A randomized clinical trial in the management of Ardhavabhedaka to review the principle - “Nasa Hi Shiraso Dwaram”

Background: The purpose of Ayurveda as a medical system is to ensure a healthier and longer life to the humanity. Awareness about its holistic approach, its natural and mostly safe methods, and its potential for maintaining health is increasing globally. Ardhavabhedaka is a disease of Shiroroga, charecterised by pain in half side of Shira, Shankha, Akshi, Karna, Bru, Lalatavedana. It is a common clinical problem which occurs by episodic attacts of headache and associated symptoms such as nausea, sensitivity to light, sound, cold and head movements. Nasa is the gateway of Shira. The drug administered through nose as Nasya reaches the brain and eliminates only morbid Doshas responsible for producing the diseases of Urdhvajatrugatapradesha. The objectives were to study in detail about Nasa Hi Shirasodwaram, Gudadi Nasya in Ardhavabhedaka from Ayurvedic view and to evaluate the efficacy of Gudadi Nasya from Sharangadhara Samhita in management of Ardhavabhedaka. Methods: Total 30 subjects, having symptoms of Ardhavabhedaka were included. 30 subjects were assigned in a single group and all subjects were administered with Gudadi Nasya for 7 days 45 days follow up was done. Results were staticstically analysed before and after treatment by using unpaired ‘t’ test. Results: Among 30 subjects studied, 17 subjects showed marked relief, 11 subjects showed moderate relief and 02 subjects showed mild relief in the overall treatment

A Clinical Study to understand the efficacy of Prasarinyadi Taila Padabhyanga in Diabetic Peripheral Neuropathy w.s.r. to Madhumeha Janya Suptavata

Diabetic Peripheral Neuropathy of Modern science is a burning issue in the society with prevalence ranging from 10% to 48% where more than 21% of diabetics are diagnosed incidentally while diagnosing diabetic peripheral neuropathy. Ayurveda, a holistic science of health understands this condition as Suptavata, a Vata Nanatmaja Vyadhi which is the ultimate result of Padadaha and Suchivat Toda in Madhumehi. Diabetic Peripheral Neuropathy is caused due to the microangiopathy occurring secondary to the Hyperglycaemia and this is taken as Srotodushti Janya Vatavikruti leading to Suptata. Prasarinyadi Taila is a Yuktikruta Taila Yoga which is prepared using Prasarinyadi Kashaya and Prasarini Taila. Prasarini is the drug of choice in diseases having Sira-Snayu Sankocha as pathology, as it can act on such issue by Prasarana of Rakta. Microangiopathy and Sira-Snayu Sankocha are having similar output. Padabhyanga done using Prasarinyadi Taila in Suptavata can increase the circulation and there by correcting the pathology of Microangiopathy

A study on Nidana and Chikitsa of Mootravaha Sroto Dushti Vikara with Ahara Vidhi of Charaka Samhita

In the present modern life style, we do not take care of our health and the consequences of our eating habits and other styles of life, which are harmful for us. Ahar Vidhi Vidhan described in our classics which are the foundation of dietetics. Which indicates the method of Ahara, these are Ushna, Snigdha, Matravat, is consumed after the digestion of previously ingested food, Virya Avirudha Ahara.[1] Any slight disturbance at the level of Mootravaha Srotas, either structurally or functionally leads to Sammurchana of Dosha and Dushya[2] and as a result disease manifests inside the body. Handling the faulty dietic habits, diseases may be originated and aggravated. To study the effect of Ahara Vidhi in detail with correlation with Mootrvaha Sroto Vikaras in this literary study. Thus properly convincing about the importance of Ahara rules to prevent from diseases is very necessary in present situation of time

