317 research outputs found
Comparison of laboratory and in situ compressional-wave velocity measurements on sediment cores from the western North Atlantic
Author Posting. © American Geophysical Union, 1979. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 84, no. B2 (1979): 687–695, doi:10.1029/JB084iB02p00687.Laboratory and in situ velocity measurements have been made on six piston cores taken in the western North Atlantic Ocean. Sediments from the southwestern Bermuda Rise and Greater Antilles Outer Ridge are clays having velocities ranging mostly from 1500 to 1530 m/s and velocity gradients near 1 s−1. In cores from the Nares Abyssal Plain, the clayey sediments have comparable velocities, but interbedded silty turbidites exhibit much higher values (up to 1690 m/s). Velocity gradients are slightly higher in the abyssal-plain cores. After the laboratory measurements are corrected to in situ conditions, they show reasonable agreement in average velocity and velocity gradient with in situ measurements, although the in situ velocities average 10–12 m/s higher in the clayey cores and 15–20 m/s higher in the turbidites. This difference may be caused by reduction in the dynamic frame bulk modulus and/or the dynamic shear modulus due to visually undetected coring disturbance. The profilometer used to obtain the in situ measurements does not record the fine-scale variations in velocity that were measured in the laboratory, but it accurately determines average velocities and velocity gradient. Where cores were closely spaced (2–12 km apart), inter-core correlations in lithology, velocity, and bulk properties are possible. Fluctuations in the latter two parameters are very similar in position and magnitude from core to core, suggesting either that effects of coring disturbance are small or that they are uniform in a given kind of sedimentary bed. Inter-core comparison also shows that some beds are laterally discontinuous as a result of local (less than a few kilometers) patterns of seafloor erosion and deposition.At Lamont-Doherty Geological Observatory the study of acoustic and physical properties of sea-floor sediments is supported by the Office of Naval Research under contract N00014-75-C-0210, and at Applied Research Laboratories, University of Texas, by ONR contract N00014-76-C-0117
MApping the Most Massive Overdensities Through Hydrogen (MAMMOTH) I: Methodology
Modern cosmology predicts that a galaxy overdensity is associated to a large
reservoir of the intergalactic gas, which can be traced by the Ly
forest absorption. We have undertaken a systematic study of the relation
between Coherently Strong intergalactic Ly Absorption systems (CoSLAs),
which have highest optical depth () in distribution, and mass
overdensities on the scales of 10 - 20 comoving Mpc. On such
large scales, our cosmological simulations show a strong correlation between
the effective optical depth () of the CoSLAs and the 3-D mass
overdensities. In moderate signal-to-noise spectra, however, the profiles of
CoSLAs can be confused with high column density absorbers. For , where
the corresponding Ly is redshifted to the optical, we have developed the
technique to differentiate between these two alternatives. We have applied this
technique to SDSS-III quasar survey at - 3.3, and we present a sample
of five CoSLA candidates with on 15 Mpc greater than
the mean optical depth. At lower redshifts of , where the
background quasar density is higher, the overdensity can be traced by
intergalactic absorption groups using multiple sight lines. Our overdensity
searches fully utilize the current and next generation of Ly forest
surveys which cover a survey volume of Gpc). In addition,
systems traced by CoSLAs will build a uniform sample of the most massive
overdensities at to constrain the models of structure formation, and
offer a unique laboratory to study the interactions between galaxy
overdensities and the intergalactic medium.Comment: 24 pages, 30 figures, 8 tables, submitted to the Astrophysical
Journa
Clinical trialist perspectives on the ethics of adaptive clinical trials: a mixed-methods analysis
Abstract
Background
In an adaptive clinical trial (ACT), key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. In addition to having distinguishing scientific features, adaptive trials also may involve ethical considerations that differ from more traditional randomized trials. Better understanding of clinical trial experts’ views about the ethical aspects of adaptive designs could assist those planning ACTs. Our aim was to elucidate the opinions of clinical trial experts regarding their beliefs about ethical aspects of ACTs.
Methods
We used a convergent, mixed-methods design employing a 22-item ACTs beliefs survey with visual analog scales and open-ended questions and mini-focus groups. We developed a coding scheme to conduct thematic searches of textual data, depicted responses to visual analog scales on box-plot diagrams, and integrated findings thematically. Fifty-three clinical trial experts from four constituent groups participated: academic biostatisticians (n = 5); consultant biostatisticians (n = 6); academic clinicians (n = 22); and other stakeholders including patient advocacy, National Institutes of Health, and U.S. Food and Drug Administration representatives (n = 20).
Results
The respondents recognized potential ethical benefits of ACTs, including a higher probability of receiving an effective intervention for participants, optimizing resource utilization, and accelerating treatment discovery. Ethical challenges voiced include developing procedures so trial participants can make informed decisions about taking part in ACTs and plausible, though unlikely risks of research personnel altering enrollment patterns.
