The Antiviral Effects of Embelin on HSV-1 in Cultured Vero Cells

Herpes simplex virus type 1 (HSV-1) is a linear double stranded DNA virus that is responsible for one of the most common sexually transmitted diseases within the United States. However, treatment drugs for HSV-1 could be costly and may have side effects. In recent years the number of cases of drug resistant HSV-1 has increased, resulting in interest for novel treatments. This study aimed to investigate the antiviral effects of the reagent Embelin on HSV-1 infection in cultured Vero Cells. Embelin is a benzoquinone isolated from the plant Embelia ribes. Cell viability and cell proliferation assays were conducted to determine the maximum noncytotoxic concentration of Embelin. Additional assays were conducted to measure cell proliferation and antiviral effect. The results of this study suggest that Embelin indeed inhibits HSV-1 with best viral inhibition between 50 μM and 54 μM. Also, Embelin seems to be most effective at inhibiting the virus at the binding stage of the viral cycle

Effects of Attention-Deficit/Hyperactivity Disorder on Patients Undergoing Percutaneous Coronary Intervention Procedure: Insights from the National Inpatient Sample

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that can affect children and adults and is characterized by deficits in attention, self-regulation, and executive functioning. Symptoms can seriously affect daily functioning and may present as hyperactivity, inattentive behaviors, or a combination of both. There are data to suggest patients with ADHD suffer from increased rates of cardiovascular disease, however not much is known specifically regarding the relationship between ADHD and undergoing Percutaneous Coronary Intervention. We sought to examine this relationship in greater detail by perusing the national inpatient sample database to describe in-hospital trends and outcomes among these patients. Methods: Data were extracted from the National Inpatient Sample (NIS) Database for the years 2019 and 2020. The NIS was searched for hospitalizations of adult patients who underwent Percutaneous Coronary Intervention. Out of this Cohort, ADHD patients were identified. Multivariate logistic was used to adjust for confounders. Results: This study included 181,944 patients who underwent PCI procedure, of which 518 (0.3%) patients were diagnosed with ADHD. ADHD patients who underwent a PCI procedure had higher prevalence of hypertension (40.1%% Vs 35.7%% p Conclusion: In this nationally representative population‐based retrospective cohort study, ADHD was associated with worse outcomes including developing arrhythmia, acute kidney injury and congestive heart failure exacerbation among patients who underwent PCI. We did not find any statistical difference between the two groups when it came to mortality, length of stay and total hospital charges. This is most likely due to the small sample size of patients with ADHD undergoing PCI. More research is needed in this area

Infective Endocarditis Secondary to Needle Embolization to The Heart

Needle embolisms in the heart are very rare, even though the number of intravenous drug users (IVDUs) has increased over the past 10 years.Due to varied symptomology-chest pain, dyspnoea, fever, or asymptomatic, this remains a complex and likely underdiagnosed condition. We describe a 31-year-old female with past medical history of IV drug use who presented to the emergency room with heart palpitations and described it as her “heart feels funny” and shortness of breath. She acknowledged intravenous (IV) heroin use and stated that the last time to use IV drugs was 2 days before coming to the hospital. To our knowledge, this is the first case to describe a patient that comes in with chief complaint of heart palpitations and after that to be found to have a needle in her heart. Clinicians should be aware of these rare presentations to aid with proper treatment and management. Although further studies are warranted, we propose here that putting needle embolization in your differential diagnosis in patients with intravenous drug abuse who present with infective endocarditis

Effects of NSTEMI on Patients with Eating Disorders: Insights from the National Inpatient Sample

