An Overview of Acute Myeloid Leukemia

Acute Myeloid Leukemia is a rare disease with an estimated 20,830 new cases in the U.S. in 2015.4 Although it is a rare disease it is crucial to understand the history, pathophysiology, and epidemiology of AML. Comprehending the steps behind treating AML is another crucial aspect in appreciating the care that must be put into AML and the patients that suffer from it. A comprehensive look into these two aspects of AML will give a better understanding for what causes AML, how it is treated, and what these patients experience. Through this comprehensive study the future of this field will also be considered

Characteristics and psychiatric symptoms of Internet Gaming Disorder among adults using self-reported DSM-5 criteria

Objective: The Section III of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) proposed nine diagnostic criteria and five cut-point criteria for Internet Gaming Disorder (IGD). We aimed to examine the efficacy of such criteria. Methods: Adults (n=3041, men: 1824, women: 1217) who engaged in internet gaming within last 6 months completed a self-report online survey using the suggested wordings of the criteria in DSM-5. Major characteristics, gaming behavior, and psychiatric symptoms of IGD were analyzed using ANOVA, chi-square, and correlation analyses. Results: The sociodemographic variables were not statistically significant between the healthy controls and the risk group. Among the participants, 419 (13.8%) were identified and labeled as the IGD risk group. The IGD risk group scored significantly higher on all motivation subscales (p<0.001). The IGD risk group showed significantly higher scores than healthy controls in all nine psychiatric symptom dimensions, i.e., somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism (p<0.001). Conclusion: The IGD risk group showed differential psychopathological manifestations according to DSM-5 IGD diagnostic criteria. Further studies are needed to evaluate the reliability and validity of the specific criteria, especially for developing screening instruments

A model for rhythmic and temperature-independent growth in ‘clock’ mutants of neurospora

The Q 10 for the frequency (number of bands per 24 hours) of the ‘clock’ mutant (strain CL11A) of Neurospora crassa over the range 20–30° C is close to 1.0. By contrast, that for the double mutant, ‘wrist watch’ (strain CL12a), is closer to 2 over this temperature range. Strain CL12a differs from ‘clock’ in other ways as well, including 1) decreased rate of linear extension and band size, 2) greater sensitivity of growth rate to high temperatures and, 3) masking of rhythmic growth below 15° C. The response to temperature of several colonial mutants and standard (‘wild-type’) strains was studied and it is shown that some strains are temperature-independent yet arhythmic. A temperature-compensation model is presented to explain the response of ‘clock’ mutants to temperature and it is concluded that they demonstrate a non-circadian free-running endogenous rhythm.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43284/1/11046_2005_Article_BF02049924.pd

Are Adolescents Engaged in the Problematic Use of Social Networking Sites More Involved in Peer Aggression and Victimization?

The problematic use of social networking sites is becoming a major public health concern. Previous research has found that adolescents who engage in a problematic use of social networking sites are likely to show maladjustment problems. However, little is known about its links with peer aggression and victimization. The main goal of this study was to analyze the relationship between problematic use of online social networking sites, peer aggression ¿overt vs. relational and reactive vs. instrumental¿, and peer victimization ¿overt physical and verbal, and relational¿, taking into account gender and age (in early and mid-adolescence). Participants were selected using randomized cluster sampling considering school and class as clusters. A battery of instruments was applied to 1,952 adolescents¿ secondary students from Spain (Andalusia) (50.4% boys), aged 11 to 16 (M = 14.07, SD = 1.39). Results showed that girls and 14¿16 adolescents were more involved in a problematic use of online social networking sites. Furthermore, adolescents with high problematic use of online social networking sites were more involved in overt¿reactive and instrumental¿and relational¿reactive and instrumental¿aggressive behaviors, and self-reported higher levels of overt¿physical and verbal¿and relational victimization. Even though boys indicated higher levels of all types of victimization, girls with high problematic use of online social networking sites scored the highest on relational victimization. Relating to age, early adolescents (aged 11¿14) with higher problematic use of online social networking sites reported the highest levels of overt verbal and relational victimization. Overall, results suggested the co-occurrence of problematic use of online social networking sites, peer aggression and victimization. In addition, results showed the influence that gender and age had on peer victimization. This study highlights the continuity between offline and online domains with regard to maladjustment problems in adolescence.Departamento de Educación y Psicología SocialVersión del edito

The Definition of GOES Infrared Lightning Initiation Interest Fields

The article of record as published may be located at http://dx.doi.org/10.1175/2010JAMC2575.1Within cumulus cloud fields that develop in conditionally unstable air masses, only a fraction of the cumuli may eventually develop into deep convection. Identifying which of these convective clouds is most likely to generate lightning often starts with little more than a qualitative visual satellite analysis. The goal of this study is to identify the observed satellite infrared (IR) signatures associated with growing cumulus clouds prior to the first lightning strike, or lightning initiation (LI). This study quantifies the behavior of 10 Geostationary Operational Environmental Satellite-12 (GOES-12) IR fields of interest in the 1 h in advance of LI. A total of 172 lightning-producing storms, which occurred during the 2009 convective season, are manually tracked and studied over four regions: northern Alabama, central Oklahoma, the Kennedy Space Center, and Washington, D.C. Four-dimensional and cloud-to-ground lightning array data provide a total cloud lightning picture (in-cloud, cloud-to-cloud, cloud-to-air, and cloud-to-ground) and thus precise LI points for each storm in both time and space. Statistical significance tests are conducted on observed trends for each of the 10 LI fields to determine the unique information each field provides in terms of behavior prior to LI. Eight out of 10 LI fields exhibited useful information at least 15 min in advance of LI, with 35 min being the average. Statistical tests on these eight fields are compared for separate large geographical areas. Median IR temperatures and 3.9-mm reflectance values are then determined for all 172 events as an outcome, which may be valuable when implementing a LI prediction algorithm into real-time satellite-based systems

