle and (15) Spaceliner 100. Forward planning programmatic incentives, and the estimated timing for an operational Spaceliner powered by combined-cycle engines are discussed

Hydrogen from Renewable Energy: Photovoltaic/Water Electrolysis as an Exemplary Approach

Potential large-scale production of liquid hydrogen and liquid oxygen from water using photovoltaic solar energy conversion at the NASA Kennedy Space Center is examined in this paper. The example non-optimized, stand-alone facility described produces about 5.76 million pounds of liquid hydrogen per year, and 8 times that much liquid oxygen, which could support about 18 Space Shuttle launches per year. A 100-MWp flat-plate photovoltaic array, neasuring 1.65 square miles, is required. The full array is made up of 249 modular 400-kWp arrays with several electrical/gas product grids considered. Hydrogen and oxygen are produced with either dispersed or central water electrolyzers. A central product liquefaction- facility with 2-weeks f storage is provided. Estimated liquid hydrogen product costs, lewelized over a 20-year facility life, range few about $3.00 to$7.50/lb liquid hydrogen, depending Mainly on the cost of installed plioCovoltaics. (The range examined was $.50 t» f2/qp.) At about$l,50/Wp, a liquid hy- dngen eomrentional/non-f ossil cos t parity vnvld areem to be achievable over the period 1990 to 2010

Mapping Review of Fieldwork Education Literature

Fieldwork is an integral phase of occupational therapy education, bolstered by a small but growing evidence base. A broad understanding of the state of that evidence base is necessary to inform the directions for future growth. The purpose of this work was to establish the current state of occupational therapy fieldwork literature, map that literature to recognized criteria for educational research, and identify gaps in the existing literature. Authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to conduct a mapping review of articles with a primary focus on fieldwork education of occupational therapy (OT) or occupational therapy assistant (OTA) students in United States (Accreditation for Occupational Therapy Education)-based programs. Mapping criteria included level of education [OT, OTA], level of fieldwork [Level I, Level II], and categories of the AOTA Education Research Agenda - Revised (2018). Sources included four databases (Academic Search Premier, CINAHL, ERIC, PubMed) and one additional journal (Journal of Occupational Therapy Education). A total of 1,619 articles were identified, with 67 articles meeting inclusion criteria. The 67 included articles disproportionately focused on Level II OT fieldwork (53%, n=36), with sparse representation of Level I OTA fieldwork (1.5%, n=1), and addressed only two categories of the Education Research Agenda (2018; 80%, n=54). Level I fieldwork, occupational therapy assistant programs, and large swaths of the association’s Education Research Agenda (2018) were dramatically (or completely) underrepresented in fieldwork education research, suggesting important priorities for the immediate future of occupational therapy fieldwork education

Long-Term Efficacy and Safety of Adalimumab in Pediatric Patients with Crohn's Disease

Background: IMAgINE 1 assessed 52-week efficacy and safety of adalimumab in children with moderate to severe Crohn's disease. Long-Term efficacy and safety of adalimumab for patients who entered the IMAgINE 2 extension are reported. Methods: Patients who completed IMAgINE 1 could enroll in IMAgINE 2. Endpoints assessed from weeks 0 to 240 of IMAgINE 2 were Pediatric Crohn's Disease Activity Index remission (Pediatric Crohn's Disease Activity Index ≤ 10) and response (Pediatric Crohn's Disease Activity Index decrease ≥15 from IMAgINE 1 baseline) using observed analysis and hybrid nonresponder imputation (hNRI). For hNRI, discontinued patients were imputed as failures unless they transitioned to commercial adalimumab (with study site closure) or adult care, where last observation was carried forward. Corticosteroid-free remission in patients receiving corticosteroids at IMAgINE 1 baseline, discontinuation of immunomodulators (IMMs) in patients receiving IMMs at IMAgINE 2 baseline, and linear growth improvement were reported as observed. Adverse events were assessed for patients receiving ≥1 adalimumab dose in IMAgINE 1 and 2 through January 2015. Results: Of 100 patients enrolled in IMAgINE 2, 41% and 48% achieved remission and response (hNRI) at IMAgINE 2 week 240. Remission rates were maintained by 45% (30/67, hNRI) of patients who entered IMAgINE 2 in remission. At IMAgINE 2 week 240, 63% (12/19) of patients receiving corticosteroids at IMAgINE 1 baseline achieved corticosteroid-free remission and 30% (6/20) of patients receiving IMMs at IMAgINE 2 baseline discontinued IMMs. Adalimumab treatment led to growth velocity normalization. No new safety signals were identified. Conclusions: Efficacy and safety profiles of prolonged adalimumab treatment in children with Crohn's disease were consistent with IMAgINE 1 and adult Crohn's disease adalimumab trials

