Determination and Application of Pont's Index in Turkish Population

Disharmony between tooth size and dental arch size induces orthodontic problems. So, dental indices were identified by various authors. One of these is Pont who determined a method of prediction of the ideal dental arch width which has become known as Pont's Index. The purpose of this study was to assess the applicability of Pont's Index to a Turkish population and to compare the results with those obtained from studies of different ethnic subjects. The sample comprised 64 male subjects and 78 female subjects with age range from 14 to 15 years. Measurements were obtained directly from plaster casts; they included mesiodistal crown diameters of the four maxillary incisors, as well as interpremolar and intermolar maxillary arch widths as specified by Pont. Correlation coefficients determined between the measured arch width values and those calculated according to Pont's Index were low in all cases, with r values ranging from 0.02 to 0.36. It was concluded that Pont's Index should not be used to predetermine ideal arch width values in Turkish individuals

The Relationship Between Malocclusion Perceptions of Patient and Clinician

Aim:To evaluate the Aesthetic Component (AC), which is part of Index of Orthodontic Treatment Need (IOTN) according to the patient and the clinician's point of view and to examine whether there is a difference between them in terms of awareness according to gender and pubertal situation.Subjects and Method:The study material of 100 patients (50 males, 50 females) with mean age 13.9 consisted of pre-treatment orthodontic models and hand-wrist films. AC images used in determination of the patient and clinician perceptions of malocclusion.Results:These 100 patients gave the same score with 32 clinicians, percentage of compliance of all patients was 32.0 % and there was no statistically significant differences (p>0.05) between clinician and patient's perceptions of malocclusion. Perceptions of malocclusion was also examined according to genders, there was no statistically significant difference between female and male patients, and clinician (p>0.05). Perceptions of malocclusion was also examined according to puberta, there was only no statistically significant difference between patients in pubertal period and clinician (p>0.05), but there was statistically significant difference (p<0.05) between patients with pre-and postpubertal period, and clinician.Conclusion:Although there was not difference between perceptions of malocclusion of the genders, the patients in pubertal period were more objective, more aware of their malocclusions and dental aesthetics than the pre-and postpubertal patients So that, a greater number of this patients referred for orthodontic treatment

Cephalometric Evaluation of Turkish Children With Class III Malocclusion in the Mixed Dentition

Objective:To investigate the cephalometric characteristics of Turkish children with Class III malocclusion and compare them with to those of children with clinically normal occlusion during the mixed dentition phase.Materials and Method:Lateral cephalometric radiographs of 80 children with Class III malocclusion (mean age, 10.23 years) and 80 subjects with normal occlusion (mean age, 10.79 years) were examined for the study. Mean values of 13 linear and 21 angular cephalometric parameters were measured and compared.Results:Sagittal skeletal measurements included SNB (Class III, 81.82 ± 4.26; control group, 74.5 ± 3.86; p<.001), ANB (Class III, −2.35 ± 2.02; control group, 2.4 ± 1.17; p<.0001), Pg to Nasion vertical (Class III, −5.70 ± 2.68; control group, −9.60 ± 3.21; p<.05), Wits appraisal (Class III, −5 ± 4.57; control group, −0.8 ± 2.44; p<.05), Co-A (Class III, 79.38 ± 2.19; control group, 83.94 ± 2.64; p<.01) and Co-Gn (Class III, 105.7 ± 2.04; control group, 102.4 ± 1.15; p<.05). Vertical skeletal analysis included Gonial angle (Class III, 132.6 ± 7.15; control group, 122.1 ± 6.6; p<.01), and S-Ar length (Class III, 28.31 ± 0.9; control group, 30.2 ± 1.4; p<.05). Dentoalveolar measurements included U1 to SN (Class III, 107.96 ± 8.13; control group, 98.4 ± 8.19; p<.05). Soft tissue measurements included soft tissue convexity (Class III, 173.4 ± 3.68; control group, 165.9 ± 3.25; p<.01).Conclusion:The findings of the study indicated that effective mandibular length was larger in Class III groups and effective maxillary length was smaller in Class III groups

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.

Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.BCAC is funded by Cancer Research UK (C1287/A10118, C1287/A12014) and by the European Community's Seventh Framework Programme under grant agreement 223175 (HEALTH-F2-2009-223175) (COGS). Meetings of the BCAC have been funded by the European Union COST programme (BM0606). Genotyping on the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710, C8197/A16565), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer program and the Ministry of Economic Development, Innovation and Export Trade of Quebec, grant PSR-SIIRI-701. Combination of the GWAS data was supported in part by the US National Institutes of Health (NIH) Cancer Post-Cancer GWAS initiative, grant 1 U19 CA148065-01 (DRIVE, part of the GAME-ON initiative). For a full description of funding and acknowledgments, see the Supplementary Note.This is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/ng.324

Correction to: Two years later: Is the SARS-CoV-2 pandemic still having an impact on emergency surgery? An international cross-sectional survey among WSES members

Background: The SARS-CoV-2 pandemic is still ongoing and a major challenge for health care services worldwide. In the first WSES COVID-19 emergency surgery survey, a strong negative impact on emergency surgery (ES) had been described already early in the pandemic situation. However, the knowledge is limited about current effects of the pandemic on patient flow through emergency rooms, daily routine and decision making in ES as well as their changes over time during the last two pandemic years. This second WSES COVID-19 emergency surgery survey investigates the impact of the SARS-CoV-2 pandemic on ES during the course of the pandemic. Methods: A web survey had been distributed to medical specialists in ES during a four-week period from January 2022, investigating the impact of the pandemic on patients and septic diseases both requiring ES, structural problems due to the pandemic and time-to-intervention in ES routine. Results: 367 collaborators from 59 countries responded to the survey. The majority indicated that the pandemic still significantly impacts on treatment and outcome of surgical emergency patients (83.1% and 78.5%, respectively). As reasons, the collaborators reported decreased case load in ES (44.7%), but patients presenting with more prolonged and severe diseases, especially concerning perforated appendicitis (62.1%) and diverticulitis (57.5%). Otherwise, approximately 50% of the participants still observe a delay in time-to-intervention in ES compared with the situation before the pandemic. Relevant causes leading to enlarged time-to-intervention in ES during the pandemic are persistent problems with in-hospital logistics, lacks in medical staff as well as operating room and intensive care capacities during the pandemic. This leads not only to the need for triage or transferring of ES patients to other hospitals, reported by 64.0% and 48.8% of the collaborators, respectively, but also to paradigm shifts in treatment modalities to non-operative approaches reported by 67.3% of the participants, especially in uncomplicated appendicitis, cholecystitis and multiple-recurrent diverticulitis. Conclusions: The SARS-CoV-2 pandemic still significantly impacts on care and outcome of patients in ES. Well-known problems with in-hospital logistics are not sufficiently resolved by now; however, medical staff shortages and reduced capacities have been dramatically aggravated over last two pandemic years

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Hızlı üst çene genişletmesinde kullanılan üç farklı apareyin üst çenenin farklı kemikleşme dönemlerinde uygulanmasıyla üst çene ve çevresindeki kemiklerde meydana gelen değişikliklerin sonlu elemanlar analizi ile değerlendirilmesi

Tez (Doktora) -- Kırıkkale Üniversitesi100215