Anomalously large oxygen-ordering contribution to the thermal expansion of untwinned YBa2Cu3O6.95 single crystals: a glass-like transition near room temperature

We present high-resolution capacitance dilatometry studies from 5 - 500 K of untwinned YBa2Cu3Ox (Y123) single crystals for x ~ 6.95 and x = 7.0. Large contributions to the thermal expansivities due to O-ordering are found for x ~ 6.95, which disappear below a kinetic glass-like transition near room temperature. The kinetics at this glass transition is governed by an energy barrier of 0.98 +- 0.07 eV, in very good agreement with other O-ordering studies. Using thermodynamic arguments, we show that O-ordering in the Y123 system is particularly sensitive to uniaxial pressure (stress) along the chain axis and that the lack of well-ordered chains in Nd123 and La123 is most likely a consequence of a chemical-pressure effect.Comment: 4 pages, 3 figures, submitted to PR

Metabolic and evolutionary insights into the closely-related species Streptomyces coelicolor and Streptomyces lividans deduced from high-resolution comparative genomic hybridization

Whilst being closely related to the model actinomycete Streptomyces coelicolor A3(2), S. lividans 66 differs from it in several significant and phenotypically observable ways, including antibiotic production. Previous comparative gene hybridization studies investigating such differences have used low-density (one probe per gene) PCR-based spotted arrays. Here we use new experimentally optimised 104,000 × 60-mer probe arrays to characterize in detail the genomic differences between wild-type S. lividans 66, a derivative industrial strain, TK24, and S. coelicolor M145

Simulations of Cosmic Chemical Enrichment

Using a new numerical model for cosmic chemical evolution, we study the influence of hypernova feedback on the star formation and metal enrichment history of the universe. For assumptions which produce plausible results in idealized collapse models of individual galaxies, our cosmological simulations of the standard Lambda-CDM cosmology show a peak of the cosmic star formation rate at z~4, with ~10% of the baryons turning into stars. We find that the majority of stars in present-day massive galaxies formed in much smaller galaxies at high redshifts, giving them a mean stellar age as old as 10 Gyr, despite their late assembly times. The hypernova feedback drives galactic outflows efficiently in low mass galaxies, and these winds eject heavy elements into the intergalactic medium. The ejected baryon fraction is larger for less massive galaxies, correlates well with stellar metallicity, and amounts to ~20% of all baryons in total. The resulting enrichment history is broadly consistent with the observed abundances of Lyman break galaxies, of damped Lyman alpha systems, and of the intergalactic medium. The metallicity of the cold gas in galaxies increases with galaxy mass, which is comparable to observations with a significant scatter. The stellar mass-metallicity relation of the observed galaxy population is well reproduced by the simulation model as a result of mass-dependent galactic winds. However, star formation does not terminate in massive galaxies at late times in our model, and too few dwarf galaxies are still forming stars. These problems may be due to a lack of resolution, to inappropriate modelling of supernova feedback, or to a neglect of other feedback processes such as active galactic nuclei.Comment: 16 pages, 20 figures. Accepted for publication in MNRA

Модернизация автоматизированной системы блока стабилизации давления магистрального насосного агрегата на нефтеперекачивающей станции

Объектом исследования является блок стабилизации давления магистрального насосного агрегата. Цель работы – модернизация автоматизированной системы блока стабилизации давления магистрального трубопровода нефтеперекачивающей станции с использованием ПЛК, на основе выбранной SCADA-системы. В данном проекте была разработана система контроля и управления технологическим процессом на базе промышленных контроллеров Modicon M340 BMXP34 2020, с применением SCADA-системы.The object of investigation is the pressure stabilization unit of the main pump unit. The purpose of the work is the modernization of the automated system for stabilizing the pressure of the main pipeline of the oil pumping station using PLCs, based on the SCADA system chosen. In this project, a system for monitoring and controlling the process was developed on the basis of industrial controllers Modicon M340 BMXP34 2020, using a SCADA system

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

A saturated map of common genetic variants associated with human height

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants

Legalität und Opportunität | Gegensätzliche Prinzipien der Anwendung von Strafrechtsnormen im Spiegel rechtstheoretischer, rechtsstaatlicher und rechtspolitischer Überlegungen

Der Autor befaßt sich mit den Problemen von Legalitäts- und Opportunitätsprinzip. Ausgangspunkt der Überlegungen, die über die Frage der "Anklage- und Ermittlungspflicht der Staatsanwaltschaft" gemäß § 152 StPO hinaus auch die richterliche Tätigkeit in die Betrachtung einbeziehen, ist die unterschiedliche Bindung des Rechtsanwenders an gesetzliche Vorgaben bei ermessensfreier und ermessensgeprägter Rechtsanwendung. Hieran anknüpfend werden Legalität und Opportunität als gegensätzliche Kategorien der Anwendung von Strafrechtsnormen dargestellt, bevor unter rechtsstaatlichen, kriminalpolitischen und justiz-praktischen Gesichtspunkten die rechtspolitische Alternative zwischen beiden Prinzipien diskutiert wird. Im Anschluß daran steht eine Untersuchung über die Eignung materiellrechtlicher und prozessualer Vorschriften zur gesetzestechnischen Umsetzung eines Kompromisses zwischen Legalitäts- und Opportunitätsprinzip. Das letzte Kapitel schließlich ist der Entwicklung konkreter Reformvorschläge gewidmet