Pedagogical conditions of primary drug abuse prevention among students of a higher education institution

The relevance of the researched problem is caused by the fact that being one of the least adapted and socially unprotected groups, young people bear the impress of general social uncertainty, lack of confidence and uneasiness, as a result of it, drug addiction problems among young people are pushed into the forefront among social-pedagogical and psychological-pedagogical problems. The purpose of the presented article consists in theoretical reasons, development experimental and research check of a complex of the pedagogical conditions providing efficiency of primary prevention of drug addiction among students of a higher education institution. The leading method to a research of this problem is the modeling method that enables to consider this problem as a purposeful and organized process of creation of the pedagogical conditions necessary for effective primary prevention of drug addiction among students of a higher education institution. The complex of the pedagogical conditions providing efficiency of process of primary drug abuse prevention is presented in the article. It consists of the pedagogical analysis of the reasons of a drug abuse, detection of specifics of a drug abuse of youthful age, the choice and use of the methods and agents of primary prophylaxis of a youth drug abuse, development of a special course for training of specialists which are carrying out activities for prophylaxis of the drug habit at educational organizations. The complex of pedagogical conditions is focused on the process organization of drug abuse prevention among students and focused on development of methodical ensuring process of training of the teachers who are carrying out activities for drug abuse prevention in educational organizations. The materials of article can be useful to teachers of higher education institutions and colleges participating in the organization and carrying out preventive measures of a drug addiction, and also to the listeners, graduates of military academies, and practical staffof Department of Internal Affairs of the Russian Federation who are interested in drug addiction problems. © Authors

The Method of Manufacturing Nonmetallic Test-Blocks on Different Sensitivity Classes

Nowadays in our modern world there is a vital question of quality control of details made from nonmetallic materials due to their wide spreading. Nondestructive penetrant testing is effective, and in some cases it is the only possible method of accidents prevention at high-risk sites. A brief review of check sample necessary for quality evaluation of penetrant materials is considered. There was offered a way of making agents for quality of penetrant materials testing according to different liquid penetrant testing sensibility classes

Long-term Follow-up of treatment of chronic foot wounds with recombinant human epidermal growth factor in patients with different complications of diabetes mellitus

BACKGROUND: Diabetic foot ulcer (DFU) is a dangerous complication of diabetes mellitus (DM), which can lead to the development of chronic wounds and amputations. Recombinant human epidermal growth factor (rhEGF) can be used as an adjuvant treatment for chronic wounds resistant to standard treatment. Studies have demonstrated its clinical efficacy, however, there is insufficient information on the long-term results of treatment, its safety and the effect on the progression of diabetes complications, adverse cardiovascular events and the development of cancer.AIM: To assess the long-term results of rhEGF therapy for trophic foot ulcers in individuals with multiple complications of diabetes.METHODS: The study included 20 patients with type 1 and type 2 diabetes and various forms of DFS without critical ischemia, who had previously been treated with DFS using rhEGF in order to assess the general condition, progression of microand macrovascular complications of diabetes, adverse cardiovascular events, the development of cancer and the quality of life.RESULTS: There was a statistically significant difference between the area of wound defects, the percentage of granulation tissue that filled the wound defect, before the start of rhEGF treatment and at the time of discharge from the hospital (p <0.05). During treatment with rhEGF, mild adverse events were observed in 35%. Complete epithelialization of wounds in most patients occurred in 3 [2; 4] months. In 11.76%, the wound was not completely epithelialized. Relapse occurred in 5.8% due to non-compliance with limb unloading. Minor amputation was performed in 1 patient. Progression of diabetic retinoand nephropathy was revealed in 23.5%. 11.76% suffered myocardial infarction of unknown age, 1 patient (5.88%) suffered acute cerebrovascular accident. Serious adverse events in the form of PE with a fatal outcome and critical ischemia of the lower limb were recorded in 5.8%.CONCLUSIONS: As a result of the study of long-term results of rhEGF treatment of chronic foot wounds, a low percentage of relapses and small amputations, the absence of high amputations and oncological diseases, the development of serious adverse events in 2 patients, the progression of diabetic retinoand nephropathy in 4 patients, the development of IM of unknown age in 2 patients was recorded. and stroke in 1 patient after rhEGF therapy

