Fermi-LAT Observations and A Broadband Study of Supernova Remnant CTB 109

CTB 109 (G109.1-1.0) is a Galactic supernova remnant (SNR) with a hemispherical shell morphology in X-rays and in the radio band. In this work we report the detection of {\gamma}-ray emission coincident with CTB 109, using 37 months of data from the Large Area Telescope on board the Fermi Gamma-ray Space Telescope. We study the broadband characteristics of the remnant using a model that includes hydrodynamics, efficient cosmic ray acceleration, nonthermal emission and a self-consistent calculation of the X-ray thermal emission. We find that the observations can be successfully fit with two distinct parameter sets, one where the {\gamma}-ray emission is produced primarily by leptons accelerated at the SNR forward shock and the other where {\gamma}-rays produced by forward shock accelerated cosmic-ray ions dominate the high-energy emission. Consideration of thermal X-ray emission introduces a novel element to the broadband fitting process, and while it does not rule out either the leptonic or the hadronic scenarios, it constrains the parameter sets required by the model to fit the observations. Moreover, the model which best fits the thermal and nonthermal emission observations is an intermediate case, where both radiation from accelerated electrons and hadrons contribute almost equally to the {\gamma}-ray flux observed.Comment: 10 pages, 6 figures. Accepted for publication in Ap

Broad-band Observations and Modeling of the Shell-Type Supernova Remnant G347.3-0.5

The supernova remnant G347.3--0.5 emits a featureless power-law in X-rays, thought to indicate shock-acceleration of electrons to high energies. We here produce a broad-band spectrum of the bright NW limb of this source by combining radio observations from the Australia Telescope Compact Array (ATCA), X-ray observations from the Advanced Satellite for Cosmology and Astrophysics (ASCA), and TeV gamma-ray observations from the CANGAROO imaging Cerenkov telescope. We assume this emission is produced by an electron population generated by diffusive shock acceleration at the remnant forward shock. The nonlinear aspects of the particle acceleration force a connection between the widely different wavelength bands and between the electrons and the unseen ions, presumably accelerated simultaneously with the electrons. This allows us to infer the relativistic proton spectrum and estimate ambient parameters such as the supernova explosion energy, magnetic field, matter density in the emission region, and efficiency of the shock acceleration process. We find convincing evidence that the shock acceleration is efficient, placing >25% of the shock kinetic energy flux into relativistic ions. Despite this high efficiency, the maximum electron and proton energies, while depending somewhat on assumptions for the compression of the magnetic field in the shock, are well below the observed `knee' at about 10^{15} eV in the Galactic cosmic-ray spectrum.Comment: Submitted to ApJ, 22 pages, 5 figure

The 24/7 approach to promoting optimal welfare for captive wild animals

We have an ethical responsibility to provide captive animals with environments that allow them to experience good welfare. Husbandry activities are often scheduled for the convenience of care staff working within the constraints of the facility, rather than considering the biological and psychological requirements of the animals themselves. The animal welfare 24/7 across the lifespan concept provides a holistic framework to map features of the animal’s life cycle, taking into account their natural history, in relation to variations in the captive environment, across day and night, weekdays, weekends, and seasons. In order for animals to have the opportunity to thrive, we argue the need to consider their lifetime experience, integrated into the environments we provide, and with their perspective in mind. Here, we propose a welfare assessment tool based upon 14 criteria, to allow care staff to determine if their animals’ welfare needs are met. We conclude that animal habitat management will be enhanced with the use of integrated technologies that provide the animals with more opportunities to engineer their own environments, providing them with complexity, choice and control

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors1,2, yet the relevant antigens remain unknown. Here we use genetic, immunohistochemical and transcriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell antigens in long-term survivors of pancreatic cancer. Using whole-exome sequencing and in silico neoantigen prediction, we found that tumours with both the highest neoantigen number and the most abundant CD8+ T-cell infiltrates, but neither alone, stratified patients with the longest survival. Investigating the specific neoantigen qualities promoting T-cell activation in long-term survivors, we discovered that these individuals were enriched in neoantigen qualities defined by a fitness model, and neoantigens in the tumour antigen MUC16 (also known as CA125). A neoantigen quality fitness model conferring greater immunogenicity to neoantigens with differential presentation and homology to infectious disease-derived peptides identified long-term survivors in two independent datasets, whereas a neoantigen quantity model ascribing greater immunogenicity to increasing neoantigen number alone did not. We detected intratumoural and lasting circulating T-cell reactivity to both high-quality and MUC16 neoantigens in long-term survivors of pancreatic cancer, including clones with specificity to both high-quality neoantigens and predicted cross-reactive microbial epitopes, consistent with neoantigen molecular mimicry. Notably, we observed selective loss of high-quality and MUC16 neoantigenic clones on metastatic progression, suggesting neoantigen immunoediting. Our results identify neoantigens with unique qualities as T-cell targets in pancreatic ductal adenocarcinoma. More broadly, we identify neoantigen quality as a biomarker for immunogenic tumours that may guide the application of immunotherapies

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

Group identities benefit well-being by satisfying needs

Although research has highlighted the importance of differentiating between different types of social ties – group ties and individual ties – no experimental work exists that investigates the claim that group ties are more beneficial than individual ties, and little is known about how group memberships influence well-being, relative to relationships. We designed a series of experiments that: a) primed either multiple group memberships or multiple interpersonal relationships (vs. films) and observed the effects on participants’ induced negative moods (S1, N = 120); b) primed different types (S2, N = 317) and features (S3, N = 183) of groups and observed which led to the greatest increases in life satisfaction; and c) investigated whether feelings of connectedness and self-worth mediated these effects (S1-3). We found that priming relationships satisfied psychological needs and restored and enhanced well-being, but that priming group memberships did so to a greater extent, especially when participants reflected on the group’s identity rather than its members. This work contributes to our understanding of why multiple group memberships are beneficial, and highlights how important social identities associated with groups can be for well-being

Rethinking Social Justice in Education: An Epistemological Approach

There are many different notions of social justice in education. For example, some argue that social justice in education means giving individuals the opportunity to succeed; for others, it means seeking equality of outcome so that everyone does succeed. So great is the diversity of views that it has been suggested the term has become meaningless, or that it can mean anything people want it to mean. This has led some to argue that trying to define social justice in education is a hopeless task. This chapter argues that an approach informed by the later philosophy of Wittgenstein can be helpful in dealing with such issues. In particular, attention is focussed on Wittgenstein’s epistemology and theory of meaning in the Philosophical Investigations. It is argued that these are helpful in understanding the multiplicity of meanings of the term social justice in education. This multiplicity however, it is argued, does not lead to a situation where the term can mean anything its users want it to mean. Nor does it lead to a situation where all attempts to define the term are ruled out, or where only one definition is acceptable, presumably to be imposed on all users of the term. Instead, the significance of contextual understanding and meaning in different language-games is highlighted. Wittgenstein’s theory of meaning is then allied to Gallie’s notion of an essentially contested concept to advance the idea of engagement between those with different views, and of the need to recontextualize rather than decontextualize the notion of social justice in education