Introduction: Eating disorders (ED) such as bulimia and anorexia nervosa have detrimental implications on the health and wellbeing of children and young adults across the country. Cardiovascular implications are known to accompany these conditions, however there is a paucity of data looking specifically on the effects of NSTEMI on patients with these disorders. We sought to analyze this relationship further by examining these disorders within the national inpatient sample database to describe in-hospital trends and outcomes among those patients. Methods: Data were extracted from the National Inpatient Sample (NIS) Database for the years 2019 and 2020. The NIS was searched for hospitalizations of adult patients with eating disorder(s) with and without a concomitant diagnosis of NSTEMI using international classification of diseases-10th revision codes. Multivariate logistic was used to adjust for confounders. The primary outcome was inpatient mortality. Secondary outcomes were hospital length of stay (LOS), and total hospital charges (TOTHCG). SPSS software was used for statistical analysis. Results: This study included 16,889 patients who were diagnosed with eating disorders, of which only 56 (0.3%) patients were diagnosed with NSTEMI. ED patients with NSTEMI had higher prevalence of hypertension, diabetes mellitus and chronic kidney disease but not statistically different compared to patients with ED only. Multivariate regression showed that patients with both ED and NSTEMI had higher inpatient mortality compared to those with ED alone (OR 1.013, CI 1.011-1.015, p Conclusion: In this nationally representative population‐based retrospective cohort study, we concluded that ED patients hospitalized with NSTEMI have increased in-hospital mortality and worse outcomes. More research is needed in this area

Memórias da Infância e da Educação: abordagens eliasianas sobre as mulheres

Relações sociais entre indivíduos estão pautadas pela experiência de educação e formação que cada um traz consigo ao longo da vida, pelo modo como se constituem individual e coletivamente. A partir de Elias e da metodologia da história oral, o objetivo foi buscar nas memórias de infância de sete mulheres, professoras de crianças, nascidas entre 1950 e 1970, a formação e a educação que se constituiu na infância em espaços privados e domésticos. Apreendeu-se que a escolha profissional tem vínculos com a educação feminina, normatizada por regras de controle e civilidade

Carcinoma de células escamosas em bovinos, ovinos e eqüinos: estudo de 50 casos no sul do Rio Grande do Sul

Squamous cell carcinoma is a malignant tumour of keratinocytes. There are several factors associated with the development of squamous cell carcinoma, including prolonged exposure to ultraviolet light, lack of a pigmented skin, lack of hair or a very sparse hair coat at the affected sites. A retrospective study of squamous cell carcinoma from 1978 to 2002 in farm animals was made. The samples were obtained at the Regional Diagnostic Laboratory of the Veterinary School in Pelotas, Southern Brazil. The distribution of the neoplasm among the species was as follows: 30 in cattle, 7 in sheep and 13 in horses. Epidemiological data as breed, sex, age, and anatomical location of the tumors were statistically analyzed. The histological classification of the tumors graded from well differentiated to poorly differentiated. A multifactorial etiology of squamous cell carcinoma in farm animals is suggested although more retrospective and prospective studies are needed, to determine the role of each factor in the pathogenesis of the neoplasm.O carcinoma de células escamosas (CCE) é um tumor maligno dos queratinócitos. O desenvolvimento desse tipo de tumor está associado a muitos fatores, incluindo a exposição prolongada à luz ultravioleta, falta de pigmento na epiderme, perda de pêlos ou cobertura de pêlos muito esparsa nos locais afetados. Realizou-se um estudo retrospectivo dos casos de carcinoma de células escamosas em animais de produção (bovinos, ovinos e eqüinos) de 1978 a 2002. O material foi obtido nos arquivos do Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas. Os 50 tumores do tipo carcinoma de células escamosas estavam distribuídos nas diferentes espécies (bovina: 30; ovina: sete e eqüina: 13). Dados como raça, sexo, idade e localização corpórea, dentro de cada espécie, foram tabulados. Classificaram-se os tumores segundo seu grau de malignidade em bem diferenciados a pobremente diferenciados, através de avaliação histológica. A etiologia multifatorial dos cce em animais de produção requer mais estudos retrospectivos e prospectivos, para determinar o papel de cada fator na patogênese desse neoplasma

Playmancer project: a serious videogame as an additional therapy tool for eating and impulse control disorders

Reviews and few non-controlled studies showed the effectiveness of several specific designed computer video-games as an additional form of treatment in several areas. However, there is a lack in the literature of specially designed serious-games for treating mental disorders. Playmancer (ICT European initiative) aims to develop and assess a serious videogame that may help to treat underlying processes (e.g. lack of self-control strategies) in Eating and Impulse control disorders. Preliminary data will be shown

