Legislative History of the Special Adoption Act (Legislative History) (2012) (Korea)

In order to focus adoption procedures on the welfare of the child, national supervision must be strengthened, and a policy must be established around the basic paradigm that the best protection of a child is for the child to be raised by his/her birth family and in his/her birth country

Special Adoption Act (2012) (Korea)

The purpose of this Act is to set forth the necessary requirements and procedures of adopting a child in need of protection, and other matters necessary to support such adoptions, which are all aimed at promoting the rights and welfare of the adopted child

Rheological characterization and modeling of Laponite gels with application to snug-like locomotion

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.Leaf 86 blank.Includes bibliographical references (leaf 81-83).Using various concentrations of Laponite, results were obtained on an AR1000 rheometer through various testing methods: stress sweep, creep tests, and large amplitude oscillatory shear tests, defined as LAOS. Concentrations of 1%, 2%, 2.5%, 3%, and 4% wt. of Laponite and distilled water solutions were tested. Laponite gels over 1% wt. concentrations were characterized as yield stress materials, as determined by stress sweep, creep test, and LAOS tests. The stress sweeps determined the yield stress, and the creep tests verified the results with a range of creep tests over and below the yield stress discovered in the stress sweep tests. The LAOS tests mapped a specific "fingerprint" of how the Laponite gel behaved on a Lissajous figure of stress and strain. These LAOS results are then fit with an evolution of deformation model in Matlab over various oscillation stresses. The results show that slug slime emulation is possible by altering the Laponite gel's properties with polymers to result in a slug slime equivalent for use in studying slug locomotion.by Douglas C. Hwang.S.B

Localizing the Neural Substrate of Reflexive Covert Orienting

The capture of covert spatial attention by salient visual events influences subsequent gaze behavior. A task irrelevant stimulus (cue) can reduce (Attention capture) or prolong (Inhi-bition of return) saccade reaction time to a subsequent target stimulus depending on the cue-target delay. Here we investigated the mechanisms that underlie the sensory-based account of AC/IOR by manipulating the visual processing stage where the cue and target interact. In Experiment 1, liquid crystal shutter goggles were used to test whether AC/IOR occur at a monocular versus binocular processing stage (before versus after signals from both eyes converge). In Experiment 2, we tested whether visual orientation selective mechanisms are critical for AC/IOR by using oriented “Gabor” stimuli. We found that the magnitude of AC and IOR was not different between monocular and interocular viewing conditions, or between iso- and ortho-oriented cue-target interactions. The results suggest that the visual mechanisms that contribute to AC/IOR arise at an orientation-independent binocular processing stage

Use of Coronary Computed Tomographic Angiography to guide management of patients with coronary disease

Background In a prospective, multicenter, randomized controlled trial, 4,146 patients were randomized to receive standard care or standard care plus coronary computed tomography angiography (CCTA). Objectives The purpose of this study was to explore the consequences of CCTA-assisted diagnosis on invasive coronary angiography, preventive treatments, and clinical outcomes. Methods In post hoc analyses, we assessed changes in invasive coronary angiography, preventive treatments, and clinical outcomes using national electronic health records. Results Despite similar overall rates (409 vs. 401; p = 0.451), invasive angiography was less likely to demonstrate normal coronary arteries (20 vs. 56; hazard ratios [HRs]: 0.39 [95% confidence interval (CI): 0.23 to 0.68]; p < 0.001) but more likely to show obstructive coronary artery disease (283 vs. 230; HR: 1.29 [95% CI: 1.08 to 1.55]; p = 0.005) in those allocated to CCTA. More preventive therapies (283 vs. 74; HR: 4.03 [95% CI: 3.12 to 5.20]; p < 0.001) were initiated after CCTA, with each drug commencing at a median of 48 to 52 days after clinic attendance. From the median time for preventive therapy initiation (50 days), fatal and nonfatal myocardial infarction was halved in patients allocated to CCTA compared with those assigned to standard care (17 vs. 34; HR: 0.50 [95% CI: 0.28 to 0.88]; p = 0.020). Cumulative 6-month costs were slightly higher with CCTA: difference $462 (95$303 to $621). Conclusions In patients with suspected angina due to coronary heart disease, CCTA leads to more appropriate use of invasive angiography and alterations in preventive therapies that were associated with a halving of fatal and non-fatal myocardial infarction. (Scottish COmputed Tomography of the HEART Trial [SCOT-HEART]; NCT01149590

Study of aluminoborane compound AlB_4H_(11) for hydrogen storage

Aluminoborane compounds AlB_4H_(11), AlB_5H_(12), and AlB_6H_(13) were reported by Himpsl and Bond in 1981, but they have eluded the attention of the worldwide hydrogen storage research community for more than a quarter of a century. These aluminoborane compounds have very attractive properties for hydrogen storage: high hydrogen capacity (i.e., 13.5, 12.9, and 12.4 wt % H, respectively) and attractive hydrogen desorption temperature (i.e., AlB_4H_(11) decomposes at ~125 °C). We have synthesized AlB_4H_(11) and studied its thermal desorption behavior using temperature-programmed desorption with mass spectrometry, gas volumetric (Sieverts) measurement, infrared (IR) spectroscopy, and solid state nuclear magnetic resonance (NMR). Rehydrogenation of hydrogen-desorbed products was performed and encouraging evidence of at least partial reversibility for hydrogenation at relatively mild conditions is observed. Our chemical analysis indicates that the formula for the compound is closer to AlB_4H_(12) than AlB_4H_(11)

