Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity

Planet Populations as a Function of Stellar Properties

Exoplanets around different types of stars provide a window into the diverse environments in which planets form. This chapter describes the observed relations between exoplanet populations and stellar properties and how they connect to planet formation in protoplanetary disks. Giant planets occur more frequently around more metal-rich and more massive stars. These findings support the core accretion theory of planet formation, in which the cores of giant planets form more rapidly in more metal-rich and more massive protoplanetary disks. Smaller planets, those with sizes roughly between Earth and Neptune, exhibit different scaling relations with stellar properties. These planets are found around stars with a wide range of metallicities and occur more frequently around lower mass stars. This indicates that planet formation takes place in a wide range of environments, yet it is not clear why planets form more efficiently around low mass stars. Going forward, exoplanet surveys targeting M dwarfs will characterize the exoplanet population around the lowest mass stars. In combination with ongoing stellar characterization, this will help us understand the formation of planets in a large range of environments.Comment: Accepted for Publication in the Handbook of Exoplanet

Habitable Zones in the Universe

Habitability varies dramatically with location and time in the universe. This was recognized centuries ago, but it was only in the last few decades that astronomers began to systematize the study of habitability. The introduction of the concept of the habitable zone was key to progress in this area. The habitable zone concept was first applied to the space around a star, now called the Circumstellar Habitable Zone. Recently, other, vastly broader, habitable zones have been proposed. We review the historical development of the concept of habitable zones and the present state of the research. We also suggest ways to make progress on each of the habitable zones and to unify them into a single concept encompassing the entire universe.Comment: 71 pages, 3 figures, 1 table; to be published in Origins of Life and Evolution of Biospheres; table slightly revise

The Herschel Gould Belt Survey in Chamaeleon II

International audienceContext. We report on the Herschel Gould Belt survey (HGBS) of the Chamaeleon II (Cha II) star-forming region, focusing on the detection of Class I to III young stellar objects (YSOs).Aims. We aim at characterizing the circumstellar material around these YSOs and at understanding which disk parameters are most likely constrained by the new HGBS data, which are expected to be crucial for studying the transition from optically thick disks to evolved debris-type disks.Methods. We recovered 29 of the 63 known YSOs in Cha II with a detection in at least one of the PACS/SPIRE pass-bands: 3 Class I YSOs (i.e.,100%), 1 flat source (i.e., 50%), 21 Class II objects (i.e., 55%), 3 Class III objects (i.e, 16%), and the unclassified far-infrared source IRAS 12522-7640. We explored PACS/SPIRE colors of this sample and modeled their spectral energy distributions (SEDs) from the optical to Herschel’s wavelengths with the RADMC-2D radiative transfer code.Results. We find that YSO colors are typically confined to the following ranges: −0.7 ≲ log (F70/F160) ≲ 0.5, −0.5 ≲ log (F160/F250) ≲ 0.6, 0.05 ≲ log (F250/F350) ≲ 0.25 and −0.1 ≲ log (F350/F500) ≲ 0.5. These color ranges are expected to be only marginally contaminated by extragalactic sources and field stars and, hence, provide a useful YSO selection tool when applied together. We were able to model the SED of 26 of the 29 detected YSOs. We discuss the degeneracy/limitations of our SED fitting results and adopted the Bayesian method to estimate the probability of different values for the derived disk parameters. The Cha II YSOs present typical disk inner radii  ≲0.1 AU, as previously estimated in the literature on the basis of Spitzer data. Our probability analysis shows that, thanks to the new Herschel data, the lower limits to the disk mass (Mdisk) and characteristic radius (RC) are well constrained, while the flaring angle (1 + φ) is only marginally constrained. The lower limit to RC is typically around 50 AU. The lower limits to Mdisk are proportional to the stellar masses with a typical 0.3% ratio, i.e., in the range estimated in the literature for young Class II stars and brown dwarfs across a broad range of stellar masses. The estimated flaring angles, although very uncertain, point toward very flat disks (1 + φ ≲ 1.2), as found for low-mass M-type YSO samples in other star-forming regions. Thus, our results support the idea that disk properties show a dependence on stellar properties

On the Adaptive Control of Group of the Technical Processes under Incomplete Information

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Nonparametric modeling of oxygen-converter processes

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