Do stellar winds play a decisive role in feeding AGN?

While the existence of a starburst-AGN connection is undisputed, there is no consensus on what the connection is. In this contribution, we begin by noting that the mechanisms which drive gas inwards in disk galaxies are generally inefficient at removing angular momentum, leading to stalled inflows. Thus, a tiered series of such processes is required to bring gas to the smallest scales, each of which on its own may not correlate with the presence of an AGN. Similarly, each may be associated with a starburst event, making it important to discriminate between 'circumnuclear' and 'nuclear' star formation. In this contribution, we show that stellar feedback on scales of tens of parsecs plays a critical role in first hindering and then helping accretion. We argue that it is only after the initial turbulent phases of a starburst that gas from slow stellar winds can accrete efficiently to smaller scales. This would imply that the properties of the obscuring torus are directly coupled to star formation and that the torus must be a complex dynamical entity. We finish by remarking on other contexts where similar processes appear to be at work.Comment: to appear in 'The central kiloparsec in Galactic Nuclei', Journal of Physics: Conference Series (JPCS), IOP Publishin

The Spitzer Survey of the Small Magellanic Cloud: S3MC Imaging and Photometry in the Mid- and Far-Infrared Wavebands

We present the initial results from the Spitzer Survey of the Small Magellanic Cloud (S3MC), which imaged the star-forming body of the Small Magellanic Cloud (SMC) in all seven MIPS and IRAC wavebands. We find that the F_8/F_24 ratio (an estimate of PAH abundance) has large spatial variations and takes a wide range of values that are unrelated to metallicity but anticorrelated with 24 um brightness and F_24/F_70 ratio. This suggests that photodestruction is primarily responsible for the low abundance of PAHs observed in star-forming low-metallicity galaxies. We use the S3MC images to compile a photometric catalog of ~400,000 mid- and far-infrared point sources in the SMC. The sources detected at the longest wavelengths fall into four main categories: 1) bright 5.8 um sources with very faint optical counterparts and very red mid-infrared colors ([5.8]-[8.0]>1.2), which we identify as YSOs. 2) Bright mid-infrared sources with mildly red colors (0.16<[5.8]-[8.0]<0.6), identified as carbon stars. 3) Bright mid-infrared sources with neutral colors and bright optical counterparts, corresponding to oxygen-rich evolved stars. And, 4) unreddened early B stars (B3 to O9) with a large 24 um excess. This excess is reminiscent of debris disks, and is detected in only a small fraction of these stars (<5%). The majority of the brightest infrared point sources in the SMC fall into groups one to three. We use this photometric information to produce a catalog of 282 bright YSOs in the SMC with a very low level of contamination (~7%).Comment: Accepted for publication in The Astrophysical Journal. Given the draconian figure file-size limits implemented in astro-ph, readers are encouraged to download the manuscript with full quality images from http://celestial.berkeley.edu/spitzer/publications/s3mcsurvey.pd

Ages and Luminosities of Young SMC/LMC Star Clusters and the recent Star Formation History of the Clouds

In this paper we discuss the age and spatial distribution of young (age$<$1Gyr) SMC and LMC clusters using data from the Magellanic Cloud Photometric Surveys. Luminosities are calculated for all age-dated clusters. Ages of 324 and 1193 populous star clusters in the Small and the Large Magellanic Cloud have been determined fitting Padova and Geneva isochrone models to their resolved color-magnitude diagrams. The clusters cover an age range between 10Myr and 1Gyr in each galaxy. For the SMC a constant distance modulus of $(m-M)_0$ = 18.90 and a metallicity of Z = 0.004 were adopted. For the LMC, we used a constant distance modulus of $(m-M)_0$ = 18.50 and a metallicity of Z = 0.008. For both galaxies, we used a variable color excess to derive the cluster ages. We find two periods of enhanced cluster formation in both galaxies at 160Myr and 630Myr (SMC) and at 125Myr and 800Myr (LMC). We present the spatially resolved recent star formation history of both Clouds based on young star clusters. The first peak may have been triggered by a close encounter between the SMC and the LMC. In both galaxies the youngest clusters reside in the supergiant shells, giant shells, the inter-shell regions, and toward regions with a high H$\alpha$ content, suggesting that their formation is related to expansion and shell-shell interaction. Most of the clusters are older than the dynamical age of the supergiant shells. No evidence for cluster dissolution was found. Computed V band luminosities show a trend for fainter magnitudes with increasing age as well as a trend for brighter magnitudes with increasing apparent cluster radii.Comment: 17 pages, 14 figures, Accepted for publication in A&

