Preface: Experiencing Cancer in Appalachian Kentucky

Connected cancer care is of increasing importance in light of the COVID-19 pandemic. The Linking & Amplifying User-Centered Networks through Connected Health (L.A.U.N.C.H.) Collaborative in Appalachian Kentucky has pioneered a new roadmap for equipping communities with the transformative power of broadband to innovate around the future of cancer care and to better scale their ideas. The roadmap involves reaching across disciplines, including public health, anthropology, telecommunications, and user-centered design. The goal is to leverage connectivity and cancer communication research and practice to make a real difference for patients and families

Plenary Session III – Medical Track: Reporting At-Risk Drivers to MassDOT Medical Advisory Board

This session will address counseling the at-risk driver, healthcare provider responsibility and liability, clinician resources to provide older drivers, and procedures for reporting. This session will also include information on recognizing the sense of loss and grief experienced by someone who must relinquish a driver’s license

Yield Response of ‘Whatley-Loretan’ Sweetpotato (Ipomoea Batatas (L.)) Transplanted in Single And Double Row at Different Dates in A Wiregrass Tunnel House

A split-plot study was conducted to evaluate the yield response of ‘Whatley-Loretan’ sweetpotato when planted in single and double rows at four planting dates (March, April, May, and June) in a Wiregrass Tunnel House located at S&B Farm in Eufaula, Alabama. The main plots consisted of planting dates, sub-plots single, and double rows, with each treatment combination, replicated three times. The results showed a significant linear and quadratic effect for US#1 grade of sweetpotato and total marketable yields. Yields were highest at the first and second planting dates and declined at the two later planting dates. Single vs. double row planting significantly affected canner grade of sweetpotatoes, while the other grades were unaffected

Experiencing Cancer in Appalachian Kentucky

Nothing tells the story of people working together better than a community quilt. A diversity of talents, colors, and materials brought together through skill and shared purpose. Perhaps never before have we as Americans needed a stronger reminder that many hands make short work of big problems. The work presented here by the L.A.U.N.C.H. Collaborative offers a new framework for health care that could be compared to a digital quilt, powered by community-based participatory design, with lived expertise and the newest advances in broadband-enabled connected health solutions. This work demonstrates the value and need to engage local communities and what can be learned when beneficiaries and traditional caregivers work together to develop healthcare solutions

The Effect of A Fifty Percent Leaf Harvest From Three Varieties of Collards (Brassica Oleracea(L)/Cultivar Group Acephala) Cropped at Selected Intervals When Grown in A Wiregrass Tunnel House

A study was conducted to determine the effects of a 50% leaf harvest from ‘Heirloom’, ‘Georgia’, and ‘Hi-Crop Hybrid’ collards on yield, when leaves were removed at 18-, 21-, and 25- day intervals, over four harvest periods of 102, 127, 152, and 177 days after transplanting in a Wiregrass Tunnel House. The experimental design used was a split-split plot with three replications, where harvest periods were main plots, cropping intervals (3) were sub-plots, and varieties were sub-sub-plots. Yield data (lbs./acre) showed significant interactions between harvest periods x cropping intervals for leaf numbers and yield, harvest periods x varieties, and cropping intervals x varieties. The 18-day cropping interval had the highest yields over all harvest periods; while varieties responded differently for each harvest period, and cropping intervals. ‘Hi-Crop Hybrid’ had the highest yield over all harvest periods and cropping intervals, followed by ‘Georgia ‘and ‘Heirloom.

The Evolution of O i over 3.2 < z < 6.5: Reionization of the Circumgalactic Medium

We present a survey for metal absorption systems traced by neutral oxygen over 3.2 0.05 Å, of which there are 49 nonproximate systems in our sample. We find that the number density does not monotonically increase with decreasing redshift, as would naively be expected from the buildup of metal-enriched circumgalactic gas with time. The number density over 4.9 < z < 5.7 is a factor of 1.7–4.1 lower (68% confidence) than that over 5.7 < z < 6.5, with a lower value at z < 5.7 favored with 99% confidence. This decrease suggests that the fraction of metals in a low-ionization phase is larger at z ~ 6 than at lower redshifts. Absorption from highly ionized metals traced by C iv is also weaker in higher-redshift O i systems, supporting this picture. The evolution of O i absorbers implies that metal-enriched circumgalactic gas at z ~ 6 is undergoing an ionization transition driven by a strengthening ultraviolet background. This in turn suggests that the reionization of the diffuse intergalactic medium may still be ongoing at or only recently ended by this epoch

Directly imaging damped Lyman-alpha galaxies at z>2. I: Methodology and First Results

