Design considerations for table-top, laser-based VUV and X-ray free electron lasers

A recent breakthrough in laser-plasma accelerators, based upon ultrashort high-intensity lasers, demonstrated the generation of quasi-monoenergetic GeV-electrons. With future Petawatt lasers ultra-high beam currents of ~100 kA in ~10 fs can be expected, allowing for drastic reduction in the undulator length of free-electron-lasers (FELs). We present a discussion of the key aspects of a table-top FEL design, including energy loss and chirps induced by space-charge and wakefields. These effects become important for an optimized table-top FEL operation. A first proof-of-principle VUV case is considered as well as a table-top X-ray-FEL which may open a brilliant light source also for new ways in clinical diagnostics.Comment: 6 pages, 4 figures; accepted for publication in Appl. Phys.

Neuron splitting in compute-bound parallel network simulations enables runtime scaling with twice as many processors

Neuron tree topology equations can be split into two subtrees and solved on different processors with no change in accuracy, stability, or computational effort; communication costs involve only sending and receiving two double precision values by each subtree at each time step. Splitting cells is useful in attaining load balance in neural network simulations, especially when there is a wide range of cell sizes and the number of cells is about the same as the number of processors. For compute-bound simulations load balance results in almost ideal runtime scaling. Application of the cell splitting method to two published network models exhibits good runtime scaling on twice as many processors as could be effectively used with whole-cell balancing

Detrended fluctuation analysis as a statistical tool to monitor the climate

Detrended fluctuation analysis is used to investigate power law relationship between the monthly averages of the maximum daily temperatures for different locations in the western US. On the map created by the power law exponents, we can distinguish different geographical regions with different power law exponents. When the power law exponents obtained from the detrended fluctuation analysis are plotted versus the standard deviation of the temperature fluctuations, we observe different data points belonging to the different climates, hence indicating that by observing the long-time trends in the fluctuations of temperature we can distinguish between different climates.Comment: 8 pages, 4 figures, submitted to JSTA

Soft X-Ray Projection Lithography Using a 1-1 Ring Field Optical-System

An iridium-coated Offner 1:1 ring field camera has been used to carry out projection lithography using 42 nm light from an undulator in the vacuum ultra violet storage ring at Brookhaven National Laboratory. Near-diffraction-limited resolution has been obtained showing features as small as 0.2-mu-m within a 2 mm x 0.25 mm image field. Images of both transmission and reflection masks have been obtained. The impact of source coherence on imagery has been investigated. Hydrocarbon contamination problems experienced in this photon energy range have been investigated and possible solutions are suggested

CLASH: z ~ 6 young galaxy candidate quintuply lensed by the frontier field cluster RXC J2248.7-4431

We present a quintuply lensed z ~ 6 candidate discovered in the field of the galaxy cluster RXC J2248.7-4431 (z ~ 0.348) targeted within the Cluster Lensing and Supernova survey with Hubble (CLASH) and selected in the deep HST Frontier Fields survey. Thanks to the CLASH 16-band HST imaging, we identify the quintuply lensed z ~ 6 candidate as an optical dropout in the inner region of the cluster, the brightest image having magAB=24.81+-0.02 in the f105w filter. We perform a detailed photometric analysis to verify its high-z and lensed nature. We get as photometric redshift z_phot ~ 5.9, and given the extended nature and NIR colours of the lensed images, we rule out low-z early type and galactic star contaminants. We perform a strong lensing analysis of the cluster, using 13 families of multiple lensed images identified in the HST images. Our final best model predicts the high-z quintuply lensed system with a position accuracy of 0.8''. The magnifications of the five images are between 2.2 and 8.3, which leads to a delensed UV luminosity of L_1600 ~ 0.5L*_1600 at z=6. We also estimate the UV slope from the observed NIR colours, finding a steep beta=-2.89+-0.38. We use singular and composite stellar population SEDs to fit the photometry of the hiz candidate, and we conclude that it is a young (age <300 Myr) galaxy with mass of M ~ 10^8Msol, subsolar metallicity (Z<0.2Zsol) and low dust content (AV ~ 0.2-0.4).Comment: 21 pages, 13 figures, 6 tables, submitted to MNRAS on 11 Aug 2013, accepted on 23 Nov 201

CLASH: New Multiple-Images Constraining the Inner Mass Profile of MACS J1206.2-0847