White paper on nuclear astrophysics and low energy nuclear physics Part 1: Nuclear astrophysics

This white paper informs the nuclear astrophysics community and funding agencies about the scientific directions and priorities of the field and provides input from this community for the 2015 Nuclear Science Long Range Plan. It summarizes the outcome of the nuclear astrophysics town meeting that was held on August 21–23, 2014 in College Station at the campus of Texas A&M University in preparation of the NSAC Nuclear Science Long Range Plan. It also reflects the outcome of an earlier town meeting of the nuclear astrophysics community organized by the Joint Institute for Nuclear Astrophysics (JINA) on October 9–10, 2012 Detroit, Michigan, with the purpose of developing a vision for nuclear astrophysics in light of the recent NRC decadal surveys in nuclear physics (NP2010) and astronomy (ASTRO2010). The white paper is furthermore informed by the town meeting of the Association of Research at University Nuclear Accelerators (ARUNA) that took place at the University of Notre Dame on June 12–13, 2014. In summary we find that nuclear astrophysics is a modern and vibrant field addressing fundamental science questions at the intersection of nuclear physics and astrophysics. These questions relate to the origin of the elements, the nuclear engines that drive life and death of stars, and the properties of dense matter. A broad range of nuclear accelerator facilities, astronomical observatories, theory efforts, and computational capabilities are needed. With the developments outlined in this white paper, answers to long standing key questions are well within reach in the coming decade

Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis

Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and cardiac function in 17 children with T1DM during and after correction of diabetic ketoacidosis (DKA). Twenty seven of the 39 measured cytokines/chemokines were elevated at 6–12 hours into treatment of DKA compared to values after DKA resolution. Eight patients displayed at least one parameter of diastolic abnormality (DA) during acute DKA. Significant associations were present between nine of the cytokine/chemokine levels and the DA over time. Interestingly, four of these nine interactive cytokines (GM-CSF, G-CSF, IL-12p40, IL-17) are associated with a Th17 mediated cell response. Both the DA and CCL7 and IL-12p40, had independent associations with African American patients. Thus, we report occurrence of a systemic inflammatory response and the presence of cardiac diastolic dysfunction in a subset of young T1DM patients during acute DKA

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.

