Lymphatic Filariasis Control in Tanzania: Effect of Six Rounds of Mass Drug Administration with Ivermectin and Albendazole on Infection and Transmission.

Control of lymphatic filariasis (LF) in most countries of sub-Saharan Africa is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole, in order to interrupt transmission. We present findings from a detailed study on the effect of six rounds of MDA with this drug combination as implemented by the National Lymphatic Filariasis Elimination Programme (NLFEP) in a highly endemic rural area of north-eastern Tanzania.\ud The effect of treatment on transmission and human infection was monitored in a community- and a school-based study during an 8-year period (one pre-intervention and 7 post-intervention years) from 2003 to 2011. Before intervention, 24.5% of the community population had microfilariae (mf) in the blood, 53.3% had circulating filarial antigens (CFA) and 78.9% had specific antibodies to the recombinant filarial antigen Bm14. One year after the sixth MDA, these values had decreased considerably to 2.7%, 19.6% and 27.5%, respectively. During the same period, the CFA prevalence among new intakes of Standard 1 pupils in 10 primary schools decreased from 25.2% to 5.6%. In line with this, transmission by the three vectors (Anopheles gambiae, An. funestus and Culex quinquefasciatus) as determined by dissection declined sharply (overall vector infectivity rate by 99.3% and mean monthly transmission potential by 99.2% between pre-intervention and fifth post-intervention period). A major shift in vector species composition, from predominantly anopheline to almost exclusively culicine was observed over the years. This may be largely unrelated to the MDAs but may have important implications for the epidemiology of LF in the area. Six MDAs caused considerable decrease in all the measured indices for transmission and human infection. In spite of this, indices were still relatively high in the late period of the study, and it may take a long time to reach the recommended cut-off levels for interruption of transmission unless extra efforts are made. These should include increased engagement of the target population in the control activities, to ensure higher treatment coverage. It is expected that the recent initiative to distribute insecticide impregnated bed nets to every household in the area will also contribute towards reaching the goal of successful LF elimination

Design of one-dimensional Lambertian diffusers of light

We describe a method for designing a one-dimensional random surface that acts as a Lambertian diffuser. The method is tested by means of rigorous computer simulations and is shown to yield the desired scattering pattern.Comment: 6 pages, 2 figure

KINETICS AND ELECTROMYOGRAPHY OF THE MARTIAL ARTS HIGH FRONT KICK

INTRODUCTION Fast unloaded movements like striking, throwing and kicking are typically performed in a proximo-distal sequence: Initially proximal segments accelerate while distal segments lag behind, then proximal segments deceler- ate while distal segments accelerate. In kicking, for instance, it is observed that the movement starts with forward angular acceleration of the thigh while the shank lags behind. Then the thigh decelerates while simultaneously the shank accelerates and the foot reaches its maximal velocity. This raises two questions: Is the thigh actively decelerated by the glutei and/or hamstring muscles, or passively decelerated by joint reaction forces from the accelerating shank7 Is acceleration of the shank enhanced by the thigh's deceleration? From a kinematic perspective this movement coordination seems disadvantageous, considering that the resulting linear velocity of the foot relative to the ground equals the vector sum of the resulting linear velocity of the knee relative to the ground and the foot relative to the knee. However, from a kinetic perspective it can be argued that thigh deceleration enhances shah acceleration to a degree where toss of knee velocity is more than accounted for in gain of foot velocity. The theory is that the angularly decelerating thigh exerts a knee joint force which causes angular acceleration of the shank, i.e. a %hip-lash" action. To obtain knowledge regarding how these kinds of movements are performed we decided to examine the martial arts high front kick. Similar to previous kicking studies we did so by kinematic measurements but in addition recorded the electrical activity of selected muscles in order to asses their temporal activation during the kick. METHODS Seventeen skilled taekwondo practitioners (14 males. 3 females) volunteered to take part in this study. Each subject performed three high front kicks aiming at a tennis ball suspended from the ceiling and adjusted to chin level. The fastest kick from each subject was selected for further analysis. The subjects were high speed filmed (200 f.p.s.) from their right side while kicking. Contrasting markers on selected anatomical landmarks enabled subsequent automatic digitisation. Displacement data were lowpass filtered with optimal cut-off frequencies (6-1 0 Hz) determined by use of residual analysis/ Jackson Knee method. Velocities and accelerations were derived from the displacement data by finite difference calculation. During kicking the electtomyographic activity (EMG) from five selected leg muscles were measured with surface electrodes. Kinetic data were obtained through inverse dynamics calculation using a two-segment link-segment model of the kicking leg and the movement equations developed by Putnam (1983). These equations enable division of the resulting moment acting on a segment into muscular components and motion de- pendant components arising from movement of adjacent segments. RESULTS Data for the thigh indicated that deceleration was caused by motion dependant moments arising from shank motion and not by active hip extensor muscles. Shank acceleration was caused partly by a knee extensor muscle moment and partly by a motion dependant moment arising from thigh angular velocity. Both thigh and shank kinetics were supported by EMG recordings. CONCLUSION As part of the accelerating moment acting on the shank was due to thigh angular velocity we suggest that the observed thigh deceleration should be considered unwanted but unavoidable due to shank acceleration. This implies that even though knee extensor muscles are important for shank acceleration the hip flexor muscles must not be neglected

