Very High Bit Rate Near-Field Communication with Low-Interference Coils and Digital Single-Bit Sampling Transceivers for Biomedical Sensor Systems

The evolution of microelectronics increased the information acquired by today’s biomedical sensor systems to an extent where the capacity of low-power communication interfaces becomes one of the central bottlenecks. Hence, this paper mathematically analyzes and experimentally verifies novel coil and transceiver topologies for near-field communication interfaces, which simultaneously allow for high data transfer rates, low power consumption, and reduced interference to nearby wireless power transfer interfaces. Data coil design is focused on presenting two particular topologies which provide sufficient coupling between a reader and a wireless sensor system, but do not couple to an energy coil situated on the same substrate, severely reducing interference between wireless data and energy transfer interfaces. A novel transceiver design combines the approaches of a minimalistic analog front-end with a fully digital single-bit sampling demodulator, in which rectangular binary signals are processed by simple digital circuits instead of sinusoidal signals being conditioned by complex analog mixers and subsequent multi-bit analog-to-digital converters. The concepts are implemented using an analog interface in discrete circuit technology and a commercial low-power field-programmable gate array, yielding a transceiver which supports data rates of up to 6.78 MBit/s with an energy consumption of just 646 pJ/bit in transmitting mode and of 364 pJ/bit in receiving mode at a bit error rate of 2×10−7, being 10 times more energy efficient than any commercial NFC interface and fully implementable without any custom CMOS technology

Clinical Trajectory and Risk Stratification for Heart Failure with Preserved Ejection Fraction in a Real-World Cohort of Patients with Suspected Coronary Artery Disease

Background: Heart failure with preserved ejection fraction (HFpEF) is a widespread condition with significant morbidity and mortality. Its clinical heterogeneity may delay the diagnosis. Aim: To identify predictors of HFpEF-related hospitalizations in ambulatory patients presenting with elevated cardiovascular risk, suspected coronary artery diseases (CADs), and positive HFpEF screenings. Methods: Consecutive patients presenting with suspected CAD, enrolled in the observational LIFE-Heart study (2006–2014, NCT00497887), and meeting HFpEF criteria per the 2016 European Society of Cardiology (ESC) guidelines were categorized according to the presence of “overlapping conditions” potentially masking or contributing to their symptoms. Additional stratification using the H2FPEF score (Results: Of 1054 patients (66 ± 10 years, 60% male, NT-pro-BNP 286, IQR 183–574 pg/mL), 53% had overlapping conditions, while 47% had “isolated HFpEF”. The H2FPEF scores classified 23%, 57%, and 20% as low-, intermediate-, and high-risk, respectively, with consistent proportions across patients with and without overlapping conditions (p = 0.91). During the follow-up observational phase, 54% were rehospitalized, 22% experienced heart failure (HF) rehospitalizations, and 11% of patients died. Multivariable logistic regression revealed a high-risk H2FPEF category as an independent predictor of HF rehospitalization in the overall cohort (odds ratio: 3.4, CI: 2.4–4.9, p 2FPEF score ≥ 6 was independently associated with higher mortality rates (hazard ratio: 1.8, CI: 1.2–2.6, p Conclusions: Ambulatory patients presenting for suspected CAD and meeting HFpEF screening criteria face elevated risks for rehospitalizations over six years. Regardless of concomitant diagnoses, quantifying cardiac damage with the H2FPEF score helps in risk-stratifying patients for HF hospitalization and mortality

Is endosonography an effective method for detection and local staging of the ampullary carcinoma? A prospective study

<p>Abstract</p> <p>Background</p> <p>The relatively rare carcinoma of the ampulla of Vater is a neoplasia with a good prognosis compared to pancreatic cancer. Preoperative staging is important in planning the most suitable surgical intervention.</p> <p>Aim</p> <p>To prospectively evaluate the diagnostic accuracy of Endoscopic Ultrasonography (EUS) in comparison with conventional US and CT scan, in staging of patients with ampullary carcinoma.</p> <p>Patients and Methods</p> <p>20 patients (7 women and 13 men) with histologically proven carcinoma of the ampulla of Vater were assessed by EUS, CT scan and US. Results were compared to surgical findings.</p> <p>Results</p> <p>Endoscopic biopsies were diagnostic in 76% of the patients. Detection of ampullary cancer with US and CT scan was 15% and 20% respectively. Only indirect signs of the disease were identified in the majority of cases using these methods. Overall accuracy of EUS in detection of ampullary tumours was 100%. The EUS was significantly (p < 0.001) superior than US and CT scan in ampullary carcinoma detection. Tumour size, tumour extension and the existence of metastatic lymph nodes were also identified and EUS proved to be very useful for the preoperative classification both for the T and the N components of the TNM staging of this neoplasia. The diagnostic accuracy for tumour extension (T) was 82% and for detection of metastatic lymph nodes (N) was 71%.</p> <p>Conclusion</p> <p>EUS is more accurate in detecting ampullary cancer than US and CT scan. Tumor extension and locally metastatic lymph nodes are more accurately assessed by means of EUS than with other imaging methods.</p