BACKGROUND: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes. RESULTS: We confirmed previously observed significant associations between coronary artery disease and low-frequency missense variants in the genes LPA and PCSK9. We also found significant associations between coronary artery disease and low-frequency missense variants in the genes SVEP1 (p.D2702G; minor-allele frequency, 3.60%; odds ratio for disease, 1.14; P=4.2×10(-10)) and ANGPTL4 (p.E40K; minor-allele frequency, 2.01%; odds ratio, 0.86; P=4.0×10(-8)), which encodes angiopoietin-like 4. Through sequencing of ANGPTL4, we identified 9 carriers of loss-of-function mutations among 6924 patients with myocardial infarction, as compared with 19 carriers among 6834 controls (odds ratio, 0.47; P=0.04); carriers of ANGPTL4 loss-of-function alleles had triglyceride levels that were 35% lower than the levels among persons who did not carry a loss-of-function allele (P=0.003). ANGPTL4 inhibits lipoprotein lipase; we therefore searched for mutations in LPL and identified a loss-of-function variant that was associated with an increased risk of coronary artery disease (p.D36N; minor-allele frequency, 1.9%; odds ratio, 1.13; P=2.0×10(-4)) and a gain-of-function variant that was associated with protection from coronary artery disease (p.S447*; minor-allele frequency, 9.9%; odds ratio, 0.94; P=2.5×10(-7)). CONCLUSIONS: We found that carriers of loss-of-function mutations in ANGPTL4 had triglyceride levels that were lower than those among noncarriers; these mutations were also associated with protection from coronary artery disease. (Funded by the National Institutes of Health and others.).Supported by a career development award from the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH) (K08HL114642 to Dr. Stitziel) and by the Foundation for Barnes–Jewish Hospital. Dr. Peloso is supported by the National Heart, Lung, and Blood Institute of the NIH (award number K01HL125751). Dr. Kathiresan is supported by a Research Scholar award from the Massachusetts General Hospital, the Donovan Family Foundation, grants from the NIH (R01HL107816 and R01HL127564), a grant from Fondation Leducq, and an investigator-initiated grant from Merck. Dr. Merlini was supported by a grant from the Italian Ministry of Health (RFPS-2007-3-644382). Drs. Ardissino and Marziliano were supported by Regione Emilia Romagna Area 1 Grants. Drs. Farrall and Watkins acknowledge the support of the Wellcome Trust core award (090532/Z/09/Z), the British Heart Foundation (BHF) Centre of Research Excellence. Dr. Schick is supported in part by a grant from the National Cancer Institute (R25CA094880). Dr. Goel acknowledges EU FP7 & Wellcome Trust Institutional strategic support fund. Dr. Deloukas’s work forms part of the research themes contributing to the translational research portfolio of Barts Cardiovascular Biomedical Research Unit, which is supported and funded by the National Institute for Health Research (NIHR). Drs. Webb and Samani are funded by the British Heart Foundation, and Dr. Samani is an NIHR Senior Investigator. Dr. Masca was supported by the NIHR Leicester Cardiovascular Biomedical Research Unit (BRU), and this work forms part of the portfolio of research supported by the BRU. Dr. Won was supported by a postdoctoral award from the American Heart Association (15POST23280019). Dr. McCarthy is a Wellcome Trust Senior Investigator (098381) and an NIHR Senior Investigator. Dr. Danesh is a British Heart Foundation Professor, European Research Council Senior Investigator, and NIHR Senior Investigator. Drs. Erdmann, Webb, Samani, and Schunkert are supported by the FP7 European Union project CVgenes@ target (261123) and the Fondation Leducq (CADgenomics, 12CVD02). Drs. Erdmann and Schunkert are also supported by the German Federal Ministry of Education and Research e:Med program (e:AtheroSysMed and sysINFLAME), and Deutsche Forschungsgemeinschaft cluster of excellence “Inflammation at Interfaces” and SFB 1123. Dr. Kessler received a DZHK Rotation Grant. The analysis was funded, in part, by a Programme Grant from the BHF (RG/14/5/30893 to Dr. Deloukas). Additional funding is listed in the Supplementary Appendix.This is the author accepted manuscript. The final version is available from the Massachusetts Medical Society via http://dx.doi.org/10.1056/NEJMoa150765

Some thoughts on the aquarius program: A prospective world effort in hydrogen-energy

Increasing discussion of what actions the US, and the world community generally, can take in the sphere of energy is being heard. The tempo is picking up; mention of 'lscrash programme' possibilities is even made. Now may be the time to bring forward focused ideas, especially those which may make long-term sense. One such idea is that of a [`]hydrogen-energy system' about which much has been written and spoken, but little yet accomplished in the sense of physical development. The United States is well known for its ability to establish an effective large-scale programme, once the stage of [`]determination' has been reached, usually late-in-the-day in the sense of our facing up to the basic problem. This paper sketches out a [`]program-matistion' of the hydrogen-energy concept somewhat in the spirit of the Apollo Program with which there are some parallels. But [`]Aquarius' would be a much more ambitious and longer termed programme. It would involve practically all US citizens and, hopefully, gain international participation. Expensive? Of course. But the monies spent are with the identical constituency who would profit from the transition from fossil fuels.