Conclusions
Clinical trial experts recognize ethical advantages but also pose potential ethical challenges of ACTs. The four constituencies differ in their weighing of ACT ethical considerations based on their professional vantage points. These data suggest further discussion about the ethics of ACTs is needed to facilitate ACT planning, design and conduct, and ultimately better allow planners to weigh ethical implications of competing trial designs.http://deepblue.lib.umich.edu/bitstream/2027.42/111302/1/12910_2015_Article_22.pd
Characterizing unknown systematics in large scale structure surveys
Photometric large scale structure (LSS) surveys probe the largest volumes in
the Universe, but are inevitably limited by systematic uncertainties. Imperfect
photometric calibration leads to biases in our measurements of the density
fields of LSS tracers such as galaxies and quasars, and as a result in
cosmological parameter estimation. Earlier studies have proposed using
cross-correlations between different redshift slices or cross-correlations
between different surveys to reduce the effects of such systematics. In this
paper we develop a method to characterize unknown systematics. We demonstrate
that while we do not have sufficient information to correct for unknown
systematics in the data, we can obtain an estimate of their magnitude. We
define a parameter to estimate contamination from unknown systematics using
cross-correlations between different redshift slices and propose discarding
bins in the angular power spectrum that lie outside a certain contamination
tolerance level. We show that this method improves estimates of the bias using
simulated data and further apply it to photometric luminous red galaxies in the
Sloan Digital Sky Survey as a case study.Comment: 24 pages, 6 figures; Expanded discussion of results, added figure 2;
Version to be published in JCA
Intravascular ultrasound scanning improves long-term patency of iliac lesions treated with balloon angioplasty and primary stenting
AbstractPurpose: Underdeployment of an intravascular stent has been identified as a cause of restenosis or occlusion of a treated arterial lesion. Intravascular ultrasound (IVUS) has been shown to initially improve the anatomic and clinical stenting. The purpose of this study was to determine whether the use of IVUS increased long-term patency of this intervention. Methods: Between March 1992 and October 1995, 71 limbs (52 patients) with symptomatic aortoiliac occlusive disease underwent balloon angioplasty with primary stenting. IVUS and arteriography were used in 49 limbs (36 patients) to evaluate stent deployment. Arteriography alone was used in 22 limbs (16 patients) to evaluate stent deployment. Patients were captured prospectively in a vascular registry and retrospectively reviewed. Results: Mean age of patients treated with IVUS was 61.1 ± 9.0 years (range, 38-85) versus 70.0 ± 10.1 years (range, 57-87) in patients treated without IVUS (P <.01). There was no difference between the groups with respect to preoperative comorbidities, ankle-brachial indices, or number of stents per limb. Mean follow-up for IVUS patients was 62.1 ± 7.3 months (range, 15-81) and 57.9 ± 8.7 months (range, 8-80) for patients treated without IVUS (P = not significant). In 40% (20/49) of limbs, IVUS demonstrated inadequate stent deployment at the time of the original procedure. Kaplan-Meier 3- and 6-year primary patency estimates were 100% and 100% in the IVUS group and 82% and 69%, respectively, in limbs treated without IVUS (P <.001). There have been no secondary procedures performed in limbs treated with IVUS and a 23% (5/22) secondary intervention rate in the non-IVUS group (P <.05). Overall Kaplan-Meier survival estimates at 3 and 6 years for all patients were 84% and 67%, respectively. Conclusion: Balloon angioplasty and primary stenting of symptomatic aortoiliac occlusive lesions is a durable treatment option. Long-term follow-up of treated patients shows outcomes that are comparable with direct surgical intervention. IVUS significantly improved the long-term patency of iliac arterial lesions treated with balloon angioplasty and stenting by defining the appropriate angioplasty diameter endpoint and adequacy of stent deployment. (J Vasc Surg 2002;35:316-23.
