Desarrollo de la práctica de farmacia centrada en la atención del paciente y formación Universitaria (II).

En esta segunda parte, y después de haber tratado una visión amplia de la formación universitaria, partiremos de un punto general de la formación del farmacéutico, no solo en el Grado sino en el postgrado, para continuar con algunos aspectos relacionados con la investigación

Desarrollo de la práctica de farmacia centrada en la atención del paciente y formación Universitaria (II).

En esta segunda parte, y después de haber tratado una visión amplia de la formación universitaria, partiremos de un punto general de la formación del farmacéutico, no solo en el Grado sino en el postgrado, para continuar con algunos aspectos relacionados con la investigación

Estudio de viabilidad de mercado para la importación de aceites y lubricantes en Cuenca - Ecuador.

Entrepreneurship, business creation, search for new markets, generation of niches, product innovation, drives the continuous research of their feasibility. The present investigation consists of the realization of the commercial viability for the import of oils and lubricants in Cuenca - Ecuador, within the administration, the formulation of projects and the analyses that arise from the management, are indispensable tools, for which the study includes a mixed analysis generating in the process a synthetic analytical method realized through primary information obtained through a sampling of consumption of oils and lubricants for automotive, that allows to demonstrate the increase of the market of oils and lubricants in the province of Azuay; Also to know the opportunity to enter the market with innovation of brands of automotive lubricants determined by an unsatisfied demand, which will demonstrate the viability of the venture and its success.El emprendimiento, la creación de negocios, búsqueda de nuevos mercados, generación de nichos, innovación en productos, impulsa a la contínua investigación de la factibilidad de los mismos. La presente investigación consta de la realización de la viabilidad comercial para la importación de aceites y lubricantes en Cuenca - Ecuador, dentro de la administración, la formulación de proyectos y los análisis que se desprenden de la gestión, son herramientas indispensables, por lo cual el estudio comprende un análisis mixto generando en el proceso un método analítico sintético realizado a través de información primaria obtenida a través de una muestreo de consumo de aceites y lubricantes para automotor, que permite demostrar el incremento de mercado de aceites y lubricantes en la provincia del Azuay; conocer además la oportunidad de ingresar al mercado con innovación de marcas de lubricantes para automotor determinado por una demanda insatisfecha, lo cual permitirá evidenciar la viabilidad del emprendimiento y su éxito

Sparse approaches for the exact distribution of patterns in long state sequences generated by a Markov source

We present two novel approaches for the computation of the exact distribution of a pattern in a long sequence. Both approaches take into account the sparse structure of the problem and are two-part algorithms. The first approach relies on a partial recursion after a fast computation of the second largest eigenvalue of the transition matrix of a Markov chain embedding. The second approach uses fast Taylor expansions of an exact bivariate rational reconstruction of the distribution. We illustrate the interest of both approaches on a simple toy-example and two biological applications: the transcription factors of the Human Chromosome 5 and the PROSITE signatures of functional motifs in proteins. On these example our methods demonstrate their complementarity and their hability to extend the domain of feasibility for exact computations in pattern problems to a new level

On the Synergistic Catalytic Properties of Bimetallic Mesoporous Materials Containing Aluminum and Zirconium: The Prins Cyclisation of Citronellal