SHORT TERM CRIME FORECASTING FOR PREVENTION OF CRIMES: A STUDY OF SATARA DISTRICT

Abstract: This research paper highlights the importance of crime forecasting in crime prevention in Satara District police station jurisdiction. Crime investigation and prevention has very significant role of police system in any country. The crime data has been stored and processed using Common Integrated Police Application [CIPA] and it become useful for getting the criminal information but it does not help for the purpose of designing an action to prevent the crime, it has become a major challenge for police system to detect and prevent crimes and criminals. There is no any kind of information is available before happening of such criminal acts and it result into increasing crime rate. The presented paper highlights the use of Forecasting technique to identify the crime in a specific area which can be useful for crime prevention

Mineral dust increases the habitability of terrestrial planets but confounds biomarker detection

Identification of habitable planets beyond our solar system is a key goal of current and future space missions. Yet habitability depends not only on the stellar irradiance, but equally on constituent parts of the planetary atmosphere. Here we show, for the first time, that radiatively active mineral dust will have a significant impact on the habitability of Earth-like exoplanets. On tidally-locked planets, dust cools the day-side and warms the night-side, significantly widening the habitable zone. Independent of orbital configuration, we suggest that airborne dust can postpone planetary water loss at the inner edge of the habitable zone, through a feedback involving decreasing ocean coverage and increased dust loading. The inclusion of dust significantly obscures key biomarker gases (e.g. ozone, methane) in simulated transmission spectra, implying an important influence on the interpretation of observations.We demonstrate that future observational and theoretical studies of terrestrial exoplanets must consider the effect of dust

Predicting cancer involvement of genes from heterogeneous data

<p>Abstract</p> <p>Background</p> <p>Systematic approaches for identifying proteins involved in different types of cancer are needed. Experimental techniques such as microarrays are being used to characterize cancer, but validating their results can be a laborious task. Computational approaches are used to prioritize between genes putatively involved in cancer, usually based on further analyzing experimental data.</p> <p>Results</p> <p>We implemented a systematic method using the PIANA software that predicts cancer involvement of genes by integrating heterogeneous datasets. Specifically, we produced lists of genes likely to be involved in cancer by relying on: (i) protein-protein interactions; (ii) differential expression data; and (iii) structural and functional properties of cancer genes. The integrative approach that combines multiple sources of data obtained positive predictive values ranging from 23% (on a list of 811 genes) to 73% (on a list of 22 genes), outperforming the use of any of the data sources alone. We analyze a list of 20 cancer gene predictions, finding that most of them have been recently linked to cancer in literature.</p> <p>Conclusion</p> <p>Our approach to identifying and prioritizing candidate cancer genes can be used to produce lists of genes likely to be involved in cancer. Our results suggest that differential expression studies yielding high numbers of candidate cancer genes can be filtered using protein interaction networks. </p

The long-term fate of the hip arthrodesis: does it remain a valid procedure for selected cases in the 21st century?

Even in current orthopaedic practice, some cases are still not suitable candidates for hip replacement and hip fusion remains the only option in these highly selected patients. In this retrospective study we describe the long-term clinical outcome, quality of life and radiological evaluation of all adjacent joints in a cohort of 47 hip fusions. The main objective of our study was to show the long-term effects of a fusion. Thirty patients were analysed after an average of 18.2 years (range 6.2–30.5 years) with a mean SMFA of 31.2 (range 9–70). The VAS for pain for the fused hip was an average 1.9 (range 0–8), for the contralateral hip 2.0 (0–8), for the ipsilateral knee 2.0 (0–8), for the contralateral knee 1.8 (0–8) and for the lower back 3.6 (0–8). Average walking distance was 115 minutes (range 10–unlimited). Although the hip arthrodesis has lost popularity, it still is an option for the young patient with severe hip disorders, while leaving the possibility to perform a THA at a later stage. If the arthrodesis is performed with an optimal alignment of the leg, complaints from the adjacent joints are minimal, even in the long-term, and an acceptable quality of life can be obtained. We believe that in highly selected cases a hip fusion, even in current practice, is still a valid option

Measurement of the top quark mass using the matrix element technique in dilepton final states

