On AdS/CFT without Massless Gravitons

We point out that it is possible to define CFT duals to AdS theories with massive gravitons only. This is achieved by considering the product of two or more CFTs on the boundary, each possessing a large-N expansion and a corresponding bulk dual. It is possible to couple the CFTs through a marginal perturbation that makes all but one of the bulk gravitons massive. In the infinite-N limit for one of the CFTs the massless graviton decouples.Comment: 4 pages; v2: minor typos corrected, version accepted for publication in Phys. Lett.

An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles.

The tumor necrosis factor (TNF) alpha gene lies within the class III region of the major histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I region. We have recently described the first polymorphism within the human TNF-alpha locus. This is biallelic and lies within the promoter region. Frequency analysis of the TNF-alpha polymorphism, using the polymerase chain reaction and single-stranded conformational polymorphism, in HLA-typed individuals, reveals a very strong association between the uncommon TNF allele and HLA A1, B8, and DR3 alleles. This is the first association between TNF-alpha and other MHC alleles and raises the possibility that the uncommon TNF-alpha allele may contribute to the many autoimmune associations of the A1,B8,DR3 haplotype

Heterotic-Heterotic String Duality and Multiple K3 Fibrations

A type IIA string compactified on a Calabi-Yau manifold which admits a K3 fibration is believed to be equivalent to a heterotic string in four dimensions. We study cases where a Calabi-Yau manifold can have more than one such fibration leading to equivalences between perturbatively inequivalent heterotic strings. This allows an analysis of an example in six dimensions due to Duff, Minasian and Witten and enables us to go some way to prove a conjecture by Kachru and Vafa. The interplay between gauge groups which arise perturbatively and nonperturbatively is seen clearly in this example. As an extreme case we discuss a Calabi-Yau manifold which admits an infinite number of K3 fibrations leading to infinite set of equivalent heterotic strings.Comment: 13 pages, LaTe

Static potential from spontaneous breaking of scale symmetry

We determine the static potential for a heavy quark-antiquark pair from the spontaneous symmetry breaking of scale invariance in a non-Abelian gauge theory. Our calculation is done within the framework of the gauge-invariant, path-dependent, variables formalism. The result satisfies the 't Hooft basic criterion for achieving confinement.Comment: 13 pages, Latex, no figures; final version accepted for publication in PLB, new references and comments, physical results unchange

Conformal Invariance and Cosmic Background Radiation

The spectrum and statistics of the cosmic microwave background radiation (CMBR) are investigated under the hypothesis that scale invariance of the primordial density fluctuations should be promoted to full conformal invariance. As in the theory of critical phenomena, this hypothesis leads in general to deviations from naive scaling. The spectral index of the two-point function of density fluctuations is given in terms of the quantum trace anomaly and is greater than one, leading to less power at large distance scales than a strict Harrison-Zel'dovich spectrum. Conformal invariance also implies non-gaussian statistics for the higher point correlations and in particular, it completely determines the large angular dependence of the three-point correlations of the CMBR.Comment: 4 pages, Revtex file, uuencoded with one figur

D-Instantons and asymptotic geometries

The large N limit of D3-branes is expected to correspond to a superconformal field theory living on the boundary of the anti-de Sitter space appearing in the near-horizon geometry. Dualizing the D3-brane to a D-instanton, we show that this limit is equivalent to a type IIB S-duality. In both cases one effectively reaches the near-horizon geometry. This provides an alternative approach to an earlier derivation of the same result that makes use of the properties of a gravitational wave instead of the D-instanton.Comment: 17 pages, LaTeX, 1 figure, minor corrections and refs adde

Self-referencing spectral interferometric probing of the onset time of relativistic transparency in intense laser-foil interactions

