A photometrically and spectroscopically confirmed population of passive spiral galaxies

We have identified a population of passive spiral galaxies from photometry and integral field spectroscopy. We selected z < 0.035 spiral galaxies that have WISE colours consistent with little mid-infrared emission from warm dust. Matched aperture photometry of 51 spiral galaxies in ultraviolet, optical and mid-infrared show these galaxies have colours consistent with passive galaxies. Six galaxies form a spectroscopic pilot study and were observed using the Wide-Field Spectrograph to check for signs of nebular emission from star formation. We see no evidence of substantial nebular emission found in previous red spiral samples. These six galaxies possess absorption-line spectra with 4000 Å breaks consistent with an average luminosity-weighted age of 2.3 Gyr. Our photometric and integral field spectroscopic observations confirm the existence of a population of local passive spiral galaxies, implying that transformation into early-type morphologies is not required for the quenching of star formation

Intervention effects and long-term changes in physical activity and cardiometabolic outcomes among children at risk of noncommunicable diseases in South Africa: a cluster-randomized controlled trial and follow-up analysis

INTRODUCTION: Risk factors for noncommunicable diseases such as insufficient physical activity (PA), overweight or hypertension are becoming increasingly predominant among children globally. While school-based interventions are promising preventive strategies, evidence of their long-term effectiveness, especially among vulnerable populations, is scarce. We aim to assess the short-term effects of the physical and health KaziKidz intervention on cardiometabolic risk factors and the long-term, pre-and post-COVID-19 pandemic changes thereof in high-risk children from marginalized communities. METHODS: The intervention was tested in a cluster-randomized controlled trial between January and October 2019 in eight primary schools near Gqeberha, South Africa. Children with overweight, elevated blood pressure, pre-diabetes, and/or borderline dyslipidemia were identified and re-assessed 2 years post-intervention. Study outcomes included accelerometry-measured PA (MVPA), body mass index (BMI), mean arterial pressure (MAP), glucose (HbA1c), and lipid levels (TC to HDL ratio). We conducted mixed regression analyses to assess intervention effects by cardiometabolic risk profile, and Wilcoxon signed-rank tests to evaluate longitudinal changes in the high-risk subpopulation. RESULTS: We found a significant intervention effect on MVPA during school hours for physically inactive children, and among active as well as inactive girls. In contrast, the intervention lowered HbA1c and TC to HDL ratio only in children with glucose or lipid values within the norm, respectively. At follow-up, the intervention effects were not maintained in at-risk children, who showed a decline in MVPA, and an increase in BMI-for-age, MAP, HbA1c and TC to HDL ratio. CONCLUSION: We conclude that schools are key settings in which to promote PA and improve health; however, structural changes are necessary to ensure that effective interventions reach marginalized school populations and achieve sustainable impact

The Clustering and Halo Masses of Star Forming Galaxies at z<1

We present clustering measurements and halo masses of star forming galaxies at 0.2 < z < 1.0. After excluding AGN, we construct a sample of 22553 24 {\mu}m sources selected from 8.42 deg^2 of the Spitzer MIPS AGN and Galaxy Evolution Survey of Bo\"otes. Mid-infrared imaging allows us to observe galaxies with the highest star formation rates (SFRs), less biased by dust obscuration afflicting the optical bands. We find that the galaxies with the highest SFRs have optical colors which are redder than typical blue cloud galaxies, with many residing within the green valley. At z > 0.4 our sample is dominated by luminous infrared galaxies (LIRGs, L_TIR > 10^11 Lsun) and is comprised entirely of LIRGs and ultra-luminous infrared galaxies (ULIRGs, L_TIR > 10^12 Lsun) at z > 0.6. We observe weak clustering of r_0 = 3-6 Mpc/h for almost all of our star forming samples. We find that the clustering and halo mass depend on L_TIR at all redshifts, where galaxies with higher L_TIR (hence higher SFRs) have stronger clustering. Galaxies with the highest SFRs at each redshift typically reside within dark matter halos of M_halo ~ 10^12.9 Msun/h. This is consistent with a transitional halo mass, above which star formation is largely truncated, although we cannot exclude that ULIRGs reside within higher mass halos. By modeling the clustering evolution of halos, we connect our star forming galaxy samples to their local descendants. Most star forming galaxies at z < 1.0 are the progenitors of L < 2.5L* blue galaxies in the local universe, but star forming galaxies with the highest SFRs (L_TIR >10^11.7 Lsun) at 0.6<z<1.0 are the progenitors of early-type galaxies in denser group environments.Comment: 18 pages, 16 figures, 2 tables. Accepted for publication in the Astrophysical Journa

