Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body

Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been amatter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) display a remarkable plasticity during development. Whether adult populations of NCSCs retain this plasticity is largely unknown. Herein, we describe that neural-crest-derived adult carotid body stem cells (CBSCs) are able to undergo endothelial differentiation in addition to their reported role in neurogenesis, contributing to both neurogenic and angiogenic processes taking place in the organ during acclimatization to hypoxia. Moreover, CBSC conversion into vascular cell types is hypoxia inducible factor (HIF) dependent and sensitive to hypoxiareleased vascular cytokines such as erythropoietin. Our data highlight a remarkable physiological plasticity in an adult population of tissue-specific stem cells and could have impact on the use of these cells for cell therapy.ERC Starting Grant: CBSCsMinisterio de Economía y Competitividad SAF2013-48535-P and SAF2016-80412-

Reflexones sobre la marcación preposicional del OD n'asturianu. Dellos datos medievales

La función d’oxetu directu (OD)n’asturianu pue ser preposicional o non (traxi a la mio amiga / traxi la mio filoxa). Alternancies asemeyaes danse n’otres munches variedaes romániques, la mayoría d’elles na Península ibérica y nel centru-sur de la Península italiana. Nesti trabayu faise un repasu de les principales cuestiones que cinquen la marcación selectiva del od na romania (orixe históricu, estensión xeográfica, marques formales, factores qu’influyen nella) pa entrar dempués na mecánica del fenómenu nel casu concretu asturianu, tema que ta bien poco estudiáu non solamente a nivel sincrónicu sinón tamién diacrónicu. Como contribución a la perspeutiva histórica, faise una comparanza ente la situación moderna y la de los sieglos xiiixv, al tenor de lo qu’amuesa un centenar aproximáu de documentos notariales del centru-occidente asturianuThe function of the Direct Object (DO) in Asturian can be prepositional or not (traxi a la mio amiga / traxi la mio filoxa). Alternations like these also appear in many other varieties of Romance languages, most of them in the Iberian Peninsula and also in the South-Central area of the Italian Peninsula. This paper gives an overview of the main themes related to the selective marking of the DO in the Romance languages (its historical origin, geographical extension, formal marks and factors that may influence them) and it also deals with the case of the Asturian Language in concrete, which has not been enough studied sufficiently neither in the synchronic aspect nor in the diachronic one. As a kind of contribution to the historical point of view, a comparison between the current situation and the situation in the 13th-15th Century is made according to what about a hundred of legal documents from the central-west area of Asturies sho

Towards the Design of a Textile Chemical Ontology

The main goal of this paper is to present the initial version of a Textile Chemical Ontology, to be used by textile professionals with the purpose of conceptualising and representing the banned and harmful chemical substances that are forbidden in this domain. After analysing different methodologies and determining that “Methontology” is the most appropriate for the purposes, this methodology is explored and applied to the domain. In this manner, an initial set of concepts are defined, together with their hierarchy and the relationships between them. This paper shows the benefits of using the ontology through a real use case in the context of Information Retrieval. The potentiality of the proposed ontology in this preliminary evaluation encourages extending the ontology with a higher number of concepts and relationships, and validating it within other Natural Language Processing applications.This research is partially funded by the European Commission under the Seventh (FP7 - 2007- 2013) Framework Programme for Research and Technological Development through the FIRST project (FP7-287607). Moreover, it has been partially funded by the Spanish Government through the Spanish Government through the projects “Análisis de Tendencias Mediante Técnicas de Opinión Semántica” (TIN2012-38536-C03-03) and “Técnicas de Deconstrucción en las Tecnologías del Lenguaje Humano” (TIN2012-31224) and by the Generalitat Valenciana (project grant ACOMP/2013/067)

Synthesis of Enantiopure Oxygen- and Nitrogen-Containing Heterocycles by Diastereoselective Ring-Closing Metathesis Reaction in Perhydro-1,3-benzoxazine Derivatives