Nitric oxide production in the exhaled air of patients with pulmonary tuberculosis in relation to HIV co-infection

<p>Abstract</p> <p>Background</p> <p>Nitric oxide (NO) is essential for host defense in rodents, but the role of NO during tuberculosis (TB) in man remains controversial. However, earlier observations that arginine supplementation facilitates anti-TB treatment, supports the hypothesis that NO is important in the host defense against TB. Local production of NO measured in fractional exhaled air (FeNO) in TB patients with and without HIV co-infection has not been reported previously. Thus, our aim was to investigate levels of FeNO in relation to clinical symptoms and urinary NO metabolites (uNO).</p> <p>Methods</p> <p>In a cross sectional study, FeNO and uNO were measured and clinical symptoms, chest x-ray, together with serum levels of arginine, tumor necrosis factor alpha (TNF-alpha) and interleukin 12 (IL-12) were evaluated in sputum smear positive TB patients (HIV+/TB, n = 36, HIV-/TB, n = 59), their household contacts (n = 17) and blood donors (n = 46) from Gondar University Hospital, Ethiopia.</p> <p>Results</p> <p>The proportion of HIV-/TB patients with an increased FeNO level (> 25 ppb) was significantly higher as compared to HIV+/TB patients, but HIV+/TB patients had significantly higher uNO than HIV-/TB patients. HIV+ and HIV-/TB patients both had lower levels of FeNO compared to blood donors and household contacts. The highest levels of both uNO and FeNO were found in household contacts. Less advanced findings on chest x-ray, as well as higher sedimentation rate were observed in HIV+/TB patients as compared to HIV-/TB patients. However, no significant correlation was found between FeNO and uNO, chest x-ray grading, clinical symptoms, TNF-alpha, IL-12, arginine levels or sedimentation rate.</p> <p>Conclusion</p> <p>In both HIV negative and HIV co infected TB patients, low levels of exhaled NO compared to blood donors and household were observed. Future studies are needed to confirm whether low levels of exhaled NO could be a risk factor in acquiring TB and the relative importance of NO in human TB.</p

Rotatividade de profissionais da saúde nos hospitais públicos e privados da Paraíba antes e durante a pandemia da COVID-19

O objetivo deste estudo foi analisar os efeitos da pandemia da COVID-19 na rotatividade dos profissionais da saúde na Paraíba. Em uma primeira etapa foram calculados os índices de rotatividade dos hospitais públicos e privados no geral e desagrupados por análises para as mesorregiões paraibanas, por carga horária semanal, categoria de profissional, vínculos trabalhistas e porte dos hospitais. Adicionalmente, foi estimado como essas características influenciam na rotatividade individual desses profissionais. Para isso, utilizou-se um modelo logit hierárquico contendo três níveis: o primeiro para os indivíduos, o segundo para os hospitais e o terceiro para os municípios. Os resultados indicam que a pandemia provocada pelo novo Coronavírus, além de ter resultado em um aumento no número de profissionais da saúde nos hospitais da Paraíba, reduziu os índices de rotatividade desses trabalhadores em 2020. Contudo, em 2021, os índices de rotatividade tenderam a retornar aos níveis dos anos pré-pandemia

Structural and optical analyses of GaP/Si and (GaAsPN/GaPN)/GaP/Si nanolayers for integrated photonics on silicon

International audienceWe report a structural study of molecular beam epitaxy-grown lattice-matched GaP/Si(0 0 1) thin layers with an emphasis on the interfacial structural properties, and optical studies of GaAsP(N)/GaP(N) quantum wells coherently grown onto the GaP/Si pseudo substrates, through a complementary set of characterization tools. Room temperature photoluminescence at 780 nm from the (GaAsPN/GaPN) quantum wells grown onto a silicon substrate is reported. Despite this good property, the time-resolved photoluminescence measurements demonstrate a clear influence of non-radiative defects initiated at the GaP/Si interface. It is shown from simulations, how x-ray diffraction can be used efficiently for analysis of antiphase domains. Then, qualitative and quantitative analyses of antiphase domains, micro-twins, and stacking faults are reported using complementarity of the local transmission electron microscopy and the statistical x-ray diffraction approaches