Pain as one of the risk factors for progression of knee osteoarthrosis

Objective: to study the impact of pain intensity on the progression of knee osteoarthrosis (OA). Subjects and methods. One hundred and ten patients with knee OA were examined at a 5-year interval. All the patients underwent a questionnaire survey and knee joint pain assessment using a visual analog scale (VAS) and standard radiography. Results. After 5-year follow-up, radiographic OA progression was seen in 40 patients (Group 2); its stage remained the same in 70 patients (Group 1). In both groups, the patients were matched for age (59.2+9.5 and 59.0+8.1 years) and disease duration (11.1+10.6 and 13.7+9.9 years). During the first examination, pain on walking was more severe in Group 1 than in Group 2: 57.8+16.6 and 48.7+13.3 mm by VAS (р=0.002), as well as severe joint pain was predominant in these patients: 22.5 and 11.4%, respectively. Over the 5-year period, there was an increase in pain intensity. At the end of the follow-up, the patients with progressive OA rated their knee joint pain as severe in 35% of cases whereas in this index the non-progression group was only 12.9 (p = 0.012). Conclusion. In the OA progression group, pain intensity was initially statistically higher than that in the non-progression group. During 5-year follow-up, Group 1 showed an increase in knee joint pain intensity on walking, which can be considered as one of the predictors of gonarthrosis progression

To the History of the Development of Molecular-Genetic Technologies in the Urals

The authors analyze the state of molecular genetic technologies in Russia and the Urals. They reveal the concept of “molecular genetic technologies”, identify the main directions of research and the use of appropriate technologies. They prove that the processes of development of this type of technology are possible only in the presence of institutional conditions.Авторы анализируют состояние молекулярно-генетических технологий в России и на Урале. Раскрывают понятие «молекулярно-генетические технологии», выявляют основные направления исследований и использования соответствующих технологий. Доказывают, что процессы развития этого вида технологий возможны только при наличии институциональных условий.Статья подготовлена при поддержке гранта РФФИ № 18-29-14059 «Правовые и этические аспекты технологий геномных исследований при врожденных ошибках иммунитета»

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival

Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML). Posttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells. In this study, we identified and characterised NRF2-regulated miRNAs in AML. An miRNA array identified miRNA expression level changes in response to NRF2 knockdown in AML cells. Further analysis of miRNAs concomitantly regulated by knockdown of the NRF2 inhibitor KEAP1 revealed the major candidate NRF2-mediated miRNAs in AML. We identified miR-125B to be upregulated and miR-29B to be downregulated by NRF2 in AML. Subsequent bioinformatic analysis identified putative NRF2 binding sites upstream of the miR-125B1 coding region and downstream of the mir-29B1 coding region. Chromatin immunoprecipitation analyses showed that NRF2 binds to these antioxidant response elements (AREs) located in the 5′ untranslated regions of miR-125B and miR-29B. Finally, primary AML samples transfected with anti-miR-125B antagomiR or miR-29B mimic showed increased cell death responsiveness either alone or co-treated with standard AML chemotherapy. In summary, we find that NRF2 regulation of miR-125B and miR-29B acts to promote leukaemic cell survival, and their manipulation enhances AML responsiveness towards cytotoxic chemotherapeutics