We present the methodology for, and the first results from, a new imaging program aimed at identifying and characterizing the host galaxies of damped Lyman-alpha absorbers (DLAs) at z>2. We target quasar sightlines with multiple optically-thick HI absorbers and use the higher-redshift system as a "blocking filter" (via its Lyman-limit absorption) to eliminate all far-ultraviolet (FUV) emission from the quasar. This allows us to directly image the rest-frame FUV continuum emission of the lower-redshift DLA, without any quasar contamination and with no bias towards large impact parameters. We introduce a formalism based on galaxy number counts and Bayesian statistics with which we quantify the probability that a candidate is the DLA host galaxy. This method will allow the identification of a bona fide sample of DLAs that are too faint to be spectroscopically confirmed. The same formalism can be adopted to the study of other quasar absorption line systems (e.g. MgII absorbers). We have applied this imaging technique to two QSO sightlines. For the z~2.69 DLA towards J073149+285449, a galaxy with impact parameter b=1.54"=11.89 kpc and implied star formation rate (SFR) of ~5 M/yr is identified as the most reliable candidate. In the case of the z~2.92 DLA towards J211444-005533, no likely host is found down to a 3-sigma SFR limit of 1.4 M/yr. Studying the HI column density as a function of the impact parameter, including 6 DLAs with known hosts from the literature, we find evidence that the observed HI distribution is more extended than what is generally predicted from numerical simulation.Comment: 22 pages, 13 figures. Accepted for publication in MNRAS. Typos correcte

MutLα heterodimers modify the molecular phenotype of Friedreich ataxia

This article has been made available through the Brunel Open Access Publishing Fund.Background: Friedreich ataxia (FRDA), the most common autosomal recessive ataxia disorder, is caused by a dynamic GAA repeat expansion mutation within intron 1 of FXN gene, resulting in down-regulation of frataxin expression. Studies of cell and mouse models have revealed a role for the mismatch repair (MMR) MutS-heterodimer complexes and the PMS2 component of the MutLα complex in the dynamics of intergenerational and somatic GAA repeat expansions: MSH2, MSH3 and MSH6 promote GAA repeat expansions, while PMS2 inhibits GAA repeat expansions. Methodology/Principal Findings: To determine the potential role of the other component of the MutLα complex, MLH1, in GAA repeat instability in FRDA, we have analyzed intergenerational and somatic GAA repeat expansions from FXN transgenic mice that have been crossed with Mlh1 deficient mice. We find that loss of Mlh1 activity reduces both intergenerational and somatic GAA repeat expansions. However, we also find that loss of either Mlh1 or Pms2 reduces FXN transcription, suggesting different mechanisms of action for Mlh1 and Pms2 on GAA repeat expansion dynamics and regulation of FXN transcription. Conclusions/Significance: Both MutLα components, PMS2 and MLH1, have now been shown to modify the molecular phenotype of FRDA. We propose that upregulation of MLH1 or PMS2 could be potential FRDA therapeutic approaches to increase FXN transcription. © 2014 Ezzatizadeh et al.This article has been made available through the Brunel Open Access Publishing Fund

‘It's all the way you look at it, you know’: reading Bill ‘Bojangles’ Robinson's film career

This paper engages with a major paradox in African American tap dancer Bill ‘Bojangles’ Robinson's film image – namely, its concurrent adherences to and contestations of dehumanising racial iconography – to reveal the complex and often ambivalent ways in which identity is staged and enacted. Although Robinson is often understood as an embodiment of popular cultural imagery historically designed to dehumanise African Americans, this paper shows that Robinson's artistry displaces these readings by providing viewing pleasure for black, as much as white, audiences. Robinson's racially segregated scenes in Dixiana (1930) and Hooray for Love (1935) illuminate classical Hollywood's racial codes, whilst also showing how his inclusion within these otherwise all-white films provides grounding for creative and self-reflexive artistry. The films' references to Robinson's stage image and artistry overlap with minstrelsy-derived constructions of ‘blackness’, with the effect that they heighten possible interpretations of his cinematic persona by evading representational conclusion. Ultimately, Robinson's films should be read as sites of representational struggle that help to uncover the slipperiness of performances of African American identities in 1930s Hollywood

Evidence that vitamin D3 promotes mast cell–dependent reduction of chronic UVB-induced skin pathology in mice

Mast cell production of interleukin-10 (IL-10) can limit the skin pathology induced by chronic low-dose ultraviolet (UV)-B irradiation. Although the mechanism that promotes mast cell IL-10 production in this setting is unknown, exposure of the skin to UVB irradiation induces increased production of the immune modifying agent 1α,25-dihydroxyvitamin D3 (1α,25[OH]2D3). We now show that 1α,25(OH)2D3 can up-regulate IL-10 mRNA expression and induce IL-10 secretion in mouse mast cells in vitro. To investigate the roles of 1α,25(OH)2D3 and mast cell vitamin D receptor (VDR) expression in chronically UVB-irradiated skin in vivo, we engrafted the skin of genetically mast cell–deficient WBB6F1-KitW/W-v mice with bone marrow–derived cultured mast cells derived from C57BL/6 wild-type or VDR−/− mice. Optimal mast cell–dependent suppression of the inflammation, local production of proinflammatory cytokines, epidermal hyperplasia, and epidermal ulceration associated with chronic UVB irradiation of the skin in KitW/W-v mice required expression of VDR by the adoptively transferred mast cells. Our findings suggest that 1α,25(OH)2D3/VDR-dependent induction of IL-10 production by cutaneous mast cells can contribute to the mast cell’s ability to suppress inflammation and skin pathology at sites of chronic UVB irradiation