We present a measurement of the top quark mass in pp¯ collisions at a center-of-mass energy of 1.96 TeV at the Fermilab Tevatron collider. The data were collected by the D0 experiment corresponding to an integrated luminosity of 9.7  fb−1. The matrix element technique is applied to tt¯ events in the final state containing leptons (electrons or muons) with high transverse momenta and at least two jets. The calibration of the jet energy scale determined in the lepton+jets final state of tt¯ decays is applied to jet energies. This correction provides a substantial reduction in systematic uncertainties. We obtain a top quark mass of mt=173.93±1.84  GeV

An expanded global inventory of allelic variation in the most extremely polymorphic region of Plasmodium falciparum merozoite surface protein 1 provided by short read sequence data.

BACKGROUND: Within Plasmodium falciparum merozoite surface protein 1 (MSP1), the N-terminal block 2 region is a highly polymorphic target of naturally acquired antibody responses. The antigenic diversity is determined by complex repeat sequences as well as non-repeat sequences, grouping into three major allelic types that appear to be maintained within populations by natural selection. Within these major types, many distinct allelic sequences have been described in different studies, but the extent and significance of the diversity remains unresolved. METHODS: To survey the diversity more extensively, block 2 allelic sequences in the msp1 gene were characterized in 2400 P. falciparum infection isolates with whole genome short read sequence data available from the Pf3K project, and compared with the data from previous studies. RESULTS: Mapping the short read sequence data in the 2400 isolates to a reference library of msp1 block 2 allelic sequences yielded 3815 allele scores at the level of major allelic family types, with 46% of isolates containing two or more of these major types. Overall frequencies were similar to those previously reported in other samples with different methods, the K1-like allelic type being most common in Africa, MAD20-like most common in Southeast Asia, and RO33-like being the third most abundant type in each continent. The rare MR type, formed by recombination between MAD20-like and RO33-like alleles, was only seen in Africa and very rarely in the Indian subcontinent but not in Southeast Asia. A combination of mapped short read assembly approaches enabled 1522 complete msp1 block 2 sequences to be determined, among which there were 363 different allele sequences, of which 246 have not been described previously. In these data, the K1-like msp1 block 2 alleles are most diverse and encode 225 distinct amino acid sequences, compared with 123 different MAD20-like, 9 RO33-like and 6 MR type sequences. Within each of the major types, the different allelic sequences show highly skewed geographical distributions, with most of the more common sequences being detected in either Africa or Asia, but not in both. CONCLUSIONS: Allelic sequences of this extremely polymorphic locus have been derived from whole genome short read sequence data by mapping to a reference library followed by assembly of mapped reads. The catalogue of sequence variation has been greatly expanded, so that there are now more than 500 different msp1 block 2 allelic sequences described. This provides an extensive reference for molecular epidemiological genotyping and sequencing studies, and potentially for design of a multi-allelic vaccine

Diffractive Dijet Production at sqrt(s)=630 and 1800 GeV at the Fermilab Tevatron

We report a measurement of the diffractive structure function $F_{jj}^D$ of the antiproton obtained from a study of dijet events produced in association with a leading antiproton in $\bar pp$ collisions at $\sqrt s=630$ GeV at the Fermilab Tevatron. The ratio of $F_{jj}^D$ at $\sqrt s=630$ GeV to $F_{jj}^D$ obtained from a similar measurement at $\sqrt s=1800$ GeV is compared with expectations from QCD factorization and with theoretical predictions. We also report a measurement of the $\xi$ ($x$-Pomeron) and $\beta$ ($x$ of parton in Pomeron) dependence of $F_{jj}^D$ at $\sqrt s=1800$ GeV. In the region $0.035<\xi<0.095$, $|t|<1$ GeV$^2$ and $\beta<0.5$, $F_{jj}^D(\beta,\xi)$ is found to be of the form $\beta^{-1.0\pm 0.1} \xi^{-0.9\pm 0.1}$, which obeys $\beta$-$\xi$ factorization.Comment: LaTeX, 9 pages, Submitted to Phys. Rev. Letter