Exactly Marginal Deformations and their Supergravity Duals

We study the space of supersymmetric AdS$_5$ solutions of type IIB supergravity corresponding to the conformal manifold of the dual $\mathcal{N}=1$ conformal field theory. We show that the background geometry naturally encodes a generalised holomorphic structure, dual to the superpotential of the field theory, with the existence of the full solution following from a continuity argument. In particular, this provides a solution to the long-standing problem of finding the gravity dual of the generic $\mathcal{N}=1$ deformations of $\mathcal{N}=4$ conformal field theory. Using this formalism, we derive a new result for the Hilbert series of the deformed field theories.Comment: 5 page

A measurement of the millimetre emission and the Sunyaev-Zel'dovich effect associated with low-frequency radio sources

We present a statistical analysis of the millimetre-wavelength properties of 1.4GHz-selected sources and a detection of the Sunyaev–Zel’dovich (SZ) effect associated with the haloes that host them. We stack data at 148, 218 and 277GHz from the Atacama Cosmology Telescope at the positions of a large sample of radio AGN selected at 1.4GHz. The thermal SZ effect associated with the haloes that host the AGN is detected at the 5σ level through its spectral signature, representing a statistical detection of the SZ effect in some of the lowest mass haloes (average M 200 ≈ 10 13 M. h −1 70 ) studied to date. The relation between the SZ effect and mass (based on weak lensing measurements of radio galaxies) is consistent with that measured by Planck for local bright galaxies. In the context of galaxy evolution models, this study confirms that galaxies with radio AGN also typically support hot gaseous haloes. Adding Herschel observations allows us to show that the SZ signal is not significantly contaminated by dust emission. Finally, we analyse the contribution of radio sources to the angular power spectrum of the cosmic microwave background

Vector-borne and other pathogens of potential relevance disseminated by relocated cats

© 2022. The Author(s).Large populations of unowned cats constitute an animal welfare, ecological, societal and public health issue worldwide. Their relocation and homing are currently carried out in many parts of the world with the intention of relieving suffering and social problems, while contributing to ethical and humane population control in these cat populations. An understanding of an individual cat's lifestyle and disease status by veterinary team professionals and those working with cat charities can help to prevent severe cat stress and the spread of feline pathogens, especially vector-borne pathogens, which can be overlooked in cats. In this article, we discuss the issue of relocation and homing of unowned cats from a global perspective. We also review zoonotic and non-zoonotic infectious agents of cats and give a list of practical recommendations for veterinary team professionals dealing with homing cats. Finally, we present a consensus statement consolidated at the 15th Symposium of the Companion Vector-Borne Diseases (CVBD) World Forum in 2020, ultimately to help veterinary team professionals understand the problem and the role they have in helping to prevent and manage vector-borne and other pathogens in relocated cats.publishersversionpublishe

A community-based, bionic leg rehabilitation program for patients with chronic stroke: clinical trial protocol

Stroke is a major global health problem whereby many survivors have unmet needs concerning mobility during recovery. As such, the use of robotic assisted devices (i.e., a bionic leg) within a community-setting may be an important adjunct to normal physiotherapy in chronic stroke survivors. This study will be a dual-centre, randomized, parallel group clinical trial to investigate the impact of a community based, training program using a bionic leg on biomechanical, cardiovascular and functional outcomes in stroke survivors. Following a baseline assessment which will assess gait, postural sway, vascular health (blood pressure, arterial stiffness) and functional outcomes (6-minute walk), participants will be randomized to a 10-week program group, incorporating either: i) physiotherapy plus community-based bionic leg training program, ii) physiotherapy only, or iii) usual care control. The training program will involve participants engaging in a minimum of 1 hour per day of bionic leg activities at home. Follow up assessment, identical to baseline, will occur after 10-weeks, 3 and 12 months post intervention. Given the practical implications of the study, the clinical significance of using the bionic leg will be assessed for each outcome variable. The potential improvements in gait, balance, vascular health and functional status may have a meaningful impact on patients’ quality of life. The integration of robotic devices within home-based rehabilitation programs may prove to be a cost effective, practical and beneficial resource for stroke survivors

From β\beta to η\eta: a new cohomology for deformed Sasaki-Einstein manifolds

We discuss in detail the different analogues of Dolbeault cohomology groups on Sasaki-Einstein manifolds and prove a new vanishing result for the transverse Dolbeault cohomology groups $H_{\bar\partial}^{(p,0)}(k)$ graded by their charge under the Reeb vector. We then introduce a new cohomology, $\eta$-cohomology, which is defined by a CR structure and a holomorphic function $f$ with non-vanishing $\eta\equiv \mathrm{d}f$. It is the natural cohomology associated to a class of supersymmetric type IIB flux backgrounds that generalise the notion of a Sasaki-Einstein manifold. These geometries are dual to finite deformations of the 4d $\mathcal{N}=1$ SCFTs described by conventional Sasaki-Einstein manifolds. As such, they are associated to Calabi-Yau algebras with a deformed superpotential. We show how to compute the $\eta$-cohomology in terms of the transverse Dolbeault cohomology of the undeformed Sasaki-Einstein space. The gauge-gravity correspondence implies a direct relation between the cyclic homologies of the Calabi-Yau algebra, or equivalently the counting of short multiplets in the deformed SCFT, and the $\eta$-cohomology groups. We verify that this relation is satisfied in the case of S$^5$, and use it to predict the reduced cyclic homology groups in the case of deformations of regular Sasaki-Einstein spaces. The corresponding Calabi-Yau algebras describe non-commutative deformations of $\mathbb{P}^2$, $\mathbb{P}^1\times\mathbb{P}^1$ and the del Pezzo surfaces.Comment: 41 page

Drosophila 3' UTRs are more complex than protein-coding sequences

The 3′ UTRs of eukaryotic genes participate in a variety of post-transcriptional (and some transcriptional) regulatory interactions. Some of these interactions are well characterised, but an undetermined number remain to be discovered. While some regulatory sequences in 3′ UTRs may be conserved over long evolutionary time scales, others may have only ephemeral functional significance as regulatory profiles respond to changing selective pressures. Here we propose a sensitive segmentation methodology for investigating patterns of composition and conservation in 3′ UTRs based on comparison of closely related species. We describe encodings of pairwise and three-way alignments integrating information about conservation, GC content and transition/transversion ratios and apply the method to three closely related Drosophila species: D. melanogaster, D. simulans and D. yakuba. Incorporating multiple data types greatly increased the number of segment classes identified compared to similar methods based on conservation or GC content alone. We propose that the number of segments and number of types of segment identified by the method can be used as proxies for functional complexity. Our main finding is that the number of segments and segment classes identified in 3′ UTRs is greater than in the same length of protein-coding sequence, suggesting greater functional complexity in 3′ UTRs. There is thus a need for sustained and extensive efforts by bioinformaticians to delineate functional elements in this important genomic fraction. C code, data and results are available upon request

changeptGUI software

changeptGUI software used to segment DNA sequences<br

Supplemental_File_S1.bb

Supplementary files for "Genome-wide identification of conserved intronic non-coding sequences using a Bayesian segmentation approach"