Producción CientíficaDiastereoselective ring‐closing metathesis reactions on chiral trienic perhydro‐1,3‐benzoxazines derived from (−)‐8‐aminomenthol featuring two diastereotopic olefin chains is described. The diastereochemical outcome of the cyclization appeared to be dependent on the length and position of the olefin chains in perhydro‐1,3‐benzoxazine, the degree of substitution of the double bonds and the ruthenium catalyst used. After separation of the diastereomers, and removal of the chiral auxiliary, enantiopure oxygen‐ and nitrogen‐containing heterocycles were obtained.Ministerio de Economía, Industria y Competitividad (Project FEDER-CTQ2014-59870-P)Junta de Castilla y León (Ref. Project FEDER-VA115P17

Exploring Quality Teaching in the Online Environment Using an Evidence-Based Approach

Online learning is increasingly ubiquitous in higher education. However, research regarding online teaching often focuses on the affordances of the online environment rather than on the quality of pedagogy. In this paper we consider how online learning could be enhanced using rich pedagogical models that are consistent with a wealth of existing knowledge on pedagogy for face-to-face settings. To do so, we apply an established framework, the Quality Teaching model, to explore pedagogy in the online environment and illustrate its potential benefits using a case study of 60 students in a tertiary mathematics teacher education program. We conclude that the use of an evidence-based pedagogical model can help guide online instructors in the development of high quality online course

The Application of LiDAR Data for the Solar Potential Analysis Based on Urban 3D Model

Solar maps are becoming a popular resource and are available via the web to help plan investments for the benefits of renewable energy. These maps are especially useful when the results have high accuracy. LiDAR technology currently offers high-resolution data sources that are very suitable for obtaining an urban 3D geometry with high precision. Three-dimensional visualization also offers a more accurate and intuitive perspective of reality than 2D maps. This paper presents a new method for the calculation and visualization of the solar potential of building roofs on an urban 3D model, based on LiDAR data. The paper describes the proposed methodology to (1) calculate the solar potential, (2) generate an urban 3D model, (3) semantize the urban 3D model with different existing and calculated data, and (4) visualize the urban 3D model in a 3D web environment. The urban 3D model is based on the CityGML standard, which offers the ability to consistently combine geometry and semantics and enable the integration of different levels (building and city) in a continuous model. The paper presents the workflow and results of application to the city of Vitoria-Gasteiz in Spain. This paper also shows the potential use of LiDAR data in different domains that can be connected using different technologies and different scales.The European Union’s Horizon 2020 research and innovation program under grant agreement No 691883, SMARTENCITY supported and funded this study

Evidence of the presence of nucleic acids and β-glucan in the matrix of non-typeable Haemophilus influenzae in vitro biofilms

13 p.-9 fig.Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative bacterium that frequently colonizes the human nasopharynx; it is a common cause of chronic and recurrent otitis media in children and of exacerbations of chronic obstructive pulmonary disease. To date, no exopolysaccharide clearly contributing to NTHi biofilms has been identified. Consequently, there is some debate as to whether NTHi forms biofilms during colonization and infection. The present work shows that NTHi can form biofilms in vitro, producing an extracellular matrix composed of proteins, nucleic acids, and a β-glucan. Extracellular DNA, visualized by immunostaining and using fluorochromes, is an important component of this matrix and appears to be essential in biofilm maintenance. Extracellular RNA appears to be required only in the first steps of biofilm formation. Evidence of a matrix polysaccharide was obtained by staining with Calcofluor white M2R and by disaggregating biofilms with cellulase. Using strain 54997, residues of Glcp(1→4) in the NTHi biofilm were confirmed by gas-liquid chromatography-mass spectrometry. Evidence that N-acetyl-L-cysteine shows notable killing activity towards in vitro NTHi biofilm-forming bacteria is also provided.This work was supported by a grant from the Ministerio de Economía y Competitividad (SAF2012-39444-C02-01). The CIBER de Enfermedades Respiratorias (CIBERES) is an initiative of the Instituto de Salud Carlos III.Peer reviewe

El delito de administración desleal y su delimitación con el delito de apropiación indebida del Art. 252 CP

Treballs Finals de Grau de Dret. Universitat de Barcelona. Curs: 2014-2015. Tutor: José-Ignacio Gallego Sole