Space radiation dose analysis for solar flare of August 1989

Potential dose and dose rate levels to astronauts in deep space are predicted for the solar flare event which occurred during the week of August 13, 1989. The Geostationary Operational Environmental Satellite (GOES-7) monitored the temporal development and energy characteristics of the protons emitted during this event. From these data, differential fluence as a function of energy was obtained in order to analyze the flare using the Langley baryon transport code, BRYNTRN, which describes the interactions of incident protons in matter. Dose equivalent estimates for the skin, ocular lens, and vital organs for 0.5 to 20 g/sq cm of aluminum shielding were predicted. For relatively light shielding (less than 2 g/sq cm), the skin and ocular lens 30-day exposure limits are exceeded within several hours of flare onset. The vital organ (5 cm depth) dose equivalent is exceeded only for the thinnest shield (0.5 g/sq cm). Dose rates (rem/hr) for the skin, ocular lens, and vital organs are also computed

Level Crossing Analysis of the Stock Markets

We investigate the average frequency of positive slope $\nu_{\alpha}^{+}$, crossing for the returns of market prices. The method is based on stochastic processes which no scaling feature is explicitly required. Using this method we define new quantity to quantify stage of development and activity of stocks exchange. We compare the Tehran and western stock markets and show that some stocks such as Tehran (TEPIX) and New Zealand (NZX) stocks exchange are emerge, and also TEPIX is a non-active market and financially motivated to absorb capital.Comment: 6 pages and 4 figure

Entropy of the Nordic electricity market: anomalous scaling, spikes, and mean-reversion

The electricity market is a very peculiar market due to the large variety of phenomena that can affect the spot price. However, this market still shows many typical features of other speculative (commodity) markets like, for instance, data clustering and mean reversion. We apply the diffusion entropy analysis (DEA) to the Nordic spot electricity market (Nord Pool). We study the waiting time statistics between consecutive spot price spikes and find it to show anomalous scaling characterized by a decaying power-law. The exponent observed in data follows a quite robust relationship with the one implied by the DEA analysis. We also in terms of the DEA revisit topics like clustering, mean-reversion and periodicities. We finally propose a GARCH inspired model but for the price itself. Models in the context of stochastic volatility processes appear under this scope to have a feasible description.Comment: 16 pages, 7 figure

Numerical study of the temperature and porosity effects on the fracture propagation in a 2D network of elastic bonds

This article reports results concerning the fracture of a 2d triangular lattice of atoms linked by springs. The lattice is submitted to controlled strain tests and the influence of both porosity and temperature on failure is investigated. The porosity is found on one hand to decrease the stiffness of the material but on the other hand it increases the deformation sustained prior to failure. Temperature is shown to control the ductility due to the presence of cavities that grow and merge. The rough surfaces resulting from the propagation of the crack exhibit self-affine properties with a roughness exponent $\zeta = 0.59 \pm 0.07$ over a range of length scales which increases with temperature. Large cavities also have rough walls which are found to be fractal with a dimension, $D$, which evolves with the distance from the crack tip. For large distances, $D$ is found to be close to 1.5, and close to 1.0 for cavities just before their coalescence with the main crack

Psychological Flexibility as a Buffer against Caregiver Distress in Families with Psychosis

Background: Research has shown that caregivers of persons with psychosis play an invaluable role in recovery, but unfortunately, often report high levels of distress. While cognitive models of caregiver distress have been well-supported, there is still limited knowledge of the psychological factors involved. Recent advances in cognitive behavioral therapy seem to converge on the importance of acceptance- and mindfulness based processes.Aim: To examine the impact of psychological flexibility on caregiver distress in the early phases of psychosis, while controlling for known predictors of caregiver distress.Method: Within a cross-sectional design, 101 caregivers of 38 persons with first-episode psychosis in a clinical epidemiological sample completed a series of self-report measures.Results: A linear mixed model analysis found that, after controlling for caregiver socio-demographic factors, service user symptoms, drug use and global functioning, psychological flexibility was a significant predictor of caregiver distress.Conclusion: Greater level of psychological flexibility in caregivers, seems to be related to lower levels of caregiver distress. This finding corresponds to studies within a broad range of emotional disorders. There may be important clinical implications in terms of facilitating the process of acceptance through interventions from the ‘third-wave’ or contextual cognitive behavioral therapies

Enzyme prodrug therapy achieves site-specific, personalized physiological responses to the locally produced nitric oxide

Nitric oxide (NO) is a highly potent but short-lived endogenous radical with a wide spectrum of physiological activities. In this work, we developed an enzymatic approach to the site-specific synthesis of NO mediated by biocatalytic surface coatings. Multilayered polyelectrolyte films were optimized as host compartments for the immobilized β-galactosidase (β-Gal) enzyme through a screen of eight polycations and eight polyanions. The lead composition was used to achieve localized production of NO through the addition of β-Gal–NONOate, a prodrug that releases NO following enzymatic bioconversion. The resulting coatings afforded physiologically relevant flux of NO matching that of the healthy human endothelium. The antiproliferative effect due to the synthesized NO in cell culture was site-specific: within a multiwell dish with freely shared media and nutrients, a 10-fold inhibition of cell growth was achieved on top of the biocatalytic coatings compared to the immediately adjacent enzyme-free microwells. The physiological effect of NO produced via the enzyme prodrug therapy was validated ex vivo in isolated arteries through the measurement of vasodilation. Biocatalytic coatings were deposited on wires produced using alloys used in clinical practice and successfully mediated a NONOate concentration-dependent vasodilation in the small arteries of rats. The results of this study present an exciting opportunity to manufacture implantable biomaterials with physiological responses controlled to the desired level for personalized treatment