13 research outputs found
Snowmass Early Career: The Key Initiatives Organization
In April 2020, the 2019 and 2020 American Physical Society's Division of
Particles and Fields (APS DPF) Early Career Executive Committee (ECEC) members
were tasked with organizing the formation of a representative body for
High-Energy Physics (HEP) early career members for the Snowmass process by the
DPF Executive Committee. Here, we outline the structure we developed and the
process we followed to help provide context and guidance for future early
career Snowmass efforts. Our organization was composed of a cross-frontier
branch with committees on Inreach, Diversity Equity and Inclusion, Survey, and
Long Term Organizational Planning; in addition to the Frontier Coordination
branch, formed by committees responsible for liaising with each Frontier.
Throughout this document, the authors reflect on the triumphs and pitfalls of a
program created from nothing over a very short period of time, by people with
good intentions, who had no prior experience in building such an organization.
Through this exercise of reflecting, we sometimes find that we would recommend
a different path to our future selves. Insomuch as there are things to find
fault with, it is in the robustness of the systems we built and refined.Comment: contribution to Snowmass 2021, 16 pages, 0 figure
Snowmass2021 cosmic frontier white paper: Ultraheavy particle dark matter
We outline the unique opportunities and challenges in the search for "ultraheavy" dark matter candidates with masses between roughly 10 TeV and the Planck scale TeV. This mass range presents a wide and relatively unexplored dark matter parameter space, with a rich space of possible models and cosmic histories. We emphasize that both current detectors and new, targeted search techniques, via both direct and indirect detection, are poised to contribute to searches for ultraheavy particle dark matter in the coming decade. We highlight the need for new developments in this space, including new analyses of current and imminent direct and indirect experiments targeting ultraheavy dark matter and development of new, ultra-sensitive detector technologies like next-generation liquid noble detectors, neutrino experiments, and specialized quantum sensing techniques
Snowmass2021 Cosmic Frontier White Paper: Ultraheavy particle dark matter
We outline the unique opportunities and challenges in the search for "ultraheavy" dark matter candidates with masses between roughly and the Planck scale . This mass range presents a wide and relatively unexplored dark matter parameter space, with a rich space of possible models and cosmic histories. We emphasize that both current detectors and new, targeted search techniques, via both direct and indirect detection, are poised to contribute to searches for ultraheavy particle dark matter in the coming decade. We highlight the need for new developments in this space, including new analyses of current and imminent direct and indirect experiments targeting ultraheavy dark matter and development of new, ultra-sensitive detector technologies like next-generation liquid noble detectors, neutrino experiments, and specialized quantum sensing techniques
Advancing the Landscape of Multimessenger Science in the Next Decade
Engel K, Lewis T, Muzio MS, et al. Advancing the Landscape of Multimessenger Science in the Next Decade. arXiv:2203.10074. 2022.The last decade has brought about a profound transformation in multimessenger
science. Ten years ago, facilities had been built or were under construction
that would eventually discover the nature of objects in our universe could be
detected through multiple messengers. Nonetheless, multimessenger science was
hardly more than a dream. The rewards for our foresight were finally realized
through IceCube's discovery of the diffuse astrophysical neutrino flux, the
first observation of gravitational waves by LIGO, and the first joint
detections in gravitational waves and photons and in neutrinos and photons.
Today we live in the dawn of the multimessenger era. The successes of the
multimessenger campaigns of the last decade have pushed multimessenger science
to the forefront of priority science areas in both the particle physics and the
astrophysics communities. Multimessenger science provides new methods of
testing fundamental theories about the nature of matter and energy,
particularly in conditions that are not reproducible on Earth. This white paper
will present the science and facilities that will provide opportunities for the
particle physics community renew its commitment and maintain its leadership in
multimessenger science
Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risks in the general population. In a previous study, we demonstrated that the minor alleles at three of these SNPs, in FGFR2, TNRC9 and MAP3K1, also confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. Three additional SNPs rs3817198 at LSP1, rs13387042 at 2q35 and rs13281615 at 8q24 have since been reported to be associated with breast cancer in the general population, and in this study we evaluated their association with breast cancer risk in 9442 BRCA1 and 5665 BRCA2 mutation carriers from 33 study centres. The minor allele of rs3817198 was associated with increased breast cancer risk only for BRCA2 mutation carriers [hazard ratio (HR) = 1.16, 95% CI: 1.07-1.25, P-trend = 2.8 x 10(-4)]. The best fit for the association of SNP rs13387042 at 2q35 with breast cancer risk was a dominant model for both BRCA1 and BRCA2 mutation carriers (BRCA1: HR = 1.14, 95% CI: 1.04-1.25, P = 0.0047; BRCA2: HR = 1.18 95% CI: 1.04-1.33, P = 0.0079). SNP rs13281615 at 8q24 was not associated with breast cancer for either BRCA1 or BRCA2 mutation carriers, but the estimated association for BRCA2 mutation carriers (per-allele HR = 1.06, 95% CI: 0.98-1.14) was consistent with odds ratio estimates derived from population-based case-control studies. The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 mutation carriers. There was no evidence that the associations vary by mutation type depending on whether the mutated protein is predicted to be stable or not
Report of the Topical Group on Cosmic Probes of Fundamental Physics for for Snowmass 2021
International audienceCosmic Probes of Fundamental Physics take two primary forms: Very high energy particles (cosmic rays, neutrinos, and gamma rays) and gravitational waves. Already today, these probes give access to fundamental physics not available by any other means, helping elucidate the underlying theory that completes the Standard Model. The last decade has witnessed a revolution of exciting discoveries such as the detection of high-energy neutrinos and gravitational waves. The scope for major developments in the next decades is dramatic, as we detail in this report
Report of the Topical Group on Cosmic Probes of Fundamental Physics for for Snowmass 2021
International audienceCosmic Probes of Fundamental Physics take two primary forms: Very high energy particles (cosmic rays, neutrinos, and gamma rays) and gravitational waves. Already today, these probes give access to fundamental physics not available by any other means, helping elucidate the underlying theory that completes the Standard Model. The last decade has witnessed a revolution of exciting discoveries such as the detection of high-energy neutrinos and gravitational waves. The scope for major developments in the next decades is dramatic, as we detail in this report