We present a strong-lensing analysis of the galaxy cluster MACS J1206.2-0847 ($z$=0.44) using UV, Optical, and IR, HST/ACS/WFC3 data taken as part of the CLASH multi-cycle treasury program, with VLT/VIMOS spectroscopy for some of the multiply-lensed arcs. The CLASH observations, combined with our mass-model, allow us to identify 47 new multiply-lensed images of 12 distant sources. These images, along with the previously known arc, span the redshift range 1\la z\la5.5, and thus enable us to derive a detailed mass distribution and to accurately constrain, for the first time, the inner mass-profile of this cluster. We find an inner profile slope of $d\log \Sigma/d\log \theta\simeq -0.55\pm 0.1$ (in the range [1\arcsec, 53\arcsec], or 5\la r \la300 kpc), as commonly found for relaxed and well-concentrated clusters. Using the many systems uncovered here we derive credible critical curves and Einstein radii for different source redshifts. For a source at $z_{s}\simeq2.5$, the critical curve encloses a large area with an effective Einstein radius of \theta_{E}=28\pm3\arcsec, and a projected mass of $1.34\pm0.15\times10^{14} M_{\odot}$. From the current understanding of structure formation in concordance cosmology, these values are relatively high for clusters at $z\sim0.5$, so that detailed studies of the inner mass distribution of clusters such as MACS J1206.2-0847 can provide stringent tests of the $\Lambda$CDM paradigm.Comment: 7 pages, 1 table, 4 figures; submitted to ApJ Letters; V3: minor correction

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo

This is the final published versionAvailable from Ivyspring International Publisher via the DOI in this recordInvasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of hematological malignancy and bone marrow transplant patients caused by the ubiquitous environmental fungus Aspergillus fumigatus. Current diagnostic tests for the disease lack sensitivity as well as specificity, and culture of the fungus from invasive lung biopsy, considered the gold standard for IPA detection, is slow and often not possible in critically ill patients. In a previous study, we reported the development of a novel non-invasive procedure for IPA diagnosis based on antibody-guided positron emission tomography and magnetic resonance imaging (immunoPET/MRI) using a [64Cu]DOTA-labeled mouse monoclonal antibody (mAb), mJF5, specific to Aspergillus. To enable translation of the tracer to the clinical setting, we report here the development of a humanised version of the antibody (hJF5), and pre-clinical imaging of lung infection using a [64Cu]NODAGA-hJF5 tracer. The humanised antibody tracer shows a significant increase in in vivo biodistribution in A. fumigatus infected lungs compared to its radiolabeled murine counterpart [64Cu]NODAGA-mJF5. Using reverse genetics of the pathogen, we show that the antibody binds to the antigenic determinant 1,5-galactofuranose (Galf) present in a diagnostic mannoprotein antigen released by the pathogen during invasive growth in the lung. The absence of the epitope Galf in mammalian carbohydrates, coupled with the enhanced imaging capabilities of the hJF5 antibody, means that the [64Cu]NODAGA-hJF5 tracer developed here represents an ideal candidate for the diagnosis of IPA and translation to the clinical setting.This work was supported by the European Union Seventh Framework Programme FP7/2007-2013 under Grant 602820, the Deutsche Forschungsgemeinschaft (Grant WI3777/1-2 to SW), and the Werner Siemens Foundation. We thank Sven Krappman for use of the A. fumigatustdTomato strain, and acknowledge the Imaging Centre Essen (IMCES) for assistance with optical imaging of lungs

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

Tight binding of Gdown1 represses RNA polymerase II (Pol II) function in a manner that is reversed by Mediator, but the structural basis of these processes is unclear. Although Gdown1 is intrinsically disordered, its Pol II interacting domains were localized and shown to occlude transcription factor IIF (TFIIF) and transcription factor IIB (TFIIB) binding by perfect positioning on their Pol II interaction sites. Robust binding of Gdown1 to Pol II is established by cooperative interactions of a strong Pol II binding region and two weaker binding modulatory regions, thus providing a mechanism both for tight Pol II binding and transcription inhibition and for its reversal. In support of a physiological function for Gdown1 in transcription repression, Gdown1 co-localizes with Pol II in transcriptionally silent nuclei of early Drosophila embryos but re-localizes to the cytoplasm during zygotic genome activation. Our study reveals a self-inactivation through Gdown1 binding as a unique mode of repression in Pol II function