Irradiation of an ultrathin foil target by a high intensity laser pulse drives collective electron motion and the generation of strong electrostatic fields, resulting in ultrabright sources of high-order harmonics and energetic ions. The ion energies can be significantly enhanced if the foil undergoes relativistic self-induced transparency during the interaction, with the degree of enhancement depending in part on the onset time of transparency. We report on a simple and effective approach to diagnose the time during the interaction at which the foil becomes transparent to the laser light, providing a route to optically controlling and optimizing ion acceleration and radiation generation. The scheme involves a self-referencing approach to spectral interferometry, in which coherent transition radiation produced at the foil rear interferes with laser light transmitted through the foil. The relative timing of the onset of transmission with respect to the transition radiation generation is determined from spectral fringe spacing and compared to simultaneous frequency-resolved optical gating measurements. The results are in excellent agreement, and are discussed with reference to particle-in-cell simulations of the interaction physics and an analytical model for the onset time of transparency in ultrathin foils

Using Heat to Characterize Streambed Water Flux Variability in Four Stream Reaches

Estimates of streambed water fl ux are needed for the interpretation of streambed chemistry and reactions. Continuous temperature and head monitoring in stream reaches within four agricultural watersheds (Leary Weber Ditch, IN; Maple Creek, NE; DR2 Drain, WA; and Merced River, CA) allowed heat to be used as a tracer to study the temporal and spatial variability of fluxes through the streambed. Synoptic methods (seepage meter and differential discharge measurements) were compared with estimates obtained by using heat as a tracer. Water flux was estimated by modeling one-dimensional vertical flow of water and heat using the model VS2DH. Flux was influenced by physical heterogeneity of the stream channel and temporal variability in stream and ground-water levels. During most of the study period (April–December 2004), flux was upward through the streambeds. At the IN, NE, and CA sites, high-stage events resulted in rapid reversal of flow direction inducing short-term surface-water flow into the streambed. During late summer at the IN site, regional ground-water levels dropped, leading to surface-water loss to ground water that resulted in drying of the ditch. Synoptic measurements of flux generally supported the model flux estimates. Water flow through the streambed was roughly an order of magnitude larger in the humid basins (IN and NE) than in the arid basins (WA and CA). Downward flux, in response to sudden high streamflows, and seasonal variability in flux was most pronounced in the humid basins and in high conductivity zones in the streambed

Accurate mitochondrial DNA sequencing using off-target reads provides a single test to identify pathogenic point mutations.

PURPOSE: Mitochondrial disorders are a common cause of inherited metabolic disease and can be due to mutations affecting mitochondrial DNA or nuclear DNA. The current diagnostic approach involves the targeted resequencing of mitochondrial DNA and candidate nuclear genes, usually proceeds step by step, and is time consuming and costly. Recent evidence suggests that variations in mitochondrial DNA sequence can be obtained from whole-exome sequence data, raising the possibility of a comprehensive single diagnostic test to detect pathogenic point mutations. METHODS: We compared the mitochondrial DNA sequence derived from off-target exome reads with conventional mitochondrial DNA Sanger sequencing in 46 subjects. RESULTS: Mitochondrial DNA sequences can be reliably obtained using three different whole-exome sequence capture kits. Coverage correlates with the relative amount of mitochondrial DNA in the original genomic DNA sample, heteroplasmy levels can be determined using variant and total read depths, and-providing there is a minimum read depth of 20-fold-rare sequencing errors occur at a rate similar to that observed with conventional Sanger sequencing. CONCLUSION: This offers the prospect of using whole-exome sequence in a diagnostic setting to screen not only all protein coding nuclear genes but also all mitochondrial DNA genes for pathogenic mutations. Off-target mitochondrial DNA reads can also be used to assess quality control and maternal ancestry, inform on ethnic origin, and allow genetic disease association studies not previously anticipated with existing whole-exome data sets

Kaluza-Klein Thresholds and Regularization (In)dependence

We present a method to control the regularization scheme dependence in the running of couplings in Kaluza-Klein theories. Specifically we consider the scalar theory in five dimensions, assuming that one dimension is compactified and we study various regularization schemes in order to analyze concretely the regularization scheme dependence of the Kaluza-Klein threshold effects. We find that in one-loop order, although the $\beta$-functions are different for the different schemes, the net difference in the running of the coupling among the different schemes is very small for the entire range of energies. Our results have been extended to include more than one radii, and the gauge coupling unification is re-examined. Strings are also used as a regulator. We obtain a particular regularization of effective field theory which can accurately describe the string Kaluza-Klein threshold effects.Comment: 39 pages, 12 figures uses epsf.st