RED SUPERGIANTS AS COSMIC ABUNDANCE PROBES: THE MAGELLANIC CLOUDS

Red Supergiants (RSGs) are cool (∼ 4000K), highly luminous stars (L ∼ 105L⊙), and are among the brightest near-infrared (NIR) sources in star-forming galaxies. This makes them powerful probes of the properties of their host galaxies, such as kinematics and chemical abundances. We have developed a technique whereby metallicities of RSGs may be extracted from a narrow spectral window around 1μm from only moderate resolution data. The method is therefore extremely efficient, allowing stars at large distances to be studied, and so has tremendous potential for extragalactic abundance work. Here, we present an abundance study of the Large and Small Magellanic Clouds (LMC and SMC respectively) using samples of 9-10 RSGs in each. We find average abundances for the two galaxies of [Z]LMC = −0.37±0.14 and [Z]SMC = −0.53±0.16 (with respect to a Solar metallicity of Z⊙=0.012). These values are consistent with other studies of young stars in these galaxies, and though our result for the SMC may appear high it is consistent with recent studies of hot stars which find 0.5-0.8dex below Solar. Our best-fit temperatures are on the whole consistent with those from fits to the optical-infrared spectral energy distributions, which is remarkable considering the narrow spectral range being studied. Combined with our recent study of RSGs in the Galactic cluster Per OB1, these results indicate that this technique performs well over a range of metallicities, paving the way for forthcoming studies of more distant galaxies beyond the Local Group

Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort

To assess long-term health effects of ovarian-stimulation drugs we followed-up for over 20 years a British cohort of 7355 women with ovulatory disorders, 43% of whom were prescribed ovarian-stimulation drugs, and identified a total of 274 deaths and 367 incident cancers. Relative to the general population, the cohort experienced lower mortality from most causes, including from all neoplasms combined, and lower incidence of cervical cancer, but higher incidence of cancers of the breast (relative risk: 1.13; 95% CI 0.97, 1.30) and corpus uteri (2.02; 1.37, 2.87). There were, however, no significant differences in the risk of cancers of the breast, corpus uteri, ovary, or of any other site, between women who had been prescribed ovarian-stimulation drugs and those who had not. Further analyses by type of drug and dose revealed a dose–response gradient in the risk of cancer of the corpus uteri (P for linear trend=0.03), with women given ⩾2250 mg of clomiphene having a 2.6-fold (2.62; 0.94, 6.82) increase in risk relative to those who were not treated. These findings do not support strong associations between ovulation-stimulation drugs and cancer risks, but they indicate the need for continued monitoring to establish whether risks are elevated in certain subgroups of users

Field Blue Stragglers and Related Mass Transfer Issues

This chapter contains my impressions and perspectives about the current state of knowledge about field blue stragglers (FBS) stars, drawn from an extensive literature that I searched. I conclude my review of issues that attend FBS and mass transfer, by a brief enumeration of a few mildly disquieting observational facts.Comment: Chapter 4, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G. Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe

Red Supergiants as Cosmic Abundance Probes: massive star clusters in M83, and the mass-metallicity relation of nearby galaxies

We present an abundance analysis of seven super-star clusters in the disk of M83. The near-infrared spectra of these clusters are dominated by Red Supergiants, and the spectral similarity in the J-band of such stars at uniform metallicity means that the integrated light from the clusters may be analysed using the same tools as those applied to single stars. Using data from VLT/KMOS we estimate metallicities for each cluster in the sample. We find that the abundance gradient in the inner regions of M83 is flat, with a central metallicity of [Z] = 0.21$\pm$0.11 relative to a Solar value of $Z_\odot$=0.014, which is in excellent agreement with the results from an analysis of luminous hot stars in the same regions. Compiling this latest study with our other recent work, we construct a mass-metallicity relation for nearby galaxies based entirely on the analysis of RSGs. We find excellent agreement with the other stellar-based technique, that of blue supergiants, as well as with temperature-sensitive (`auroral' or `direct') \hii-region studies. Of all the HII-region strong-line calibrations, those which are empirically calibrated to direct-method studies (N2 and O3N2) provide the most consistent results

The Eat Smart Study: A randomised controlled trial of a reduced carbohydrate versus a low fat diet for weight loss in obese adolescents

