134 research outputs found
Sociologia moral das dependências motivadas: o caso da dependência amorosa
Este artigo propõe um panorama do procedimento e dos métodos da sociologia moral, que se baseiam em uma etnofilosofia da existência social comum e em uma antropologia natural. A primeira parte do texto situa a sociologia moral em relação ao desenvolvimento contemporâneo das pesquisas empíricas sobre a ética, sobretudo no âmbito da psicologia experimental e evolucionista. A segunda parte apresenta alguns elementos de uma teoria das dependências motivadas aos prazeres e às recompensas, desenvolvida a partir do aporte das neurociências da adição e de pesquisas de campo sobre as condutas aditivas e as tentativas de restabelecimento. A terceira parte propõe uma ilustração do método a partir de uma pesquisa recente sobre a dependência amorosa, feita principalmente a partir de um corpus literário e cinematográfico
First results from Faint Infrared Grism Survey (FIGS): first simultaneous detection of Lyman-alpha emission and Lyman break from a galaxy at z=7.51
Galaxies at high redshifts provide a valuable tool to study cosmic dawn, and
therefore it is crucial to reliably identify these galaxies. Here, we present
an unambiguous and first simultaneous detection of both the Lyman-alpha
emission and the Lyman break from a z = 7.512+/- 0.004 galaxy, observed in the
Faint Infrared Grism Survey (FIGS). These spectra, taken with G102 grism on
Hubble Space Telescope (HST), show a significant emission line detection (6
sigma) in multiple observational position angles (PA), with total integrated
Ly{\alpha} line flux of 1.06+/- 0.12 e10-17erg s-1cm-2. The line flux is nearly
a factor of four higher than the previous MOSFIRE spectroscopic observations of
faint Ly{\alpha} emission at {\lambda} = 1.0347{\mu}m, yielding z = 7.5078+/-
0.0004. This is consistent with other recent observations implying that
ground-based near-infrared spectroscopy underestimates total emission line
fluxes, and if confirmed, can have strong implications for reionization studies
that are based on ground-based Lyman-{\alpha} measurements. A 4-{\sigma}
detection of the NV line in one PA also suggests a weak Active Galactic Nucleus
(AGN), potentially making this source the highest-redshift AGN yet found. Thus,
this observation from the Hubble Space Telescope clearly demonstrates the
sensitivity of the FIGS survey, and the capability of grism spectroscopy to
study the epoch of reionization.Comment: Published in ApJL; matches published versio
Sedimentation in an artificial lake -Lake Matahina, Bay of Plenty
Lake Matahina, an 8 km long hydroelectric storage reservoir, is a small (2.5 km2), 50 m deep, warm monomictic, gorge-type lake whose internal circulation is controlled by the inflowing Rangitaiki River which drains a greywacke and acid volcanic catchment. Three major proximal to distal subenvironments are defined for the lake on the basis of surficial sediment character and dominant depositional process: (a) fluvial-glassy, quartzofeld-spathic, and lithic gravel-sand mixtures deposited from contact and saltation loads in less than 3 m depth; (b) (pro-)deltaic-quartzofeldspathic and glassy sand-silt mixtures deposited from graded and uniform suspension loads in 3-20 m depth; and (c) basinal-diatomaceous, argillaceous, and glassy silt-clay mixtures deposited from uniform and pelagic suspension loads in 20-50 m depth. The delta face has been prograding into the lake at a rate of 35-40 m/year and vertical accretion rates in pro-delta areas are 15-20 cm/year. Basinal deposits are fed mainly from river plume dispersion involving overflows, interflows, and underflows, and by pelagic settling, and sedimentation rates behind the dam have averaged about 2 cm/year. Occasional fine sand layers in muds of basinal cores attest to density currents or underflows generated during river flooding flowing the length of the lake along a sublacustrine channel marking the position of the now submerged channel of the Rangitaiki River
FIGS -- Faint Infrared Grism Survey: Description and Data Reduction
The Faint Infrared Grism Survey (FIGS) is a deep Hubble Space Telescope (HST)
WFC3/IR (Wide Field Camera 3 Infrared) slitless spectroscopic survey of four
deep fields. Two fields are located in the Great Observatories Origins Deep
Survey-North (GOODS-N) area and two fields are located in the Great
Observatories Origins Deep Survey-South (GOODS-S) area. One of the southern
fields selected is the Hubble Ultra Deep Field. Each of these four fields were
observed using the WFC3/G102 grism (0.8-1.15 continuous coverage)
with a total exposure time of 40 orbits (~ 100 kilo-seconds) per field. This
reaches a 3 sigma continuum depth of ~26 AB magnitudes and probes emission
lines to . This paper details the four
FIGS fields and the overall observational strategy of the project. A detailed
description of the Simulation Based Extraction (SBE) method used to extract and
combine over 10000 spectra of over 2000 distinct sources brighter than
m_F105W=26.5 mag is provided. High fidelity simulations of the observations is
shown to significantly improve the background subtraction process, the spectral
contamination estimates, and the final flux calibration. This allows for the
combination of multiple spectra to produce a final high quality, deep,
1D-spectra for each object in the survey.Comment: 21 Pages. 17 Figures. To appear in Ap
Onset of Cosmic Reionization: Evidence of An Ionized Bubble Merely 680 Myrs after the Big Bang
While most of the inter-galactic medium (IGM) today is permeated by ionized
hydrogen, it was largely filled with neutral hydrogen for the first 700 million
years after the Big Bang. The process that ionized the IGM (cosmic
reionization) is expected to be spatially inhomogeneous, with fainter galaxies