GOODS-Herschel: Separating High Redshift active galactic Nuclei and star forming galaxies Using Infrared Color Diagnostics

We have compiled a large sample of 151 high redshift (z=0.5-4) galaxies selected at 24 microns (S24>100 uJy) in the GOODS-N and ECDFS fields for which we have deep Spitzer IRS spectroscopy, allowing us to decompose the mid-infrared spectrum into contributions from star formation and activity in the galactic nuclei. In addition, we have a wealth of photometric data from Spitzer IRAC/MIPS and Herschel PACS/SPIRE. We explore how effective different infrared color combinations are at separating our mid-IR spectroscopically determined active galactic nuclei from our star forming galaxies. We look in depth at existing IRAC color diagnostics, and we explore new color-color diagnostics combining mid-IR, far-IR, and near-IR photometry, since these combinations provide the most detail about the shape of a source's IR spectrum. An added benefit of using a color that combines far-IR and mid-IR photometry is that it is indicative of the power source driving the IR luminosity. For our data set, the optimal color selections are S250/S24 vs. S8.0/S3.6 and S100/S24 vs. S8.0/S3.6; both diagnostics have ~10% contamination rate in the regions occupied primarily by star forming galaxies and active galactic nuclei, respectively. Based on the low contamination rate, these two new IR color-color diagnostics are ideal for estimating both the mid-IR power source of a galaxy when spectroscopy is unavailable and the dominant power source contributing to the IR luminosity. In the absence of far-IR data, we present color diagnostics using the WISE mid-IR bands which can efficiently select out high z (z~2) star forming galaxies.Comment: Accepted for publication in ApJ. 13 pages, 8 figure

Evidence for a wide range of UV obscuration in z ~ 2 dusty galaxies from the GOODS-Herschel survey

Dusty galaxies at z ~ 2 span a wide range of relative brightness between rest-frame mid-infrared (8um) and ultraviolet wavelengths. We attempt to determine the physical mechanism responsible for this diversity. Dust-obscured galaxies (DOGs), which have rest-frame mid-IR to UV flux density ratios > 1000, might be abnormally bright in the mid-IR, perhaps due to prominent AGN and/or PAH emission, or abnormally faint in the UV. We use far-infrared data from the GOODS-Herschel survey to show that most DOGs with 10^12 L_Sun < L_IR < 10^13 L_Sun are not abnormally bright in the mid-IR when compared to other dusty galaxies with similar IR (8--1000um) luminosities. We observe a relation between the median IR to UV luminosity ratios and the median UV continuum power-law indices for these galaxies, and we find that only 24% have specific star formation rates which indicate the dominance of compact star-forming regions. This circumstantial evidence supports the idea that the UV- and IR-emitting regions in these galaxies are spatially coincident, which implies a connection between the abnormal UV faintness of DOGs and dust obscuration. We conclude that the range in rest-frame mid-IR to UV flux density ratios spanned by dusty galaxies at z ~ 2 is due to differing amounts of UV obscuration. Of galaxies with these IR luminosities, DOGs are the most obscured. We attribute differences in UV obscuration to either: 1) differences in the degree of alignment between the spatial distributions of dust and massive stars, or 2) differences in the total dust content.Comment: 9 pages, 9 figures. Accepted by Ap

Safety and Availability of Clofazimine in the Treatment of Multidrug and Extensively Drug-Resistant Tuberculosis: Analysis of Published Guidance and Meta-Analysis of Cohort Studies

Objectives: Given the spread of multidrug-resistant tuberculosis (MDR-TB), new therapies are urgently needed, including the repurposing of existing drugs. We aimed to assess key considerations for the clinical and programmatic use of clofazimine (Cfz), a riminophenazine with anti-mycobacterial activity currently used to treat leprosy. Design: Fixed and random effects meta-analysis of cohort studies and systematic review Setting: Electronic and manual searches were combined. Inclusion criteria: Observational studies on treatment of multidrug- and extremely drug- resistant tuberculosis with clofazimine or a clofazimine-containing regimen, and published guidance and documents relating to cost and availability were eligible. Results: Five observational studies enrolled 861 patients, of which 602 received Cfz. The pooled proportion of adverse drug reactions requiring discontinuation of Cfz treatment was 0.1% (95% CI: [0.0, 0.6%]), and the median frequency of all adverse events was 5.1%. Cfz showed in vitro efficacy against Mycobacterium tuberculosis, and Cfz-containing regimens may have had a useful role in the treatment of patients with drug-resistant strains and who had limited alternative treatment options. However, Cfz uptake remains insufficient to meet global needs; there is only one internationally quality-assured manufacturer, which produces a limited quantity of the drug prioritised for treatment of leprosy, the only indication for which the drug is registered. Conclusions: While the data were limited, Cfz was associated with a risk for adverse drug reactions comparable to that of first-line TB treatment, which could be reasonably managed under programmatic conditions. However, low market availability and high cost are important barriers to access to Cfz for MDR-TB patients.Other Research Uni