Clustering of the AKARI NEP deep field 24<i>μ</i>m selected galaxies

Aims. We present a method of selection of 24 μm galaxies from the AKARI north ecliptic pole (NEP) deep field down to 150 μJy and measurements of their two-point correlation function. We aim to associate various 24 μm selected galaxy populations with present day galaxies and to investigate the impact of their environment on the direction of their subsequent evolution. Methods. We discuss using of Support Vector Machines (SVM) algorithm applied to infrared photometric data to perform star-galaxy separation, in which we achieve an accuracy higher than 80%. The photometric redshift information, obtained through the CIGALE code, is used to explore the redshift dependence of the correlation function parameter (r0) as well as the linear bias evolution. This parameter relates galaxy distribution to the one of the underlying dark matter. We connect the investigated sources to their potential local descendants through a simplified model of the clustering evolution without interactions. Results. We observe two different populations of star-forming galaxies, at zmed ∼ 0.25, zmed ∼ 0.9. Measurements of total infrared luminosities (LTIR) show that the sample at zmed ∼ 0.25 is composed mostly of local star-forming galaxies, while the sample at zmed ∼ 0.9 is composed of luminous infrared galaxies (LIRGs) with LTIR ∼ 1011.62 L⨀. We find that dark halo mass is not necessarily correlated with the LTIR: for subsamples with LTIR = 1011.15 L⨀ at zmed ∼ 0.7 we observe a higher clustering length (r0 = 6.21 ± 0.78 [h−1Mpc]) than for a subsample with mean LTIR = 1011.84 L⨀ at zmed ∼ 1.1 (r0 = 5.86 ± 0.69 h−1Mpc). We find that galaxies at zmed ∼ 0.9 can be ancestors of present day L∗ early type galaxies, which exhibit a very high r0 ∼ 8h−1 Mpc.</p

Genome wide association study identifies KCNMA1 contributing to human obesity

<p>Abstract</p> <p>Background</p> <p>Recent genome-wide association (GWA) analyses have identified common single nucleotide polymorphisms (SNPs) that are associated with obesity. However, the reported genetic variation in obesity explains only a minor fraction of the total genetic variation expected to be present in the population. Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity.</p> <p>Methods</p> <p>We performed a GWA analysis in 164 morbidly obese subjects (BMI:body mass index > 40 kg/m²) and 163 Swedish subjects (> 45 years) who had always been lean. The 700 SNPs displaying the strongest association with obesity in the GWA were analyzed in a second cohort comprising 460 morbidly obese subjects and 247 consistently lean Swedish adults. 23 SNPs remained significantly associated with obesity (nominal <it>P</it>< 0.05) and were in a step-wise manner followed up in five additional cohorts from Sweden, France, and Germany together comprising 4214 obese and 5417 lean or population-based control individuals. Three samples, n = 4133, were used to investigate the population-based associations with BMI. Gene expression in abdominal subcutaneous adipose tissue in relation to obesity was investigated for14 adults.</p> <p>Results</p> <p>Potassium channel, calcium activated, large conductance, subfamily M, alpha member <it>(KCNMA1) </it>rs2116830*G and <it>BDNF </it>rs988712*G were associated with obesity in five of six investigated case-control cohorts. In meta-analysis of 4838 obese and 5827 control subjects we obtained genome-wide significant allelic association with obesity for <it>KCNMA1 </it>rs2116830*G with <it>P </it>= 2.82 × 10^-10and an odds ratio (OR) based on cases vs controls of 1.26 [95% C.I. 1.12-1.41] and for <it>BDNF </it>rs988712*G with <it>P </it>= 5.2 × 10^-17and an OR of 1.36 [95% C.I. 1.20-1.55]. <it>KCNMA1 </it>rs2116830*G was not associated with BMI in the population-based samples. Adipose tissue (<it>P </it>= 0.0001) and fat cell (<it>P </it>= 0.04) expression of <it>KCNMA1 </it>was increased in obesity.</p> <p>Conclusions</p> <p>We have identified <it>KCNMA1 </it>as a new susceptibility locus for obesity, and confirmed the association of the <it>BDNF </it>locus at the genome-wide significant level.</p

Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma?

International audienceBackground: The growth factor Angiotensin-2 signals through Angiotensin receptor type 1 (AT1-R) in a broad range of cell types and tumours and through the type-2 receptor (AT2-R) in a more restricted group of cell types. Although numerous forms of cancer have been shown to overexpress AT1-R, expression of AT1-R and AT2-R by human renal clear-cell carcinoma (RCCC) is not well understood. In this study, the expression of both angiotensin receptors was quantified in a retrospective series of RCCC and correlated with prognostic factors.Methods: Angiotensin receptor type 1 and AT2-R expressions were quantified on tumour tissues by immunohistochemistry (IHC), western blot and quantitative reverse transcriptase PCR (qRT–PCR). IHC results were correlated to Fuhrman's grade and patient progression-free survival (PFS).Results: A total of 84 RCCC were analysed. By IHC, AT1-R and AT2-R were expressed to a greater level in high-grade tumours (AT1-R: P<0.001, AT2-R: P<0.001). Univariate analysis showed a correlation between PFS and AT1-R or AT2-R expression (P=0.001). By multivariate analysis, only AT2-R expression correlated with PFS (HR 1.021, P=0.006) and cancer stage (P<0.001). By western blot, AT1-R and AT1-R were also found to be overexpressed in higher Fuhrman's grade (P<0.01 and P=0.001 respectively). By qRT–PCR, AT1-R but not AT2-R mRNA were downregulated (P=0.001 and P=0.118, respectively).Conclusion: Our results show that AT1-R and AT2-R proteins are overexpressed in the most aggressive forms of RCCC and that AT2-R expression correlates with PFS. AT1-R or AT2-R blockage could, therefore, offer novel directions for anti-RCCC therapy

Dietary factors impact on the association between CTSS variants and obesity related traits.

Cathepsin S, a protein coded by the CTSS gene, is implicated in adipose tissue biology--this protein enhances adipose tissue development. Our hypothesis is that common variants in CTSS play a role in body weight regulation and in the development of obesity and that these effects are influenced by dietary factors--increased by high protein, glycemic index and energy diets