playing a significant role. However, we still have only a few direct
constraints on the reionization process. Here we report the first spectroscopic
confirmation of two galaxies and very likely a third galaxy in a group
(hereafter EGS77) at redshift z = 7.7, merely 680 Myrs after the Big Bang. The
physical separation among the three members is < 0.7 Mpc. We estimate the
radius of ionized bubble of the brightest galaxy to be about 1.02 Mpc, and show
that the individual ionized bubbles formed by all three galaxies likely overlap
significantly, forming a large yet localized ionized region, which leads to the
spatial inhomogeneity in the reionization process. It is striking that two of
three galaxies in EGS77 are quite faint in the continuum, thanks to our
selection of reionizing sources using their Lyman-alpha line emission. Indeed,
one is the faintest spectroscopically confirmed galaxy yet discovered at such
high redshifts. Our observations provide direct constraints in the process of
cosmic reionization, and allow us to investigate the properties of sources
responsible for reionizing the universe.Comment: Submitted after addressing referee's comment
Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile
Background and Aims Primary sclerosing cholangitis (PSC) is associated with increased risk of cholangiocarcinoma (CCA). Early and accurate CCA detection represents an unmet clinical need as the majority of patients with PSC are diagnosed at an advanced stage of malignancy. In the present study, we aimed at establishing robust DNA methylation biomarkers in bile for early and accurate diagnosis of CCA in PSC. Approach and Results Droplet digital PCR (ddPCR) was used to analyze 344 bile samples from 273 patients with sporadic and PSC-associated CCA, PSC, and other nonmalignant liver diseases for promoter methylation of cysteine dioxygenase type 1, cannabinoid receptor interacting protein 1, septin 9, and vimentin. Receiver operating characteristic (ROC) curve analyses revealed high AUCs for all four markers (0.77-0.87) for CCA detection among patients with PSC. Including only samples from patients with PSC diagnosed with CCA 36 months) as controls, and remained high (83%) when only including patients with PSC and dysplasia as controls (n = 23). Importantly, the bile samples from the CCA-PSCPeer reviewe
The Role of Properdin in Zymosan-and Escherichia coli-Induced Complement Activation
Properdin is well known as an enhancer of the alternative complement amplification loop when C3 is activated, whereas its role as a recognition molecule of exogenous pathogen-associated molecular patterns and initiator of complement activation is less understood. We therefore studied the role of properdin in activation of complement in normal human serum by zymosan and various Escherichia coli strains. In ELISA, microtiter plates coated with zymosan induced efficient complement activation with deposition of C4b and terminal complement complex on the solid phase. Virtually no deposition of C4b or terminal complement complex was observed with mannose-binding lectin (MBL)-deficient serum. Reconstitution with purified MBL showed distinct activation in both readouts. In ELISA, normal human serum-induced deposition of properdin by zymosan was abolished by the C3-inhibiting peptide compstatin. Flow cytometry was used to further explore whether properdin acts as an initial recognition molecule reacting directly with zymosan and three E. coli strains. Experiments reported by other authors were made with EGTA Mg 2+ buffer, permitting autoactivation of C3. We found inhibition by compstatin on these substrates, indicating that properdin deposition depended on initial C3b deposition followed by properdin in a second step. Properdin released from human polymorphonuclear cells stimulated with PMA did not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin bound efficiently to both substrates in a strictly C3-dependent manner, as the binding was abolished by compstatin. Collectively, these data indicate that properdin in serum as well as polymorphonuclear-released properdin is unable to bind and initiate direct alternative pathway activation on these substrates
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.
BACKGROUND: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced. The tammar has many unusual biological characteristics, including the longest period of embryonic diapause of any mammal, extremely synchronized seasonal breeding and prolonged and sophisticated lactation within a well-defined pouch. Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development. RESULTS: The genome has been sequenced to 2 × coverage using Sanger sequencing, enhanced with additional next generation sequencing and the integration of extensive physical and linkage maps to build the genome assembly. We also sequenced the tammar transcriptome across many tissues and developmental time points. Our analyses of these data shed light on mammalian reproduction, development and genome evolution: there is innovation in reproductive and lactational genes, rapid evolution of germ cell genes, and incomplete, locus-specific X inactivation. We also observe novel retrotransposons and a highly rearranged major histocompatibility complex, with many class I genes located outside the complex. Novel microRNAs in the tammar HOX clusters uncover new potential mammalian HOX regulatory elements. CONCLUSIONS: Analyses of these resources enhance our understanding of marsupial gene evolution, identify marsupial-specific conserved non-coding elements and critical genes across a range of biological systems, including reproduction, development and immunity, and provide new insight into marsupial and mammalian biology and genome evolution
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