Bimetallic three-dimensional amorphous mesoporous materials, Al-Zr-TUD-1 materials, were synthesised by using a surfactant-free, one-pot procedure employing triethanolamine (TEA) as a complexing reagent. The amount of aluminium and zirconium was varied in order to study the effect of these metals on the Brønsted and Lewis acidity, as well as on the resulting catalytic activity of the material. The materials were characterised by various techniques, including elemental analysis, X-ray diffraction, high-resolution TEM, N2 physisorption, temperature-programmed desorption (TPD) of NH3, and 27Al MAS NMR, XPS and FT-IR spectroscopy using pyridine and CO as probe molecules. Al-Zr-TUD-1 materials are mesoporous with surface areas ranging from 700–900 m2 g−1, an average pore size of around 4 nm and a pore volume of around 0.70 cm3 g−1. The synthesised Al-Zr-TUD-1 materials were tested as catalyst materials in the Lewis acid catalysed Meerwein–Ponndorf–Verley reduction of 4-tert-butylcyclohexanone, the intermolecular Prins synthesis of nopol and in the intramolecular Prins cyclisation of citronellal. Although Al-Zr-TUD-1 catalysts possess a lower amount of acid sites than their monometallic counterparts, according to TPD of NH3, these materials outperformed those of the monometallic Al-TUD-1 as well as Zr-TUD-1 in the Prins cyclisation of citronellal. This proves the existence of synergistic properties of Al-Zr-TUD-1. Due to the intramolecular nature of the Prins cyclisation of citronellal, the hydrophilic surface of the catalyst as well as the presence of both Brønsted and Lewis acid sites synergy could be obtained with bimetallic Al-Zr-TUD-1. Besides spectroscopic investigation of the active sites of the catalyst material a thorough testing of the catalyst in different types of reactions is crucial in identifying its specific active sites

Serrparñatsoxhno : Historias y relatos - Yanesha - Inicial

Los relatos son historias propias de cada pueblo contadas por los abuelos y abuelas, las cuales recogen sucesos y acontecimientos que visibilizan la cosmovisión de las culturas. Pueden ser leídos por la profesora, profesor o algún invitado. Este material está dirigido para el II ciclo de educación inicial EIB. Tienen como propósito el apoyo en la profundización de los saberes de los pueblos originarios. Ayuda al desarrollo de las competencias comunicativas. Motiva a la o el docente a crear múltiples situaciones de aprendizaje y organizar el aula con materiales escritos en la lengua de las niñas y niños, que le serán muy útiles para el acercamiento al mundo escrito y fortalecimiento de su identidad cultural

Yeñóchepa´ch párro mothtá : cuaderno de trabajo y folder - inicial 4 años - Yanesha

Contiene actividades que apoyan el desarrollo de competencias de las áreas curriculares a partir de situaciones de aprendizaje vinculados a las actividades del calendario socio-productivo de la comunidad, usando la lengua materna de los estudiantes como instrumento de aprendizaje y mejora la relación asertiva

Morreñtsorrom : cancionero - Yanesha Inicial

El cancionero es una recopilación de canciones tradicionales y de canciones creadas para niñas y niños en la lengua originaria, a través de las cuales trasmiten mensajes, emociones, sensaciones y estados de ánimos. Estas canciones, pueden ser acompañadas por instrumentos musicales de su cultura u otros elaborados con el apoyo de tu familia

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

Paneth cells are key epithelial cells providing an antimicrobial barrier and maintaining integrity of the small intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and often associated with digestive pathologies such as Crohn's disease or infections. Similar alterations are observed in individuals with impaired autophagy, a process which recycles cellular components. The direct effect of autophagy-impairment on Paneth cells has not been analysed. To investigate this, we generated a mouse model lacking Atg16l1 specifically in intestinal epithelial cells making these cells impaired in autophagy. Using 3D intestinal organoids enriched for Paneth cells, we compared the proteomic profiles of wild-type (WT) and autophagy-impaired organoids. We used an integrated computational approach combining protein-protein interaction networks, autophagy targeted proteins and functional information to identify the mechanistic link between autophagy-impairment and disrupted pathways. Of the 284 altered proteins, 198 (70%) were more abundant in autophagy-impaired organoids, suggesting reduced protein degradation. Interestingly, these differentially abundant proteins comprised 116 proteins (41%), predicted targets of the selective autophagy proteins p62, LC3 and ATG16L1. Our integrative analysis revealed autophagy-mediated mechanisms degrading proteins key to Paneth cell functions, such as exocytosis, apoptosis and DNA damage repair. Transcriptomic profiling of additional organoids confirmed that 90% of the observed changes upon autophagy alteration affect protein level and not gene expression. We performed further validation experiments showing differential lysozyme secretion, confirming our computationally inferred down-regulation of exocytosis. Our observations could explain how protein level alterations affect Paneth cell homeostatic functions upon autophagy impairment