An Infrared/X-ray Survey for New Members of the Taurus Star-Forming Region

We present the results of a search for new members of the Taurus star-forming region using data from the Spitzer Space Telescope and the XMM-Newton Observatory. We have obtained optical and near-infrared spectra of 44 sources that exhibit red Spitzer colors that are indicative of stars with circumstellar disks and 51 candidate young stars that were identified by Scelsi and coworkers using XMM-Newton. We also performed spectroscopy on four possible companions to members of Taurus that were reported by Kraus and Hillenbrand. Through these spectra, we have demonstrated the youth and membership of 41 sources, 10 of which were independently confirmed as young stars by Scelsi and coworkers. Five of the new Taurus members are likely to be brown dwarfs based on their late spectral types (>M6). One of the brown dwarfs has a spectral type of L0, making it the first known L-type member of Taurus and the least massive known member of the region (M=4-7 M_Jup). Another brown dwarf exhibits a flat infrared spectral energy distribution, which indicates that it could be in the protostellar class I stage (star+disk+envelope). Upon inspection of archival images from various observatories, we find that one of the new young stars has a large edge-on disk (r=2.5=350 AU). The scattered light from this disk has undergone significant variability on a time scale of days in optical images from the Canada-France-Hawaii Telescope. Using the updated census of Taurus, we have measured the initial mass function for the fields observed by XMM-Newton. The resulting mass function is similar to previous ones that we have reported for Taurus, showing a surplus of stars at spectral types of K7-M1 (0.6-0.8 M_sun) relative to other nearby star-forming regions like IC 348, Chamaeleon I, and the Orion Nebula Cluster

The mechanism of state regulation of regional services markets as an imperative to reduce territorial socio-economic disparities

© 2016, Econjournals. All rights reserved.The relevance of the study is conditioned by the development of regional services’ markets, as components ensuring the balanced socio-economic development of territories in a Federal state. Balanced territorial development of a Federal state involves the creation of conditions that allow each region to have necessary and sufficient resources to ensure decent living conditions of citizens, complex development and increase of competitiveness of the regional economy. The development of regional services markets can be considered as the imperative to reduce territorial socio-economic differentiation to the level, due to objective differences of the regions and to ensure balance of their revenue base and expenditure commitments. The purpose of this paper is to develop a mechanism of state regulation of regional services markets, ensuring the reduction of territorial socio-economic differentiation. A leading approach is the institutional approach that considers state regulation of the regional markets of services in the Federal state as a system of state control measures oriented on the goal that contributes to maximizing of the value of the assets of the service sector in the process of socio-economic activities and aimed at ensuring of a balanced socio-economic development of regions. The service sector is one of the most dynamic and growing segments of regional markets, as well as one of the characteristics of effective socio-economic policy in the region. The growth of assets yield from the service sector while risk diversification, focused on the development of regional services markets, meeting the needs of the population for public goods and improving the life quality will ensure a sustainable development of the Federal state. The paper presents perspectives on the content of the economic mechanism; identifies the functions of regional services markets; reveals the essence of the mechanism of state regulation of regional services markets and the characteristics of its structural components (goals, objectives, principles, actors, objects, forms, methods, tools); establishes the regularities in the process of state regulation of regional services markets. The paper submissions can be useful for specialists of Federal and regional authorities, local governments, line ministries, scientists interested in issues of regional economy and management of services sphere

Experience in Utilization of Phylogenetic Analysis for Epidemiological Investigation of HIV Infection Case

Objective of the study was to investigate a criminal case of infection with HIV, applying molecular-genetic analysis of blood plasma samples from an estimated source of an infection and the recipient for evaluation of probability of epidemiological connection between them. Materials and methods. The study involved genotyping and phylogenetic analysis of nucleotide sequences of HIV-1 variants, isolated from patients in the investigated group and the control one (19 nucleotide sequences of the HIV-1 from the patients living in the Saratov region, and 15 nucleotide sequences from GenBank). Genotyping was performed using the commercial ViroSeq HIV-1 Genotyping System. The sub-typing of HIV-1 strains was carried out on-line, through the COMET HIV-1/2 and HCV and REGA HIV-1 Sybtyping Tool programs. Phylogenetic analysis of nucleotide sequences was carried out by Mega software, version 5.2. Phylogenetic trees were constructed; nucleotide distances were calculated by Kimura method (bootstrap level 1000). Results and conclusions. Virus variants, isolated from the studied samples, were defined as HIV-1 A subtype. Performed phylogenetic analysis showed that nucleotide sequences of the studied samples authentically grouped on the phylogenetic tree, forming a common cluster, which mismatched that of control group. Calculation of the genetic distance testifies that the genetic relation between the samples within the investigated group is higher, than between the same samples and those of the control group. Thus, by means of phylogenetic analysis it is shown that the strains received from an estimated source of infection and the recipient are genetically closer to each other, than to the strains from the group of comparison. In this regard, it is possible to claim with a big share of confidence that probability of epidemiological connection between them exists