4,040 research outputs found
Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits
Limited evidence suggests that GLP-I may also preserve ventricular function and improve outcomes in human subjects with heart failure or myocardial infarction (11,12). [...] both exenatide and liraglutide reduce blood pressure, body weight, and plasma lipid profiles in subjects with type 2 diabetes (13), raising the hope that longterm treatment with these agents may reduce the incidence of cardiovascular events.\n However, two safety issues have been raised - pancreatitis and medullary carcinoma of the thyroid
I RAPPORTI ECONOMICO-FINANZIARI TRA ITALIA E REPUBBLICA DI SAN MARINO
Circadian clocks coordinate 24-hr rhythms of behavior and physiology. In mammals, a master clock residing in the suprachiasmatic nucleus (SCN) is reset by the light-dark cycle, while timed food intake is a potent synchronizer of peripheral clocks such as the liver. Alterations in food intake rhythms can uncouple peripheral clocks from the SCN, resulting in internal desynchrony, which promotes obesity and metabolic disorders. Pancreas-derived hormones such as insulin and glucagon have been implicated in signaling mealtime to peripheral clocks. In this study, we identify a novel, more direct pathway of food-driven liver clock resetting involving oxyntomodulin (OXM). In mice, food intake stimulates OXM secretion from the gut, which resets liver transcription rhythms via induction of the core clock genes Per1 and 2. Inhibition of OXM signaling blocks food-mediated resetting of hepatocyte clocks. These data reveal a direct link between gastric filling with food and circadian rhythm phasing in metabolic tissues
Preservação e organização da geoinformação em instituições: o caso da construção da Infraestrutura de Dados Espaciais da Embrapa.
O objetivo deste trabalho é apresentar a estratégia da Embrapa para construir sua Infraestrutura de Dados Espaciais de forma a contribuir com o debate sobre a organização, preservação e integração de dados geoespaciais heterogêneos de acordo com as diretrizes federais estabelecidas pela INDE. Para esse fim, apresentaremos as etapas do processo interno realizado na Embrapa para elaboração o plano de adesão à INDE, o qual contou com a formação de um grupo de trabalho e, em seguida, descreveremos a estratégia elaborada
Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold
A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown
Glucagon-Like Peptide-1 Receptor Activation Modulates Pancreatitis-Associated Gene Expression But Does Not Modify the Susceptibility to Experimental Pancreatitis in Mice
Nonprofit governance: Improving performance in troubled economic times
Nonprofit management is currently pressured to perform effectively in a weak economy. Yet, nonprofit governance continues to suffer from unclear conceptions of the division of labor between board of directors and executive directors. This online survey of 114 executive directors aims to provide clarification and recommendations for social administration
A Full Characterization of Quantum Advice
We prove the following surprising result: given any quantum state rho on n
qubits, there exists a local Hamiltonian H on poly(n) qubits (e.g., a sum of
two-qubit interactions), such that any ground state of H can be used to
simulate rho on all quantum circuits of fixed polynomial size. In terms of
complexity classes, this implies that BQP/qpoly is contained in QMA/poly, which
supersedes the previous result of Aaronson that BQP/qpoly is contained in
PP/poly. Indeed, we can exactly characterize quantum advice, as equivalent in
power to untrusted quantum advice combined with trusted classical advice.
Proving our main result requires combining a large number of previous tools --
including a result of Alon et al. on learning of real-valued concept classes, a
result of Aaronson on the learnability of quantum states, and a result of
Aharonov and Regev on "QMA+ super-verifiers" -- and also creating some new
ones. The main new tool is a so-called majority-certificates lemma, which is
closely related to boosting in machine learning, and which seems likely to find
independent applications. In its simplest version, this lemma says the
following. Given any set S of Boolean functions on n variables, any function f
in S can be expressed as the pointwise majority of m=O(n) functions f1,...,fm
in S, such that each fi is the unique function in S compatible with O(log|S|)
input/output constraints.Comment: We fixed two significant issues: 1. The definition of YQP machines
needed to be changed to preserve our results. The revised definition is more
natural and has the same intuitive interpretation. 2. We needed properties of
Local Hamiltonian reductions going beyond those proved in previous works
(whose results we'd misstated). We now prove the needed properties. See p. 6
for more on both point
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