Low-cost, smartphone-based frequency doubling technology visual field testing using a head-mounted display

BackgroundCurrent visual field screening machines are bulky and expensive, limiting their accessibility, affordability and use. We report the design and evaluation of a novel, portable, cost-effective system for glaucoma screening using smartphone-based visual field screening using frequency doubling technology (FDT) and a head-mounted display.MethodsNineteen eyes of 10 subjects with new-onset or chronic primary open angle glaucoma were tested and compared with the Humphrey Zeiss FDT and the newly developed Mobile Virtual Perimetry (MVP) FDT with the C-20 testing pattern. Mann-Whitney, Bland-Altman and linear regression analyses were performed to assess statistical difference, agreement and correlation, respectively, between the two devices.ResultsThe average age of the participants was 58±15 years. No statistically significant difference was found between the MVP FDT and the Humphrey Zeiss FDT (p>0.05). Bland-Altman and linear regression analyses demonstrated good agreement and correlation between the two devices.ConclusionThe MVP FDT is a low-cost, portable visual field screening device that produces comparable results to the Humphrey Zeiss FDT and may be used as an easily accessible screening tool for glaucoma

The Effects of a Multi-Ingredient Performance Supplement on Hormonal Profiles and Body Composition in Male College Athletes

Periods of intense training can elicit an acute decline in performance and body composition associated with weakened hormone profiles. This study investigated the effects of a multi-ingredient performance supplement (MIPS) on body composition and hormone levels in college athletes following a six-week training protocol. Twenty male college athletes were equally assigned to MIPS and placebo (PLA) groups for supplementation (three pills, twice daily) in conjunction with resistance training and specialized sports training (e.g., nine total sessions/week) for six weeks. Dual Energy X-ray Absorptiometry determined body composition at weeks 0 and 6. Serum samples collected at weeks 0 and 6 determined free testosterone (FT), total testosterone (TT), IGF-1 and total estrogen (TE) levels. PLA experienced a significant decline in lean body mass (LBM) (−1.5 kg; p &lt; 0.05) whereas the MIPS sustained LBM. The MIPS increased TT 21.9% (541.5 ± 48.7 to 639.1 ± 31.7) and increased FT 15.2% (13.28 ± 1.1 to 15.45 ± 1.3 ng/dL) (p &lt; 0.05). Conversely, PLA decreased TT 7.9% (554.5 ± 43.3 to 497.2 ± 39.1 ng/dL), decreased FT 17.4% (13.41 ± 1.8 to 11.23 ± 2.55 ng/dL), and decreased FT:E 12.06% (p &lt; 0.05). These findings suggest the MIPS can prevent decrements in LBM and anabolic hormone profiles during intense training periods

Phytoplankton Supplementation Lowers Muscle Damage and Sustains Performance across Repeated Exercise Bouts in Humans and Improves Antioxidant Capacity in a Mechanistic Animal

The purpose of this study was to investigate the impact of antioxidant-rich marine phytoplankton supplementation (Oceanix, OCX) on performance and muscle damage following a cross-training event in endurance-trained subjects. Additionally, an animal model was carried out to assess the effects of varying dosages of OCX, with exercise, on intramuscular antioxidant capacity. Methods: In the human trial, endurance-trained subjects (average running distance = 29.5 ± 2.6 miles × week−1) were randomly divided into placebo (PLA) and OCX (25 mg) conditions for 14 days. The subjects were pre-tested on a one-mile uphill run, maximal isometric strength, countermovement jump (CMJ) and squat jump (SJ) power, and for muscle damage (creatine kinase (CK)). On Day 12, the subjects underwent a strenuous cross-training event. Measures were reassessed on Day 13 and 14 (24 h and 48 h Post event). In the animal model, Wistar rats were divided into four groups (n = 7): (i) Control (no exercise and placebo (CON)), (ii) Exercise (E), (iii) Exercise + OCX 1 (Oceanix, 2.55 mg/kg/day, (iv) Exercise + OCX 2 (5.1 mg/kg/day). The rats performed treadmill exercise five days a week for 6 weeks. Intramuscular antioxidant capacity (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px)) and muscle damage (CK and myoglobin (MYOB) were collected. The data were analyzed using repeated measures ANOVA and t-test for select variables. The alpha value was set at p &lt; 0.05. Results: For the human trial, SJ power lowered in PLA relative to OCX at 24 h Post (−15%, p &lt; 0.05). Decrements in isometric strength from Pre to 48 h Post were greater in the PLA group (−12%, p &lt; 0.05) than in the OCX. Serum CK levels were greater in the PLA compared to the OCX (+14%, p &lt; 0.05). For the animal trial, the intramuscular antioxidant capacity was increased in a general dose-dependent manner (E + Oc2 &gt; E + Oc1 &gt; E &gt; CON). Additionally, CK and MYOB were lower in supplemented compared to E alone. Conclusions: Phytoplankton supplementation (Oceanix) sustains performance and lowers muscle damage across repeated exercise bouts. The ingredient appears to operate through an elevating oxidative capacity in skeletal muscle