The clustering of Galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey : including covariance matrix errors
JP acknowledges support from the UK Science & Technology Facilities Council (STFC) through the consolidated grant ST/K0090X/1 and from the European Research Council through the ‘Starting Independent Research’ grant 202686, MDEPUGS. AGS acknowledges support from the Trans-regional Collaborative Research Centre TR33 ‘The Dark Universe’ of the German Research Foundation (DFG).We present improved methodology for including covariance matrices in the error budget of Baryon Oscillation Spectroscopic Survey (BOSS) galaxy clustering measurements, revisiting Data Release 9 (DR9) analyses, and describing a method that is used in DR10/11 analyses presented in companion papers. The precise analysis method adopted is becoming increasingly important, due to the precision that BOSS can now reach: even using as many as 600 mock catalogues to estimate covariance of two-point clustering measurements can still lead to an increase in the errors of ∼20 per cent, depending on how the cosmological parameters of interest are measured. In this paper, we extend previous work on this contribution to the error budget, deriving formulae for errors measured by integrating over the likelihood, and to the distribution of recovered best-fitting parameters fitting the simulations also used to estimate the covariance matrix. Both are situations that previous analyses of BOSS have considered. We apply the formulae derived to baryon acoustic oscillation (BAO) and redshift-space distortion (RSD) measurements from BOSS in our companion papers. To further aid these analyses, we consider the optimum number of bins to use for two-point measurements using the monopole power spectrum or correlation function for BAO, and the monopole and quadrupole moments of the correlation function for anisotropic-BAO and RSD measurements.Publisher PDFPeer reviewe
Sloan Digital Sky Survey III Photometric Quasar Clustering: Probing the Initial Conditions of the Universe using the Largest Volume
The Sloan Digital Sky Survey has surveyed 14,555 square degrees of the sky,
and delivered over a trillion pixels of imaging data. We present the
large-scale clustering of 1.6 million quasars between z = 0.5 and z = 2.5 that
have been classified from this imaging, representing the highest density of
quasars ever studied for clustering measurements. This data set spans ~11,000
square degrees and probes a volume of 80(Gpc/h)^3. In principle, such a large
volume and medium density of tracers should facilitate high-precision
cosmological constraints. We measure the angular clustering of photometrically
classified quasars using an optimal quadratic estimator in four redshift slices
with an accuracy of ~25% over a bin width of l ~10 - 15 on scales corresponding
to matter-radiation equality and larger (l ~ 2 - 30). Observational systematics
can strongly bias clustering measurements on large scales, which can mimic
cosmologically relevant signals such as deviations from Gaussianity in the
spectrum of primordial perturbations. We account for systematics by employing a
new method recently proposed by Agarwal et al. (2014) to the clustering of
photometrically classified quasars. We carefully apply our methodology to
mitigate known observational systematics and further remove angular bins that
are contaminated by unknown systematics. Combining quasar data with the
photometric luminous red galaxy (LRG) sample of Ross et al. (2011) and Ho et
al. (2012), and marginalizing over all bias and shot noise-like parameters, we
obtain a constraint on local primordial non-Gaussianity of fNL = -113+/-154
(1\sigma error). [Abridged]Comment: 35 pages, 15 figure
The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey : cosmological implications of the full shape of the clustering wedges in the data release 10 and 11 galaxy samples
We explore the cosmological implications of the angle-averaged correlation function, ξ(s), and the clustering wedges, ξ⊥(s) and ξ∥(s), of the LOWZ and CMASS galaxy samples from Data Releases 10 and 11 of the Sloan Digital Sky Survey III (SDSS-III) Baryon Oscillation Spectroscopic Survey. Our results show no significant evidence for a deviation from the standard Λ cold dark matter model. The combination of the information from our clustering measurements with recent data from the cosmic microwave background is sufficient to constrain the curvature of the Universe to Ωk = 0.0010 ± 0.0029, the total neutrino mass to ∑mν < 0.23 eV (95 per cent confidence level), the effective number of relativistic species to Neff = 3.31 ± 0.27 and the dark energy equation of state to wDE = −1.051 ± 0.076. These limits are further improved by adding information from Type Ia supernovae and baryon acoustic oscillations from other samples. In particular, this data set combination is completely consistent with a time-independent dark energy equation of state, in which case we find wDE = −1.024 ± 0.052. We explore the constraints on the growth rate of cosmic structures assuming f(z) = Ωm(z)γ and obtain γ = 0.69 ± 0.15, consistent with the predictions of general relativity of γ = 0.55.Publisher PDFPeer reviewe
The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: single-probe measurements from CMASS anisotropic galaxy clustering
With the largest spectroscopic galaxy survey volume drawn from the SDSS-III
Baryon Oscillation Spectroscopic Survey (BOSS), we can extract cosmological
constraints from the measurements of redshift and geometric distortions at
quasi-linear scales (e.g. above 50 Mpc). We analyze the broad-range
shape of the monopole and quadrupole correlation functions of the BOSS Data
Release 12 (DR12) CMASS galaxy sample, at the effective redshift , to
obtain constraints on the Hubble expansion rate , the angular-diameter
distance , the normalized growth rate , and the
physical matter density . We obtain robust measurements by
including a polynomial as the model for the systematic errors, and find it
works very well against the systematic effects, e.g., ones induced by stars and
seeing. We provide accurate measurements ,
, , = , , , ,
where is the comoving sound horizon at the drag epoch and
Mpc is the sound scale of the fiducial cosmology used in
this study. The parameters which are not well constrained by our galaxy
clustering analysis are marginalized over with wide flat priors. Since no
priors from other data sets, e.g., cosmic microwave background (CMB), are
adopted and no dark energy models are assumed, our results from BOSS CMASS
galaxy clustering alone may be combined with other data sets, i.e., CMB, SNe,
lensing or other galaxy clustering data to constrain the parameters of a given
cosmological model. The uncertainty on the dark energy equation of state
parameter, , from CMB+CMASS is about 8 per cent. The uncertainty on the
curvature fraction, , is 0.3 per cent. We do not find deviation from
flat CDM.Comment: 15 pages, 11 figures. The latest version matches and the accepted
version by MNRAS. A bug in the first version has been identified and fixed in
the new version. We have redone the analysis with newest data (BOSS DR12
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