Background Despite the recognition of obesity in young people as a key health issue, there is limited evidence to inform health professionals regarding the most appropriate treatment options. The Eat Smart study aims to contribute to the knowledge base of effective dietary strategies for the clinical management of the obese adolescent and examine the cardiometablic effects of a reduced carbohydrate diet versus a low fat diet. Methods and design Eat Smart is a randomised controlled trial and aims to recruit 100 adolescents over a 2½ year period. Families will be invited to participate following referral by their health professional who has recommended weight management. Participants will be overweight as defined by a body mass index (BMI) greater than the 90th percentile, using CDC 2000 growth charts. An accredited 6-week psychological life skills program ‘FRIENDS for Life’, which is designed to provide behaviour change and coping skills will be undertaken prior to volunteers being randomised to group. The intervention arms include a structured reduced carbohydrate or a structured low fat dietary program based on an individualised energy prescription. The intervention will involve a series of dietetic appointments over 24 weeks. The control group will commence the dietary program of their choice after a 12 week period. Outcome measures will be assessed at baseline, week 12 and week 24. The primary outcome measure will be change in BMI z-score. A range of secondary outcome measures including body composition, lipid fractions, inflammatory markers, social and psychological measures will be measured. Discussion The chronic and difficult nature of treating the obese adolescent is increasingly recognised by clinicians and has highlighted the need for research aimed at providing effective intervention strategies, particularly for use in the tertiary setting. A structured reduced carbohydrate approach may provide a dietary pattern that some families will find more sustainable and effective than the conventional low fat dietary approach currently advocated. This study aims to investigate the acceptability and effectiveness of a structured reduced dietary carbohydrate intervention and will compare the outcomes of this approach with a structured low fat eating plan. Trial Registration: The protocol for this study is registered with the International Clinical Trials Registry (ISRCTN49438757)

Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

Background: The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs. Methods: First, we performed an international consultation through a four-stage consensus process to develop a multidomain index for hospital-level assessment (surgical preparedness index; SPI). Second, we measured surgical preparedness across a global network of hospitals in high-income countries (HICs), middle-income countries (MICs), and low-income countries (LICs) to explore the distribution of the SPI at national, subnational, and hospital levels. Finally, using COVID-19 as an example of an external system shock, we compared hospitals' SPI to their planned surgical volume ratio (SVR; ie, operations for which the decision for surgery was made before hospital admission), calculated as the ratio of the observed surgical volume over a 1-month assessment period between June 6 and Aug 5, 2021, against the expected surgical volume based on hospital administrative data from the same period in 2019 (ie, a pre-pandemic baseline). A linear mixed-effects regression model was used to determine the effect of increasing SPI score. Findings: In the first phase, from a longlist of 103 candidate indicators, 23 were prioritised as core indicators of elective surgical system preparedness by 69 clinicians (23 [33%] women; 46 [67%] men; 41 from HICs, 22 from MICs, and six from LICs) from 32 countries. The multidomain SPI included 11 indicators on facilities and consumables, two on staffing, two on prioritisation, and eight on systems. Hospitals were scored from 23 (least prepared) to 115 points (most prepared). In the second phase, surgical preparedness was measured in 1632 hospitals by 4714 clinicians from 119 countries. 745 (45·6%) of 1632 hospitals were in MICs or LICs. The mean SPI score was 84·5 (95% CI 84·1–84·9), which varied between HIC (88·5 [89·0–88·0]), MIC (81·8 [82·5–81·1]), and LIC (66·8 [64·9–68·7]) settings. In the third phase, 1217 (74·6%) hospitals did not maintain their expected SVR during the COVID-19 pandemic, of which 625 (51·4%) were from HIC, 538 (44·2%) from MIC, and 54 (4·4%) from LIC settings. In the mixed-effects model, a 10-point increase in SPI corresponded to a 3·6% (95% CI 3·0–4·1; p<0·0001) increase in SVR. This was consistent in HIC (4·8% [4·1–5·5]; p<0·0001), MIC (2·8 [2·0–3·7]; p<0·0001), and LIC (3·8 [1·3–6·7%]; p<0·0001) settings. Interpretation: The SPI contains 23 indicators that are globally applicable, relevant across different system stressors, vary at a subnational level, and are collectable by front-line teams. In the case study of COVID-19, a higher SPI was associated with an increased planned surgical volume ratio independent of country income status, COVID-19 burden, and hospital type. Hospitals should perform annual self-assessment of their surgical preparedness to identify areas that can be improved, create resilience in local surgical systems, and upscale capacity to address elective surgery backlogs. Funding: National Institute for Health Research (NIHR) Global Health Research Unit on Global Surgery, NIHR Academy, Association of Coloproctology of Great Britain and Ireland, Bowel Research UK, British Association of Surgical Oncology, British Gynaecological Cancer Society, and Medtronic